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Q9UBW9

- Q9UBW9_HUMAN

UniProt

Q9UBW9 - Q9UBW9_HUMAN

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Protein
Submitted name: Antithrombin III
Gene
AT3
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. serine-type endopeptidase inhibitor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. negative regulation of inflammatory response Source: Ensembl
  2. regulation of blood coagulation, intrinsic pathway Source: InterPro
  3. response to nutrient Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Antithrombin IIIImported
Submitted name:
Antithrombin III gene 3' (aa 375-432)Imported
Gene namesi
Name:AT3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9UBW9.

Expressioni

Gene expression databases

ArrayExpressiQ9UBW9.
BgeeiQ9UBW9.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9UBW9.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Family and domain databases

InterProiIPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UBW9-1 [UniParc]FASTAAdd to Basket

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VNEEGSEAAA STAVVIAGRS LNPNRVTFKA NRPFLVFIRE VPLNTIIFMG   50
RVANPCVK 58
Length:58
Mass (Da):6,286
Last modified:May 1, 2000 - v1
Checksum:i1F2FCCB302E643A3
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21645 Genomic DNA. Translation: AAA51795.1.
X03204 Genomic DNA. Translation: CAA26952.1.
UniGeneiHs.75599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21645 Genomic DNA. Translation: AAA51795.1 .
X03204 Genomic DNA. Translation: CAA26952.1 .
UniGenei Hs.75599.

3D structure databases

ProteinModelPortali Q9UBW9.
ModBasei Search...

Chemistry

BindingDBi Q9UBW9.

Proteomic databases

PRIDEi Q9UBW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q9UBW9.
Bgeei Q9UBW9.

Family and domain databases

InterProi IPR015555. AT-III.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF53. PTHR11461:SF53. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Location of two of the introns in the antithrombin-III gene."
    Jagd S., Vibe-Pedersen K., Magnusson S.
    FEBS Lett. 193:213-216(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Antithrombin III Utah: proline-407 to leucine mutation in a highly conserved region near the inhibitor reactive site."
    Bock S.C., Marrinan J.A., Radziejewska E.
    Biochemistry 27:6171-6178(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UBW9_HUMAN
AccessioniPrimary (citable) accession number: Q9UBW9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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