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Protein

Kallikrein-11

Gene

KLK11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Charge relay systemBy similarity1
Active sitei142Charge relay systemBy similarity1
Active sitei235Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167757-MONOMER.
BRENDAi3.4.21.35. 2681.
3.4.21.B42. 2681.

Protein family/group databases

MEROPSiS01.257.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-11 (EC:3.4.21.-)
Short name:
hK11
Alternative name(s):
Hippostasin
Serine protease 20
Trypsin-like protease
Cleaved into the following 2 chains:
Gene namesi
Name:KLK11
Synonyms:PRSS20, TLSP
ORF Names:UNQ649/PRO1279
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6359. KLK11.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11012.
OpenTargetsiENSG00000167757.
PharmGKBiPA30148.

Polymorphism and mutation databases

BioMutaiKLK11.
DMDMi88984315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 50Sequence analysisAdd BLAST50
PropeptideiPRO_000002795451 – 53Activation peptideSequence analysis3
ChainiPRO_000002795554 – 282Kallikrein-11Add BLAST229
ChainiPRO_000030206154 – 188Kallikrein-11 inactive chain 1Add BLAST135
ChainiPRO_0000302062189 – 282Kallikrein-11 inactive chain 2Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 195PROSITE-ProRule annotation
Disulfide bondi79 ↔ 95PROSITE-ProRule annotation
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi167 ↔ 269PROSITE-ProRule annotation
Disulfide bondi174 ↔ 241PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi206 ↔ 220PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi231 ↔ 256PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9UBX7.
PeptideAtlasiQ9UBX7.
PRIDEiQ9UBX7.

PTM databases

iPTMnetiQ9UBX7.
PhosphoSitePlusiQ9UBX7.

Miscellaneous databases

PMAP-CutDBQ9UBX7.

Expressioni

Tissue specificityi

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000167757.
CleanExiHS_KLK11.
ExpressionAtlasiQ9UBX7. baseline and differential.
GenevisibleiQ9UBX7. HS.

Organism-specific databases

HPAiCAB026340.

Interactioni

Protein-protein interaction databases

BioGridi116202. 27 interactors.
STRINGi9606.ENSP00000473047.

Structurei

3D structure databases

ProteinModelPortaliQ9UBX7.
SMRiQ9UBX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 280Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UBX7.
KOiK09620.
OMAiSRYVVHL.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UBX7.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9UBX7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG
60 70 80 90 100
ETRIIKGFEC KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY
110 120 130 140 150
IVHLGQHNLQ KEEGCEQTRT ATESFPHPGF NNSLPNKDHR NDIMLVKMAS
160 170 180 190 200
PVSITWAVRP LTLSSRCVTA GTSCLISGWG STSSPQLRLP HTLRCANITI
210 220 230 240 250
IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV CNQSLQGIIS
260 270 280
WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN
Length:282
Mass (Da):31,059
Last modified:February 21, 2006 - v2
Checksum:iB442DDE613EE0A17
GO
Isoform 1 (identifier: Q9UBX7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:250
Mass (Da):27,466
Checksum:i192D910BBCDC7A56
GO
Isoform 3 (identifier: Q9UBX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

Note: Localized in the prostate secretory epithelium.
Show »
Length:307
Mass (Da):33,759
Checksum:iE5C0EE949DBAFA2B
GO
Isoform 4 (identifier: Q9UBX7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

Show »
Length:275
Mass (Da):30,166
Checksum:i257A42B28F40E2C4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05185632A → T.Corresponds to variant rs2288892dbSNPEnsembl.1
Natural variantiVAR_02194349G → E.Corresponds to variant rs3745539dbSNPEnsembl.1
Natural variantiVAR_024296166R → C.Corresponds to variant rs1048328dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0054021 – 32Missing in isoform 1 and isoform 4. 4 PublicationsAdd BLAST32
Alternative sequenceiVSP_04332698P → PWVSLTSPTHVSPDLSSSNY CLSHLS in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012917 mRNA. Translation: BAA33404.1.
AB013730 mRNA. Translation: BAA88713.1.
AB041036 mRNA. Translation: BAA96797.1.
AF164623 Genomic DNA. Translation: AAD47815.1.
AF243527 Genomic DNA. Translation: AAG33364.1.
AB078780 mRNA. Translation: BAC54105.1.
AB261897 mRNA. Translation: BAE95335.1.
AB259014 mRNA. Translation: BAF02733.1.
AY359014 mRNA. Translation: AAQ89373.1.
AC011473 Genomic DNA. Translation: AAG23257.1.
CH471135 Genomic DNA. Translation: EAW71971.1.
BC022068 mRNA. Translation: AAH22068.1.
CCDSiCCDS12818.1. [Q9UBX7-2]
CCDS12819.1. [Q9UBX7-1]
CCDS54297.1. [Q9UBX7-4]
RefSeqiNP_001129504.1. NM_001136032.2. [Q9UBX7-1]
NP_001161077.1. NM_001167605.1. [Q9UBX7-4]
NP_006844.1. NM_006853.2. [Q9UBX7-1]
NP_659196.1. NM_144947.1. [Q9UBX7-2]
XP_011524671.1. XM_011526369.1. [Q9UBX7-3]
XP_011524672.1. XM_011526370.2. [Q9UBX7-4]
XP_011524673.1. XM_011526371.2. [Q9UBX7-4]
XP_011524674.1. XM_011526372.2. [Q9UBX7-4]
XP_011524675.1. XM_011526373.1. [Q9UBX7-4]
UniGeneiHs.57771.

Genome annotation databases

EnsembliENST00000319720; ENSP00000324269; ENSG00000167757. [Q9UBX7-1]
ENST00000391804; ENSP00000375680; ENSG00000167757. [Q9UBX7-4]
ENST00000453757; ENSP00000413958; ENSG00000167757. [Q9UBX7-1]
ENST00000594768; ENSP00000473047; ENSG00000167757. [Q9UBX7-2]
GeneIDi11012.
KEGGihsa:11012.
UCSCiuc002pvb.3. human. [Q9UBX7-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012917 mRNA. Translation: BAA33404.1.
AB013730 mRNA. Translation: BAA88713.1.
AB041036 mRNA. Translation: BAA96797.1.
AF164623 Genomic DNA. Translation: AAD47815.1.
AF243527 Genomic DNA. Translation: AAG33364.1.
AB078780 mRNA. Translation: BAC54105.1.
AB261897 mRNA. Translation: BAE95335.1.
AB259014 mRNA. Translation: BAF02733.1.
AY359014 mRNA. Translation: AAQ89373.1.
AC011473 Genomic DNA. Translation: AAG23257.1.
CH471135 Genomic DNA. Translation: EAW71971.1.
BC022068 mRNA. Translation: AAH22068.1.
CCDSiCCDS12818.1. [Q9UBX7-2]
CCDS12819.1. [Q9UBX7-1]
CCDS54297.1. [Q9UBX7-4]
RefSeqiNP_001129504.1. NM_001136032.2. [Q9UBX7-1]
NP_001161077.1. NM_001167605.1. [Q9UBX7-4]
NP_006844.1. NM_006853.2. [Q9UBX7-1]
NP_659196.1. NM_144947.1. [Q9UBX7-2]
XP_011524671.1. XM_011526369.1. [Q9UBX7-3]
XP_011524672.1. XM_011526370.2. [Q9UBX7-4]
XP_011524673.1. XM_011526371.2. [Q9UBX7-4]
XP_011524674.1. XM_011526372.2. [Q9UBX7-4]
XP_011524675.1. XM_011526373.1. [Q9UBX7-4]
UniGeneiHs.57771.

3D structure databases

ProteinModelPortaliQ9UBX7.
SMRiQ9UBX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116202. 27 interactors.
STRINGi9606.ENSP00000473047.

Protein family/group databases

MEROPSiS01.257.

PTM databases

iPTMnetiQ9UBX7.
PhosphoSitePlusiQ9UBX7.

Polymorphism and mutation databases

BioMutaiKLK11.
DMDMi88984315.

Proteomic databases

PaxDbiQ9UBX7.
PeptideAtlasiQ9UBX7.
PRIDEiQ9UBX7.

Protocols and materials databases

DNASUi11012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319720; ENSP00000324269; ENSG00000167757. [Q9UBX7-1]
ENST00000391804; ENSP00000375680; ENSG00000167757. [Q9UBX7-4]
ENST00000453757; ENSP00000413958; ENSG00000167757. [Q9UBX7-1]
ENST00000594768; ENSP00000473047; ENSG00000167757. [Q9UBX7-2]
GeneIDi11012.
KEGGihsa:11012.
UCSCiuc002pvb.3. human. [Q9UBX7-2]

Organism-specific databases

CTDi11012.
DisGeNETi11012.
GeneCardsiKLK11.
HGNCiHGNC:6359. KLK11.
HPAiCAB026340.
MIMi604434. gene.
neXtProtiNX_Q9UBX7.
OpenTargetsiENSG00000167757.
PharmGKBiPA30148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UBX7.
KOiK09620.
OMAiSRYVVHL.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UBX7.
TreeFamiTF331065.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167757-MONOMER.
BRENDAi3.4.21.35. 2681.
3.4.21.B42. 2681.

Miscellaneous databases

GeneWikiiKLK11.
GenomeRNAii11012.
PMAP-CutDBQ9UBX7.
PROiQ9UBX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167757.
CleanExiHS_KLK11.
ExpressionAtlasiQ9UBX7. baseline and differential.
GenevisibleiQ9UBX7. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK11_HUMAN
AccessioniPrimary (citable) accession number: Q9UBX7
Secondary accession number(s): O75837
, Q0WXX5, Q8IXD7, Q9NS65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 21, 2006
Last modified: November 2, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.