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Q9UC06

- ZNF70_HUMAN

UniProt

Q9UC06 - ZNF70_HUMAN

Protein

Zinc finger protein 70

Gene

ZNF70

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41322C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 70
    Alternative name(s):
    Zinc finger protein N27C7-1
    Gene namesi
    Name:ZNF70
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:13140. ZNF70.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37714.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Zinc finger protein 70PRO_0000047380Add
    BLAST

    Proteomic databases

    PaxDbiQ9UC06.
    PRIDEiQ9UC06.

    PTM databases

    PhosphoSiteiQ9UC06.

    Expressioni

    Gene expression databases

    BgeeiQ9UC06.
    CleanExiHS_ZNF70.
    GenevestigatoriQ9UC06.

    Organism-specific databases

    HPAiHPA018821.

    Interactioni

    Protein-protein interaction databases

    BioGridi113441. 1 interaction.
    STRINGi9606.ENSP00000339314.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UC06.
    SMRiQ9UC06. Positions 66-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri140 – 16223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri168 – 19023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41322C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9UC06.
    OMAiCSSPVQH.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9UC06.
    TreeFamiTF337055.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UC06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE    50
    IPLGEQDEEN DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD 100
    LSMCQIIHSE EPSPCDCAET DRGDSGPNAP HRTPQPAKPY ACRECGKAFS 150
    QSSHLLRHLV IHTGEKPYEC CECGKAFSQS SHLLRHQIIH TGEKPYECRE 200
    CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR KHERIHTGER 250
    PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR 300
    IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS 350
    LIEHQRIHTG EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF 400
    RHRSALIEHY KTHTREKPYV CNLCGKSFRG SSHLIRHQKI HSGEKL 446
    Length:446
    Mass (Da):50,802
    Last modified:March 27, 2002 - v2
    Checksum:iE79A25ED2BD816D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050771 Genomic DNA. Translation: BAB83033.1.
    CR456615 mRNA. Translation: CAG30501.1.
    BC040161 mRNA. Translation: AAH40161.1.
    X60077 Genomic DNA. Translation: CAC16148.1.
    CCDSiCCDS13812.1.
    PIRiD42825.
    RefSeqiNP_068735.1. NM_021916.2.
    UniGeneiHs.382874.

    Genome annotation databases

    EnsembliENST00000341976; ENSP00000339314; ENSG00000187792.
    GeneIDi7621.
    KEGGihsa:7621.
    UCSCiuc002zxs.3. human.

    Polymorphism databases

    DMDMi20141062.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050771 Genomic DNA. Translation: BAB83033.1 .
    CR456615 mRNA. Translation: CAG30501.1 .
    BC040161 mRNA. Translation: AAH40161.1 .
    X60077 Genomic DNA. Translation: CAC16148.1 .
    CCDSi CCDS13812.1.
    PIRi D42825.
    RefSeqi NP_068735.1. NM_021916.2.
    UniGenei Hs.382874.

    3D structure databases

    ProteinModelPortali Q9UC06.
    SMRi Q9UC06. Positions 66-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113441. 1 interaction.
    STRINGi 9606.ENSP00000339314.

    PTM databases

    PhosphoSitei Q9UC06.

    Polymorphism databases

    DMDMi 20141062.

    Proteomic databases

    PaxDbi Q9UC06.
    PRIDEi Q9UC06.

    Protocols and materials databases

    DNASUi 7621.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341976 ; ENSP00000339314 ; ENSG00000187792 .
    GeneIDi 7621.
    KEGGi hsa:7621.
    UCSCi uc002zxs.3. human.

    Organism-specific databases

    CTDi 7621.
    GeneCardsi GC22M024083.
    HGNCi HGNC:13140. ZNF70.
    HPAi HPA018821.
    MIMi 194544. gene.
    neXtProti NX_Q9UC06.
    PharmGKBi PA37714.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9UC06.
    OMAi CSSPVQH.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9UC06.
    TreeFami TF337055.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 7621.
    NextBioi 29709.
    PROi Q9UC06.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UC06.
    CleanExi HS_ZNF70.
    Genevestigatori Q9UC06.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of N27C7-1 gene."
      Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)."
      Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O., Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.
      Genomics 13:641-648(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 245-335.

    Entry informationi

    Entry nameiZNF70_HUMAN
    AccessioniPrimary (citable) accession number: Q9UC06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3