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Q9UBY0

- SL9A2_HUMAN

UniProt

Q9UBY0 - SL9A2_HUMAN

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Protein
Sodium/hydrogen exchanger 2
Gene
SLC9A2, NHE2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

GO - Molecular functioni

  1. sodium:proton antiporter activity Source: ProtInc

GO - Biological processi

  1. ion transport Source: Reactome
  2. protein localization Source: Ensembl
  3. regulation of pH Source: Ensembl
  4. sodium ion transmembrane transport Source: GOC
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19314. Sodium/Proton exchangers.

Protein family/group databases

TCDBi2.A.36.1.17. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 2
Alternative name(s):
Na(+)/H(+) exchanger 2
Short name:
NHE-2
Solute carrier family 9 member 2
Gene namesi
Name:SLC9A2
Synonyms:NHE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11072. SLC9A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313Cytoplasmic Reviewed prediction
Add
BLAST
Intramembranei14 – 3320Name=A/M1; By similarity
Add
BLAST
Topological domaini34 – 7946Cytoplasmic Reviewed prediction
Add
BLAST
Intramembranei80 – 10021Name=B/M2; By similarity
Add
BLAST
Topological domaini101 – 1066Cytoplasmic Reviewed prediction
Transmembranei107 – 12721Helical; Name=C/M3; Reviewed prediction
Add
BLAST
Topological domaini128 – 13811Extracellular Reviewed prediction
Add
BLAST
Transmembranei139 – 15921Helical; Name=D/M4; Reviewed prediction
Add
BLAST
Topological domaini160 – 1689Cytoplasmic Reviewed prediction
Transmembranei169 – 18921Helical; Name=E/M5; Reviewed prediction
Add
BLAST
Topological domaini190 – 20819Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Name=F/M5A; Reviewed prediction
Add
BLAST
Topological domaini230 – 2367Cytoplasmic Reviewed prediction
Transmembranei237 – 25721Helical; Name=G/M5B; Reviewed prediction
Add
BLAST
Topological domaini258 – 27720Extracellular Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Name=H/M6; Reviewed prediction
Add
BLAST
Topological domaini299 – 3079Cytoplasmic Reviewed prediction
Transmembranei308 – 32821Helical; Name=I/M7; Reviewed prediction
Add
BLAST
Topological domaini329 – 36032Extracellular Reviewed prediction
Add
BLAST
Transmembranei361 – 38121Helical; Name=J/M8; Reviewed prediction
Add
BLAST
Topological domaini382 – 39110Cytoplasmic Reviewed prediction
Transmembranei392 – 41221Helical; Name=K/M9; Reviewed prediction
Add
BLAST
Topological domaini413 – 42917Extracellular Reviewed prediction
Add
BLAST
Intramembranei430 – 45021Name=L; By similarity
Add
BLAST
Topological domaini451 – 4588Extracellular Reviewed prediction
Transmembranei459 – 47921Helical; Name=M13; Reviewed prediction
Add
BLAST
Topological domaini480 – 812333Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Sodium/hydrogen exchanger 2
PRO_0000052352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated (Possible).

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UBY0.
PaxDbiQ9UBY0.
PRIDEiQ9UBY0.

PTM databases

PhosphoSiteiQ9UBY0.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.

Gene expression databases

BgeeiQ9UBY0.
CleanExiHS_SLC9A2.
GenevestigatoriQ9UBY0.

Organism-specific databases

HPAiHPA035121.

Interactioni

Subunit structurei

Interacts with CHP1 and CHP2 By similarity.

Protein-protein interaction databases

BioGridi112439. 7 interactions.
IntActiQ9UBY0. 1 interaction.
STRINGi9606.ENSP00000233969.

Structurei

3D structure databases

ProteinModelPortaliQ9UBY0.
SMRiQ9UBY0. Positions 483-524.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0025.
HOGENOMiHOG000247044.
HOVERGENiHBG052615.
InParanoidiQ9UBY0.
KOiK14722.
OMAiPQSYKME.
OrthoDBiEOG7PCJGB.
PhylomeDBiQ9UBY0.
TreeFamiTF317212.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR001953. Na/H_exchanger_2.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01086. NAHEXCHNGR2.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UBY0-1 [UniParc]FASTAAdd to Basket

« Hide

MEPLGNWRSL RAPLPPMLLL LLLQVAGPVG ALAETLLNAP RAMGTSSSPP    50
SPASVVAPGT TLFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL 100
YHKLPTIVPE SCLLIMVGLL LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV 150
LDAGYFMPTR PFFENIGTIF WYAVVGTLWN SIGIGVSLFG ICQIEAFGLS 200
DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF GESLLNDAVT 250
VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT 300
RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN 350
VSQKSYTTIK YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF 400
CLMWRALGVF VLTQVINRFR TIPLTFKDQF IIAYGGLRGA ICFALVFLLP 450
AAVFPRKKLF ITAAIVVIFF TVFILGITIR PLVEFLDVKR SNKKQQAVSE 500
EIYCRLFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK LLIRENQPKS 550
SIVSLYKKLE IKHAIEMAET GMISTVPTFA SLNDCREEKI RKVTSSETDE 600
IRELLSRNLY QIRQRTLSYN RHSLTADTSE RQAKEILIRR RHSLRESIRK 650
DSSLNREHRA STSTSRYLSL PKNTKLPEKL QKRRTISIAD GNSSDSDADA 700
GTTVLNLQPR ARRFLPEQFS KKSPQSYKME WKNEVDVDSG RDMPSTPPTP 750
HSREKGTQTS GLLQQPLLSK DQSGSEREDS LTEGIPPKPP PRLVWRASEP 800
GSRKARFGSE KP 812
Length:812
Mass (Da):91,520
Last modified:May 1, 2000 - v1
Checksum:i17EE177DC3830D0A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti299 – 2991T → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_035964
Natural varianti806 – 8061R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_035965

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073299 mRNA. Translation: AAD41635.1.
AC007239 Genomic DNA. Translation: AAF19248.1.
CH471127 Genomic DNA. Translation: EAX01789.1.
BC136377 mRNA. Translation: AAI36378.1.
BC136378 mRNA. Translation: AAI36379.1.
CCDSiCCDS2062.1.
RefSeqiNP_003039.2. NM_003048.3.
UniGeneiHs.250083.

Genome annotation databases

EnsembliENST00000233969; ENSP00000233969; ENSG00000115616.
GeneIDi6549.
KEGGihsa:6549.
UCSCiuc002tca.3. human.

Polymorphism databases

DMDMi19924293.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073299 mRNA. Translation: AAD41635.1 .
AC007239 Genomic DNA. Translation: AAF19248.1 .
CH471127 Genomic DNA. Translation: EAX01789.1 .
BC136377 mRNA. Translation: AAI36378.1 .
BC136378 mRNA. Translation: AAI36379.1 .
CCDSi CCDS2062.1.
RefSeqi NP_003039.2. NM_003048.3.
UniGenei Hs.250083.

3D structure databases

ProteinModelPortali Q9UBY0.
SMRi Q9UBY0. Positions 483-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112439. 7 interactions.
IntActi Q9UBY0. 1 interaction.
STRINGi 9606.ENSP00000233969.

Chemistry

BindingDBi Q9UBY0.
ChEMBLi CHEMBL3133.

Protein family/group databases

TCDBi 2.A.36.1.17. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSitei Q9UBY0.

Polymorphism databases

DMDMi 19924293.

Proteomic databases

MaxQBi Q9UBY0.
PaxDbi Q9UBY0.
PRIDEi Q9UBY0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233969 ; ENSP00000233969 ; ENSG00000115616 .
GeneIDi 6549.
KEGGi hsa:6549.
UCSCi uc002tca.3. human.

Organism-specific databases

CTDi 6549.
GeneCardsi GC02P103236.
HGNCi HGNC:11072. SLC9A2.
HPAi HPA035121.
MIMi 600530. gene.
neXtProti NX_Q9UBY0.
PharmGKBi PA35929.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0025.
HOGENOMi HOG000247044.
HOVERGENi HBG052615.
InParanoidi Q9UBY0.
KOi K14722.
OMAi PQSYKME.
OrthoDBi EOG7PCJGB.
PhylomeDBi Q9UBY0.
TreeFami TF317212.

Enzyme and pathway databases

Reactomei REACT_19314. Sodium/Proton exchangers.

Miscellaneous databases

GeneWikii SLC9A2.
GenomeRNAii 6549.
NextBioi 25489.
PROi Q9UBY0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBY0.
CleanExi HS_SLC9A2.
Genevestigatori Q9UBY0.

Family and domain databases

InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR001953. Na/H_exchanger_2.
IPR004709. NaH_exchanger.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
Pfami PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
PRINTSi PR01084. NAHEXCHNGR.
PR01086. NAHEXCHNGR2.
TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2."
    Malakooti J., Dahdal R.Y., Schmidt L., Layden T.J., Dudeja P.K., Ramaswamy K.
    Am. J. Physiol. 277:G383-G390(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-299 AND GLN-806.

Entry informationi

Entry nameiSL9A2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBY0
Secondary accession number(s): B2RMS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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