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Protein

Zinc finger protein 69

Gene

ZNF69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 69
Alternative name(s):
hZNF3
Gene namesi
Name:ZNF69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198429.9.
HGNCiHGNC:13138. ZNF69.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198429.
PharmGKBiPA37712.

Polymorphism and mutation databases

BioMutaiZNF69.
DMDMi158520002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002955451 – 566Zinc finger protein 69Add BLAST566

Proteomic databases

EPDiQ9UC07.
PeptideAtlasiQ9UC07.
PRIDEiQ9UC07.

PTM databases

iPTMnetiQ9UC07.
PhosphoSitePlusiQ9UC07.

Expressioni

Gene expression databases

BgeeiENSG00000198429.
CleanExiHS_ZNF69.
ExpressionAtlasiQ9UC07. baseline and differential.

Organism-specific databases

HPAiHPA047845.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113440. 2 interactors.
IntActiQ9UC07. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9UC07.
SMRiQ9UC07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 106KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00890000140040.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UC07.
OMAiGKAFRSM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UC07.
TreeFamiTF340042.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UC07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCCSHRRCR EDPGTSESQE MDPVAFDDVA VNFTQEEWAL LDISQRKLYK
60 70 80 90 100
EVMLETFRNL TSVGKSWKDQ NIEYEYQNPR RNFRSLIEKK VNEIKDDSHC
110 120 130 140 150
GETFTQVPDD RLNFQEKKAS PEIKSCDSFV CGEVGLGNSS FNMNIRGDIG
160 170 180 190 200
HKAYEYQEYG PKPCKCQQPK KAFRYHPSFR TPQRDHTGEK PYACKECGKT
210 220 230 240 250
FISHSSIQRH VVMHSGDGPY KCKFCGKAFH CLSLYLIHER IHTGEKPYEC
260 270 280 290 300
KQCGKSFSYS ATLRIHERTH TGEKPYECQQ CGKAFHSPRC YRRHERIHTG
310 320 330 340 350
EKAYQCKECG KAFTCPQYVR IHERTHSRKK PYECTQCGKA LSSLTSFQTH
360 370 380 390 400
IRMHSGERPY ECKICGKGFC SANSFQRHEK THSGEKPYKC KQCGKAFIHS
410 420 430 440 450
SSLRYHERIH TGEKPYECKQ CGKAFRSSSH LQLHGRTHTG EKPYECQECG
460 470 480 490 500
KAFRSMKNLQ SHERTQTHVR IHSGERPYKC KLCGKGFYCP KSLQRHEKTH
510 520 530 540 550
TGEKLYECKQ CGEAFSSSSS FRYHERTHTG EKPYKCKQCG KAFRAASVLR
560
MHGRTHPEDK PYECKQ
Length:566
Mass (Da):65,761
Last modified:July 24, 2007 - v2
Checksum:iDA1D46CBFD266AD6
GO
Isoform 2 (identifier: Q9UC07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-35: Missing.
     164-566: Missing.

Show »
Length:149
Mass (Da):17,398
Checksum:iA962EAEAD4468286
GO

Sequence cautioni

The sequence AK001669 differs from that shown. Reason: Frameshift at position 415.Curated
The sequence CAC16147 differs from that shown. Reason: Frameshift at positions 367 and 369.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02692722 – 35Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_026928164 – 566Missing in isoform 2. 1 PublicationAdd BLAST403

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051309 mRNA. Translation: AAH51309.1.
AC008770 Genomic DNA. No translation available.
X60076 Genomic DNA. Translation: CAC16147.1. Frameshift.
AK001669 mRNA. No translation available.
CCDSiCCDS32914.1. [Q9UC07-2]
PIRiC42825.
RefSeqiNP_068734.1. NM_021915.3. [Q9UC07-2]
UniGeneiHs.565280.
Hs.661955.
Hs.735590.

Genome annotation databases

EnsembliENST00000340180; ENSP00000345333; ENSG00000198429. [Q9UC07-2]
ENST00000429654; ENSP00000402985; ENSG00000198429. [Q9UC07-1]
GeneIDi7620.
KEGGihsa:7620.
UCSCiuc002mst.5. human. [Q9UC07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZNF69_HUMAN
AccessioniPrimary (citable) accession number: Q9UC07
Secondary accession number(s): Q86VA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families