Q9UBX3 (DIC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial dicarboxylate carrier

Alternative name(s):
Solute carrier family 25 member 10

Gene names

Name:	SLC25A10
Synonyms:	DIC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue specificity	Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed. Ref.1
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular nitrogen compound metabolic process Traceable author statement. Source: Reactome gluconeogenesis Traceable author statement. Source: Reactome mitochondrial transport Inferred from electronic annotation. Source: InterPro sulfide oxidation, using sulfide:quinone oxidoreductase Traceable author statement. Source: Reactome sulfur amino acid catabolic process Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Traceable author statement. Source: Reactome nucleus Inferred from direct assay. Source: HPA
Molecular_function	dicarboxylic acid transmembrane transporter activity Traceable author statement PubMed 9733776. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	3	EBI-750394,EBI-724076

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UBX3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UBX3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: A → AAAGDEPPPQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Mitochondrial dicarboxylate carrier		PRO_0000090609
Regions
	Transmembrane	10 – 30	21	Helical; Name=1; Potential
	Transmembrane	63 – 82	20	Helical; Name=2; Potential
	Transmembrane	103 – 123	21	Helical; Name=3; Potential
	Transmembrane	163 – 182	20	Helical; Name=4; Potential
	Transmembrane	203 – 223	21	Helical; Name=5; Potential
	Transmembrane	255 – 275	21	Helical; Name=6; Potential
	Repeat	8 – 88	81	Solcar 1
	Repeat	101 – 188	88	Solcar 2
	Repeat	197 – 280	84	Solcar 3
Natural variations
	Alternative sequence	209	1	A → AAAGDEPPPQ in isoform 2.		VSP_003267
Experimental info
	Sequence conflict	188	1	L → R in CAB60007. Ref.1
	Sequence conflict	188	1	L → R in CAB59892. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 11, 2002. Version 2. Checksum: 32BE9920C7CD8ADF	FASTA	287	31,282
	10 20 30 40 50 60 MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 70 80 90 100 110 120 YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 130 140 150 160 170 180 DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 190 200 210 220 230 240 CYDQAKQLVL STGYLSDNIF THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC 250 260 270 280 AVETAKLGPL AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS
	Isoform 2 [UniParc]. Checksum: A8B1484218C4125C	FASTA	296	32,145
	10 20 30 40 50 60 MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 70 80 90 100 110 120 YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 130 140 150 160 170 180 DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 190 200 210 220 230 240 CYDQAKQLVL STGYLSDNIF THFVASFIAA AGDEPPPQGG CATFLCQPLD VLKTRLMNSK 250 260 270 280 290 GEYQGVFHCA VETAKLGPLA FYKGLVPAGI RLIPHTVLTF VFLEQLRKNF GIKVPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family." Fiermonte G., Dolce V., Arrigoni R., Runswick M.J., Walker J.E., Palmieri F. Biochem. J. 344:953-960(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thyroid.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Skin and Uterus.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ131612 Genomic DNA. Translation: CAB60007.1. AJ131613 mRNA. Translation: CAB59892.1. AK075249 mRNA. Translation: BAC11497.1. CH471099 Genomic DNA. Translation: EAW89682.1. BC007355 mRNA. Translation: AAH07355.1. BC015797 mRNA. Translation: AAH15797.1.
IPI	IPI00015920. IPI00217277.
RefSeq	NP_001257817.1. NM_001270888.1. NP_001257882.1. NM_001270953.1. NP_036272.2. NM_012140.4.
UniGene	Hs.548187.
3D structure databases
ProteinModelPortal	Q9UBX3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UBX3. 6 interactions.
MINT	MINT-1477100.
STRING	9606.ENSP00000345580.
Protein family/group databases
TCDB	2.A.29.2.7. mitochondrial carrier (MC) family.
PTM databases
PhosphoSite	Q9UBX3.
Polymorphism databases
DMDM	20137671.
Proteomic databases
PaxDb	Q9UBX3.
PRIDE	Q9UBX3.
Protocols and materials databases
DNASU	1468.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331531; ENSP00000328403; ENSG00000183048. ENST00000350690; ENSP00000345580; ENSG00000183048.
GeneID	1468.
KEGG	hsa:1468.
UCSC	uc002kbi.3. human. uc010dif.3. human.
Organism-specific databases
CTD	1468.
GeneCards	GC17P079674.
HGNC	HGNC:10980. SLC25A10.
HPA	HPA023048.
MIM	606794. gene.
neXtProt	NX_Q9UBX3.
PharmGKB	PA35856.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300113.
HOGENOM	HOG000165139.
HOVERGEN	HBG009528.
KO	K13577.
OMA	FGIYETV.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15518. Transmembrane transport of small molecules. REACT_19419. Amino acid and oligopeptide SLC transporters.
Gene expression databases
ArrayExpress	Q9UBX3.
Bgee	Q9UBX3.
CleanEx	HS_SLC25A10.
Genevestigator	Q9UBX3.
GermOnline	ENSG00000183048. Homo sapiens.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002030. Mit_uncoupling. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00784. MTUNCOUPLING.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC25A10. human.
DrugBank	DB00139. Succinic acid.
GenomeRNAi	1468.
NextBio	6027.
SOURCE	Search...

Entry information

Entry name

DIC_HUMAN

Accession

Primary (citable) accession number: Q9UBX3
Secondary accession number(s): Q542Z3, Q96BA1, Q96IP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	February 11, 2002
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.