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Protein

Heat shock protein beta-7

Gene

HSPB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • filamin binding Source: Ensembl
  • protein C-terminus binding Source: ProtInc

GO - Biological processi

  • regulation of heart contraction Source: ProtInc
  • response to unfolded protein Source: ProtInc

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-7
Short name:
HspB7
Alternative name(s):
Cardiovascular heat shock protein
Short name:
cvHsp
Gene namesi
Name:HSPB7
Synonyms:CVHSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:5249. HSPB7.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: Ensembl
  • aggresome Source: HPA
  • Cajal body Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27129.
OpenTargetsiENSG00000173641.
PharmGKBiPA29514.

Polymorphism and mutation databases

BioMutaiHSPB7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259411 – 170Heat shock protein beta-7Add BLAST170

Proteomic databases

PaxDbiQ9UBY9.
PeptideAtlasiQ9UBY9.
PRIDEiQ9UBY9.

2D gel databases

UCD-2DPAGEiQ9UBY9.

PTM databases

iPTMnetiQ9UBY9.
PhosphoSitePlusiQ9UBY9.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.

Gene expression databases

BgeeiENSG00000173641.
CleanExiHS_HSPB7.
ExpressionAtlasiQ9UBY9. baseline and differential.
GenevisibleiQ9UBY9. HS.

Organism-specific databases

HPAiHPA027639.

Interactioni

Subunit structurei

Interacts with C-terminal domain of actin-binding protein 280.

Binary interactionsi

Show more details

GO - Molecular functioni

  • filamin binding Source: Ensembl
  • protein C-terminus binding Source: ProtInc

Protein-protein interaction databases

BioGridi118020. 14 interactors.
IntActiQ9UBY9. 18 interactors.
STRINGi9606.ENSP00000310111.

Structurei

3D structure databases

ProteinModelPortaliQ9UBY9.
SMRiQ9UBY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 170sHSPPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71Required for localization to SC35 splicing specklesAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 31Poly-SerAdd BLAST15

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00390000010674.
HOGENOMiHOG000072715.
HOVERGENiHBG052040.
InParanoidiQ9UBY9.
KOiK09546.
OMAiWMSHRTS.
PhylomeDBiQ9UBY9.
TreeFamiTF350564.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiView protein in Pfam
PF00011. HSP20. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS01031. SHSP. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD
60 70 80 90 100
DFGSFMRPHS EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT
110 120 130 140 150
SNNHIEVRAE KLAADGTVMN TFAHKCQLPE DVDPTSVTSA LREDGSLTIR
160 170
ARRHPHTEHV QQTFRTEIKI
Length:170
Mass (Da):18,611
Last modified:May 1, 2000 - v1
Checksum:i0A6F47931AE67B3E
GO
Isoform 2 (identifier: Q9UBY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: A → AAHPTA

Show »
Length:175
Mass (Da):19,088
Checksum:iE8A9AC71D6DA9069
GO
Isoform 3 (identifier: Q9UBY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: R → K
     69-170: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:68
Mass (Da):7,344
Checksum:i83465ACD0B48C6FF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00242467A → AAHPTA in isoform 2. 2 Publications1
Alternative sequenceiVSP_00242568R → K in isoform 3. 1 Publication1
Alternative sequenceiVSP_00242669 – 170Missing in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243191 mRNA. Translation: CAB63258.1.
AF155908 mRNA. Translation: AAF20022.1.
AK057295 mRNA. Translation: BAG51899.1.
CR749298 mRNA. Translation: CAH18153.1.
AL096775 Genomic DNA. Translation: CAB86671.1.
AL355994 Genomic DNA. No translation available.
BC006319 mRNA. Translation: AAH06319.1.
CCDSiCCDS30611.1. [Q9UBY9-1]
RefSeqiNP_055239.1. NM_014424.4. [Q9UBY9-1]
UniGeneiHs.502612.

Genome annotation databases

EnsembliENST00000311890; ENSP00000310111; ENSG00000173641. [Q9UBY9-1]
ENST00000487046; ENSP00000419477; ENSG00000173641. [Q9UBY9-2]
GeneIDi27129.
KEGGihsa:27129.
UCSCiuc001axo.2. human. [Q9UBY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243191 mRNA. Translation: CAB63258.1.
AF155908 mRNA. Translation: AAF20022.1.
AK057295 mRNA. Translation: BAG51899.1.
CR749298 mRNA. Translation: CAH18153.1.
AL096775 Genomic DNA. Translation: CAB86671.1.
AL355994 Genomic DNA. No translation available.
BC006319 mRNA. Translation: AAH06319.1.
CCDSiCCDS30611.1. [Q9UBY9-1]
RefSeqiNP_055239.1. NM_014424.4. [Q9UBY9-1]
UniGeneiHs.502612.

3D structure databases

ProteinModelPortaliQ9UBY9.
SMRiQ9UBY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118020. 14 interactors.
IntActiQ9UBY9. 18 interactors.
STRINGi9606.ENSP00000310111.

PTM databases

iPTMnetiQ9UBY9.
PhosphoSitePlusiQ9UBY9.

Polymorphism and mutation databases

BioMutaiHSPB7.

2D gel databases

UCD-2DPAGEiQ9UBY9.

Proteomic databases

PaxDbiQ9UBY9.
PeptideAtlasiQ9UBY9.
PRIDEiQ9UBY9.

Protocols and materials databases

DNASUi27129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311890; ENSP00000310111; ENSG00000173641. [Q9UBY9-1]
ENST00000487046; ENSP00000419477; ENSG00000173641. [Q9UBY9-2]
GeneIDi27129.
KEGGihsa:27129.
UCSCiuc001axo.2. human. [Q9UBY9-1]

Organism-specific databases

CTDi27129.
DisGeNETi27129.
GeneCardsiHSPB7.
HGNCiHGNC:5249. HSPB7.
HPAiHPA027639.
MIMi610692. gene.
neXtProtiNX_Q9UBY9.
OpenTargetsiENSG00000173641.
PharmGKBiPA29514.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00390000010674.
HOGENOMiHOG000072715.
HOVERGENiHBG052040.
InParanoidiQ9UBY9.
KOiK09546.
OMAiWMSHRTS.
PhylomeDBiQ9UBY9.
TreeFamiTF350564.

Miscellaneous databases

ChiTaRSiHSPB7. human.
GenomeRNAii27129.
PROiPR:Q9UBY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173641.
CleanExiHS_HSPB7.
ExpressionAtlasiQ9UBY9. baseline and differential.
GenevisibleiQ9UBY9. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiView protein in Pfam
PF00011. HSP20. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS01031. SHSP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB7_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY9
Secondary accession number(s): B3KQ37, C9K0Y0, Q9NU17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.