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Q9UD57 (NKX12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NK1 transcription factor-related protein 2
Alternative name(s):
Homeobox protein SAX-1
NKX-1.1
Gene names
Name:NKX1-2
Synonyms:C10orf121, NKX1.1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function in cell specification, particularly in the CNS By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the NK-1 homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310NK1 transcription factor-related protein 2
PRO_0000325972

Regions

DNA binding163 – 22260Homeobox
Compositional bias88 – 936Poly-Glu
Compositional bias134 – 1374Poly-Gly
Compositional bias150 – 1556Poly-Arg
Compositional bias224 – 25936Gly-rich

Sequences

Sequence LengthMass (Da)Tools
Q9UD57 [UniParc].

Last modified June 28, 2011. Version 3.
Checksum: FF2D02B4DCFC5689

FASTA31032,381
        10         20         30         40         50         60 
MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR PAPREARKSL AEVEAGKDAS 

        70         80         90        100        110        120 
SRDPVRQLET PDAAGPGAGQ ASPLEGSEAE EEEDAEDPRR PRLRERAARL LPGLARSPDA 

       130        140        150        160        170        180 
PAGALASGEP CEDGGGGPVR SPPGSPGSPR PRRRRLEPNC AKPRRARTAF TYEQLVALEN 

       190        200        210        220        230        240 
KFRATRYLSV CERLNLALSL SLTETQVKIW FQNRRTKWKK QNPGADGAAQ VGGGAPQPGA 

       250        260        270        280        290        300 
AGGGGGGGSG GSPGPPGTGA LHFQTFPSYS AANVLFPSAA SFPLTAAAPG SPFAPFLGPS 

       310 
YLTPFYAPRL 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of homeobox genes expressed in human haemopoietic progenitor cells."
Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-209.
Tissue: Bone marrow.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL445237 Genomic DNA. No translation available.
CCDSCCDS59221.1.
RefSeqNP_001139812.1. NM_001146340.1.
UniGeneHs.712041.

3D structure databases

ProteinModelPortalQ9UD57.
SMRQ9UD57. Positions 164-220.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9UD57.

Polymorphism databases

DMDM338817978.

Proteomic databases

PRIDEQ9UD57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000451024; ENSP00000451945; ENSG00000229544.
GeneID390010.
KEGGhsa:390010.
UCSCuc010quf.2. human.

Organism-specific databases

CTD390010.
GeneCardsGC10M126135.
H-InvDBHIX0170557.
HGNCHGNC:31652. NKX1-2.
HPAHPA029367.
neXtProtNX_Q9UD57.
PharmGKBPA134977174.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG052632.
KOK09309.
OrthoDBEOG7R2BM5.
TreeFamTF316128.

Gene expression databases

CleanExHS_NKX1-2.
GenevestigatorQ9UD57.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio103265.
PROQ9UD57.

Entry information

Entry nameNKX12_HUMAN
AccessionPrimary (citable) accession number: Q9UD57
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM