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Protein

Zinc finger protein 69

Gene

ZNF69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 18623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 47229C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 69
Alternative name(s):
hZNF3
Gene namesi
Name:ZNF69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13138. ZNF69.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37712.

Polymorphism and mutation databases

BioMutaiZNF69.
DMDMi158520002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Zinc finger protein 69PRO_0000295545Add
BLAST

Proteomic databases

EPDiQ9UC07.
PeptideAtlasiQ9UC07.
PRIDEiQ9UC07.

PTM databases

iPTMnetiQ9UC07.
PhosphoSiteiQ9UC07.

Expressioni

Gene expression databases

BgeeiENSG00000198429.
CleanExiHS_ZNF69.
ExpressionAtlasiQ9UC07. baseline and differential.

Organism-specific databases

HPAiHPA047845.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KATNAL1Q9BW623EBI-10320266,EBI-743591
KRT31Q153233EBI-10320266,EBI-948001

Protein-protein interaction databases

BioGridi113440. 2 interactions.
IntActiQ9UC07. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UC07.
SMRiQ9UC07. Positions 24-73, 162-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10683KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 18623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri416 – 43823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 47229C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00830000128470.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UC07.
OMAiGKAFRSM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UC07.
TreeFamiTF340042.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UC07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCCSHRRCR EDPGTSESQE MDPVAFDDVA VNFTQEEWAL LDISQRKLYK
60 70 80 90 100
EVMLETFRNL TSVGKSWKDQ NIEYEYQNPR RNFRSLIEKK VNEIKDDSHC
110 120 130 140 150
GETFTQVPDD RLNFQEKKAS PEIKSCDSFV CGEVGLGNSS FNMNIRGDIG
160 170 180 190 200
HKAYEYQEYG PKPCKCQQPK KAFRYHPSFR TPQRDHTGEK PYACKECGKT
210 220 230 240 250
FISHSSIQRH VVMHSGDGPY KCKFCGKAFH CLSLYLIHER IHTGEKPYEC
260 270 280 290 300
KQCGKSFSYS ATLRIHERTH TGEKPYECQQ CGKAFHSPRC YRRHERIHTG
310 320 330 340 350
EKAYQCKECG KAFTCPQYVR IHERTHSRKK PYECTQCGKA LSSLTSFQTH
360 370 380 390 400
IRMHSGERPY ECKICGKGFC SANSFQRHEK THSGEKPYKC KQCGKAFIHS
410 420 430 440 450
SSLRYHERIH TGEKPYECKQ CGKAFRSSSH LQLHGRTHTG EKPYECQECG
460 470 480 490 500
KAFRSMKNLQ SHERTQTHVR IHSGERPYKC KLCGKGFYCP KSLQRHEKTH
510 520 530 540 550
TGEKLYECKQ CGEAFSSSSS FRYHERTHTG EKPYKCKQCG KAFRAASVLR
560
MHGRTHPEDK PYECKQ
Length:566
Mass (Da):65,761
Last modified:July 24, 2007 - v2
Checksum:iDA1D46CBFD266AD6
GO
Isoform 2 (identifier: Q9UC07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-35: Missing.
     164-566: Missing.

Show »
Length:149
Mass (Da):17,398
Checksum:iA962EAEAD4468286
GO

Sequence cautioni

The sequence AK001669 differs from that shown. Reason: Frameshift at position 415. Curated
The sequence CAC16147 differs from that shown. Reason: Frameshift at positions 367 and 369. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 3514Missing in isoform 2. 1 PublicationVSP_026927Add
BLAST
Alternative sequencei164 – 566403Missing in isoform 2. 1 PublicationVSP_026928Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051309 mRNA. Translation: AAH51309.1.
AC008770 Genomic DNA. No translation available.
X60076 Genomic DNA. Translation: CAC16147.1. Frameshift.
AK001669 mRNA. No translation available.
CCDSiCCDS32914.1. [Q9UC07-2]
PIRiC42825.
RefSeqiNP_068734.1. NM_021915.3. [Q9UC07-2]
UniGeneiHs.565280.
Hs.661955.
Hs.735590.

Genome annotation databases

EnsembliENST00000340180; ENSP00000345333; ENSG00000198429. [Q9UC07-2]
ENST00000429654; ENSP00000402985; ENSG00000198429. [Q9UC07-1]
GeneIDi7620.
KEGGihsa:7620.
UCSCiuc002mst.5. human. [Q9UC07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051309 mRNA. Translation: AAH51309.1.
AC008770 Genomic DNA. No translation available.
X60076 Genomic DNA. Translation: CAC16147.1. Frameshift.
AK001669 mRNA. No translation available.
CCDSiCCDS32914.1. [Q9UC07-2]
PIRiC42825.
RefSeqiNP_068734.1. NM_021915.3. [Q9UC07-2]
UniGeneiHs.565280.
Hs.661955.
Hs.735590.

3D structure databases

ProteinModelPortaliQ9UC07.
SMRiQ9UC07. Positions 24-73, 162-556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113440. 2 interactions.
IntActiQ9UC07. 2 interactions.

PTM databases

iPTMnetiQ9UC07.
PhosphoSiteiQ9UC07.

Polymorphism and mutation databases

BioMutaiZNF69.
DMDMi158520002.

Proteomic databases

EPDiQ9UC07.
PeptideAtlasiQ9UC07.
PRIDEiQ9UC07.

Protocols and materials databases

DNASUi7620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340180; ENSP00000345333; ENSG00000198429. [Q9UC07-2]
ENST00000429654; ENSP00000402985; ENSG00000198429. [Q9UC07-1]
GeneIDi7620.
KEGGihsa:7620.
UCSCiuc002mst.5. human. [Q9UC07-1]

Organism-specific databases

CTDi7620.
GeneCardsiZNF69.
HGNCiHGNC:13138. ZNF69.
HPAiHPA047845.
MIMi194543. gene.
neXtProtiNX_Q9UC07.
PharmGKBiPA37712.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00830000128470.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UC07.
OMAiGKAFRSM.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UC07.
TreeFamiTF340042.

Miscellaneous databases

GenomeRNAii7620.
PROiQ9UC07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198429.
CleanExiHS_ZNF69.
ExpressionAtlasiQ9UC07. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF69_HUMAN
AccessioniPrimary (citable) accession number: Q9UC07
Secondary accession number(s): Q86VA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.