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Protein

COP9 signalosome complex subunit 7a

Gene

COPS7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

GO - Biological processi

  • cullin deneddylation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7a
Short name:
SGN7a
Short name:
Signalosome subunit 7a
Alternative name(s):
Dermal papilla-derived protein 10
JAB1-containing signalosome subunit 7a
Gene namesi
Name:COPS7A
Synonyms:CSN7A, DERP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16758. COPS7A.

Subcellular locationi

GO - Cellular componenti

  • COP9 signalosome Source: UniProtKB
  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26758.

Polymorphism and mutation databases

BioMutaiCOPS7A.
DMDMi55976618.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 275274COP9 signalosome complex subunit 7aPRO_0000120996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

Phosphorylated by CK2 and PKD kinases.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9UBW8.
PaxDbiQ9UBW8.
PeptideAtlasiQ9UBW8.
PRIDEiQ9UBW8.

PTM databases

PhosphoSiteiQ9UBW8.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high level in brain, heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9UBW8.
CleanExiHS_COPS7A.
ExpressionAtlasiQ9UBW8. baseline and differential.
GenevisibleiQ9UBW8. HS.

Organism-specific databases

HPAiHPA026915.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD. Interacts directly with ID3.4 Publications

Protein-protein interaction databases

BioGridi119130. 55 interactions.
DIPiDIP-53412N.
IntActiQ9UBW8. 7 interactions.
MINTiMINT-1393951.
STRINGi9606.ENSP00000229251.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80G/O1-218[»]
4D18X-ray4.08G/O1-218[»]
ProteinModelPortaliQ9UBW8.
SMRiQ9UBW8. Positions 8-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 156105PCIAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili185 – 23349Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated
Contains 1 PCI domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG289374.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ9UBW8.
KOiK12180.
OMAiXTYADYL.
OrthoDBiEOG7N63NJ.
PhylomeDBiQ9UBW8.
TreeFamiTF101149.

Family and domain databases

InterProiIPR000717. PCI_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP
60 70 80 90 100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS
110 120 130 140 150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ
160 170 180 190 200
RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE
210 220 230 240 250
QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN
260 270
QRQPSKKASK GKGLRGSAKI WSKSN
Length:275
Mass (Da):30,277
Last modified:May 1, 2000 - v1
Checksum:i20888B35BFFF6326
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181K → E in BAA91620 (PubMed:14702039).Curated
Sequence conflicti253 – 2531Q → H in AAF04307 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210052 mRNA. Translation: AAF19205.1.
AB014764 mRNA. Translation: BAB87805.1.
AB033603 mRNA. Translation: BAA85390.1.
AF193844 mRNA. Translation: AAF04307.1.
AK001318 mRNA. Translation: BAA91620.1.
AK021721 mRNA. Translation: BAG51042.1.
AK022488 mRNA. Translation: BAB14052.1.
AK292621 mRNA. Translation: BAF85310.1.
CH471116 Genomic DNA. Translation: EAW88745.1.
CH471116 Genomic DNA. Translation: EAW88747.1.
CH471116 Genomic DNA. Translation: EAW88748.1.
BC011789 mRNA. Translation: AAH11789.1.
CCDSiCCDS8558.1.
RefSeqiNP_001157565.1. NM_001164093.1.
NP_001157566.1. NM_001164094.1.
NP_001157567.1. NM_001164095.2.
NP_057403.1. NM_016319.3.
XP_005253751.1. XM_005253694.1.
XP_005253752.1. XM_005253695.1.
UniGeneiHs.530823.

Genome annotation databases

EnsembliENST00000229251; ENSP00000229251; ENSG00000111652.
ENST00000534877; ENSP00000438363; ENSG00000111652.
ENST00000534947; ENSP00000446039; ENSG00000111652.
ENST00000539735; ENSP00000441852; ENSG00000111652.
ENST00000543155; ENSP00000438115; ENSG00000111652.
GeneIDi50813.
KEGGihsa:50813.
UCSCiuc001qqh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210052 mRNA. Translation: AAF19205.1.
AB014764 mRNA. Translation: BAB87805.1.
AB033603 mRNA. Translation: BAA85390.1.
AF193844 mRNA. Translation: AAF04307.1.
AK001318 mRNA. Translation: BAA91620.1.
AK021721 mRNA. Translation: BAG51042.1.
AK022488 mRNA. Translation: BAB14052.1.
AK292621 mRNA. Translation: BAF85310.1.
CH471116 Genomic DNA. Translation: EAW88745.1.
CH471116 Genomic DNA. Translation: EAW88747.1.
CH471116 Genomic DNA. Translation: EAW88748.1.
BC011789 mRNA. Translation: AAH11789.1.
CCDSiCCDS8558.1.
RefSeqiNP_001157565.1. NM_001164093.1.
NP_001157566.1. NM_001164094.1.
NP_001157567.1. NM_001164095.2.
NP_057403.1. NM_016319.3.
XP_005253751.1. XM_005253694.1.
XP_005253752.1. XM_005253695.1.
UniGeneiHs.530823.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80G/O1-218[»]
4D18X-ray4.08G/O1-218[»]
ProteinModelPortaliQ9UBW8.
SMRiQ9UBW8. Positions 8-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119130. 55 interactions.
DIPiDIP-53412N.
IntActiQ9UBW8. 7 interactions.
MINTiMINT-1393951.
STRINGi9606.ENSP00000229251.

PTM databases

PhosphoSiteiQ9UBW8.

Polymorphism and mutation databases

BioMutaiCOPS7A.
DMDMi55976618.

Proteomic databases

MaxQBiQ9UBW8.
PaxDbiQ9UBW8.
PeptideAtlasiQ9UBW8.
PRIDEiQ9UBW8.

Protocols and materials databases

DNASUi50813.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229251; ENSP00000229251; ENSG00000111652.
ENST00000534877; ENSP00000438363; ENSG00000111652.
ENST00000534947; ENSP00000446039; ENSG00000111652.
ENST00000539735; ENSP00000441852; ENSG00000111652.
ENST00000543155; ENSP00000438115; ENSG00000111652.
GeneIDi50813.
KEGGihsa:50813.
UCSCiuc001qqh.3. human.

Organism-specific databases

CTDi50813.
GeneCardsiGC12P006833.
HGNCiHGNC:16758. COPS7A.
HPAiHPA026915.
MIMi616009. gene.
neXtProtiNX_Q9UBW8.
PharmGKBiPA26758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289374.
GeneTreeiENSGT00390000013069.
HOGENOMiHOG000006003.
HOVERGENiHBG051138.
InParanoidiQ9UBW8.
KOiK12180.
OMAiXTYADYL.
OrthoDBiEOG7N63NJ.
PhylomeDBiQ9UBW8.
TreeFamiTF101149.

Miscellaneous databases

ChiTaRSiCOPS7A. human.
GeneWikiiCOPS7A.
GenomeRNAii50813.
NextBioi53257.
PROiQ9UBW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBW8.
CleanExiHS_COPS7A.
ExpressionAtlasiQ9UBW8. baseline and differential.
GenevisibleiQ9UBW8. HS.

Family and domain databases

InterProiIPR000717. PCI_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression."
    Wang Y., Devereux W., Stewart T.M., Casero R.A. Jr.
    Biochem. J. 366:79-86(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PMF1.
    Tissue: Placenta.
  2. "Molecular cloning of a dermal papilla derived gene."
    Ikeda A., Ukai Y., Yamashita M., Yoshimoto M.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair follicle dermal papilla.
  3. "Cop9 complex subunit 7a."
    Okaze H., Hayashi A., Kozuma S., Saito T.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Molecular cloning and characterization of a novel cDNA encoding human COP9 complex subunit 7a (COPS7a)."
    Lau S.K., Au T.C.C., Kok L.D.S., Lee C.Y., Tsui S.K.W., Waye M.M.Y., Fung K.P.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo, Mammary gland and Thymus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  8. "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits."
    Seeger M., Kraft R., Ferrell K., Bech-Otschir D., Dumdey R., Schade R., Gordon C., Naumann M., Dubiel W.
    FASEB J. 12:469-478(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION.
  9. "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system."
    Bech-Otschir D., Kraft R., Huang X., Henklein P., Kapelari B., Pollmann C., Dubiel W.
    EMBO J. 20:1630-1639(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: FUNCTION, COMPOSITION OF THE CSN COMPLEX.
  11. "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome."
    Hoareau Alves K., Bochard V., Rety S., Jalinot P.
    FEBS Lett. 527:15-21(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EIF3S6.
  12. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."
    Groisman R., Polanowska J., Kuraoka I., Sawada J., Saijo M., Drapkin R., Kisselev A.F., Tanaka K., Nakatani Y.
    Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome."
    Uhle S., Medalia O., Waldron R., Dumdey R., Henklein P., Bech-Otschir D., Huang X., Berse M., Sperling J., Schade R., Dubiel W.
    EMBO J. 22:1302-1312(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION, INTERACTION WITH CK2 AND PKD.
  14. "Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry."
    Fang L., Wang X., Yamoah K., Chen P.L., Pan Z.Q., Huang L.
    J. Proteome Res. 7:4914-4925(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CSN COMPLEX, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCSN7A_HUMAN
AccessioniPrimary (citable) accession number: Q9UBW8
Secondary accession number(s): A8K9A6, Q9NVX3, Q9UJW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.