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Protein

Zinc finger protein 70

Gene

ZNF70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 70
Alternative name(s):
Zinc finger protein N27C7-1
Gene namesi
Name:ZNF70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000187792.4
HGNCiHGNC:13140 ZNF70
MIMi194544 gene
neXtProtiNX_Q9UC06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187792
PharmGKBiPA37714

Polymorphism and mutation databases

BioMutaiZNF70
DMDMi20141062

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473801 – 446Zinc finger protein 70Add BLAST446

Proteomic databases

MaxQBiQ9UC06
PaxDbiQ9UC06
PeptideAtlasiQ9UC06
PRIDEiQ9UC06

PTM databases

iPTMnetiQ9UC06
PhosphoSitePlusiQ9UC06

Expressioni

Gene expression databases

BgeeiENSG00000187792
CleanExiHS_ZNF70
GenevisibleiQ9UC06 HS

Organism-specific databases

HPAiHPA018821

Interactioni

Protein-protein interaction databases

BioGridi113441, 10 interactors
STRINGi9606.ENSP00000339314

Structurei

3D structure databases

ProteinModelPortaliQ9UC06
SMRiQ9UC06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144315
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UC06
OMAiAFCHRSH
OrthoDBiEOG091G02KC
PhylomeDBiQ9UC06
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q9UC06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE
60 70 80 90 100
IPLGEQDEEN DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD
110 120 130 140 150
LSMCQIIHSE EPSPCDCAET DRGDSGPNAP HRTPQPAKPY ACRECGKAFS
160 170 180 190 200
QSSHLLRHLV IHTGEKPYEC CECGKAFSQS SHLLRHQIIH TGEKPYECRE
210 220 230 240 250
CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR KHERIHTGER
260 270 280 290 300
PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR
310 320 330 340 350
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS
360 370 380 390 400
LIEHQRIHTG EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF
410 420 430 440
RHRSALIEHY KTHTREKPYV CNLCGKSFRG SSHLIRHQKI HSGEKL
Length:446
Mass (Da):50,802
Last modified:March 27, 2002 - v2
Checksum:iE79A25ED2BD816D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050771 Genomic DNA Translation: BAB83033.1
CR456615 mRNA Translation: CAG30501.1
BC040161 mRNA Translation: AAH40161.1
X60077 Genomic DNA Translation: CAC16148.1
CCDSiCCDS13812.1
PIRiD42825
RefSeqiNP_068735.1, NM_021916.3
UniGeneiHs.382874
Hs.547601

Genome annotation databases

EnsembliENST00000341976; ENSP00000339314; ENSG00000187792
GeneIDi7621
KEGGihsa:7621
UCSCiuc002zxs.4 human

Similar proteinsi

Entry informationi

Entry nameiZNF70_HUMAN
AccessioniPrimary (citable) accession number: Q9UC06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health