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Q9UD57

- NKX12_HUMAN

UniProt

Q9UD57 - NKX12_HUMAN

Protein

NK1 transcription factor-related protein 2

Gene

NKX1-2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 3 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    May function in cell specification, particularly in the CNS.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi163 – 22260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NK1 transcription factor-related protein 2
    Alternative name(s):
    Homeobox protein SAX-1
    NKX-1.1
    Gene namesi
    Name:NKX1-2
    Synonyms:C10orf121, NKX1.1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:31652. NKX1-2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977174.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310NK1 transcription factor-related protein 2PRO_0000325972Add
    BLAST

    Proteomic databases

    PRIDEiQ9UD57.

    PTM databases

    PhosphoSiteiQ9UD57.

    Expressioni

    Gene expression databases

    CleanExiHS_NKX1-2.
    GenevestigatoriQ9UD57.

    Organism-specific databases

    HPAiHPA029367.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UD57.
    SMRiQ9UD57. Positions 164-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi88 – 936Poly-Glu
    Compositional biasi134 – 1374Poly-Gly
    Compositional biasi150 – 1556Poly-Arg
    Compositional biasi224 – 25936Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NK-1 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG052632.
    KOiK09309.
    OrthoDBiEOG7R2BM5.
    TreeFamiTF316128.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UD57-1 [UniParc]FASTAAdd to Basket

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    MLAWQDGGAK AAPSHHKISF SVLDILDPQK FTRAALPAVR PAPREARKSL    50
    AEVEAGKDAS SRDPVRQLET PDAAGPGAGQ ASPLEGSEAE EEEDAEDPRR 100
    PRLRERAARL LPGLARSPDA PAGALASGEP CEDGGGGPVR SPPGSPGSPR 150
    PRRRRLEPNC AKPRRARTAF TYEQLVALEN KFRATRYLSV CERLNLALSL 200
    SLTETQVKIW FQNRRTKWKK QNPGADGAAQ VGGGAPQPGA AGGGGGGGSG 250
    GSPGPPGTGA LHFQTFPSYS AANVLFPSAA SFPLTAAAPG SPFAPFLGPS 300
    YLTPFYAPRL 310
    Length:310
    Mass (Da):32,381
    Last modified:June 28, 2011 - v3
    Checksum:iFF2D02B4DCFC5689
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445237 Genomic DNA. No translation available.
    CCDSiCCDS59221.1.
    RefSeqiNP_001139812.1. NM_001146340.1.
    UniGeneiHs.712041.

    Genome annotation databases

    EnsembliENST00000451024; ENSP00000451945; ENSG00000229544.
    GeneIDi390010.
    KEGGihsa:390010.
    UCSCiuc010quf.2. human.

    Polymorphism databases

    DMDMi338817978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL445237 Genomic DNA. No translation available.
    CCDSi CCDS59221.1.
    RefSeqi NP_001139812.1. NM_001146340.1.
    UniGenei Hs.712041.

    3D structure databases

    ProteinModelPortali Q9UD57.
    SMRi Q9UD57. Positions 164-220.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9UD57.

    Polymorphism databases

    DMDMi 338817978.

    Proteomic databases

    PRIDEi Q9UD57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000451024 ; ENSP00000451945 ; ENSG00000229544 .
    GeneIDi 390010.
    KEGGi hsa:390010.
    UCSCi uc010quf.2. human.

    Organism-specific databases

    CTDi 390010.
    GeneCardsi GC10M126135.
    H-InvDB HIX0170557.
    HGNCi HGNC:31652. NKX1-2.
    HPAi HPA029367.
    neXtProti NX_Q9UD57.
    PharmGKBi PA134977174.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG052632.
    KOi K09309.
    OrthoDBi EOG7R2BM5.
    TreeFami TF316128.

    Miscellaneous databases

    NextBioi 103265.
    PROi Q9UD57.

    Gene expression databases

    CleanExi HS_NKX1-2.
    Genevestigatori Q9UD57.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
      Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
      Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 171-209.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiNKX12_HUMAN
    AccessioniPrimary (citable) accession number: Q9UD57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3