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Q9UBW8

- CSN7A_HUMAN

UniProt

Q9UBW8 - CSN7A_HUMAN

Protein

COP9 signalosome complex subunit 7a

Gene

COPS7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

    GO - Biological processi

    1. cullin deneddylation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COP9 signalosome complex subunit 7a
    Short name:
    SGN7a
    Short name:
    Signalosome subunit 7a
    Alternative name(s):
    Dermal papilla-derived protein 10
    JAB1-containing signalosome subunit 7a
    Gene namesi
    Name:COPS7A
    Synonyms:CSN7A, DERP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Organism-specific databases

    HGNCiHGNC:16758. COPS7A.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. COP9 signalosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Signalosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 275274COP9 signalosome complex subunit 7aPRO_0000120996Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Post-translational modificationi

    Phosphorylated by CK2 and PKD kinases.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBW8.
    PaxDbiQ9UBW8.
    PeptideAtlasiQ9UBW8.
    PRIDEiQ9UBW8.

    PTM databases

    PhosphoSiteiQ9UBW8.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed at high level in brain, heart and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9UBW8.
    BgeeiQ9UBW8.
    CleanExiHS_COPS7A.
    GenevestigatoriQ9UBW8.

    Organism-specific databases

    HPAiHPA026915.

    Interactioni

    Subunit structurei

    Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD. Interacts directly with ID3.4 Publications

    Protein-protein interaction databases

    BioGridi119130. 55 interactions.
    DIPiDIP-53412N.
    IntActiQ9UBW8. 7 interactions.
    MINTiMINT-1393951.
    STRINGi9606.ENSP00000229251.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBW8.
    SMRiQ9UBW8. Positions 13-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 156105PCIAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili185 – 23349Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated
    Contains 1 PCI domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG289374.
    HOGENOMiHOG000006003.
    HOVERGENiHBG051138.
    InParanoidiQ9UBW8.
    KOiK12180.
    OMAiINALAPF.
    OrthoDBiEOG7N63NJ.
    PhylomeDBiQ9UBW8.
    TreeFamiTF101149.

    Family and domain databases

    InterProiIPR000717. PCI_dom.
    [Graphical view]
    PfamiPF01399. PCI. 1 hit.
    [Graphical view]
    SMARTiSM00088. PINT. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UBW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP    50
    NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS 100
    VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ 150
    RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE 200
    QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN 250
    QRQPSKKASK GKGLRGSAKI WSKSN 275
    Length:275
    Mass (Da):30,277
    Last modified:May 1, 2000 - v1
    Checksum:i20888B35BFFF6326
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti218 – 2181K → E in BAA91620. (PubMed:14702039)Curated
    Sequence conflicti253 – 2531Q → H in AAF04307. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF210052 mRNA. Translation: AAF19205.1.
    AB014764 mRNA. Translation: BAB87805.1.
    AB033603 mRNA. Translation: BAA85390.1.
    AF193844 mRNA. Translation: AAF04307.1.
    AK001318 mRNA. Translation: BAA91620.1.
    AK021721 mRNA. Translation: BAG51042.1.
    AK022488 mRNA. Translation: BAB14052.1.
    AK292621 mRNA. Translation: BAF85310.1.
    CH471116 Genomic DNA. Translation: EAW88745.1.
    CH471116 Genomic DNA. Translation: EAW88747.1.
    CH471116 Genomic DNA. Translation: EAW88748.1.
    BC011789 mRNA. Translation: AAH11789.1.
    CCDSiCCDS8558.1.
    RefSeqiNP_001157565.1. NM_001164093.1.
    NP_001157566.1. NM_001164094.1.
    NP_001157567.1. NM_001164095.2.
    NP_057403.1. NM_016319.3.
    XP_005253751.1. XM_005253694.1.
    XP_005253752.1. XM_005253695.1.
    UniGeneiHs.530823.

    Genome annotation databases

    EnsembliENST00000229251; ENSP00000229251; ENSG00000111652.
    ENST00000534877; ENSP00000438363; ENSG00000111652.
    ENST00000534947; ENSP00000446039; ENSG00000111652.
    ENST00000539735; ENSP00000441852; ENSG00000111652.
    ENST00000543155; ENSP00000438115; ENSG00000111652.
    GeneIDi50813.
    KEGGihsa:50813.
    UCSCiuc001qqh.3. human.

    Polymorphism databases

    DMDMi55976618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF210052 mRNA. Translation: AAF19205.1 .
    AB014764 mRNA. Translation: BAB87805.1 .
    AB033603 mRNA. Translation: BAA85390.1 .
    AF193844 mRNA. Translation: AAF04307.1 .
    AK001318 mRNA. Translation: BAA91620.1 .
    AK021721 mRNA. Translation: BAG51042.1 .
    AK022488 mRNA. Translation: BAB14052.1 .
    AK292621 mRNA. Translation: BAF85310.1 .
    CH471116 Genomic DNA. Translation: EAW88745.1 .
    CH471116 Genomic DNA. Translation: EAW88747.1 .
    CH471116 Genomic DNA. Translation: EAW88748.1 .
    BC011789 mRNA. Translation: AAH11789.1 .
    CCDSi CCDS8558.1.
    RefSeqi NP_001157565.1. NM_001164093.1.
    NP_001157566.1. NM_001164094.1.
    NP_001157567.1. NM_001164095.2.
    NP_057403.1. NM_016319.3.
    XP_005253751.1. XM_005253694.1.
    XP_005253752.1. XM_005253695.1.
    UniGenei Hs.530823.

    3D structure databases

    ProteinModelPortali Q9UBW8.
    SMRi Q9UBW8. Positions 13-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119130. 55 interactions.
    DIPi DIP-53412N.
    IntActi Q9UBW8. 7 interactions.
    MINTi MINT-1393951.
    STRINGi 9606.ENSP00000229251.

    PTM databases

    PhosphoSitei Q9UBW8.

    Polymorphism databases

    DMDMi 55976618.

    Proteomic databases

    MaxQBi Q9UBW8.
    PaxDbi Q9UBW8.
    PeptideAtlasi Q9UBW8.
    PRIDEi Q9UBW8.

    Protocols and materials databases

    DNASUi 50813.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229251 ; ENSP00000229251 ; ENSG00000111652 .
    ENST00000534877 ; ENSP00000438363 ; ENSG00000111652 .
    ENST00000534947 ; ENSP00000446039 ; ENSG00000111652 .
    ENST00000539735 ; ENSP00000441852 ; ENSG00000111652 .
    ENST00000543155 ; ENSP00000438115 ; ENSG00000111652 .
    GeneIDi 50813.
    KEGGi hsa:50813.
    UCSCi uc001qqh.3. human.

    Organism-specific databases

    CTDi 50813.
    GeneCardsi GC12P006833.
    HGNCi HGNC:16758. COPS7A.
    HPAi HPA026915.
    neXtProti NX_Q9UBW8.
    PharmGKBi PA26758.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289374.
    HOGENOMi HOG000006003.
    HOVERGENi HBG051138.
    InParanoidi Q9UBW8.
    KOi K12180.
    OMAi INALAPF.
    OrthoDBi EOG7N63NJ.
    PhylomeDBi Q9UBW8.
    TreeFami TF101149.

    Miscellaneous databases

    ChiTaRSi COPS7A. human.
    GeneWikii COPS7A.
    GenomeRNAii 50813.
    NextBioi 53257.
    PROi Q9UBW8.

    Gene expression databases

    ArrayExpressi Q9UBW8.
    Bgeei Q9UBW8.
    CleanExi HS_COPS7A.
    Genevestigatori Q9UBW8.

    Family and domain databases

    InterProi IPR000717. PCI_dom.
    [Graphical view ]
    Pfami PF01399. PCI. 1 hit.
    [Graphical view ]
    SMARTi SM00088. PINT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression."
      Wang Y., Devereux W., Stewart T.M., Casero R.A. Jr.
      Biochem. J. 366:79-86(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PMF1.
      Tissue: Placenta.
    2. "Molecular cloning of a dermal papilla derived gene."
      Ikeda A., Ukai Y., Yamashita M., Yoshimoto M.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hair follicle dermal papilla.
    3. "Cop9 complex subunit 7a."
      Okaze H., Hayashi A., Kozuma S., Saito T.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Molecular cloning and characterization of a novel cDNA encoding human COP9 complex subunit 7a (COPS7a)."
      Lau S.K., Au T.C.C., Kok L.D.S., Lee C.Y., Tsui S.K.W., Waye M.M.Y., Fung K.P.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo, Mammary gland and Thymus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    8. "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits."
      Seeger M., Kraft R., Ferrell K., Bech-Otschir D., Dumdey R., Schade R., Gordon C., Naumann M., Dubiel W.
      FASEB J. 12:469-478(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION.
    9. "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."
      Bech-Otschir D., Kraft R., Huang X., Henklein P., Kapelari B., Pollmann C., Dubiel W.
      EMBO J. 20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. Cited for: FUNCTION, COMPOSITION OF THE CSN COMPLEX.
    11. "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."
      Hoareau Alves K., Bochard V., Rety S., Jalinot P.
      FEBS Lett. 527:15-21(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EIF3S6.
    12. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."
      Groisman R., Polanowska J., Kuraoka I., Sawada J., Saijo M., Drapkin R., Kisselev A.F., Tanaka K., Nakatani Y.
      Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."
      Uhle S., Medalia O., Waldron R., Dumdey R., Henklein P., Bech-Otschir D., Huang X., Berse M., Sperling J., Schade R., Dubiel W.
      EMBO J. 22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH CK2 AND PKD.
    14. "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."
      Fang L., Wang X., Yamoah K., Chen P.L., Pan Z.Q., Huang L.
      J. Proteome Res. 7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CSN COMPLEX, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCSN7A_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBW8
    Secondary accession number(s): A8K9A6, Q9NVX3, Q9UJW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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