##gff-version 3
Q9UBZ4	UniProtKB	Chain	1	518	.	.	.	ID=PRO_0000200014;Note=DNA-(apurinic or apyrimidinic site) endonuclease 2	
Q9UBZ4	UniProtKB	Zinc finger	469	518	.	.	.	Note=GRF-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01343	
Q9UBZ4	UniProtKB	Region	355	407	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q9UBZ4	UniProtKB	Region	390	397	.	.	.	Note=Required for the interaction and colocalization with PCNA in nuclear foci in presence of oxidative-induced DNA damaging agents;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11376153,ECO:0000269|PubMed:32516598;Dbxref=PMID:11376153,PMID:32516598	
Q9UBZ4	UniProtKB	Active site	156	156	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27695	
Q9UBZ4	UniProtKB	Active site	197	197	.	.	.	Note=Proton donor/acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27695	
Q9UBZ4	UniProtKB	Active site	304	304	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	8	8	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	48	48	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	197	197	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	199	199	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	303	303	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	304	304	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00764	
Q9UBZ4	UniProtKB	Binding site	469	469	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01343	
Q9UBZ4	UniProtKB	Binding site	472	472	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01343	
Q9UBZ4	UniProtKB	Binding site	495	495	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01343	
Q9UBZ4	UniProtKB	Binding site	509	509	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01343	
Q9UBZ4	UniProtKB	Site	199	199	.	.	.	Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27695	
Q9UBZ4	UniProtKB	Site	277	277	.	.	.	Note=Important for catalytic activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27695	
Q9UBZ4	UniProtKB	Site	304	304	.	.	.	Note=Interaction with DNA substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27695	
Q9UBZ4	UniProtKB	Natural variant	141	141	.	.	.	ID=VAR_023390;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs2301416	
Q9UBZ4	UniProtKB	Natural variant	141	141	.	.	.	ID=VAR_048261;Note=R->W;Dbxref=dbSNP:rs2301416	
Q9UBZ4	UniProtKB	Natural variant	269	269	.	.	.	ID=VAR_064033;Note=Identified in a patient with mtDNA maintenance disorders. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20843780;Dbxref=dbSNP:rs145122391,PMID:20843780	
Q9UBZ4	UniProtKB	Natural variant	392	392	.	.	.	ID=VAR_064034;Note=Identified in a patient with mtDNA maintenance disorders. N->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20843780;Dbxref=dbSNP:rs201964062,PMID:20843780	
Q9UBZ4	UniProtKB	Mutagenesis	48	48	.	.	.	Note=Abolished 3'-5' exonuclease activity%3B when associated with Asn-197. Synthetic lethality in a BRCA1 or BRCA2 mutant cell line background%3B when associated with Asn-197. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32516598;Dbxref=PMID:32516598	
Q9UBZ4	UniProtKB	Mutagenesis	197	197	.	.	.	Note=Abolished 3'-5' exonuclease activity%3B when associated with Gln-48. Synthetic lethality in a BRCA1 or BRCA2 mutant cell line background%3B when associated with Gln-48. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32516598;Dbxref=PMID:32516598	
Q9UBZ4	UniProtKB	Mutagenesis	269	269	.	.	.	Note=Abolishes AP endodeoxyribonuclease%2C 3'-5' exonuclease activity and 3'-phosphodiesterase activities. H->A	
Q9UBZ4	UniProtKB	Mutagenesis	277	277	.	.	.	Note=Abolishes AP endodeoxyribonuclease%2C 3'-5' exonuclease activity and 3'-phosphodiesterase activities. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16687656;Dbxref=PMID:16687656	
Q9UBZ4	UniProtKB	Mutagenesis	396	397	.	.	.	Note=Loss of interaction with PCNA. YF->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32516598;Dbxref=PMID:32516598	
Q9UBZ4	UniProtKB	Mutagenesis	396	396	.	.	.	Note=Reduces 3'-5' exonuclease activity in presence of PCNA. Does not abolish the 3'-5' exonuclease activity. Does only partially redistributes together with PCNA in nuclear foci in presence of oxidative-induced DNA damaging agents. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19443450;Dbxref=PMID:19443450	
Q9UBZ4	UniProtKB	Mutagenesis	397	397	.	.	.	Note=Reduces 3'-5' exonuclease activity in presence of PCNA. Does not abolish the 3'-5' exonuclease activity. Does only partially redistributes together with PCNA in nuclear foci in presence of oxidative-induced DNA damaging agents. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19443450;Dbxref=PMID:19443450	
Q9UBZ4	UniProtKB	Sequence conflict	399	399	.	.	.	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305