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Q9UC06 (ZNF70_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 70
Alternative name(s):
Zinc finger protein N27C7-1
Gene names
Name:ZNF70
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Zinc finger protein 70
PRO_0000047380

Regions

Zinc finger140 – 16223C2H2-type 1
Zinc finger168 – 19023C2H2-type 2
Zinc finger196 – 21823C2H2-type 3
Zinc finger224 – 24623C2H2-type 4
Zinc finger252 – 27423C2H2-type 5
Zinc finger280 – 30223C2H2-type 6
Zinc finger308 – 33023C2H2-type 7
Zinc finger336 – 35823C2H2-type 8
Zinc finger364 – 38623C2H2-type 9
Zinc finger392 – 41322C2H2-type 10
Zinc finger419 – 44123C2H2-type 11

Sequences

Sequence LengthMass (Da)Tools
Q9UC06 [UniParc].

Last modified March 27, 2002. Version 2.
Checksum: E79A25ED2BD816D9

FASTA44650,802
        10         20         30         40         50         60 
MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE IPLGEQDEEN 

        70         80         90        100        110        120 
DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET 

       130        140        150        160        170        180 
DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS 

       190        200        210        220        230        240 
SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR 

       250        260        270        280        290        300 
KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR 

       310        320        330        340        350        360 
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG 

       370        380        390        400        410        420 
EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV 

       430        440 
CNLCGKSFRG SSHLIRHQKI HSGEKL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of N27C7-1 gene."
Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 245-335.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB050771 Genomic DNA. Translation: BAB83033.1.
CR456615 mRNA. Translation: CAG30501.1.
BC040161 mRNA. Translation: AAH40161.1.
X60077 Genomic DNA. Translation: CAC16148.1.
PIRD42825.
RefSeqNP_068735.1. NM_021916.2.
UniGeneHs.382874.

3D structure databases

ProteinModelPortalQ9UC06.
SMRQ9UC06. Positions 6-445.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113441. 1 interaction.
STRING9606.ENSP00000339314.

PTM databases

PhosphoSiteQ9UC06.

Polymorphism databases

DMDM20141062.

Proteomic databases

PaxDbQ9UC06.
PRIDEQ9UC06.

Protocols and materials databases

DNASU7621.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341976; ENSP00000339314; ENSG00000187792.
GeneID7621.
KEGGhsa:7621.
UCSCuc002zxs.3. human.

Organism-specific databases

CTD7621.
GeneCardsGC22M024083.
HGNCHGNC:13140. ZNF70.
HPAHPA018821.
MIM194544. gene.
neXtProtNX_Q9UC06.
PharmGKBPA37714.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9UC06.
OMACSSPVQH.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9UC06.
TreeFamTF337055.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ9UC06.
CleanExHS_ZNF70.
GenevestigatorQ9UC06.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7621.
NextBio29709.
PROQ9UC06.
SOURCESearch...

Entry information

Entry nameZNF70_HUMAN
AccessionPrimary (citable) accession number: Q9UC06
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: March 19, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM