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Q9UBX3

- DIC_HUMAN

UniProt

Q9UBX3 - DIC_HUMAN

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Protein
Mitochondrial dicarboxylate carrier
Gene
SLC25A10, DIC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

GO - Molecular functioni

  1. dicarboxylic acid transmembrane transporter activity Source: ProtInc
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cellular nitrogen compound metabolic process Source: Reactome
  3. dicarboxylic acid transport Source: ProtInc
  4. gluconeogenesis Source: Reactome
  5. glucose metabolic process Source: Reactome
  6. ion transport Source: Reactome
  7. mitochondrial transport Source: InterPro
  8. small molecule metabolic process Source: Reactome
  9. sulfide oxidation, using sulfide:quinone oxidoreductase Source: Reactome
  10. sulfur amino acid catabolic process Source: Reactome
  11. sulfur amino acid metabolic process Source: Reactome
  12. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_116010. Sulfide oxidation to sulfate.
REACT_1520. Gluconeogenesis.
REACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.29.2.7. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene namesi
Synonyms:DIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10980. SLC25A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei63 – 8220Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei163 – 18220Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei203 – 22321Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Mitochondrial dicarboxylate carrier
PRO_0000090609Add
BLAST

Proteomic databases

MaxQBiQ9UBX3.
PaxDbiQ9UBX3.
PRIDEiQ9UBX3.

PTM databases

PhosphoSiteiQ9UBX3.

Expressioni

Tissue specificityi

Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.1 Publication

Gene expression databases

BgeeiQ9UBX3.
CleanExiHS_SLC25A10.
GenevestigatoriQ9UBX3.

Organism-specific databases

HPAiHPA023048.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997504EBI-750394,EBI-724076

Protein-protein interaction databases

BioGridi107850. 31 interactions.
IntActiQ9UBX3. 9 interactions.
MINTiMINT-1477100.
STRINGi9606.ENSP00000345580.

Structurei

3D structure databases

ProteinModelPortaliQ9UBX3.
SMRiQ9UBX3. Positions 13-279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 8881Solcar 1
Add
BLAST
Repeati101 – 18888Solcar 2
Add
BLAST
Repeati197 – 28084Solcar 3
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300113.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
KOiK13577.
OMAiFIPAWAR.
PhylomeDBiQ9UBX3.
TreeFamiTF312920.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBX3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR    50
VVRTDGILAL YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH 100
EKVLLGSVSG LAGGFVGTPA DLVNVRMQND VKLPQGQRRN YAHALDGLYR 150
VAREEGLRRL FSGATMASSR GALVTVGQLS CYDQAKQLVL STGYLSDNIF 200
THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC AVETAKLGPL 250
AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS 287
Length:287
Mass (Da):31,282
Last modified:February 11, 2002 - v2
Checksum:i32BE9920C7CD8ADF
GO
Isoform 2 (identifier: Q9UBX3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: A → AAAGDEPPPQ

Note: No experimental confirmation available.

Show »
Length:296
Mass (Da):32,145
Checksum:iA8B1484218C4125C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 2091A → AAAGDEPPPQ in isoform 2.
VSP_003267

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881L → R in CAB60007. 1 Publication
Sequence conflicti188 – 1881L → R in CAB59892. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131612 Genomic DNA. Translation: CAB60007.1.
AJ131613 mRNA. Translation: CAB59892.1.
AK075249 mRNA. Translation: BAC11497.1.
CH471099 Genomic DNA. Translation: EAW89682.1.
BC007355 mRNA. Translation: AAH07355.1.
BC015797 mRNA. Translation: AAH15797.1.
CCDSiCCDS11786.1. [Q9UBX3-1]
CCDS59301.1. [Q9UBX3-2]
RefSeqiNP_001257817.1. NM_001270888.1. [Q9UBX3-2]
NP_001257882.1. NM_001270953.1.
NP_036272.2. NM_012140.4. [Q9UBX3-1]
UniGeneiHs.548187.

Genome annotation databases

EnsembliENST00000331531; ENSP00000328403; ENSG00000183048. [Q9UBX3-2]
ENST00000350690; ENSP00000345580; ENSG00000183048. [Q9UBX3-1]
GeneIDi1468.
KEGGihsa:1468.
UCSCiuc002kbi.4. human. [Q9UBX3-1]
uc010dif.4. human. [Q9UBX3-2]

Polymorphism databases

DMDMi20137671.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ131612 Genomic DNA. Translation: CAB60007.1 .
AJ131613 mRNA. Translation: CAB59892.1 .
AK075249 mRNA. Translation: BAC11497.1 .
CH471099 Genomic DNA. Translation: EAW89682.1 .
BC007355 mRNA. Translation: AAH07355.1 .
BC015797 mRNA. Translation: AAH15797.1 .
CCDSi CCDS11786.1. [Q9UBX3-1 ]
CCDS59301.1. [Q9UBX3-2 ]
RefSeqi NP_001257817.1. NM_001270888.1. [Q9UBX3-2 ]
NP_001257882.1. NM_001270953.1.
NP_036272.2. NM_012140.4. [Q9UBX3-1 ]
UniGenei Hs.548187.

3D structure databases

ProteinModelPortali Q9UBX3.
SMRi Q9UBX3. Positions 13-279.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107850. 31 interactions.
IntActi Q9UBX3. 9 interactions.
MINTi MINT-1477100.
STRINGi 9606.ENSP00000345580.

Chemistry

DrugBanki DB00139. Succinic acid.

Protein family/group databases

TCDBi 2.A.29.2.7. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q9UBX3.

Polymorphism databases

DMDMi 20137671.

Proteomic databases

MaxQBi Q9UBX3.
PaxDbi Q9UBX3.
PRIDEi Q9UBX3.

Protocols and materials databases

DNASUi 1468.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331531 ; ENSP00000328403 ; ENSG00000183048 . [Q9UBX3-2 ]
ENST00000350690 ; ENSP00000345580 ; ENSG00000183048 . [Q9UBX3-1 ]
GeneIDi 1468.
KEGGi hsa:1468.
UCSCi uc002kbi.4. human. [Q9UBX3-1 ]
uc010dif.4. human. [Q9UBX3-2 ]

Organism-specific databases

CTDi 1468.
GeneCardsi GC17P079674.
HGNCi HGNC:10980. SLC25A10.
HPAi HPA023048.
MIMi 606794. gene.
neXtProti NX_Q9UBX3.
PharmGKBi PA35856.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300113.
HOGENOMi HOG000165139.
HOVERGENi HBG009528.
KOi K13577.
OMAi FIPAWAR.
PhylomeDBi Q9UBX3.
TreeFami TF312920.

Enzyme and pathway databases

Reactomei REACT_116010. Sulfide oxidation to sulfate.
REACT_1520. Gluconeogenesis.
REACT_19372. Organic anion transporters.

Miscellaneous databases

ChiTaRSi SLC25A10. human.
GeneWikii SLC25A10.
GenomeRNAii 1468.
NextBioi 6027.
PROi Q9UBX3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBX3.
CleanExi HS_SLC25A10.
Genevestigatori Q9UBX3.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00784. MTUNCOUPLING.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family."
    Fiermonte G., Dolce V., Arrigoni R., Runswick M.J., Walker J.E., Palmieri F.
    Biochem. J. 344:953-960(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDIC_HUMAN
AccessioniPrimary (citable) accession number: Q9UBX3
Secondary accession number(s): Q542Z3, Q96BA1, Q96IP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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