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Protein

Mitochondrial dicarboxylate carrier

Gene

SLC25A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

GO - Molecular functioni

  • dicarboxylic acid transmembrane transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_116010. Sulfide oxidation to sulfate.
REACT_1520. Gluconeogenesis.
REACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.29.2.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene namesi
Name:SLC25A10
Synonyms:DIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10980. SLC25A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei63 – 8220Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35856.

Chemistry

DrugBankiDB00139. Succinic acid.

Polymorphism and mutation databases

DMDMi20137671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Mitochondrial dicarboxylate carrierPRO_0000090609Add
BLAST

Proteomic databases

MaxQBiQ9UBX3.
PaxDbiQ9UBX3.
PRIDEiQ9UBX3.

PTM databases

PhosphoSiteiQ9UBX3.

Expressioni

Tissue specificityi

Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.1 Publication

Gene expression databases

BgeeiQ9UBX3.
CleanExiHS_SLC25A10.
ExpressionAtlasiQ9UBX3. baseline.
GenevisibleiQ9UBX3. HS.

Organism-specific databases

HPAiHPA023048.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-750394,EBI-10171697
KRTAP10-8P604103EBI-750394,EBI-10171774
KRTAP4-2Q9BYR53EBI-750394,EBI-10172511
KRTAP5-9P263713EBI-750394,EBI-3958099
MDFIQ997507EBI-750394,EBI-724076
NOTCH2NLQ7Z3S93EBI-750394,EBI-945833

Protein-protein interaction databases

BioGridi107850. 43 interactions.
IntActiQ9UBX3. 16 interactions.
MINTiMINT-1477100.
STRINGi9606.ENSP00000345580.

Structurei

3D structure databases

ProteinModelPortaliQ9UBX3.
SMRiQ9UBX3. Positions 13-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 8881Solcar 1Add
BLAST
Repeati101 – 18888Solcar 2Add
BLAST
Repeati197 – 28084Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300113.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9UBX3.
KOiK13577.
OMAiFIPAWAR.
PhylomeDBiQ9UBX3.
TreeFamiTF312920.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR
60 70 80 90 100
VVRTDGILAL YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH
110 120 130 140 150
EKVLLGSVSG LAGGFVGTPA DLVNVRMQND VKLPQGQRRN YAHALDGLYR
160 170 180 190 200
VAREEGLRRL FSGATMASSR GALVTVGQLS CYDQAKQLVL STGYLSDNIF
210 220 230 240 250
THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC AVETAKLGPL
260 270 280
AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS
Length:287
Mass (Da):31,282
Last modified:February 11, 2002 - v2
Checksum:i32BE9920C7CD8ADF
GO
Isoform 2 (identifier: Q9UBX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: A → AAAGDEPPPQ

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):32,145
Checksum:iA8B1484218C4125C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881L → R in CAB60007 (PubMed:10585886).Curated
Sequence conflicti188 – 1881L → R in CAB59892 (PubMed:10585886).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 2091A → AAAGDEPPPQ in isoform 2. 1 PublicationVSP_003267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131612 Genomic DNA. Translation: CAB60007.1.
AJ131613 mRNA. Translation: CAB59892.1.
AK075249 mRNA. Translation: BAC11497.1.
CH471099 Genomic DNA. Translation: EAW89682.1.
BC007355 mRNA. Translation: AAH07355.1.
BC015797 mRNA. Translation: AAH15797.1.
CCDSiCCDS11786.1. [Q9UBX3-1]
CCDS59301.1. [Q9UBX3-2]
RefSeqiNP_001257817.1. NM_001270888.1. [Q9UBX3-2]
NP_001257882.1. NM_001270953.1.
NP_036272.2. NM_012140.4. [Q9UBX3-1]
UniGeneiHs.548187.

Genome annotation databases

EnsembliENST00000331531; ENSP00000328403; ENSG00000183048. [Q9UBX3-2]
ENST00000350690; ENSP00000345580; ENSG00000183048. [Q9UBX3-1]
GeneIDi1468.
KEGGihsa:1468.
UCSCiuc002kbi.4. human. [Q9UBX3-1]
uc010dif.4. human. [Q9UBX3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131612 Genomic DNA. Translation: CAB60007.1.
AJ131613 mRNA. Translation: CAB59892.1.
AK075249 mRNA. Translation: BAC11497.1.
CH471099 Genomic DNA. Translation: EAW89682.1.
BC007355 mRNA. Translation: AAH07355.1.
BC015797 mRNA. Translation: AAH15797.1.
CCDSiCCDS11786.1. [Q9UBX3-1]
CCDS59301.1. [Q9UBX3-2]
RefSeqiNP_001257817.1. NM_001270888.1. [Q9UBX3-2]
NP_001257882.1. NM_001270953.1.
NP_036272.2. NM_012140.4. [Q9UBX3-1]
UniGeneiHs.548187.

3D structure databases

ProteinModelPortaliQ9UBX3.
SMRiQ9UBX3. Positions 13-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107850. 43 interactions.
IntActiQ9UBX3. 16 interactions.
MINTiMINT-1477100.
STRINGi9606.ENSP00000345580.

Chemistry

DrugBankiDB00139. Succinic acid.

Protein family/group databases

TCDBi2.A.29.2.7. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ9UBX3.

Polymorphism and mutation databases

DMDMi20137671.

Proteomic databases

MaxQBiQ9UBX3.
PaxDbiQ9UBX3.
PRIDEiQ9UBX3.

Protocols and materials databases

DNASUi1468.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331531; ENSP00000328403; ENSG00000183048. [Q9UBX3-2]
ENST00000350690; ENSP00000345580; ENSG00000183048. [Q9UBX3-1]
GeneIDi1468.
KEGGihsa:1468.
UCSCiuc002kbi.4. human. [Q9UBX3-1]
uc010dif.4. human. [Q9UBX3-2]

Organism-specific databases

CTDi1468.
GeneCardsiGC17P079674.
HGNCiHGNC:10980. SLC25A10.
HPAiHPA023048.
MIMi606794. gene.
neXtProtiNX_Q9UBX3.
PharmGKBiPA35856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG300113.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ9UBX3.
KOiK13577.
OMAiFIPAWAR.
PhylomeDBiQ9UBX3.
TreeFamiTF312920.

Enzyme and pathway databases

ReactomeiREACT_116010. Sulfide oxidation to sulfate.
REACT_1520. Gluconeogenesis.
REACT_19372. Organic anion transporters.

Miscellaneous databases

ChiTaRSiSLC25A10. human.
GeneWikiiSLC25A10.
GenomeRNAii1468.
NextBioi6027.
PROiQ9UBX3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBX3.
CleanExiHS_SLC25A10.
ExpressionAtlasiQ9UBX3. baseline.
GenevisibleiQ9UBX3. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family."
    Fiermonte G., Dolce V., Arrigoni R., Runswick M.J., Walker J.E., Palmieri F.
    Biochem. J. 344:953-960(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDIC_HUMAN
AccessioniPrimary (citable) accession number: Q9UBX3
Secondary accession number(s): Q542Z3, Q96BA1, Q96IP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: June 24, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.