Q9UC06 (ZNF70_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 70

Alternative name(s):
Zinc finger protein N27C7-1

Gene names

Name:

ZNF70

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Zinc finger protein 70		PRO_0000047380
Regions
	Zinc finger	140 – 162	23	C2H2-type 1
	Zinc finger	168 – 190	23	C2H2-type 2
	Zinc finger	196 – 218	23	C2H2-type 3
	Zinc finger	224 – 246	23	C2H2-type 4
	Zinc finger	252 – 274	23	C2H2-type 5
	Zinc finger	280 – 302	23	C2H2-type 6
	Zinc finger	308 – 330	23	C2H2-type 7
	Zinc finger	336 – 358	23	C2H2-type 8
	Zinc finger	364 – 386	23	C2H2-type 9
	Zinc finger	392 – 413	22	C2H2-type 10
	Zinc finger	419 – 441	23	C2H2-type 11

Sequences

	Sequence		Length	Mass (Da)
	Q9UC06 [UniParc]. Last modified March 27, 2002. Version 2. Checksum: E79A25ED2BD816D9	FASTA	446	50,802
	10 20 30 40 50 60 MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE IPLGEQDEEN 70 80 90 100 110 120 DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET 130 140 150 160 170 180 DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS 190 200 210 220 230 240 SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR 250 260 270 280 290 300 KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR 310 320 330 340 350 360 IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG 370 380 390 400 410 420 EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV 430 440 CNLCGKSFRG SSHLIRHQKI HSGEKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of N27C7-1 gene." Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)." Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A. Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 245-335.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB050771 Genomic DNA. Translation: BAB83033.1. CR456615 mRNA. Translation: CAG30501.1. BC040161 mRNA. Translation: AAH40161.1. X60077 Genomic DNA. Translation: CAC16148.1.
IPI	IPI00045732.
PIR	D42825.
RefSeq	NP_068735.1. NM_021916.2.
UniGene	Hs.382874.
3D structure databases
ProteinModelPortal	Q9UC06.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000339314.
PTM databases
PhosphoSite	Q9UC06.
Polymorphism databases
DMDM	20141062.
Proteomic databases
PaxDb	Q9UC06.
PRIDE	Q9UC06.
Protocols and materials databases
DNASU	7621.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341976; ENSP00000339314; ENSG00000187792.
GeneID	7621.
KEGG	hsa:7621.
UCSC	uc002zxs.3. human.
Organism-specific databases
CTD	7621.
GeneCards	GC22M024083.
HGNC	HGNC:13140. ZNF70.
HPA	HPA018821.
MIM	194544. gene.
neXtProt	NX_Q9UC06.
PharmGKB	PA37714.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9UC06.
OMA	HRSALIE.
OrthoDB	EOG4KSPJM.
PhylomeDB	Q9UC06.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q9UC06.
CleanEx	HS_ZNF70.
Genevestigator	Q9UC06.
GermOnline	ENSG00000187792. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 11 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 11 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7621.
NextBio	29709.
SOURCE	Search...

Entry information

Entry name

ZNF70_HUMAN

Accession

Primary (citable) accession number: Q9UC06

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 27, 2002
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.