ID ZNF70_HUMAN Reviewed; 446 AA. AC Q9UC06; DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot. DT 27-MAR-2002, sequence version 2. DT 27-MAR-2024, entry version 182. DE RecName: Full=Zinc finger protein 70; DE AltName: Full=Zinc finger protein N27C7-1; GN Name=ZNF70; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.; RT "Molecular cloning of N27C7-1 gene."; RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84; RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., RA Beare D.M., Dunham I.; RT "A genome annotation-driven approach to cloning the human ORFeome."; RL Genome Biol. 5:R84.1-R84.11(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 245-335. RX PubMed=1639391; DOI=10.1016/0888-7543(92)90135-f; RA Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., RA Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.; RT "Cloning of six new genes with zinc finger motifs mapping to short and long RT arms of human acrocentric chromosome 22 (p and q11.2)."; RL Genomics 13:641-648(1992). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB050771; BAB83033.1; -; Genomic_DNA. DR EMBL; CR456615; CAG30501.1; -; mRNA. DR EMBL; BC040161; AAH40161.1; -; mRNA. DR EMBL; X60077; CAC16148.1; -; Genomic_DNA. DR CCDS; CCDS13812.1; -. DR PIR; D42825; D42825. DR RefSeq; NP_068735.1; NM_021916.3. DR AlphaFoldDB; Q9UC06; -. DR SMR; Q9UC06; -. DR BioGRID; 113441; 35. DR IntAct; Q9UC06; 8. DR STRING; 9606.ENSP00000339314; -. DR GlyGen; Q9UC06; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9UC06; -. DR PhosphoSitePlus; Q9UC06; -. DR BioMuta; ZNF70; -. DR DMDM; 20141062; -. DR jPOST; Q9UC06; -. DR MassIVE; Q9UC06; -. DR MaxQB; Q9UC06; -. DR PaxDb; 9606-ENSP00000339314; -. DR PeptideAtlas; Q9UC06; -. DR ProteomicsDB; 84108; -. DR Antibodypedia; 9369; 116 antibodies from 23 providers. DR DNASU; 7621; -. DR Ensembl; ENST00000341976.5; ENSP00000339314.3; ENSG00000187792.5. DR GeneID; 7621; -. DR KEGG; hsa:7621; -. DR MANE-Select; ENST00000341976.5; ENSP00000339314.3; NM_021916.4; NP_068735.1. DR UCSC; uc002zxs.4; human. DR AGR; HGNC:13140; -. DR CTD; 7621; -. DR DisGeNET; 7621; -. DR GeneCards; ZNF70; -. DR HGNC; HGNC:13140; ZNF70. DR HPA; ENSG00000187792; Low tissue specificity. DR MIM; 194544; gene. DR neXtProt; NX_Q9UC06; -. DR OpenTargets; ENSG00000187792; -. DR PharmGKB; PA37714; -. DR VEuPathDB; HostDB:ENSG00000187792; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000163200; -. DR HOGENOM; CLU_002678_44_13_1; -. DR InParanoid; Q9UC06; -. DR OMA; VCQIIHG; -. DR OrthoDB; 5340761at2759; -. DR PhylomeDB; Q9UC06; -. DR TreeFam; TF337055; -. DR PathwayCommons; Q9UC06; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; Q9UC06; -. DR BioGRID-ORCS; 7621; 16 hits in 1165 CRISPR screens. DR ChiTaRS; ZNF70; human. DR GenomeRNAi; 7621; -. DR Pharos; Q9UC06; Tdark. DR PRO; PR:Q9UC06; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q9UC06; Protein. DR Bgee; ENSG00000187792; Expressed in tibia and 140 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0043076; C:megasporocyte nucleus; IDA:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1. DR PANTHER; PTHR23226:SF416; ZINC FINGER PROTEIN 46; 1. DR Pfam; PF00096; zf-C2H2; 9. DR Pfam; PF13465; zf-H2C2_2; 1. DR SMART; SM00355; ZnF_C2H2; 11. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11. DR Genevisible; Q9UC06; HS. PE 2: Evidence at transcript level; KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..446 FT /note="Zinc finger protein 70" FT /id="PRO_0000047380" FT ZN_FING 140..162 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 168..190 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 196..218 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 224..246 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 252..274 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 280..302 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 308..330 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 336..358 FT /note="C2H2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 364..386 FT /note="C2H2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 392..413 FT /note="C2H2-type 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 419..441 FT /note="C2H2-type 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 114..138 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 446 AA; 50802 MW; E79A25ED2BD816D9 CRC64; MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE IPLGEQDEEN DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV CNLCGKSFRG SSHLIRHQKI HSGEKL //