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Protein

Zinc finger protein 69

Gene

ZNF69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 69
Alternative name(s):
hZNF3
Gene namesi
Name:ZNF69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198429.9
HGNCiHGNC:13138 ZNF69
MIMi194543 gene
neXtProtiNX_Q9UC07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198429
PharmGKBiPA37712

Polymorphism and mutation databases

BioMutaiZNF69
DMDMi158520002

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002955451 – 566Zinc finger protein 69Add BLAST566

Proteomic databases

EPDiQ9UC07
PeptideAtlasiQ9UC07
PRIDEiQ9UC07

PTM databases

iPTMnetiQ9UC07
PhosphoSitePlusiQ9UC07

Expressioni

Gene expression databases

BgeeiENSG00000198429
CleanExiHS_ZNF69
ExpressionAtlasiQ9UC07 baseline and differential

Organism-specific databases

HPAiHPA047845

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113440, 3 interactors
IntActiQ9UC07, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9UC07
SMRiQ9UC07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 106KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 186C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri248 – 270C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00900000141134
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UC07
OMAiGKAFRSM
OrthoDBiEOG091G02KC
PhylomeDBiQ9UC07
TreeFamiTF340042

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UC07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCCSHRRCR EDPGTSESQE MDPVAFDDVA VNFTQEEWAL LDISQRKLYK
60 70 80 90 100
EVMLETFRNL TSVGKSWKDQ NIEYEYQNPR RNFRSLIEKK VNEIKDDSHC
110 120 130 140 150
GETFTQVPDD RLNFQEKKAS PEIKSCDSFV CGEVGLGNSS FNMNIRGDIG
160 170 180 190 200
HKAYEYQEYG PKPCKCQQPK KAFRYHPSFR TPQRDHTGEK PYACKECGKT
210 220 230 240 250
FISHSSIQRH VVMHSGDGPY KCKFCGKAFH CLSLYLIHER IHTGEKPYEC
260 270 280 290 300
KQCGKSFSYS ATLRIHERTH TGEKPYECQQ CGKAFHSPRC YRRHERIHTG
310 320 330 340 350
EKAYQCKECG KAFTCPQYVR IHERTHSRKK PYECTQCGKA LSSLTSFQTH
360 370 380 390 400
IRMHSGERPY ECKICGKGFC SANSFQRHEK THSGEKPYKC KQCGKAFIHS
410 420 430 440 450
SSLRYHERIH TGEKPYECKQ CGKAFRSSSH LQLHGRTHTG EKPYECQECG
460 470 480 490 500
KAFRSMKNLQ SHERTQTHVR IHSGERPYKC KLCGKGFYCP KSLQRHEKTH
510 520 530 540 550
TGEKLYECKQ CGEAFSSSSS FRYHERTHTG EKPYKCKQCG KAFRAASVLR
560
MHGRTHPEDK PYECKQ
Length:566
Mass (Da):65,761
Last modified:July 24, 2007 - v2
Checksum:iDA1D46CBFD266AD6
GO
Isoform 2 (identifier: Q9UC07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-35: Missing.
     164-566: Missing.

Show »
Length:149
Mass (Da):17,398
Checksum:iA962EAEAD4468286
GO

Sequence cautioni

The sequence AK001669 differs from that shown. Reason: Frameshift at position 415.Curated
The sequence CAC16147 differs from that shown. Reason: Frameshift at positions 367 and 369.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02692722 – 35Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_026928164 – 566Missing in isoform 2. 1 PublicationAdd BLAST403

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051309 mRNA Translation: AAH51309.1
AC008770 Genomic DNA No translation available.
X60076 Genomic DNA Translation: CAC16147.1 Frameshift.
AK001669 mRNA No translation available.
CCDSiCCDS32914.1 [Q9UC07-2]
PIRiC42825
RefSeqiNP_068734.1, NM_021915.3 [Q9UC07-2]
UniGeneiHs.565280
Hs.661955
Hs.735590

Genome annotation databases

EnsembliENST00000340180; ENSP00000345333; ENSG00000198429 [Q9UC07-2]
ENST00000429654; ENSP00000402985; ENSG00000198429 [Q9UC07-1]
GeneIDi7620
KEGGihsa:7620
UCSCiuc002mst.5 human [Q9UC07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZNF69_HUMAN
AccessioniPrimary (citable) accession number: Q9UC07
Secondary accession number(s): Q86VA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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