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Protein

DNA repair protein REV1

Gene

REV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei357dCTPBy similarity1
Metal bindingi423Magnesium 1PROSITE-ProRule annotation1
Metal bindingi423Magnesium 2PROSITE-ProRule annotation1
Binding sitei522dCTPBy similarity1
Metal bindingi570Magnesium 1PROSITE-ProRule annotation1
Binding sitei570dCTPBy similarity1
Metal bindingi571Magnesium 1PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi423 – 427dCTP bindingBy similarity5
Nucleotide bindingi510 – 516dCTP bindingBy similarity7

GO - Molecular functioni

  • damaged DNA binding Source: ProtInc
  • deoxycytidyl transferase activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • DNA replication Source: ProtInc
  • error-prone translesion synthesis Source: UniProtKB
  • response to UV Source: UniProtKB
  • translesion synthesis Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA synthesis

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135945-MONOMER.
ReactomeiR-HSA-110312. Translesion synthesis by REV1.
R-HSA-5655862. Translesion synthesis by POLK.
R-HSA-5656121. Translesion synthesis by POLI.
R-HSA-5656169. Termination of translesion DNA synthesis.
SignaLinkiQ9UBZ9.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein REV1 (EC:2.7.7.-)
Alternative name(s):
Alpha integrin-binding protein 80
Short name:
AIBP80
Rev1-like terminal deoxycytidyl transferase
Gene namesi
Name:REV1
Synonyms:REV1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14060. REV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi570D → A: Abolishes transferase activity; when associated with A-571. 1 Publication1
Mutagenesisi571E → A: Abolishes transferase activity; when associated with A-570. 1 Publication1

Organism-specific databases

DisGeNETi51455.
OpenTargetsiENSG00000135945.
PharmGKBiPA162401120.

Polymorphism and mutation databases

BioMutaiREV1.
DMDMi59798439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001739921 – 1251DNA repair protein REV1Add BLAST1251

Proteomic databases

PaxDbiQ9UBZ9.
PeptideAtlasiQ9UBZ9.
PRIDEiQ9UBZ9.

PTM databases

iPTMnetiQ9UBZ9.
PhosphoSitePlusiQ9UBZ9.

Expressioni

Tissue specificityi

Ubiquitous.3 Publications

Gene expression databases

BgeeiENSG00000135945.
CleanExiHS_REV1.
ExpressionAtlasiQ9UBZ9. baseline and differential.
GenevisibleiQ9UBZ9. HS.

Organism-specific databases

HPAiHPA044534.
HPA051036.

Interactioni

Subunit structurei

Monomer. Interacts with the DNA polymerase zeta which is composed of REV3L and MAD2L2; the interaction with MAD2L2 is direct and requires that REV3L is in its closed conformation. Interacts with POLH, POLI and POLK. May bind ITGA3. Interacts with FAAP20/C1orf86.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei770Interaction with target DNABy similarity1
Sitei783Interaction with target DNABy similarity1

Binary interactionsi

WithEntry#Exp.IntActNotes
FAAP20Q6NZ362EBI-7353917,EBI-2817693

Protein-protein interaction databases

BioGridi119551. 26 interactors.
IntActiQ9UBZ9. 4 interactors.
MINTiMINT-140323.
STRINGi9606.ENSP00000258428.

Structurei

Secondary structure

11251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni48 – 51Combined sources4
Beta strandi53 – 56Combined sources4
Helixi64 – 73Combined sources10
Beta strandi84 – 86Combined sources3
Beta strandi89 – 91Combined sources3
Helixi99 – 102Combined sources4
Beta strandi104 – 106Combined sources3
Helixi112 – 120Combined sources9
Helixi127 – 129Combined sources3
Helixi345 – 355Combined sources11
Helixi357 – 375Combined sources19
Helixi384 – 387Combined sources4
Beta strandi419 – 424Combined sources6
Helixi427 – 432Combined sources6
Turni433 – 435Combined sources3
Turni437 – 441Combined sources5
Beta strandi444 – 446Combined sources3
Helixi463 – 471Combined sources9
Turni472 – 475Combined sources4
Helixi500 – 502Combined sources3
Beta strandi509 – 511Combined sources3
Helixi513 – 516Combined sources4
Turni517 – 519Combined sources3
Helixi526 – 532Combined sources7
Beta strandi537 – 539Combined sources3
Helixi543 – 558Combined sources16
Beta strandi564 – 568Combined sources5
Beta strandi571 – 575Combined sources5
Helixi577 – 583Combined sources7
Helixi587 – 602Combined sources16
Beta strandi606 – 613Combined sources8
Helixi614 – 624Combined sources11
Beta strandi629 – 631Combined sources3
Helixi634 – 636Combined sources3
Helixi637 – 643Combined sources7
Helixi646 – 648Combined sources3
Helixi654 – 662Combined sources9
Helixi668 – 671Combined sources4
Helixi676 – 683Combined sources8
Helixi685 – 694Combined sources10
Turni695 – 697Combined sources3
Beta strandi712 – 716Combined sources5
Helixi725 – 745Combined sources21
Beta strandi748 – 760Combined sources13
Beta strandi776 – 790Combined sources15
Helixi793 – 805Combined sources13
Helixi811 – 813Combined sources3
Beta strandi814 – 826Combined sources13
Beta strandi1160 – 1162Combined sources3
Helixi1165 – 1178Combined sources14
Helixi1184 – 1199Combined sources16
Helixi1203 – 1218Combined sources16
Helixi1223 – 1243Combined sources21
Beta strandi1245 – 1248Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBWNMR-A44-133[»]
2LSINMR-A1156-1251[»]
2LSKNMR-A1158-1251[»]
2LSYNMR-A1158-1251[»]
2N1GNMR-A1158-1251[»]
3GQCX-ray2.50A/B/C/D330-833[»]
3VU7X-ray2.80H1140-1251[»]
4BA9X-ray2.73A/B/C/D/E/F1158-1242[»]
4EXTX-ray1.90A1156-1251[»]
4GK0X-ray2.70E/F1117-1251[»]
4GK5X-ray3.21E/F1117-1251[»]
ProteinModelPortaliQ9UBZ9.
SMRiQ9UBZ9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBZ9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 131BRCTPROSITE-ProRule annotationAdd BLAST88
Domaini419 – 653UmuCPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni352 – 362Interaction with target DNABy similarityAdd BLAST11
Regioni653 – 656Interaction with target DNABy similarity4
Regioni709 – 717Interaction with target DNABy similarity9
Regioni1150 – 1249Protein interaction domain; mediates interaction with DNA polymerase zetaAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1071 – 1078Nuclear localization signalSequence analysis8

Domaini

The C-terminal domain is necessary for protein interactions.

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.Curated
Contains 1 BRCT domain.PROSITE-ProRule annotation
Contains 1 umuC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2093. Eukaryota.
COG0389. LUCA.
GeneTreeiENSGT00530000062942.
HOGENOMiHOG000154094.
HOVERGENiHBG054140.
InParanoidiQ9UBZ9.
KOiK03515.
OMAiYRFCRGL.
OrthoDBiEOG091G02UI.
PhylomeDBiQ9UBZ9.
TreeFamiTF314488.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di3.30.1490.100. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR017961. DNA_pol_Y-fam_little_finger.
IPR025527. DUF4414.
IPR012112. REV1.
IPR031991. Rev1_C.
IPR001126. UmuC.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF14377. DUF4414. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF16727. REV1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF036573. REV1. 1 hit.
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS50173. UMUC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBZ9-1) [UniParc]FASTAAdd to basket
Also known as: REV1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS
60 70 80 90 100
GVAIYVNGYT DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI
110 120 130 140 150
KELKGEKVIR PEWIVESIKA GRLLSYIPYQ LYTKQSSVQK GLSFNPVCRP
160 170 180 190 200
EDPLPGPSNI AKQLNNRVNH IVKKIETENE VKVNGMNSWN EEDENNDFSF
210 220 230 240 250
VDLEQTSPGR KQNGIPHPRG STAIFNGHTP SSNGALKTQD CLVPMVNSVA
260 270 280 290 300
SRLSPAFSQE EDKAEKSSTD FRDCTLQQLQ QSTRNTDALR NPHRTNSFSL
310 320 330 340 350
SPLHSNTKIN GAHHSTVQGP SSTKSTSSVS TFSKAAPSVP SKPSDCNFIS
360 370 380 390 400
NFYSHSRLHH ISMWKCELTE FVNTLQRQSN GIFPGREKLK KMKTGRSALV
410 420 430 440 450
VTDTGDMSVL NSPRHQSCIM HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR
460 470 480 490 500
GTGRAPLRPG ANPQLEWQYY QNKILKGKAA DIPDSSLWEN PDSAQANGID
510 520 530 540 550
SVLSRAEIAS CSYEARQLGI KNGMFFGHAK QLCPNLQAVP YDFHAYKEVA
560 570 580 590 600
QTLYETLASY THNIEAVSCD EALVDITEIL AETKLTPDEF ANAVRMEIKD
610 620 630 640 650
QTKCAASVGI GSNILLARMA TRKAKPDGQY HLKPEEVDDF IRGQLVTNLP
660 670 680 690 700
GVGHSMESKL ASLGIKTCGD LQYMTMAKLQ KEFGPKTGQM LYRFCRGLDD
710 720 730 740 750
RPVRTEKERK SVSAEINYGI RFTQPKEAEA FLLSLSEEIQ RRLEATGMKG
760 770 780 790 800
KRLTLKIMVR KPGAPVETAK FGGHGICDNI ARTVTLDQAT DNAKIIGKAM
810 820 830 840 850
LNMFHTMKLN ISDMRGVGIH VNQLVPTNLN PSTCPSRPSV QSSHFPSGSY
860 870 880 890 900
SVRDVFQVQK AKKSTEEEHK EVFRAAVDLE ISSASRTCTF LPPFPAHLPT
910 920 930 940 950
SPDTNKAESS GKWNGLHTPV SVQSRLNLSI EVPSPSQLDQ SVLEALPPDL
960 970 980 990 1000
REQVEQVCAV QQAESHGDKK KEPVNGCNTG ILPQPVGTVL LQIPEPQESN
1010 1020 1030 1040 1050
SDAGINLIAL PAFSQVDPEV FAALPAELQR ELKAAYDQRQ RQGENSTHQQ
1060 1070 1080 1090 1100
SASASVPKNP LLHLKAAVKE KKRNKKKKTI GSPKRIQSPL NNKLLNSPAK
1110 1120 1130 1140 1150
TLPGACGSPQ KLIDGFLKHE GPPAEKPLEE LSASTSGVPG LSSLQSDPAG
1160 1170 1180 1190 1200
CVRPPAPNLA GAVEFNDVKT LLREWITTIS DPMEEDILQV VKYCTDLIEE
1210 1220 1230 1240 1250
KDLEKLDLVI KYMKRLMQQS VESVWNMAFD FILDNVQVVL QQTYGSTLKV

T
Length:1,251
Mass (Da):138,248
Last modified:May 1, 2000 - v1
Checksum:i010E261D537DBA80
GO
Isoform 2 (identifier: Q9UBZ9-2) [UniParc]FASTAAdd to basket
Also known as: REV1S

The sequence of this isoform differs from the canonical sequence as follows:
     479-479: Missing.

Show »
Length:1,250
Mass (Da):138,177
Checksum:iB4B1606DB6E866F2
GO
Isoform 3 (identifier: Q9UBZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     406-413: DMSVLNSP → RYLLKLSS
     414-1251: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):43,649
Checksum:iA0EA83A568AD74F9
GO

Sequence cautioni

The sequence AAK43708 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021249138V → M.Corresponds to variant rs3087403dbSNPEnsembl.1
Natural variantiVAR_021250257F → S.Corresponds to variant rs3087386dbSNPEnsembl.1
Natural variantiVAR_029193306N → D.Corresponds to variant rs28382882dbSNPEnsembl.1
Natural variantiVAR_021251373N → S.Corresponds to variant rs3087399dbSNPEnsembl.1
Natural variantiVAR_029194656M → V.Corresponds to variant rs3087394dbSNPEnsembl.1
Natural variantiVAR_029195660L → W.Corresponds to variant rs3087398dbSNPEnsembl.1
Natural variantiVAR_029196700D → N.Corresponds to variant rs28382941dbSNPEnsembl.1
Natural variantiVAR_029197704R → Q.Corresponds to variant rs28382942dbSNPEnsembl.1
Natural variantiVAR_029199902P → H.Corresponds to variant rs28382961dbSNPEnsembl.1
Natural variantiVAR_029198902P → S.Corresponds to variant rs28382960dbSNPEnsembl.1
Natural variantiVAR_029200921S → I.Corresponds to variant rs3087396dbSNPEnsembl.1
Natural variantiVAR_0244361003A → T.Corresponds to variant rs3087401dbSNPEnsembl.1
Natural variantiVAR_0292011060P → T.Corresponds to variant rs3087388dbSNPEnsembl.1
Natural variantiVAR_0292021074N → K.Corresponds to variant rs3087393dbSNPEnsembl.1
Natural variantiVAR_0292031091N → T.Corresponds to variant rs3087392dbSNPEnsembl.1
Natural variantiVAR_0292041102L → P.Corresponds to variant rs3087400dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0128091 – 21Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012810406 – 413DMSVLNSP → RYLLKLSS in isoform 3. 1 Publication8
Alternative sequenceiVSP_012811414 – 1251Missing in isoform 3. 1 PublicationAdd BLAST838
Alternative sequenceiVSP_012812479Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151538 mRNA. Translation: AAF06731.1.
AF206019 mRNA. Translation: AAF18986.1.
AB047646 mRNA. Translation: BAB21441.1.
AF357886 mRNA. Translation: AAK43708.1. Different initiation.
AK002087 mRNA. Translation: BAA92079.1.
AC018690 Genomic DNA. Translation: AAY24314.1.
AJ131720 mRNA. Translation: CAB38231.1.
CCDSiCCDS2045.1. [Q9UBZ9-1]
CCDS42722.1. [Q9UBZ9-2]
RefSeqiNP_001032961.1. NM_001037872.2. [Q9UBZ9-2]
NP_001308383.1. NM_001321454.1.
NP_001308384.1. NM_001321455.1.
NP_001308387.1. NM_001321458.1.
NP_001308388.1. NM_001321459.1.
NP_001308389.1. NM_001321460.1.
NP_057400.1. NM_016316.3. [Q9UBZ9-1]
UniGeneiHs.443077.

Genome annotation databases

EnsembliENST00000258428; ENSP00000258428; ENSG00000135945. [Q9UBZ9-1]
ENST00000393445; ENSP00000377091; ENSG00000135945. [Q9UBZ9-2]
GeneIDi51455.
KEGGihsa:51455.
UCSCiuc002tac.4. human. [Q9UBZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151538 mRNA. Translation: AAF06731.1.
AF206019 mRNA. Translation: AAF18986.1.
AB047646 mRNA. Translation: BAB21441.1.
AF357886 mRNA. Translation: AAK43708.1. Different initiation.
AK002087 mRNA. Translation: BAA92079.1.
AC018690 Genomic DNA. Translation: AAY24314.1.
AJ131720 mRNA. Translation: CAB38231.1.
CCDSiCCDS2045.1. [Q9UBZ9-1]
CCDS42722.1. [Q9UBZ9-2]
RefSeqiNP_001032961.1. NM_001037872.2. [Q9UBZ9-2]
NP_001308383.1. NM_001321454.1.
NP_001308384.1. NM_001321455.1.
NP_001308387.1. NM_001321458.1.
NP_001308388.1. NM_001321459.1.
NP_001308389.1. NM_001321460.1.
NP_057400.1. NM_016316.3. [Q9UBZ9-1]
UniGeneiHs.443077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBWNMR-A44-133[»]
2LSINMR-A1156-1251[»]
2LSKNMR-A1158-1251[»]
2LSYNMR-A1158-1251[»]
2N1GNMR-A1158-1251[»]
3GQCX-ray2.50A/B/C/D330-833[»]
3VU7X-ray2.80H1140-1251[»]
4BA9X-ray2.73A/B/C/D/E/F1158-1242[»]
4EXTX-ray1.90A1156-1251[»]
4GK0X-ray2.70E/F1117-1251[»]
4GK5X-ray3.21E/F1117-1251[»]
ProteinModelPortaliQ9UBZ9.
SMRiQ9UBZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119551. 26 interactors.
IntActiQ9UBZ9. 4 interactors.
MINTiMINT-140323.
STRINGi9606.ENSP00000258428.

PTM databases

iPTMnetiQ9UBZ9.
PhosphoSitePlusiQ9UBZ9.

Polymorphism and mutation databases

BioMutaiREV1.
DMDMi59798439.

Proteomic databases

PaxDbiQ9UBZ9.
PeptideAtlasiQ9UBZ9.
PRIDEiQ9UBZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258428; ENSP00000258428; ENSG00000135945. [Q9UBZ9-1]
ENST00000393445; ENSP00000377091; ENSG00000135945. [Q9UBZ9-2]
GeneIDi51455.
KEGGihsa:51455.
UCSCiuc002tac.4. human. [Q9UBZ9-1]

Organism-specific databases

CTDi51455.
DisGeNETi51455.
GeneCardsiREV1.
HGNCiHGNC:14060. REV1.
HPAiHPA044534.
HPA051036.
MIMi606134. gene.
neXtProtiNX_Q9UBZ9.
OpenTargetsiENSG00000135945.
PharmGKBiPA162401120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2093. Eukaryota.
COG0389. LUCA.
GeneTreeiENSGT00530000062942.
HOGENOMiHOG000154094.
HOVERGENiHBG054140.
InParanoidiQ9UBZ9.
KOiK03515.
OMAiYRFCRGL.
OrthoDBiEOG091G02UI.
PhylomeDBiQ9UBZ9.
TreeFamiTF314488.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135945-MONOMER.
ReactomeiR-HSA-110312. Translesion synthesis by REV1.
R-HSA-5655862. Translesion synthesis by POLK.
R-HSA-5656121. Translesion synthesis by POLI.
R-HSA-5656169. Termination of translesion DNA synthesis.
SignaLinkiQ9UBZ9.

Miscellaneous databases

ChiTaRSiREV1. human.
EvolutionaryTraceiQ9UBZ9.
GeneWikiiREV1.
GenomeRNAii51455.
PROiQ9UBZ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135945.
CleanExiHS_REV1.
ExpressionAtlasiQ9UBZ9. baseline and differential.
GenevisibleiQ9UBZ9. HS.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di3.30.1490.100. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR017961. DNA_pol_Y-fam_little_finger.
IPR025527. DUF4414.
IPR012112. REV1.
IPR031991. Rev1_C.
IPR001126. UmuC.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF14377. DUF4414. 1 hit.
PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF16727. REV1_C. 1 hit.
[Graphical view]
PIRSFiPIRSF036573. REV1. 1 hit.
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS50173. UMUC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREV1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBZ9
Secondary accession number(s): O95941
, Q53SI7, Q9C0J4, Q9NUP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.