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Q9UBX7

- KLK11_HUMAN

UniProt

Q9UBX7 - KLK11_HUMAN

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Protein

Kallikrein-11

Gene

KLK11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Charge relay systemBy similarity
Active sitei142 – 1421Charge relay systemBy similarity
Active sitei235 – 2351Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.257.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-11 (EC:3.4.21.-)
Short name:
hK11
Alternative name(s):
Hippostasin
Serine protease 20
Trypsin-like protease
Cleaved into the following 2 chains:
Gene namesi
Name:KLK11
Synonyms:PRSS20, TLSP
ORF Names:UNQ649/PRO1279
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6359. KLK11.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. extracellular vesicular exosome Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050Sequence AnalysisAdd
BLAST
Propeptidei51 – 533Activation peptideSequence AnalysisPRO_0000027954
Chaini54 – 282229Kallikrein-11PRO_0000027955Add
BLAST
Chaini54 – 188135Kallikrein-11 inactive chain 1PRO_0000302061Add
BLAST
Chaini189 – 28294Kallikrein-11 inactive chain 2PRO_0000302062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 195PROSITE-ProRule annotation
Disulfide bondi79 ↔ 95PROSITE-ProRule annotation
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi167 ↔ 269PROSITE-ProRule annotation
Disulfide bondi174 ↔ 241PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi206 ↔ 220PROSITE-ProRule annotation
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi231 ↔ 256PROSITE-ProRule annotation
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9UBX7.
PRIDEiQ9UBX7.

PTM databases

PhosphoSiteiQ9UBX7.

Miscellaneous databases

PMAP-CutDBQ9UBX7.

Expressioni

Tissue specificityi

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).2 Publications

Gene expression databases

BgeeiQ9UBX7.
CleanExiHS_KLK11.
ExpressionAtlasiQ9UBX7. baseline and differential.
GenevestigatoriQ9UBX7.

Organism-specific databases

HPAiCAB026340.

Interactioni

Protein-protein interaction databases

BioGridi116202. 26 interactions.
STRINGi9606.ENSP00000324414.

Structurei

3D structure databases

ProteinModelPortaliQ9UBX7.
SMRiQ9UBX7. Positions 17-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 280228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9UBX7.
KOiK09620.
OMAiSSRCVTA.
PhylomeDBiQ9UBX7.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q9UBX7-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG
60 70 80 90 100
ETRIIKGFEC KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY
110 120 130 140 150
IVHLGQHNLQ KEEGCEQTRT ATESFPHPGF NNSLPNKDHR NDIMLVKMAS
160 170 180 190 200
PVSITWAVRP LTLSSRCVTA GTSCLISGWG STSSPQLRLP HTLRCANITI
210 220 230 240 250
IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV CNQSLQGIIS
260 270 280
WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN
Length:282
Mass (Da):31,059
Last modified:February 21, 2006 - v2
Checksum:iB442DDE613EE0A17
GO
Isoform 1 (identifier: Q9UBX7-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:250
Mass (Da):27,466
Checksum:i192D910BBCDC7A56
GO
Isoform 3 (identifier: Q9UBX7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

Note: Localized in the prostate secretory epithelium.

Show »
Length:307
Mass (Da):33,759
Checksum:iE5C0EE949DBAFA2B
GO
Isoform 4 (identifier: Q9UBX7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     98-98: P → PWVSLTSPTHVSPDLSSSNYCLSHLS

Show »
Length:275
Mass (Da):30,166
Checksum:i257A42B28F40E2C4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321A → T.
Corresponds to variant rs2288892 [ dbSNP | Ensembl ].
VAR_051856
Natural varianti49 – 491G → E.
Corresponds to variant rs3745539 [ dbSNP | Ensembl ].
VAR_021943
Natural varianti166 – 1661R → C.
Corresponds to variant rs1048328 [ dbSNP | Ensembl ].
VAR_024296

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 1 and isoform 4. 4 PublicationsVSP_005402Add
BLAST
Alternative sequencei98 – 981P → PWVSLTSPTHVSPDLSSSNY CLSHLS in isoform 3 and isoform 4. 1 PublicationVSP_043326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012917 mRNA. Translation: BAA33404.1.
AB013730 mRNA. Translation: BAA88713.1.
AB041036 mRNA. Translation: BAA96797.1.
AF164623 Genomic DNA. Translation: AAD47815.1.
AF243527 Genomic DNA. Translation: AAG33364.1.
AB078780 mRNA. Translation: BAC54105.1.
AB261897 mRNA. Translation: BAE95335.1.
AB259014 mRNA. Translation: BAF02733.1.
AY359014 mRNA. Translation: AAQ89373.1.
AC011473 Genomic DNA. Translation: AAG23257.1.
CH471135 Genomic DNA. Translation: EAW71971.1.
BC022068 mRNA. Translation: AAH22068.1.
CCDSiCCDS12818.1. [Q9UBX7-2]
CCDS12819.1. [Q9UBX7-1]
CCDS54297.1. [Q9UBX7-4]
RefSeqiNP_001129504.1. NM_001136032.2. [Q9UBX7-1]
NP_001161077.1. NM_001167605.1. [Q9UBX7-4]
NP_006844.1. NM_006853.2. [Q9UBX7-1]
NP_659196.1. NM_144947.1. [Q9UBX7-2]
UniGeneiHs.57771.

Genome annotation databases

EnsembliENST00000319720; ENSP00000324269; ENSG00000167757. [Q9UBX7-1]
ENST00000391804; ENSP00000375680; ENSG00000167757. [Q9UBX7-4]
ENST00000453757; ENSP00000413958; ENSG00000167757. [Q9UBX7-1]
ENST00000594768; ENSP00000473047; ENSG00000167757. [Q9UBX7-2]
GeneIDi11012.
KEGGihsa:11012.
UCSCiuc002pvb.2. human. [Q9UBX7-3]
uc002pvc.4. human. [Q9UBX7-2]

Polymorphism databases

DMDMi88984315.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012917 mRNA. Translation: BAA33404.1 .
AB013730 mRNA. Translation: BAA88713.1 .
AB041036 mRNA. Translation: BAA96797.1 .
AF164623 Genomic DNA. Translation: AAD47815.1 .
AF243527 Genomic DNA. Translation: AAG33364.1 .
AB078780 mRNA. Translation: BAC54105.1 .
AB261897 mRNA. Translation: BAE95335.1 .
AB259014 mRNA. Translation: BAF02733.1 .
AY359014 mRNA. Translation: AAQ89373.1 .
AC011473 Genomic DNA. Translation: AAG23257.1 .
CH471135 Genomic DNA. Translation: EAW71971.1 .
BC022068 mRNA. Translation: AAH22068.1 .
CCDSi CCDS12818.1. [Q9UBX7-2 ]
CCDS12819.1. [Q9UBX7-1 ]
CCDS54297.1. [Q9UBX7-4 ]
RefSeqi NP_001129504.1. NM_001136032.2. [Q9UBX7-1 ]
NP_001161077.1. NM_001167605.1. [Q9UBX7-4 ]
NP_006844.1. NM_006853.2. [Q9UBX7-1 ]
NP_659196.1. NM_144947.1. [Q9UBX7-2 ]
UniGenei Hs.57771.

3D structure databases

ProteinModelPortali Q9UBX7.
SMRi Q9UBX7. Positions 17-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116202. 26 interactions.
STRINGi 9606.ENSP00000324414.

Protein family/group databases

MEROPSi S01.257.

PTM databases

PhosphoSitei Q9UBX7.

Polymorphism databases

DMDMi 88984315.

Proteomic databases

PaxDbi Q9UBX7.
PRIDEi Q9UBX7.

Protocols and materials databases

DNASUi 11012.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319720 ; ENSP00000324269 ; ENSG00000167757 . [Q9UBX7-1 ]
ENST00000391804 ; ENSP00000375680 ; ENSG00000167757 . [Q9UBX7-4 ]
ENST00000453757 ; ENSP00000413958 ; ENSG00000167757 . [Q9UBX7-1 ]
ENST00000594768 ; ENSP00000473047 ; ENSG00000167757 . [Q9UBX7-2 ]
GeneIDi 11012.
KEGGi hsa:11012.
UCSCi uc002pvb.2. human. [Q9UBX7-3 ]
uc002pvc.4. human. [Q9UBX7-2 ]

Organism-specific databases

CTDi 11012.
GeneCardsi GC19M051525.
HGNCi HGNC:6359. KLK11.
HPAi CAB026340.
MIMi 604434. gene.
neXtProti NX_Q9UBX7.
PharmGKBi PA30148.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q9UBX7.
KOi K09620.
OMAi SSRCVTA.
PhylomeDBi Q9UBX7.
TreeFami TF331065.

Miscellaneous databases

GeneWikii KLK11.
GenomeRNAii 11012.
NextBioi 41831.
PMAP-CutDB Q9UBX7.
PROi Q9UBX7.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBX7.
CleanExi HS_KLK11.
ExpressionAtlasi Q9UBX7. baseline and differential.
Genevestigatori Q9UBX7.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression of a novel serine protease, TLSP."
    Yoshida S., Taniguchi M., Suemoto T., Oka T., He X.P., Shiosaka S.
    Biochim. Biophys. Acta 1399:225-228(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  2. "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate."
    Mitsui S., Yamada T., Okui A., Kominami K., Uemura H., Yamaguchi N.
    Biochem. Biophys. Res. Commun. 272:205-211(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Hippocampus and Prostate.
  3. "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family."
    Yousef G.M., Scorilas A., Diamandis E.P.
    Genomics 63:88-96(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate."
    Nakamura T., Mitsui S., Okui A., Miki T., Yamaguchi N.
    Prostate 54:299-305(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  6. "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin."
    Mitsui S., Nakamura T., Okui A., Kominami K., Uemura H., Yamaguchi N.
    FEBS J. 273:3678-3686(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  11. "Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma."
    Luo L.Y., Shan S.J., Elliott M.B., Soosaipillai A., Diamandis E.P.
    Clin. Cancer Res. 12:742-750(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKLK11_HUMAN
AccessioniPrimary (citable) accession number: Q9UBX7
Secondary accession number(s): O75837
, Q0WXX5, Q8IXD7, Q9NS65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 21, 2006
Last modified: November 26, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3