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Q9UBW7

- ZMYM2_HUMAN

UniProt

Q9UBW7 - ZMYM2_HUMAN

Protein

Zinc finger MYM-type protein 2

Gene

ZMYM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May function as a transcription factor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei913 – 9142Breakpoint for translocation to form ZMYM2-FGFR1

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri352 – 38635MYM-type 1Add
    BLAST
    Zinc fingeri398 – 43639MYM-type 2Add
    BLAST
    Zinc fingeri445 – 48036MYM-type 3Add
    BLAST
    Zinc fingeri491 – 54959MYM-type 4Add
    BLAST
    Zinc fingeri559 – 59739MYM-type 5Add
    BLAST
    Zinc fingeri605 – 65248MYM-type 6Add
    BLAST
    Zinc fingeri660 – 69435MYM-type 7Add
    BLAST
    Zinc fingeri701 – 74040MYM-type 8Add
    BLAST
    Zinc fingeri747 – 78135MYM-type 9Add
    BLAST

    GO - Molecular functioni

    1. ubiquitin conjugating enzyme binding Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger MYM-type protein 2
    Alternative name(s):
    Fused in myeloproliferative disorders protein
    Rearranged in atypical myeloproliferative disorder protein
    Zinc finger protein 198
    Gene namesi
    Name:ZMYM2
    Synonyms:FIM, RAMP, ZNF198
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:12989. ZMYM2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. PML body Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.

    Organism-specific databases

    PharmGKBiPA37569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13771377Zinc finger MYM-type protein 2PRO_0000191382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei303 – 3031Phosphoserine1 Publication
    Modified residuei305 – 3051Phosphoserine2 Publications
    Modified residuei838 – 8381Phosphoserine2 Publications
    Modified residuei958 – 9581Phosphoserine1 Publication
    Modified residuei1376 – 13761Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBW7.
    PaxDbiQ9UBW7.
    PRIDEiQ9UBW7.

    PTM databases

    PhosphoSiteiQ9UBW7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBW7.
    BgeeiQ9UBW7.
    GenevestigatoriQ9UBW7.

    Organism-specific databases

    HPAiHPA031765.

    Interactioni

    Subunit structurei

    May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.1 Publication

    Protein-protein interaction databases

    BioGridi113534. 36 interactions.
    IntActiQ9UBW7. 16 interactions.
    MINTiMINT-267007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBW7.
    SMRiQ9UBW7. Positions 316-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 9 MYM-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri352 – 38635MYM-type 1Add
    BLAST
    Zinc fingeri398 – 43639MYM-type 2Add
    BLAST
    Zinc fingeri445 – 48036MYM-type 3Add
    BLAST
    Zinc fingeri491 – 54959MYM-type 4Add
    BLAST
    Zinc fingeri559 – 59739MYM-type 5Add
    BLAST
    Zinc fingeri605 – 65248MYM-type 6Add
    BLAST
    Zinc fingeri660 – 69435MYM-type 7Add
    BLAST
    Zinc fingeri701 – 74040MYM-type 8Add
    BLAST
    Zinc fingeri747 – 78135MYM-type 9Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG86062.
    HOVERGENiHBG058385.
    InParanoidiQ9UBW7.
    OMAiRRPNGES.
    OrthoDBiEOG7JT6VN.
    PhylomeDBiQ9UBW7.
    TreeFamiTF336988.

    Family and domain databases

    InterProiIPR021893. DUF3504.
    IPR011017. TRASH_dom.
    IPR010507. Znf_MYM.
    [Graphical view]
    PfamiPF12012. DUF3504. 1 hit.
    PF06467. zf-FCS. 9 hits.
    [Graphical view]
    SMARTiSM00746. TRASH. 9 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTSSVGGLE LTDQTPVLLG STAMATSLTN VGNSFSGPAN PLVSRSNKFQ     50
    NSSVEDDDDV VFIEPVQPPP PSVPVVADQR TITFTSSKNE ELQGNDSKIT 100
    PSSKELASQK GSVSETIVID DEEDMETNQG QEKNSSNFIE RRPPETKNRT 150
    NDVDFSTSSF SRSKVNAGMG NSGITTEPDS EIQIANVTTL ETGVSSVNDG 200
    QLENTDGRDM NLMITHVTSL QNTNLGDVSN GLQSSNFGVN IQTYTPSLTS 250
    QTKTGVGPFN PGRMNVAGDV FQNGESATHH NPDSWISQSA SFPRNQKQPG 300
    VDSLSPVASL PKQIFQPSVQ QQPTKPVKVT CANCKKPLQK GQTAYQRKGS 350
    AHLFCSTTCL SSFSHKPAPK KLCVMCKKDI TTMKGTIVAQ VDSSESFQEF 400
    CSTSCLSLYE DKQNPTKGAL NKSRCTICGK LTEIRHEVSF KNMTHKLCSD 450
    HCFNRYRMAN GLIMNCCEQC GEYLPSKGAG NNVLVIDGQQ KRFCCQSCVS 500
    EYKQVGSHPS FLKEVRDHMQ DSFLMQPEKY GKLTTCTGCR TQCRFFDMTQ 550
    CIGPNGYMEP YCSTACMNSH KTKYAKSQSL GIICHFCKRN SLPQYQATMP 600
    DGKLYNFCNS SCVAKFQALS MQSSPNGQFV APSDIQLKCN YCKNSFCSKP 650
    EILEWENKVH QFCSKTCSDD YKKLHCIVTY CEYCQEEKTL HETVNFSGVK 700
    RPFCSEGCKL LYKQDFARRL GLRCVTCNYC SQLCKKGATK ELDGVVRDFC 750
    SEDCCKKFQD WYYKAARCDC CKSQGTLKER VQWRGEMKHF CDQHCLLRFY 800
    CQQNEPNMTT QKGPENLHYD QGCQTSRTKM TGSAPPPSPT PNKEMKNKAV 850
    LCKPLTMTKA TYCKPHMQTK SCQTDDTWRT EYVPVPIPVP VYIPVPMHMY 900
    SQNIPVPTTV PVPVPVPVFL PAPLDSSEKI PAAIEELKSK VSSDALDTEL 950
    LTMTDMMSED EGKTETTNIN SVIIETDIIG SDLLKNSDPE TQSSMPDVPY 1000
    EPDLDIEIDF PRAAEELDME NEFLLPPVFG EEYEEQPRPR SKKKGAKRKA 1050
    VSGYQSHDDS SDNSECSFPF KYTYGVNAWK HWVKTRQLDE DLLVLDELKS 1100
    SKSVKLKEDL LSHTTAELNY GLAHFVNEIR RPNGENYAPD SIYYLCLGIQ 1150
    EYLCGSNRKD NIFIDPGYQT FEQELNKILR SWQPSILPDG SIFSRVEEDY 1200
    LWRIKQLGSH SPVALLNTLF YFNTKYFGLK TVEQHLRLSF GTVFRHWKKN 1250
    PLTMENKACL RYQVSSLCGT DNEDKITTGK RKHEDDEPVF EQIENTANPS 1300
    RCPVKMFECY LSKSPQNLNQ RMDVFYLQPE CSSSTDSPVW YTSTSLDRNT 1350
    LENMLVRVLL VKDIYDKDNY ELDEDTD 1377
    Length:1,377
    Mass (Da):154,911
    Last modified:May 1, 2000 - v1
    Checksum:i2652D4C766492FF9
    GO
    Isoform 2 (identifier: Q9UBW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         165-251: Missing.
         529-549: KYGKLTTCTGCRTQCRFFDMT → VSRNVNGVQGLNIFEHCYYCH
         550-1377: Missing.

    Show »
    Length:462
    Mass (Da):50,809
    Checksum:iE906383363CB8D65
    GO

    Sequence cautioni

    The sequence AAB88464.1 differs from that shown. Reason: Frameshift at positions 330, 966, 1009 and 1017.
    The sequence AAC23591.1 differs from that shown. Reason: Frameshift at position 330.
    The sequence CAA73875.1 differs from that shown. Reason: Frameshift at positions 388, 403, 406, 409 and 418.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021S → P in CAH56193. (PubMed:11230166)Curated
    Sequence conflicti110 – 1101K → E in AAH36372. 1 PublicationCurated
    Sequence conflicti304 – 3041L → V in CAB66556. (PubMed:11230166)Curated
    Sequence conflicti330 – 3301T → S in CAB66556. (PubMed:11230166)Curated
    Sequence conflicti411 – 4122DK → EQ in CAA73875. (PubMed:9576949)Curated
    Sequence conflicti424 – 4241R → G in CAB66556. (PubMed:11230166)Curated
    Sequence conflicti657 – 6593NKV → ASL in CAH70133. (PubMed:17974005)Curated
    Sequence conflicti657 – 6593NKV → ASL in CAH71822. (PubMed:17974005)Curated
    Sequence conflicti736 – 7361K → G in CAA73875. (PubMed:9576949)Curated
    Sequence conflicti766 – 7672Missing in CAH70133. (PubMed:17974005)Curated
    Sequence conflicti766 – 7672Missing in CAH71822. (PubMed:17974005)Curated
    Sequence conflicti856 – 8561T → I in AAH36372. 1 PublicationCurated
    Sequence conflicti967 – 9671Missing in AAB88464. (PubMed:9694738)Curated
    Sequence conflicti1009 – 10102DF → IS in AAB88464. (PubMed:9694738)Curated
    Sequence conflicti1016 – 10161Missing in AAB88464. (PubMed:9694738)Curated
    Sequence conflicti1259 – 12591C → R in AAH36372. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei165 – 25187Missing in isoform 2. 1 PublicationVSP_039065Add
    BLAST
    Alternative sequencei529 – 54921KYGKL…FFDMT → VSRNVNGVQGLNIFEHCYYC H in isoform 2. 1 PublicationVSP_039066Add
    BLAST
    Alternative sequencei550 – 1377828Missing in isoform 2. 1 PublicationVSP_039067Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13472 mRNA. Translation: CAA73875.1. Frameshift.
    AJ224901 mRNA. Translation: CAA12204.1.
    AJ007676
    , AJ007677, AJ007678, AJ007679, AJ007680, AJ007681, AJ007682, AJ007683, AJ007684, AJ007685, AJ007686, AJ007687, AJ007688, AJ007689, AJ007690, AJ007691, AJ007692, AJ007693, AJ007694, AJ007695, AJ007696 Genomic DNA. Translation: CAA07604.1.
    AL136621 mRNA. Translation: CAB66556.2.
    BX647944 mRNA. Translation: CAH56193.1.
    AL137119, AL138688 Genomic DNA. Translation: CAH70133.1.
    AL137119 Genomic DNA. Translation: CAH70134.1.
    AL138688, AL137119 Genomic DNA. Translation: CAH71822.1.
    CH471075 Genomic DNA. Translation: EAX08244.1.
    CH471075 Genomic DNA. Translation: EAX08247.1.
    BC036372 mRNA. Translation: AAH36372.1.
    AF060181 mRNA. Translation: AAC23591.1. Frameshift.
    AF035374 mRNA. Translation: AAB88464.1. Frameshift.
    AF012126 mRNA. Translation: AAC01561.1.
    CCDSiCCDS45016.1. [Q9UBW7-1]
    PIRiT45119.
    RefSeqiNP_001177893.1. NM_001190964.2. [Q9UBW7-1]
    NP_001177894.1. NM_001190965.2. [Q9UBW7-1]
    NP_003444.1. NM_003453.4. [Q9UBW7-1]
    NP_932072.1. NM_197968.3. [Q9UBW7-1]
    XP_005266574.1. XM_005266517.1. [Q9UBW7-1]
    XP_005266575.1. XM_005266518.1. [Q9UBW7-1]
    XP_005266576.1. XM_005266519.1. [Q9UBW7-1]
    XP_005266577.1. XM_005266520.1. [Q9UBW7-1]
    UniGeneiHs.507433.

    Genome annotation databases

    EnsembliENST00000382871; ENSP00000372324; ENSG00000121741. [Q9UBW7-1]
    ENST00000382874; ENSP00000372327; ENSG00000121741. [Q9UBW7-1]
    GeneIDi7750.
    KEGGihsa:7750.
    UCSCiuc001umq.3. human. [Q9UBW7-2]
    uc001umr.3. human. [Q9UBW7-1]

    Polymorphism databases

    DMDMi17369677.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13472 mRNA. Translation: CAA73875.1 . Frameshift.
    AJ224901 mRNA. Translation: CAA12204.1 .
    AJ007676
    , AJ007677 , AJ007678 , AJ007679 , AJ007680 , AJ007681 , AJ007682 , AJ007683 , AJ007684 , AJ007685 , AJ007686 , AJ007687 , AJ007688 , AJ007689 , AJ007690 , AJ007691 , AJ007692 , AJ007693 , AJ007694 , AJ007695 , AJ007696 Genomic DNA. Translation: CAA07604.1 .
    AL136621 mRNA. Translation: CAB66556.2 .
    BX647944 mRNA. Translation: CAH56193.1 .
    AL137119 , AL138688 Genomic DNA. Translation: CAH70133.1 .
    AL137119 Genomic DNA. Translation: CAH70134.1 .
    AL138688 , AL137119 Genomic DNA. Translation: CAH71822.1 .
    CH471075 Genomic DNA. Translation: EAX08244.1 .
    CH471075 Genomic DNA. Translation: EAX08247.1 .
    BC036372 mRNA. Translation: AAH36372.1 .
    AF060181 mRNA. Translation: AAC23591.1 . Frameshift.
    AF035374 mRNA. Translation: AAB88464.1 . Frameshift.
    AF012126 mRNA. Translation: AAC01561.1 .
    CCDSi CCDS45016.1. [Q9UBW7-1 ]
    PIRi T45119.
    RefSeqi NP_001177893.1. NM_001190964.2. [Q9UBW7-1 ]
    NP_001177894.1. NM_001190965.2. [Q9UBW7-1 ]
    NP_003444.1. NM_003453.4. [Q9UBW7-1 ]
    NP_932072.1. NM_197968.3. [Q9UBW7-1 ]
    XP_005266574.1. XM_005266517.1. [Q9UBW7-1 ]
    XP_005266575.1. XM_005266518.1. [Q9UBW7-1 ]
    XP_005266576.1. XM_005266519.1. [Q9UBW7-1 ]
    XP_005266577.1. XM_005266520.1. [Q9UBW7-1 ]
    UniGenei Hs.507433.

    3D structure databases

    ProteinModelPortali Q9UBW7.
    SMRi Q9UBW7. Positions 316-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113534. 36 interactions.
    IntActi Q9UBW7. 16 interactions.
    MINTi MINT-267007.

    PTM databases

    PhosphoSitei Q9UBW7.

    Polymorphism databases

    DMDMi 17369677.

    Proteomic databases

    MaxQBi Q9UBW7.
    PaxDbi Q9UBW7.
    PRIDEi Q9UBW7.

    Protocols and materials databases

    DNASUi 7750.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382871 ; ENSP00000372324 ; ENSG00000121741 . [Q9UBW7-1 ]
    ENST00000382874 ; ENSP00000372327 ; ENSG00000121741 . [Q9UBW7-1 ]
    GeneIDi 7750.
    KEGGi hsa:7750.
    UCSCi uc001umq.3. human. [Q9UBW7-2 ]
    uc001umr.3. human. [Q9UBW7-1 ]

    Organism-specific databases

    CTDi 7750.
    GeneCardsi GC13P020532.
    HGNCi HGNC:12989. ZMYM2.
    HPAi HPA031765.
    MIMi 602221. gene.
    neXtProti NX_Q9UBW7.
    PharmGKBi PA37569.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86062.
    HOVERGENi HBG058385.
    InParanoidi Q9UBW7.
    OMAi RRPNGES.
    OrthoDBi EOG7JT6VN.
    PhylomeDBi Q9UBW7.
    TreeFami TF336988.

    Enzyme and pathway databases

    Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.

    Miscellaneous databases

    ChiTaRSi ZMYM2. human.
    GeneWikii ZMYM2.
    GenomeRNAii 7750.
    NextBioi 29992.
    PROi Q9UBW7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBW7.
    Bgeei Q9UBW7.
    Genevestigatori Q9UBW7.

    Family and domain databases

    InterProi IPR021893. DUF3504.
    IPR011017. TRASH_dom.
    IPR010507. Znf_MYM.
    [Graphical view ]
    Pfami PF12012. DUF3504. 1 hit.
    PF06467. zf-FCS. 9 hits.
    [Graphical view ]
    SMARTi SM00746. TRASH. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)."
      Popovici C., Adelaide J., Ollendorff V., Chaffanet M., Guasch G., Jacrot M., Leroux D., Birnbaum D., Pebusque M.-J.
      Proc. Natl. Acad. Sci. U.S.A. 95:5712-5717(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome."
      Reiter A., Sohal J., Kulkarni S., Chase A., Macdonald D.H.C., Aguiar R.C.T., Goncalves C., Hernandez J.M., Jennings B.A., Goldman J.M., Cross N.C.P.
      Blood 92:1735-1742(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome."
      Kulkarni S., Reiter A.J., Smedley D., Goldman J.M., Cross N.C.P.
      Genomics 55:118-121(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Endometrial tumor.
    6. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    9. "The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13."
      Still I.H., Cowell J.K.
      Blood 92:1456-1458(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-1377 (ISOFORM 1).
    10. "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP."
      Smedley D., Hamoudi R., Clark J., Warren W., Abdul-Rauf M., Somers G., Venter D., Fagan K., Cooper C., Shipley J.
      Hum. Mol. Genet. 7:637-642(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-1020 (ISOFORM 1).
    11. "FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome."
      Xiao S., Nalabolu S.R., Aster J.C., Ma J., Abruzzo L., Jaffe E.S., Stone R., Weissman S.M., Hudson T.J., Fletcher J.A.
      Nat. Genet. 18:84-87(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 621-1377 (ISOFORM 1).
    12. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."
      Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R.
      J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; KDM1A; RCOR1; PHF21A; ZNF217; ZMYM3; KIAA0182 AND GTF2I.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-838 AND THR-1376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND THR-1376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303; SER-305; SER-838 AND SER-958, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZMYM2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBW7
    Secondary accession number(s): A6NDG0
    , A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UEU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3