Q9UBY5 (LPAR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysophosphatidic acid receptor 3
Short name=LPA receptor 3
Short name=LPA-3

Alternative name(s):
Lysophosphatidic acid receptor Edg-7

Gene names

Name:	LPAR3
Synonyms:	EDG7, LPA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.1. Source: ProtInc activation of MAPK activity Inferred from electronic annotation. Source: Compara bleb assembly Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Traceable author statement Ref.1. Source: ProtInc elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of calcium ion transport Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc lipid binding Traceable author statement Ref.1. Source: ProtInc lysophosphatidic acid receptor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Lysophosphatidic acid receptor 3		PRO_0000069433
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	Helical; Name=1; Potential
	Topological domain	53 – 67	15	Cytoplasmic Potential
	Transmembrane	68 – 88	21	Helical; Name=2; Potential
	Topological domain	89 – 101	13	Extracellular Potential
	Transmembrane	102 – 124	23	Helical; Name=3; Potential
	Topological domain	125 – 146	22	Cytoplasmic Potential
	Transmembrane	147 – 167	21	Helical; Name=4; Potential
	Topological domain	168 – 186	19	Extracellular Potential
	Transmembrane	187 – 207	21	Helical; Name=5; Potential
	Topological domain	208 – 240	33	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Helical; Name=6; Potential
	Topological domain	262 – 276	15	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Name=7; Potential
	Topological domain	298 – 353	56	Cytoplasmic Potential
Amino acid modifications
	Lipidation	309	1	S-palmitoyl cysteine By similarity
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	231	1	R → Q. Corresponds to variant rs35745543 [ dbSNP | Ensembl ].		VAR_049415

Sequences

	Sequence		Length	Mass (Da)
	Q9UBY5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 105DC9DD185E2CE7	FASTA	353	40,128
	10 20 30 40 50 60 MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVIKNRK 70 80 90 100 110 120 FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL 130 140 150 160 170 180 LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA 190 200 210 220 230 240 PIYSRSYLVF WTVSNLMAFL IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT 250 260 270 280 290 300 VMTVLGAFVV CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM 310 320 330 340 350 YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid." Bandoh K., Aoki J., Hosono H., Kobayashi S., Kobayashi T., Murakami-Murofushi K., Tsujimoto M., Arai H., Inoue K. J. Biol. Chem. 274:27776-27785(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[2]	"Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate." Im D.-S., Heise C.E., Harding M.A., George S.R., O'Dowd B.F., Theodorescu D., Lynch K.R. Mol. Pharmacol. 57:753-759(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryonic kidney.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Lysophosphatidic acid receptors." Contos J.J.A., Ishii I., Chun J. Mol. Pharmacol. 58:1188-1196(2000) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF127138 mRNA. Translation: AAD56311.1. AF186380 mRNA. Translation: AAF00530.1. AY322547 mRNA. Translation: AAP84360.1. BC126268 mRNA. Translation: AAI26269.1. BC126270 mRNA. Translation: AAI26271.1.
IPI	IPI00015940.
RefSeq	NP_036284.1. NM_012152.2.
UniGene	Hs.674915.
3D structure databases
ProteinModelPortal	Q9UBY5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000359643.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9UBY5.
Polymorphism databases
DMDM	26393418.
Proteomic databases
PaxDb	Q9UBY5.
PRIDE	Q9UBY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370611; ENSP00000359643; ENSG00000171517. ENST00000440886; ENSP00000395389; ENSG00000171517.
GeneID	23566.
KEGG	hsa:23566.
UCSC	uc001dkl.2. human.
Organism-specific databases
CTD	23566.
GeneCards	GC01M085277.
HGNC	HGNC:14298. LPAR3.
HPA	HPA013421.
MIM	605106. gene.
neXtProt	NX_Q9UBY5.
PharmGKB	PA162394213.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288678.
HOVERGEN	HBG103071.
InParanoid	Q9UBY5.
KO	K04294.
OMA	WTVSNLM.
OrthoDB	EOG4G1MGP.
PhylomeDB	Q9UBY5.
Enzyme and pathway databases
Pathway_Interaction_DB	lysophospholipid_pathway. LPA receptor mediated events.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q9UBY5.
CleanEx	HS_LPAR3.
Genevestigator	Q9UBY5.
GermOnline	ENSG00000171517. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR004065. LPA_rcpt. IPR005385. LPA_rcpt_EDG7. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01560. EDG7RECEPTOR. PR00237. GPCRRHODOPSN. PR01527. LPARECEPTOR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9UBY5.
ChEMBL	CHEMBL3250.
ChiTaRS	LPAR3. human.
GenomeRNAi	23566.
NextBio	46160.
SOURCE	Search...

Entry information

Entry name

LPAR3_HUMAN

Accession

Primary (citable) accession number: Q9UBY5
Secondary accession number(s): A0AVA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.