SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UBX7

- KLK11_HUMAN

UniProt

Q9UBX7 - KLK11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Kallikrein-11
Gene
KLK11, PRSS20, TLSP, UNQ649/PRO1279
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Charge relay system By similarity
Active sitei142 – 1421Charge relay system By similarity
Active sitei235 – 2351Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.257.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-11 (EC:3.4.21.-)
    Short name:
    hK11
    Alternative name(s):
    Hippostasin
    Serine protease 20
    Trypsin-like protease
    Cleaved into the following 2 chains:
    Gene namesi
    Name:KLK11
    Synonyms:PRSS20, TLSP
    ORF Names:UNQ649/PRO1279
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6359. KLK11.

    Subcellular locationi

    Isoform 1 : Secreted 1 Publication
    Isoform 2 : Golgi apparatus 1 Publication

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. extracellular space Source: UniProt
    Complete GO annotation...

    Keywords - Cellular componenti

    Golgi apparatus, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30148.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5050 Reviewed prediction
    Add
    BLAST
    Propeptidei51 – 533Activation peptide Reviewed prediction
    PRO_0000027954
    Chaini54 – 282229Kallikrein-11
    PRO_0000027955Add
    BLAST
    Chaini54 – 188135Kallikrein-11 inactive chain 1
    PRO_0000302061Add
    BLAST
    Chaini189 – 28294Kallikrein-11 inactive chain 2
    PRO_0000302062Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi60 ↔ 195 By similarity
    Disulfide bondi79 ↔ 95 By similarity
    Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi167 ↔ 269 By similarity
    Disulfide bondi174 ↔ 241 By similarity
    Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi206 ↔ 220 By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi231 ↔ 256 By similarity
    Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction

    Post-translational modificationi

    About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9UBX7.
    PRIDEiQ9UBX7.

    PTM databases

    PhosphoSiteiQ9UBX7.

    Miscellaneous databases

    PMAP-CutDBQ9UBX7.

    Expressioni

    Tissue specificityi

    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ9UBX7.
    BgeeiQ9UBX7.
    CleanExiHS_KLK11.
    GenevestigatoriQ9UBX7.

    Organism-specific databases

    HPAiCAB026340.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000324414.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBX7.
    SMRiQ9UBX7. Positions 17-282.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 280228Peptidase S1
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ9UBX7.
    KOiK09620.
    OMAiSSRCVTA.
    PhylomeDBiQ9UBX7.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q9UBX7-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG    50
    ETRIIKGFEC KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY 100
    IVHLGQHNLQ KEEGCEQTRT ATESFPHPGF NNSLPNKDHR NDIMLVKMAS 150
    PVSITWAVRP LTLSSRCVTA GTSCLISGWG STSSPQLRLP HTLRCANITI 200
    IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV CNQSLQGIIS 250
    WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN 282
    Length:282
    Mass (Da):31,059
    Last modified:February 21, 2006 - v2
    Checksum:iB442DDE613EE0A17
    GO
    Isoform 1 (identifier: Q9UBX7-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-32: Missing.

    Show »
    Length:250
    Mass (Da):27,466
    Checksum:i192D910BBCDC7A56
    GO
    Isoform 3 (identifier: Q9UBX7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

    Note: Localized in the prostate secretory epithelium.

    Show »
    Length:307
    Mass (Da):33,759
    Checksum:iE5C0EE949DBAFA2B
    GO
    Isoform 4 (identifier: Q9UBX7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-32: Missing.
         98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

    Show »
    Length:275
    Mass (Da):30,166
    Checksum:i257A42B28F40E2C4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321A → T.
    Corresponds to variant rs2288892 [ dbSNP | Ensembl ].
    VAR_051856
    Natural varianti49 – 491G → E.
    Corresponds to variant rs3745539 [ dbSNP | Ensembl ].
    VAR_021943
    Natural varianti166 – 1661R → C.
    Corresponds to variant rs1048328 [ dbSNP | Ensembl ].
    VAR_024296

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3232Missing in isoform 1 and isoform 4.
    VSP_005402Add
    BLAST
    Alternative sequencei98 – 981P → PWVSLTSPTHVSPDLSSSNY CLSHLS in isoform 3 and isoform 4.
    VSP_043326

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012917 mRNA. Translation: BAA33404.1.
    AB013730 mRNA. Translation: BAA88713.1.
    AB041036 mRNA. Translation: BAA96797.1.
    AF164623 Genomic DNA. Translation: AAD47815.1.
    AF243527 Genomic DNA. Translation: AAG33364.1.
    AB078780 mRNA. Translation: BAC54105.1.
    AB261897 mRNA. Translation: BAE95335.1.
    AB259014 mRNA. Translation: BAF02733.1.
    AY359014 mRNA. Translation: AAQ89373.1.
    AC011473 Genomic DNA. Translation: AAG23257.1.
    CH471135 Genomic DNA. Translation: EAW71971.1.
    BC022068 mRNA. Translation: AAH22068.1.
    CCDSiCCDS12818.1. [Q9UBX7-2]
    CCDS12819.1. [Q9UBX7-1]
    CCDS54297.1. [Q9UBX7-4]
    RefSeqiNP_001129504.1. NM_001136032.2. [Q9UBX7-1]
    NP_001161077.1. NM_001167605.1. [Q9UBX7-4]
    NP_006844.1. NM_006853.2. [Q9UBX7-1]
    NP_659196.1. NM_144947.1. [Q9UBX7-2]
    UniGeneiHs.57771.

    Genome annotation databases

    EnsembliENST00000319720; ENSP00000324269; ENSG00000167757. [Q9UBX7-1]
    ENST00000391804; ENSP00000375680; ENSG00000167757. [Q9UBX7-4]
    ENST00000453757; ENSP00000413958; ENSG00000167757. [Q9UBX7-1]
    ENST00000594768; ENSP00000473047; ENSG00000167757. [Q9UBX7-2]
    GeneIDi11012.
    KEGGihsa:11012.
    UCSCiuc002pvb.2. human. [Q9UBX7-3]
    uc002pvc.4. human. [Q9UBX7-2]

    Polymorphism databases

    DMDMi88984315.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB012917 mRNA. Translation: BAA33404.1 .
    AB013730 mRNA. Translation: BAA88713.1 .
    AB041036 mRNA. Translation: BAA96797.1 .
    AF164623 Genomic DNA. Translation: AAD47815.1 .
    AF243527 Genomic DNA. Translation: AAG33364.1 .
    AB078780 mRNA. Translation: BAC54105.1 .
    AB261897 mRNA. Translation: BAE95335.1 .
    AB259014 mRNA. Translation: BAF02733.1 .
    AY359014 mRNA. Translation: AAQ89373.1 .
    AC011473 Genomic DNA. Translation: AAG23257.1 .
    CH471135 Genomic DNA. Translation: EAW71971.1 .
    BC022068 mRNA. Translation: AAH22068.1 .
    CCDSi CCDS12818.1. [Q9UBX7-2 ]
    CCDS12819.1. [Q9UBX7-1 ]
    CCDS54297.1. [Q9UBX7-4 ]
    RefSeqi NP_001129504.1. NM_001136032.2. [Q9UBX7-1 ]
    NP_001161077.1. NM_001167605.1. [Q9UBX7-4 ]
    NP_006844.1. NM_006853.2. [Q9UBX7-1 ]
    NP_659196.1. NM_144947.1. [Q9UBX7-2 ]
    UniGenei Hs.57771.

    3D structure databases

    ProteinModelPortali Q9UBX7.
    SMRi Q9UBX7. Positions 17-282.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000324414.

    Chemistry

    BindingDBi Q9UBX7.

    Protein family/group databases

    MEROPSi S01.257.

    PTM databases

    PhosphoSitei Q9UBX7.

    Polymorphism databases

    DMDMi 88984315.

    Proteomic databases

    PaxDbi Q9UBX7.
    PRIDEi Q9UBX7.

    Protocols and materials databases

    DNASUi 11012.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319720 ; ENSP00000324269 ; ENSG00000167757 . [Q9UBX7-1 ]
    ENST00000391804 ; ENSP00000375680 ; ENSG00000167757 . [Q9UBX7-4 ]
    ENST00000453757 ; ENSP00000413958 ; ENSG00000167757 . [Q9UBX7-1 ]
    ENST00000594768 ; ENSP00000473047 ; ENSG00000167757 . [Q9UBX7-2 ]
    GeneIDi 11012.
    KEGGi hsa:11012.
    UCSCi uc002pvb.2. human. [Q9UBX7-3 ]
    uc002pvc.4. human. [Q9UBX7-2 ]

    Organism-specific databases

    CTDi 11012.
    GeneCardsi GC19M051525.
    HGNCi HGNC:6359. KLK11.
    HPAi CAB026340.
    MIMi 604434. gene.
    neXtProti NX_Q9UBX7.
    PharmGKBi PA30148.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q9UBX7.
    KOi K09620.
    OMAi SSRCVTA.
    PhylomeDBi Q9UBX7.
    TreeFami TF331065.

    Miscellaneous databases

    GeneWikii KLK11.
    GenomeRNAii 11012.
    NextBioi 41831.
    PMAP-CutDB Q9UBX7.
    PROi Q9UBX7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBX7.
    Bgeei Q9UBX7.
    CleanExi HS_KLK11.
    Genevestigatori Q9UBX7.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "cDNA cloning and expression of a novel serine protease, TLSP."
      Yoshida S., Taniguchi M., Suemoto T., Oka T., He X.P., Shiosaka S.
      Biochim. Biophys. Acta 1399:225-228(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Hippocampus.
    2. "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate."
      Mitsui S., Yamada T., Okui A., Kominami K., Uemura H., Yamaguchi N.
      Biochem. Biophys. Res. Commun. 272:205-211(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Hippocampus and Prostate.
    3. "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family."
      Yousef G.M., Scorilas A., Diamandis E.P.
      Genomics 63:88-96(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate."
      Nakamura T., Mitsui S., Okui A., Miki T., Yamaguchi N.
      Prostate 54:299-305(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    6. "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin."
      Mitsui S., Nakamura T., Okui A., Kominami K., Uemura H., Yamaguchi N.
      FEBS J. 273:3678-3686(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    11. "Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma."
      Luo L.Y., Shan S.J., Elliott M.B., Soosaipillai A., Diamandis E.P.
      Clin. Cancer Res. 12:742-750(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKLK11_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBX7
    Secondary accession number(s): O75837
    , Q0WXX5, Q8IXD7, Q9NS65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 21, 2006
    Last modified: September 3, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi