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Protein

Lysophosphatidic acid receptor 3

Gene

LPAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

GO - Molecular functioni

  • G-protein alpha-subunit binding Source: Ensembl
  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: ProtInc
  • lysophosphatidic acid receptor activity Source: InterPro
  • phospholipid binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ9UBY5.

Chemistry databases

SwissLipidsiSLP:000001572.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
Gene namesi
Name:LPAR3
Synonyms:EDG7, LPA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171517.5.
HGNCiHGNC:14298. LPAR3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 67CytoplasmicSequence analysisAdd BLAST15
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 101ExtracellularSequence analysisAdd BLAST13
Transmembranei102 – 124Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini125 – 146CytoplasmicSequence analysisAdd BLAST22
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 186ExtracellularSequence analysisAdd BLAST19
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 240CytoplasmicSequence analysisAdd BLAST33
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 353CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23566.
OpenTargetsiENSG00000171517.
PharmGKBiPA162394213.

Chemistry databases

ChEMBLiCHEMBL3250.
GuidetoPHARMACOLOGYi274.

Polymorphism and mutation databases

BioMutaiLPAR3.
DMDMi26393418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694331 – 353Lysophosphatidic acid receptor 3Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9UBY5.
PeptideAtlasiQ9UBY5.
PRIDEiQ9UBY5.

PTM databases

iPTMnetiQ9UBY5.
PhosphoSitePlusiQ9UBY5.

Expressioni

Tissue specificityi

Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000171517.
CleanExiHS_LPAR3.
GenevisibleiQ9UBY5. HS.

Organism-specific databases

HPAiHPA013421.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117108. 2 interactors.
IntActiQ9UBY5. 16 interactors.
STRINGi9606.ENSP00000359643.

Chemistry databases

BindingDBiQ9UBY5.

Structurei

3D structure databases

ProteinModelPortaliQ9UBY5.
SMRiQ9UBY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOVERGENiHBG103071.
InParanoidiQ9UBY5.
KOiK04294.
OMAiHSNLTKR.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9UBY5.
TreeFamiTF330052.

Family and domain databases

CDDicd15343. 7tmA_LPAR3_Edg7. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UBY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL
60 70 80 90 100
VIAAVIKNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN
110 120 130 140 150
RWFLRQGLLD SSLTASLTNL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL
160 170 180 190 200
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLVF WTVSNLMAFL
210 220 230 240 250
IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT VMTVLGAFVV
260 270 280 290 300
CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM
310 320 330 340 350
YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK

STS
Length:353
Mass (Da):40,128
Last modified:May 1, 2000 - v1
Checksum:i105DC9DD185E2CE7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049415231R → Q. Corresponds to variant dbSNP:rs35745543Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127138 mRNA. Translation: AAD56311.1.
AF186380 mRNA. Translation: AAF00530.1.
AY322547 mRNA. Translation: AAP84360.1.
BC126268 mRNA. Translation: AAI26269.1.
BC126270 mRNA. Translation: AAI26271.1.
CCDSiCCDS700.1.
RefSeqiNP_036284.1. NM_012152.2.
UniGeneiHs.527909.
Hs.674915.

Genome annotation databases

EnsembliENST00000370611; ENSP00000359643; ENSG00000171517.
ENST00000440886; ENSP00000395389; ENSG00000171517.
GeneIDi23566.
KEGGihsa:23566.
UCSCiuc001dkl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLPAR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY5
Secondary accession number(s): A0AVA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families