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Protein

Lysophosphatidic acid receptor 3

Gene

LPAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: ProtInc
  • lysophosphatidic acid receptor activity Source: InterPro
  • phospholipid binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ9UBY5.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
Gene namesi
Name:LPAR3
Synonyms:EDG7, LPA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14298. LPAR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 6715CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10113ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12423Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14622CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 18619ExtracellularSequence analysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini208 – 24033CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 35356CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394213.

Chemistry

ChEMBLiCHEMBL3250.
GuidetoPHARMACOLOGYi274.

Polymorphism and mutation databases

BioMutaiLPAR3.
DMDMi26393418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Lysophosphatidic acid receptor 3PRO_0000069433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis
Lipidationi309 – 3091S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9UBY5.
PRIDEiQ9UBY5.

PTM databases

iPTMnetiQ9UBY5.
PhosphoSiteiQ9UBY5.

Expressioni

Tissue specificityi

Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.

Gene expression databases

BgeeiQ9UBY5.
CleanExiHS_LPAR3.
GenevisibleiQ9UBY5. HS.

Organism-specific databases

HPAiHPA013421.

Interactioni

Protein-protein interaction databases

BioGridi117108. 1 interaction.
STRINGi9606.ENSP00000359643.

Chemistry

BindingDBiQ9UBY5.

Structurei

3D structure databases

ProteinModelPortaliQ9UBY5.
SMRiQ9UBY5. Positions 3-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOVERGENiHBG103071.
InParanoidiQ9UBY5.
KOiK04294.
OMAiMYSTMKR.
OrthoDBiEOG7HTHH1.
PhylomeDBiQ9UBY5.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL
60 70 80 90 100
VIAAVIKNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN
110 120 130 140 150
RWFLRQGLLD SSLTASLTNL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL
160 170 180 190 200
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLVF WTVSNLMAFL
210 220 230 240 250
IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT VMTVLGAFVV
260 270 280 290 300
CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM
310 320 330 340 350
YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK

STS
Length:353
Mass (Da):40,128
Last modified:May 1, 2000 - v1
Checksum:i105DC9DD185E2CE7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti231 – 2311R → Q.
Corresponds to variant rs35745543 [ dbSNP | Ensembl ].
VAR_049415

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127138 mRNA. Translation: AAD56311.1.
AF186380 mRNA. Translation: AAF00530.1.
AY322547 mRNA. Translation: AAP84360.1.
BC126268 mRNA. Translation: AAI26269.1.
BC126270 mRNA. Translation: AAI26271.1.
CCDSiCCDS700.1.
RefSeqiNP_036284.1. NM_012152.2.
XP_011539451.1. XM_011541149.1.
UniGeneiHs.527909.
Hs.674915.

Genome annotation databases

EnsembliENST00000370611; ENSP00000359643; ENSG00000171517.
ENST00000440886; ENSP00000395389; ENSG00000171517.
GeneIDi23566.
KEGGihsa:23566.
UCSCiuc001dkl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127138 mRNA. Translation: AAD56311.1.
AF186380 mRNA. Translation: AAF00530.1.
AY322547 mRNA. Translation: AAP84360.1.
BC126268 mRNA. Translation: AAI26269.1.
BC126270 mRNA. Translation: AAI26271.1.
CCDSiCCDS700.1.
RefSeqiNP_036284.1. NM_012152.2.
XP_011539451.1. XM_011541149.1.
UniGeneiHs.527909.
Hs.674915.

3D structure databases

ProteinModelPortaliQ9UBY5.
SMRiQ9UBY5. Positions 3-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117108. 1 interaction.
STRINGi9606.ENSP00000359643.

Chemistry

BindingDBiQ9UBY5.
ChEMBLiCHEMBL3250.
GuidetoPHARMACOLOGYi274.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9UBY5.
PhosphoSiteiQ9UBY5.

Polymorphism and mutation databases

BioMutaiLPAR3.
DMDMi26393418.

Proteomic databases

PaxDbiQ9UBY5.
PRIDEiQ9UBY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370611; ENSP00000359643; ENSG00000171517.
ENST00000440886; ENSP00000395389; ENSG00000171517.
GeneIDi23566.
KEGGihsa:23566.
UCSCiuc001dkl.3. human.

Organism-specific databases

CTDi23566.
GeneCardsiLPAR3.
HGNCiHGNC:14298. LPAR3.
HPAiHPA013421.
MIMi605106. gene.
neXtProtiNX_Q9UBY5.
PharmGKBiPA162394213.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOVERGENiHBG103071.
InParanoidiQ9UBY5.
KOiK04294.
OMAiMYSTMKR.
OrthoDBiEOG7HTHH1.
PhylomeDBiQ9UBY5.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ9UBY5.

Miscellaneous databases

ChiTaRSiLPAR3. human.
GeneWikiiLPAR3.
GenomeRNAii23566.
PROiQ9UBY5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBY5.
CleanExiHS_LPAR3.
GenevisibleiQ9UBY5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid."
    Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., Murakami-Murofushi K., Tsujimoto M., Arai H., Inoue K.
    J. Biol. Chem. 274:27776-27785(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.
  2. "Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate."
    Im D.-S., Heise C.E., Harding M.A., George S.R., O'Dowd B.F., Theodorescu D., Lynch K.R.
    Mol. Pharmacol. 57:753-759(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic kidney.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Lysophosphatidic acid receptors."
    Contos J.J.A., Ishii I., Chun J.
    Mol. Pharmacol. 58:1188-1196(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiLPAR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY5
Secondary accession number(s): A0AVA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.