Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UBX3 (DIC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial dicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 10
Gene names
Name:SLC25A10
Synonyms:DIC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Tissue specificity

Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed. Ref.1

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Traceable author statement. Source: Reactome

cellular nitrogen compound metabolic process

Traceable author statement. Source: Reactome

dicarboxylic acid transport

Traceable author statement PubMed 9733776. Source: ProtInc

gluconeogenesis

Traceable author statement. Source: Reactome

glucose metabolic process

Traceable author statement. Source: Reactome

ion transport

Traceable author statement. Source: Reactome

mitochondrial transport

Inferred from electronic annotation. Source: InterPro

small molecule metabolic process

Traceable author statement. Source: Reactome

sulfide oxidation, using sulfide:quinone oxidoreductase

Traceable author statement. Source: Reactome

sulfur amino acid catabolic process

Traceable author statement. Source: Reactome

sulfur amino acid metabolic process

Traceable author statement. Source: Reactome

thiosulfate transport

Inferred from electronic annotation. Source: Ensembl

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Traceable author statement. Source: Reactome

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: Ensembl

dicarboxylic acid transmembrane transporter activity

Traceable author statement PubMed 9733776. Source: ProtInc

malate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

phosphate ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

succinate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

sulfate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

thiosulfate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MDFIQ997504EBI-750394,EBI-724076

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UBX3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UBX3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: A → AAAGDEPPPQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Mitochondrial dicarboxylate carrier
PRO_0000090609

Regions

Transmembrane10 – 3021Helical; Name=1; Potential
Transmembrane63 – 8220Helical; Name=2; Potential
Transmembrane103 – 12321Helical; Name=3; Potential
Transmembrane163 – 18220Helical; Name=4; Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Transmembrane255 – 27521Helical; Name=6; Potential
Repeat8 – 8881Solcar 1
Repeat101 – 18888Solcar 2
Repeat197 – 28084Solcar 3

Natural variations

Alternative sequence2091A → AAAGDEPPPQ in isoform 2.
VSP_003267

Experimental info

Sequence conflict1881L → R in CAB60007. Ref.1
Sequence conflict1881L → R in CAB59892. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 11, 2002. Version 2.
Checksum: 32BE9920C7CD8ADF

FASTA28731,282
        10         20         30         40         50         60 
MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 

        70         80         90        100        110        120 
YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 

       130        140        150        160        170        180 
DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 

       190        200        210        220        230        240 
CYDQAKQLVL STGYLSDNIF THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC 

       250        260        270        280 
AVETAKLGPL AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS 

« Hide

Isoform 2 [UniParc].

Checksum: A8B1484218C4125C
Show »

FASTA29632,145

References

« Hide 'large scale' references
[1]"Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family."
Fiermonte G., Dolce V., Arrigoni R., Runswick M.J., Walker J.E., Palmieri F.
Biochem. J. 344:953-960(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thyroid.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Skin and Uterus.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ131612 Genomic DNA. Translation: CAB60007.1.
AJ131613 mRNA. Translation: CAB59892.1.
AK075249 mRNA. Translation: BAC11497.1.
CH471099 Genomic DNA. Translation: EAW89682.1.
BC007355 mRNA. Translation: AAH07355.1.
BC015797 mRNA. Translation: AAH15797.1.
RefSeqNP_001257817.1. NM_001270888.1.
NP_001257882.1. NM_001270953.1.
NP_036272.2. NM_012140.4.
UniGeneHs.548187.

3D structure databases

ProteinModelPortalQ9UBX3.
SMRQ9UBX3. Positions 13-279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107850. 28 interactions.
IntActQ9UBX3. 9 interactions.
MINTMINT-1477100.
STRING9606.ENSP00000345580.

Chemistry

DrugBankDB00139. Succinic acid.

Protein family/group databases

TCDB2.A.29.2.7. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteQ9UBX3.

Polymorphism databases

DMDM20137671.

Proteomic databases

PaxDbQ9UBX3.
PRIDEQ9UBX3.

Protocols and materials databases

DNASU1468.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331531; ENSP00000328403; ENSG00000183048. [Q9UBX3-2]
ENST00000350690; ENSP00000345580; ENSG00000183048. [Q9UBX3-1]
GeneID1468.
KEGGhsa:1468.
UCSCuc002kbi.4. human. [Q9UBX3-1]
uc010dif.4. human. [Q9UBX3-2]

Organism-specific databases

CTD1468.
GeneCardsGC17P079674.
HGNCHGNC:10980. SLC25A10.
HPAHPA023048.
MIM606794. gene.
neXtProtNX_Q9UBX3.
PharmGKBPA35856.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG300113.
HOGENOMHOG000165139.
HOVERGENHBG009528.
KOK13577.
OMAFIPAWAR.
PhylomeDBQ9UBX3.
TreeFamTF312920.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

BgeeQ9UBX3.
CleanExHS_SLC25A10.
GenevestigatorQ9UBX3.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00784. MTUNCOUPLING.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC25A10. human.
GeneWikiSLC25A10.
GenomeRNAi1468.
NextBio6027.
PROQ9UBX3.
SOURCESearch...

Entry information

Entry nameDIC_HUMAN
AccessionPrimary (citable) accession number: Q9UBX3
Secondary accession number(s): Q542Z3, Q96BA1, Q96IP1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM