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Protein

Mitochondrial dicarboxylate carrier

Gene

SLC25A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-1614517 Sulfide oxidation to sulfate
R-HSA-428643 Organic anion transporters
R-HSA-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.29.2.7 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene namesi
Name:SLC25A10
Synonyms:DIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000183048.11
HGNCiHGNC:10980 SLC25A10
MIMi606794 gene
neXtProtiNX_Q9UBX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei63 – 82Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei163 – 182Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1468
OpenTargetsiENSG00000183048
PharmGKBiPA35856

Chemistry databases

DrugBankiDB00139 Succinic acid

Polymorphism and mutation databases

DMDMi20137671

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906091 – 287Mitochondrial dicarboxylate carrierAdd BLAST287

Proteomic databases

EPDiQ9UBX3
PaxDbiQ9UBX3
PeptideAtlasiQ9UBX3
PRIDEiQ9UBX3

PTM databases

iPTMnetiQ9UBX3
PhosphoSitePlusiQ9UBX3
SwissPalmiQ9UBX3

Expressioni

Tissue specificityi

Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.1 Publication

Gene expression databases

BgeeiENSG00000183048
CleanExiHS_SLC25A10
ExpressionAtlasiQ9UBX3 baseline and differential
GenevisibleiQ9UBX3 HS

Organism-specific databases

HPAiHPA023048

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107850, 50 interactors
IntActiQ9UBX3, 24 interactors
MINTiQ9UBX3
STRINGi9606.ENSP00000345580

Structurei

3D structure databases

ProteinModelPortaliQ9UBX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 88Solcar 1Add BLAST81
Repeati101 – 188Solcar 2Add BLAST88
Repeati197 – 280Solcar 3Add BLAST84

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759 Eukaryota
ENOG410XQHU LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165139
HOVERGENiHBG009528
InParanoidiQ9UBX3
KOiK13577
OMAiLKTRAMN
PhylomeDBiQ9UBX3
TreeFamiTF312920

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR
60 70 80 90 100
VVRTDGILAL YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH
110 120 130 140 150
EKVLLGSVSG LAGGFVGTPA DLVNVRMQND VKLPQGQRRN YAHALDGLYR
160 170 180 190 200
VAREEGLRRL FSGATMASSR GALVTVGQLS CYDQAKQLVL STGYLSDNIF
210 220 230 240 250
THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC AVETAKLGPL
260 270 280
AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS
Length:287
Mass (Da):31,282
Last modified:February 11, 2002 - v2
Checksum:i32BE9920C7CD8ADF
GO
Isoform 2 (identifier: Q9UBX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: A → AAAGDEPPPQ

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):32,145
Checksum:iA8B1484218C4125C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188L → R in CAB60007 (PubMed:10585886).Curated1
Sequence conflicti188L → R in CAB59892 (PubMed:10585886).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003267209A → AAAGDEPPPQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131612 Genomic DNA Translation: CAB60007.1
AJ131613 mRNA Translation: CAB59892.1
AK075249 mRNA Translation: BAC11497.1
CH471099 Genomic DNA Translation: EAW89682.1
BC007355 mRNA Translation: AAH07355.1
BC015797 mRNA Translation: AAH15797.1
CCDSiCCDS11786.1 [Q9UBX3-1]
CCDS59301.1 [Q9UBX3-2]
RefSeqiNP_001257817.1, NM_001270888.1 [Q9UBX3-2]
NP_001257882.1, NM_001270953.1
NP_036272.2, NM_012140.4 [Q9UBX3-1]
UniGeneiHs.548187

Genome annotation databases

EnsembliENST00000331531; ENSP00000328403; ENSG00000183048 [Q9UBX3-2]
ENST00000350690; ENSP00000345580; ENSG00000183048 [Q9UBX3-1]
GeneIDi1468
KEGGihsa:1468
UCSCiuc002kbi.5 human [Q9UBX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDIC_HUMAN
AccessioniPrimary (citable) accession number: Q9UBX3
Secondary accession number(s): Q542Z3, Q96BA1, Q96IP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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