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Q9UBX3

- DIC_HUMAN

UniProt

Q9UBX3 - DIC_HUMAN

Protein

Mitochondrial dicarboxylate carrier

Gene

SLC25A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

    GO - Molecular functioni

    1. dicarboxylic acid transmembrane transporter activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cellular nitrogen compound metabolic process Source: Reactome
    3. dicarboxylic acid transport Source: ProtInc
    4. gluconeogenesis Source: Reactome
    5. glucose metabolic process Source: Reactome
    6. ion transport Source: Reactome
    7. mitochondrial transport Source: InterPro
    8. small molecule metabolic process Source: Reactome
    9. sulfide oxidation, using sulfide:quinone oxidoreductase Source: Reactome
    10. sulfur amino acid catabolic process Source: Reactome
    11. sulfur amino acid metabolic process Source: Reactome
    12. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_116010. Sulfide oxidation to sulfate.
    REACT_1520. Gluconeogenesis.
    REACT_19372. Organic anion transporters.

    Protein family/group databases

    TCDBi2.A.29.2.7. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Alternative name(s):
    Solute carrier family 25 member 10
    Gene namesi
    Name:SLC25A10
    Synonyms:DIC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10980. SLC25A10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35856.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Mitochondrial dicarboxylate carrierPRO_0000090609Add
    BLAST

    Proteomic databases

    MaxQBiQ9UBX3.
    PaxDbiQ9UBX3.
    PRIDEiQ9UBX3.

    PTM databases

    PhosphoSiteiQ9UBX3.

    Expressioni

    Tissue specificityi

    Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.1 Publication

    Gene expression databases

    BgeeiQ9UBX3.
    CleanExiHS_SLC25A10.
    GenevestigatoriQ9UBX3.

    Organism-specific databases

    HPAiHPA023048.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDFIQ997504EBI-750394,EBI-724076

    Protein-protein interaction databases

    BioGridi107850. 31 interactions.
    IntActiQ9UBX3. 9 interactions.
    MINTiMINT-1477100.
    STRINGi9606.ENSP00000345580.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBX3.
    SMRiQ9UBX3. Positions 13-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati8 – 8881Solcar 1Add
    BLAST
    Repeati101 – 18888Solcar 2Add
    BLAST
    Repeati197 – 28084Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300113.
    HOGENOMiHOG000165139.
    HOVERGENiHBG009528.
    KOiK13577.
    OMAiFIPAWAR.
    PhylomeDBiQ9UBX3.
    TreeFamiTF312920.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBX3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR    50
    VVRTDGILAL YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH 100
    EKVLLGSVSG LAGGFVGTPA DLVNVRMQND VKLPQGQRRN YAHALDGLYR 150
    VAREEGLRRL FSGATMASSR GALVTVGQLS CYDQAKQLVL STGYLSDNIF 200
    THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC AVETAKLGPL 250
    AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS 287
    Length:287
    Mass (Da):31,282
    Last modified:February 11, 2002 - v2
    Checksum:i32BE9920C7CD8ADF
    GO
    Isoform 2 (identifier: Q9UBX3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         209-209: A → AAAGDEPPPQ

    Note: No experimental confirmation available.

    Show »
    Length:296
    Mass (Da):32,145
    Checksum:iA8B1484218C4125C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 1881L → R in CAB60007. (PubMed:10585886)Curated
    Sequence conflicti188 – 1881L → R in CAB59892. (PubMed:10585886)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei209 – 2091A → AAAGDEPPPQ in isoform 2. 1 PublicationVSP_003267

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ131612 Genomic DNA. Translation: CAB60007.1.
    AJ131613 mRNA. Translation: CAB59892.1.
    AK075249 mRNA. Translation: BAC11497.1.
    CH471099 Genomic DNA. Translation: EAW89682.1.
    BC007355 mRNA. Translation: AAH07355.1.
    BC015797 mRNA. Translation: AAH15797.1.
    CCDSiCCDS11786.1. [Q9UBX3-1]
    CCDS59301.1. [Q9UBX3-2]
    RefSeqiNP_001257817.1. NM_001270888.1. [Q9UBX3-2]
    NP_001257882.1. NM_001270953.1.
    NP_036272.2. NM_012140.4. [Q9UBX3-1]
    UniGeneiHs.548187.

    Genome annotation databases

    EnsembliENST00000331531; ENSP00000328403; ENSG00000183048. [Q9UBX3-2]
    ENST00000350690; ENSP00000345580; ENSG00000183048. [Q9UBX3-1]
    GeneIDi1468.
    KEGGihsa:1468.
    UCSCiuc002kbi.4. human. [Q9UBX3-1]
    uc010dif.4. human. [Q9UBX3-2]

    Polymorphism databases

    DMDMi20137671.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ131612 Genomic DNA. Translation: CAB60007.1 .
    AJ131613 mRNA. Translation: CAB59892.1 .
    AK075249 mRNA. Translation: BAC11497.1 .
    CH471099 Genomic DNA. Translation: EAW89682.1 .
    BC007355 mRNA. Translation: AAH07355.1 .
    BC015797 mRNA. Translation: AAH15797.1 .
    CCDSi CCDS11786.1. [Q9UBX3-1 ]
    CCDS59301.1. [Q9UBX3-2 ]
    RefSeqi NP_001257817.1. NM_001270888.1. [Q9UBX3-2 ]
    NP_001257882.1. NM_001270953.1.
    NP_036272.2. NM_012140.4. [Q9UBX3-1 ]
    UniGenei Hs.548187.

    3D structure databases

    ProteinModelPortali Q9UBX3.
    SMRi Q9UBX3. Positions 13-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107850. 31 interactions.
    IntActi Q9UBX3. 9 interactions.
    MINTi MINT-1477100.
    STRINGi 9606.ENSP00000345580.

    Chemistry

    DrugBanki DB00139. Succinic acid.

    Protein family/group databases

    TCDBi 2.A.29.2.7. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q9UBX3.

    Polymorphism databases

    DMDMi 20137671.

    Proteomic databases

    MaxQBi Q9UBX3.
    PaxDbi Q9UBX3.
    PRIDEi Q9UBX3.

    Protocols and materials databases

    DNASUi 1468.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331531 ; ENSP00000328403 ; ENSG00000183048 . [Q9UBX3-2 ]
    ENST00000350690 ; ENSP00000345580 ; ENSG00000183048 . [Q9UBX3-1 ]
    GeneIDi 1468.
    KEGGi hsa:1468.
    UCSCi uc002kbi.4. human. [Q9UBX3-1 ]
    uc010dif.4. human. [Q9UBX3-2 ]

    Organism-specific databases

    CTDi 1468.
    GeneCardsi GC17P079674.
    HGNCi HGNC:10980. SLC25A10.
    HPAi HPA023048.
    MIMi 606794. gene.
    neXtProti NX_Q9UBX3.
    PharmGKBi PA35856.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300113.
    HOGENOMi HOG000165139.
    HOVERGENi HBG009528.
    KOi K13577.
    OMAi FIPAWAR.
    PhylomeDBi Q9UBX3.
    TreeFami TF312920.

    Enzyme and pathway databases

    Reactomei REACT_116010. Sulfide oxidation to sulfate.
    REACT_1520. Gluconeogenesis.
    REACT_19372. Organic anion transporters.

    Miscellaneous databases

    ChiTaRSi SLC25A10. human.
    GeneWikii SLC25A10.
    GenomeRNAii 1468.
    NextBioi 6027.
    PROi Q9UBX3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBX3.
    CleanExi HS_SLC25A10.
    Genevestigatori Q9UBX3.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family."
      Fiermonte G., Dolce V., Arrigoni R., Runswick M.J., Walker J.E., Palmieri F.
      Biochem. J. 344:953-960(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thyroid.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin and Uterus.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDIC_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBX3
    Secondary accession number(s): Q542Z3, Q96BA1, Q96IP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3