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Q9UBY0

- SL9A2_HUMAN

UniProt

Q9UBY0 - SL9A2_HUMAN

Protein

Sodium/hydrogen exchanger 2

Gene

SLC9A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

    GO - Molecular functioni

    1. sodium:proton antiporter activity Source: ProtInc

    GO - Biological processi

    1. ion transport Source: Reactome
    2. protein localization Source: Ensembl
    3. regulation of pH Source: Ensembl
    4. sodium ion transmembrane transport Source: GOC
    5. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19314. Sodium/Proton exchangers.

    Protein family/group databases

    TCDBi2.A.36.1.17. the monovalent cation:proton antiporter-1 (cpa1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchanger 2
    Alternative name(s):
    Na(+)/H(+) exchanger 2
    Short name:
    NHE-2
    Solute carrier family 9 member 2
    Gene namesi
    Name:SLC9A2
    Synonyms:NHE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11072. SLC9A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35929.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 812812Sodium/hydrogen exchanger 2PRO_0000052352Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated (Possible).

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBY0.
    PaxDbiQ9UBY0.
    PRIDEiQ9UBY0.

    PTM databases

    PhosphoSiteiQ9UBY0.

    Expressioni

    Tissue specificityi

    Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.

    Gene expression databases

    BgeeiQ9UBY0.
    CleanExiHS_SLC9A2.
    GenevestigatoriQ9UBY0.

    Organism-specific databases

    HPAiHPA035121.

    Interactioni

    Subunit structurei

    Interacts with CHP1 and CHP2.By similarity

    Protein-protein interaction databases

    BioGridi112439. 7 interactions.
    IntActiQ9UBY0. 1 interaction.
    STRINGi9606.ENSP00000233969.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBY0.
    SMRiQ9UBY0. Positions 483-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 7946CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini101 – 1066CytoplasmicSequence Analysis
    Topological domaini128 – 13811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini160 – 1689CytoplasmicSequence Analysis
    Topological domaini190 – 20819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 2367CytoplasmicSequence Analysis
    Topological domaini258 – 27720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 3079CytoplasmicSequence Analysis
    Topological domaini329 – 36032ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 39110CytoplasmicSequence Analysis
    Topological domaini413 – 42917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini451 – 4588ExtracellularSequence Analysis
    Topological domaini480 – 812333CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei14 – 3320Name=A/M1By similarityAdd
    BLAST
    Intramembranei80 – 10021Name=B/M2By similarityAdd
    BLAST
    Intramembranei430 – 45021Name=LBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei107 – 12721Helical; Name=C/M3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=D/M4Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921Helical; Name=E/M5Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=F/M5ASequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=G/M5BSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=H/M6Sequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821Helical; Name=I/M7Sequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121Helical; Name=J/M8Sequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221Helical; Name=K/M9Sequence AnalysisAdd
    BLAST
    Transmembranei459 – 47921Helical; Name=M13Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0025.
    HOGENOMiHOG000247044.
    HOVERGENiHBG052615.
    InParanoidiQ9UBY0.
    KOiK14722.
    OMAiPQSYKME.
    OrthoDBiEOG7PCJGB.
    PhylomeDBiQ9UBY0.
    TreeFamiTF317212.

    Family and domain databases

    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR001953. Na/H_exchanger_2.
    IPR004709. NaH_exchanger.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PfamiPF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    PRINTSiPR01084. NAHEXCHNGR.
    PR01086. NAHEXCHNGR2.
    TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UBY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLGNWRSL RAPLPPMLLL LLLQVAGPVG ALAETLLNAP RAMGTSSSPP    50
    SPASVVAPGT TLFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL 100
    YHKLPTIVPE SCLLIMVGLL LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV 150
    LDAGYFMPTR PFFENIGTIF WYAVVGTLWN SIGIGVSLFG ICQIEAFGLS 200
    DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF GESLLNDAVT 250
    VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT 300
    RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN 350
    VSQKSYTTIK YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF 400
    CLMWRALGVF VLTQVINRFR TIPLTFKDQF IIAYGGLRGA ICFALVFLLP 450
    AAVFPRKKLF ITAAIVVIFF TVFILGITIR PLVEFLDVKR SNKKQQAVSE 500
    EIYCRLFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK LLIRENQPKS 550
    SIVSLYKKLE IKHAIEMAET GMISTVPTFA SLNDCREEKI RKVTSSETDE 600
    IRELLSRNLY QIRQRTLSYN RHSLTADTSE RQAKEILIRR RHSLRESIRK 650
    DSSLNREHRA STSTSRYLSL PKNTKLPEKL QKRRTISIAD GNSSDSDADA 700
    GTTVLNLQPR ARRFLPEQFS KKSPQSYKME WKNEVDVDSG RDMPSTPPTP 750
    HSREKGTQTS GLLQQPLLSK DQSGSEREDS LTEGIPPKPP PRLVWRASEP 800
    GSRKARFGSE KP 812
    Length:812
    Mass (Da):91,520
    Last modified:May 1, 2000 - v1
    Checksum:i17EE177DC3830D0A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti299 – 2991T → S in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035964
    Natural varianti806 – 8061R → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035965

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073299 mRNA. Translation: AAD41635.1.
    AC007239 Genomic DNA. Translation: AAF19248.1.
    CH471127 Genomic DNA. Translation: EAX01789.1.
    BC136377 mRNA. Translation: AAI36378.1.
    BC136378 mRNA. Translation: AAI36379.1.
    CCDSiCCDS2062.1.
    RefSeqiNP_003039.2. NM_003048.3.
    UniGeneiHs.250083.

    Genome annotation databases

    EnsembliENST00000233969; ENSP00000233969; ENSG00000115616.
    GeneIDi6549.
    KEGGihsa:6549.
    UCSCiuc002tca.3. human.

    Polymorphism databases

    DMDMi19924293.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073299 mRNA. Translation: AAD41635.1 .
    AC007239 Genomic DNA. Translation: AAF19248.1 .
    CH471127 Genomic DNA. Translation: EAX01789.1 .
    BC136377 mRNA. Translation: AAI36378.1 .
    BC136378 mRNA. Translation: AAI36379.1 .
    CCDSi CCDS2062.1.
    RefSeqi NP_003039.2. NM_003048.3.
    UniGenei Hs.250083.

    3D structure databases

    ProteinModelPortali Q9UBY0.
    SMRi Q9UBY0. Positions 483-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112439. 7 interactions.
    IntActi Q9UBY0. 1 interaction.
    STRINGi 9606.ENSP00000233969.

    Chemistry

    BindingDBi Q9UBY0.
    ChEMBLi CHEMBL3133.

    Protein family/group databases

    TCDBi 2.A.36.1.17. the monovalent cation:proton antiporter-1 (cpa1) family.

    PTM databases

    PhosphoSitei Q9UBY0.

    Polymorphism databases

    DMDMi 19924293.

    Proteomic databases

    MaxQBi Q9UBY0.
    PaxDbi Q9UBY0.
    PRIDEi Q9UBY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233969 ; ENSP00000233969 ; ENSG00000115616 .
    GeneIDi 6549.
    KEGGi hsa:6549.
    UCSCi uc002tca.3. human.

    Organism-specific databases

    CTDi 6549.
    GeneCardsi GC02P103236.
    HGNCi HGNC:11072. SLC9A2.
    HPAi HPA035121.
    MIMi 600530. gene.
    neXtProti NX_Q9UBY0.
    PharmGKBi PA35929.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0025.
    HOGENOMi HOG000247044.
    HOVERGENi HBG052615.
    InParanoidi Q9UBY0.
    KOi K14722.
    OMAi PQSYKME.
    OrthoDBi EOG7PCJGB.
    PhylomeDBi Q9UBY0.
    TreeFami TF317212.

    Enzyme and pathway databases

    Reactomei REACT_19314. Sodium/Proton exchangers.

    Miscellaneous databases

    GeneWikii SLC9A2.
    GenomeRNAii 6549.
    NextBioi 25489.
    PROi Q9UBY0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBY0.
    CleanExi HS_SLC9A2.
    Genevestigatori Q9UBY0.

    Family and domain databases

    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR001953. Na/H_exchanger_2.
    IPR004709. NaH_exchanger.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    Pfami PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    PRINTSi PR01084. NAHEXCHNGR.
    PR01086. NAHEXCHNGR2.
    TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2."
      Malakooti J., Dahdal R.Y., Schmidt L., Layden T.J., Dudeja P.K., Ramaswamy K.
      Am. J. Physiol. 277:G383-G390(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-299 AND GLN-806.

    Entry informationi

    Entry nameiSL9A2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBY0
    Secondary accession number(s): B2RMS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3