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Protein

NK1 transcription factor-related protein 2

Gene

NKX1-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function in cell specification, particularly in the CNS.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi163 – 22260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 2
Alternative name(s):
Homeobox protein SAX-1
NKX-1.1
Gene namesi
Name:NKX1-2
Synonyms:C10orf121, NKX1.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:31652. NKX1-2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977174.

Polymorphism and mutation databases

BioMutaiNKX1-2.
DMDMi338817978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310NK1 transcription factor-related protein 2PRO_0000325972Add
BLAST

Proteomic databases

PRIDEiQ9UD57.

PTM databases

PhosphoSiteiQ9UD57.

Expressioni

Gene expression databases

CleanExiHS_NKX1-2.

Organism-specific databases

HPAiHPA029367.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000450924.

Structurei

3D structure databases

ProteinModelPortaliQ9UD57.
SMRiQ9UD57. Positions 164-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 936Poly-Glu
Compositional biasi134 – 1374Poly-Gly
Compositional biasi150 – 1556Poly-Arg
Compositional biasi224 – 25936Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the NK-1 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG052632.
InParanoidiQ9UD57.
KOiK09309.
OrthoDBiEOG7R2BM5.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UD57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR PAPREARKSL
60 70 80 90 100
AEVEAGKDAS SRDPVRQLET PDAAGPGAGQ ASPLEGSEAE EEEDAEDPRR
110 120 130 140 150
PRLRERAARL LPGLARSPDA PAGALASGEP CEDGGGGPVR SPPGSPGSPR
160 170 180 190 200
PRRRRLEPNC AKPRRARTAF TYEQLVALEN KFRATRYLSV CERLNLALSL
210 220 230 240 250
SLTETQVKIW FQNRRTKWKK QNPGADGAAQ VGGGAPQPGA AGGGGGGGSG
260 270 280 290 300
GSPGPPGTGA LHFQTFPSYS AANVLFPSAA SFPLTAAAPG SPFAPFLGPS
310
YLTPFYAPRL
Length:310
Mass (Da):32,381
Last modified:June 28, 2011 - v3
Checksum:iFF2D02B4DCFC5689
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445237 Genomic DNA. No translation available.
CCDSiCCDS59221.1.
RefSeqiNP_001139812.1. NM_001146340.1.
UniGeneiHs.712041.

Genome annotation databases

EnsembliENST00000451024; ENSP00000451945; ENSG00000229544.
GeneIDi390010.
KEGGihsa:390010.
UCSCiuc010quf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445237 Genomic DNA. No translation available.
CCDSiCCDS59221.1.
RefSeqiNP_001139812.1. NM_001146340.1.
UniGeneiHs.712041.

3D structure databases

ProteinModelPortaliQ9UD57.
SMRiQ9UD57. Positions 164-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000450924.

PTM databases

PhosphoSiteiQ9UD57.

Polymorphism and mutation databases

BioMutaiNKX1-2.
DMDMi338817978.

Proteomic databases

PRIDEiQ9UD57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451024; ENSP00000451945; ENSG00000229544.
GeneIDi390010.
KEGGihsa:390010.
UCSCiuc010quf.2. human.

Organism-specific databases

CTDi390010.
GeneCardsiGC10M126135.
H-InvDBHIX0170557.
HGNCiHGNC:31652. NKX1-2.
HPAiHPA029367.
neXtProtiNX_Q9UD57.
PharmGKBiPA134977174.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118940.
HOVERGENiHBG052632.
InParanoidiQ9UD57.
KOiK09309.
OrthoDBiEOG7R2BM5.
TreeFamiTF316128.

Miscellaneous databases

NextBioi103265.
PROiQ9UD57.

Gene expression databases

CleanExiHS_NKX1-2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
    Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
    Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-209.
    Tissue: Bone marrow.

Entry informationi

Entry nameiNKX12_HUMAN
AccessioniPrimary (citable) accession number: Q9UD57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: June 24, 2015
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.