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Q9UD57

- NKX12_HUMAN

UniProt

Q9UD57 - NKX12_HUMAN

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Protein
NK1 transcription factor-related protein 2
Gene
NKX1-2, C10orf121, NKX1.1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May function in cell specification, particularly in the CNS By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi163 – 22260Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 2
Alternative name(s):
Homeobox protein SAX-1
NKX-1.1
Gene namesi
Name:NKX1-2
Synonyms:C10orf121, NKX1.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:31652. NKX1-2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310NK1 transcription factor-related protein 2
PRO_0000325972Add
BLAST

Proteomic databases

PRIDEiQ9UD57.

PTM databases

PhosphoSiteiQ9UD57.

Expressioni

Gene expression databases

CleanExiHS_NKX1-2.
GenevestigatoriQ9UD57.

Organism-specific databases

HPAiHPA029367.

Structurei

3D structure databases

ProteinModelPortaliQ9UD57.
SMRiQ9UD57. Positions 164-220.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 936Poly-Glu
Compositional biasi134 – 1374Poly-Gly
Compositional biasi150 – 1556Poly-Arg
Compositional biasi224 – 25936Gly-rich
Add
BLAST

Sequence similaritiesi

Belongs to the NK-1 homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG052632.
KOiK09309.
OrthoDBiEOG7R2BM5.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UD57-1 [UniParc]FASTAAdd to Basket

« Hide

MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR PAPREARKSL    50
AEVEAGKDAS SRDPVRQLET PDAAGPGAGQ ASPLEGSEAE EEEDAEDPRR 100
PRLRERAARL LPGLARSPDA PAGALASGEP CEDGGGGPVR SPPGSPGSPR 150
PRRRRLEPNC AKPRRARTAF TYEQLVALEN KFRATRYLSV CERLNLALSL 200
SLTETQVKIW FQNRRTKWKK QNPGADGAAQ VGGGAPQPGA AGGGGGGGSG 250
GSPGPPGTGA LHFQTFPSYS AANVLFPSAA SFPLTAAAPG SPFAPFLGPS 300
YLTPFYAPRL 310
Length:310
Mass (Da):32,381
Last modified:June 28, 2011 - v3
Checksum:iFF2D02B4DCFC5689
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445237 Genomic DNA. No translation available.
CCDSiCCDS59221.1.
RefSeqiNP_001139812.1. NM_001146340.1.
UniGeneiHs.712041.

Genome annotation databases

EnsembliENST00000451024; ENSP00000451945; ENSG00000229544.
GeneIDi390010.
KEGGihsa:390010.
UCSCiuc010quf.2. human.

Polymorphism databases

DMDMi338817978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445237 Genomic DNA. No translation available.
CCDSi CCDS59221.1.
RefSeqi NP_001139812.1. NM_001146340.1.
UniGenei Hs.712041.

3D structure databases

ProteinModelPortali Q9UD57.
SMRi Q9UD57. Positions 164-220.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9UD57.

Polymorphism databases

DMDMi 338817978.

Proteomic databases

PRIDEi Q9UD57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000451024 ; ENSP00000451945 ; ENSG00000229544 .
GeneIDi 390010.
KEGGi hsa:390010.
UCSCi uc010quf.2. human.

Organism-specific databases

CTDi 390010.
GeneCardsi GC10M126135.
H-InvDB HIX0170557.
HGNCi HGNC:31652. NKX1-2.
HPAi HPA029367.
neXtProti NX_Q9UD57.
PharmGKBi PA134977174.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG052632.
KOi K09309.
OrthoDBi EOG7R2BM5.
TreeFami TF316128.

Miscellaneous databases

NextBioi 103265.
PROi Q9UD57.

Gene expression databases

CleanExi HS_NKX1-2.
Genevestigatori Q9UD57.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
    Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
    Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-209.
    Tissue: Bone marrow.

Entry informationi

Entry nameiNKX12_HUMAN
AccessioniPrimary (citable) accession number: Q9UD57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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