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Q9UBW9

- Q9UBW9_HUMAN

UniProt

Q9UBW9 - Q9UBW9_HUMAN

Protein
Submitted name:

Antithrombin III

Gene

AT3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
  1. Functioni

    GO - Molecular functioni

    1. heparin binding Source: Ensembl
    2. serine-type endopeptidase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of inflammatory response Source: Ensembl
    2. regulation of blood coagulation, intrinsic pathway Source: InterPro
    3. response to nutrient Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Antithrombin IIIImported
    Submitted name:
    Antithrombin III gene 3' (aa 375-432)Imported
    Gene namesi
    Name:AT3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9UBW9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBW9.
    BgeeiQ9UBW9.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Family and domain databases

    InterProiIPR015555. AT-III.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9UBW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    VNEEGSEAAA STAVVIAGRS LNPNRVTFKA NRPFLVFIRE VPLNTIIFMG   50
    RVANPCVK 58
    Length:58
    Mass (Da):6,286
    Last modified:May 1, 2000 - v1
    Checksum:i1F2FCCB302E643A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21645 Genomic DNA. Translation: AAA51795.1.
    X03204 Genomic DNA. Translation: CAA26952.1.
    UniGeneiHs.75599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21645 Genomic DNA. Translation: AAA51795.1 .
    X03204 Genomic DNA. Translation: CAA26952.1 .
    UniGenei Hs.75599.

    3D structure databases

    ProteinModelPortali Q9UBW9.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9UBW9.

    Proteomic databases

    PRIDEi Q9UBW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q9UBW9.
    Bgeei Q9UBW9.

    Family and domain databases

    InterProi IPR015555. AT-III.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF53. PTHR11461:SF53. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Location of two of the introns in the antithrombin-III gene."
      Jagd S., Vibe-Pedersen K., Magnusson S.
      FEBS Lett. 193:213-216(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Antithrombin III Utah: proline-407 to leucine mutation in a highly conserved region near the inhibitor reactive site."
      Bock S.C., Marrinan J.A., Radziejewska E.
      Biochemistry 27:6171-6178(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UBW9_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBW9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.