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Protein

Heat shock protein beta-7

Gene

HSPB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein C-terminus binding Source: ProtInc

GO - Biological processi

  • regulation of heart contraction Source: ProtInc
  • response to heat Source: Ensembl
  • response to unfolded protein Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-7
Short name:
HspB7
Alternative name(s):
Cardiovascular heat shock protein
Short name:
cvHsp
Gene namesi
Name:HSPB7
Synonyms:CVHSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:5249. HSPB7.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: Ensembl
  • aggresome Source: HPA
  • Cajal body Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29514.

Polymorphism and mutation databases

BioMutaiHSPB7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Heat shock protein beta-7PRO_0000125941Add
BLAST

Proteomic databases

MaxQBiQ9UBY9.
PaxDbiQ9UBY9.
PRIDEiQ9UBY9.

2D gel databases

UCD-2DPAGEQ9UBY9.

PTM databases

iPTMnetiQ9UBY9.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.

Gene expression databases

BgeeiQ9UBY9.
CleanExiHS_HSPB7.
ExpressionAtlasiQ9UBY9. baseline and differential.
GenevisibleiQ9UBY9. HS.

Organism-specific databases

HPAiHPA027639.

Interactioni

Subunit structurei

Interacts with C-terminal domain of actin-binding protein 280.

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP76Q8TAP63EBI-739361,EBI-742887
FLNAP21333-23EBI-739361,EBI-9641086
HSPB8Q9UJY18EBI-739361,EBI-739074
PLEKHF2Q9H8W43EBI-739361,EBI-742388
PRDM14Q9GZV83EBI-739361,EBI-3957793
RELQ048643EBI-739361,EBI-307352
SF3B4Q154273EBI-739361,EBI-348469
SYCE1Q8N0S23EBI-739361,EBI-6872807
TCF4P158843EBI-739361,EBI-533224
TRIM23P364063EBI-739361,EBI-740098

GO - Molecular functioni

  • protein C-terminus binding Source: ProtInc

Protein-protein interaction databases

BioGridi118020. 14 interactions.
IntActiQ9UBY9. 10 interactions.
STRINGi9606.ENSP00000310111.

Structurei

3D structure databases

ProteinModelPortaliQ9UBY9.
SMRiQ9UBY9. Positions 40-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7171Required for localization to SC35 splicing specklesAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 3115Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00390000010674.
HOGENOMiHOG000072715.
HOVERGENiHBG052040.
InParanoidiQ9UBY9.
KOiK09546.
OMAiWMSHRTS.
PhylomeDBiQ9UBY9.
TreeFamiTF350564.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD
60 70 80 90 100
DFGSFMRPHS EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT
110 120 130 140 150
SNNHIEVRAE KLAADGTVMN TFAHKCQLPE DVDPTSVTSA LREDGSLTIR
160 170
ARRHPHTEHV QQTFRTEIKI
Length:170
Mass (Da):18,611
Last modified:May 1, 2000 - v1
Checksum:i0A6F47931AE67B3E
GO
Isoform 2 (identifier: Q9UBY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-67: A → AAHPTA

Show »
Length:175
Mass (Da):19,088
Checksum:iE8A9AC71D6DA9069
GO
Isoform 3 (identifier: Q9UBY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: R → K
     69-170: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:68
Mass (Da):7,344
Checksum:i83465ACD0B48C6FF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 671A → AAHPTA in isoform 2. 2 PublicationsVSP_002424
Alternative sequencei68 – 681R → K in isoform 3. 1 PublicationVSP_002425
Alternative sequencei69 – 170102Missing in isoform 3. 1 PublicationVSP_002426Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243191 mRNA. Translation: CAB63258.1.
AF155908 mRNA. Translation: AAF20022.1.
AK057295 mRNA. Translation: BAG51899.1.
CR749298 mRNA. Translation: CAH18153.1.
AL096775 Genomic DNA. Translation: CAB86671.1.
AL355994 Genomic DNA. No translation available.
BC006319 mRNA. Translation: AAH06319.1.
CCDSiCCDS30611.1. [Q9UBY9-1]
RefSeqiNP_055239.1. NM_014424.4. [Q9UBY9-1]
UniGeneiHs.502612.

Genome annotation databases

EnsembliENST00000311890; ENSP00000310111; ENSG00000173641. [Q9UBY9-1]
ENST00000487046; ENSP00000419477; ENSG00000173641. [Q9UBY9-2]
GeneIDi27129.
KEGGihsa:27129.
UCSCiuc001axo.2. human. [Q9UBY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243191 mRNA. Translation: CAB63258.1.
AF155908 mRNA. Translation: AAF20022.1.
AK057295 mRNA. Translation: BAG51899.1.
CR749298 mRNA. Translation: CAH18153.1.
AL096775 Genomic DNA. Translation: CAB86671.1.
AL355994 Genomic DNA. No translation available.
BC006319 mRNA. Translation: AAH06319.1.
CCDSiCCDS30611.1. [Q9UBY9-1]
RefSeqiNP_055239.1. NM_014424.4. [Q9UBY9-1]
UniGeneiHs.502612.

3D structure databases

ProteinModelPortaliQ9UBY9.
SMRiQ9UBY9. Positions 40-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118020. 14 interactions.
IntActiQ9UBY9. 10 interactions.
STRINGi9606.ENSP00000310111.

PTM databases

iPTMnetiQ9UBY9.

Polymorphism and mutation databases

BioMutaiHSPB7.

2D gel databases

UCD-2DPAGEQ9UBY9.

Proteomic databases

MaxQBiQ9UBY9.
PaxDbiQ9UBY9.
PRIDEiQ9UBY9.

Protocols and materials databases

DNASUi27129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311890; ENSP00000310111; ENSG00000173641. [Q9UBY9-1]
ENST00000487046; ENSP00000419477; ENSG00000173641. [Q9UBY9-2]
GeneIDi27129.
KEGGihsa:27129.
UCSCiuc001axo.2. human. [Q9UBY9-1]

Organism-specific databases

CTDi27129.
GeneCardsiHSPB7.
HGNCiHGNC:5249. HSPB7.
HPAiHPA027639.
MIMi610692. gene.
neXtProtiNX_Q9UBY9.
PharmGKBiPA29514.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00390000010674.
HOGENOMiHOG000072715.
HOVERGENiHBG052040.
InParanoidiQ9UBY9.
KOiK09546.
OMAiWMSHRTS.
PhylomeDBiQ9UBY9.
TreeFamiTF350564.

Miscellaneous databases

ChiTaRSiHSPB7. human.
GenomeRNAii27129.
PROiQ9UBY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBY9.
CleanExiHS_HSPB7.
ExpressionAtlasiQ9UBY9. baseline and differential.
GenevisibleiQ9UBY9. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues."
    Krief S., Faivre J.-F., Robert P., Le Douarin B., Brument-Larignon N., Lefrere I., Bouzyk M.M., Anderson K.M., Greller L.D., Tobin F.L., Souchet M., Bril A.
    J. Biol. Chem. 274:36592-36600(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Salivary gland.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.
  6. "HSPB7 is a SC35 speckle resident small heat shock protein."
    Vos M.J., Kanon B., Kampinga H.H.
    Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHSPB7_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY9
Secondary accession number(s): B3KQ37, C9K0Y0, Q9NU17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.