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Q9UC06

- ZNF70_HUMAN

UniProt

Q9UC06 - ZNF70_HUMAN

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Protein

Zinc finger protein 70

Gene

ZNF70

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41322C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 70
Alternative name(s):
Zinc finger protein N27C7-1
Gene namesi
Name:ZNF70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:13140. ZNF70.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Zinc finger protein 70PRO_0000047380Add
BLAST

Proteomic databases

PaxDbiQ9UC06.
PRIDEiQ9UC06.

PTM databases

PhosphoSiteiQ9UC06.

Expressioni

Gene expression databases

BgeeiQ9UC06.
CleanExiHS_ZNF70.
GenevestigatoriQ9UC06.

Organism-specific databases

HPAiHPA018821.

Interactioni

Protein-protein interaction databases

BioGridi113441. 4 interactions.
STRINGi9606.ENSP00000339314.

Structurei

3D structure databases

ProteinModelPortaliQ9UC06.
SMRiQ9UC06. Positions 66-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41322C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119440.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UC06.
OMAiCSSPVQH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UC06.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UC06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE
60 70 80 90 100
IPLGEQDEEN DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD
110 120 130 140 150
LSMCQIIHSE EPSPCDCAET DRGDSGPNAP HRTPQPAKPY ACRECGKAFS
160 170 180 190 200
QSSHLLRHLV IHTGEKPYEC CECGKAFSQS SHLLRHQIIH TGEKPYECRE
210 220 230 240 250
CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR KHERIHTGER
260 270 280 290 300
PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR
310 320 330 340 350
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS
360 370 380 390 400
LIEHQRIHTG EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF
410 420 430 440
RHRSALIEHY KTHTREKPYV CNLCGKSFRG SSHLIRHQKI HSGEKL
Length:446
Mass (Da):50,802
Last modified:March 27, 2002 - v2
Checksum:iE79A25ED2BD816D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050771 Genomic DNA. Translation: BAB83033.1.
CR456615 mRNA. Translation: CAG30501.1.
BC040161 mRNA. Translation: AAH40161.1.
X60077 Genomic DNA. Translation: CAC16148.1.
CCDSiCCDS13812.1.
PIRiD42825.
RefSeqiNP_068735.1. NM_021916.2.
UniGeneiHs.382874.

Genome annotation databases

EnsembliENST00000341976; ENSP00000339314; ENSG00000187792.
GeneIDi7621.
KEGGihsa:7621.
UCSCiuc002zxs.3. human.

Polymorphism databases

DMDMi20141062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050771 Genomic DNA. Translation: BAB83033.1 .
CR456615 mRNA. Translation: CAG30501.1 .
BC040161 mRNA. Translation: AAH40161.1 .
X60077 Genomic DNA. Translation: CAC16148.1 .
CCDSi CCDS13812.1.
PIRi D42825.
RefSeqi NP_068735.1. NM_021916.2.
UniGenei Hs.382874.

3D structure databases

ProteinModelPortali Q9UC06.
SMRi Q9UC06. Positions 66-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113441. 4 interactions.
STRINGi 9606.ENSP00000339314.

PTM databases

PhosphoSitei Q9UC06.

Polymorphism databases

DMDMi 20141062.

Proteomic databases

PaxDbi Q9UC06.
PRIDEi Q9UC06.

Protocols and materials databases

DNASUi 7621.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341976 ; ENSP00000339314 ; ENSG00000187792 .
GeneIDi 7621.
KEGGi hsa:7621.
UCSCi uc002zxs.3. human.

Organism-specific databases

CTDi 7621.
GeneCardsi GC22M024083.
HGNCi HGNC:13140. ZNF70.
HPAi HPA018821.
MIMi 194544. gene.
neXtProti NX_Q9UC06.
PharmGKBi PA37714.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119440.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9UC06.
OMAi CSSPVQH.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9UC06.
TreeFami TF337055.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 7621.
NextBioi 29709.
PROi Q9UC06.
SOURCEi Search...

Gene expression databases

Bgeei Q9UC06.
CleanExi HS_ZNF70.
Genevestigatori Q9UC06.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of N27C7-1 gene."
    Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
    Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
    Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 245-335.

Entry informationi

Entry nameiZNF70_HUMAN
AccessioniPrimary (citable) accession number: Q9UC06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3