Reviewed, UniProtKB/Swiss-Prot Q9UBW7 (ZMYM2_HUMAN)

Names and origin

Protein names

Recommended name:
    Zinc finger MYM-type protein 2
Alternative name(s):
    Zinc finger protein 198
    Fused in myeloproliferative disorders protein
    Rearranged in atypical myeloproliferative disorder protein

Gene names

Name:	ZMYM2
Synonyms:	FIM, RAMP, ZNF198

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May function as a transcription factor.
Subunit structure	May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
Subcellular location	Nucleus Potential.
Involvement in disease	A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.
Sequence similarities	Contains 9 MYM-type zinc fingers.
Sequence caution	The sequence AAB88464.1 differs from that shown. Reason: Frameshift at positions 330, 966, 1009 and 1017. The sequence AAC23591.1 differs from that shown. Reason: Frameshift at position 330.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Chromosomal rearrangement
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	PML body Inferred from direct assay. Source: UniProtKB
Molecular function	ubiquitin conjugating enzyme binding Inferred from physical interaction. Source: UniProtKB zinc ion binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1377	1377	Zinc finger MYM-type protein 2		PRO_0000191382
Regions
	Zinc finger	352 – 386	35	MYM-type 1
	Zinc finger	398 – 436	39	MYM-type 2
	Zinc finger	445 – 480	36	MYM-type 3
	Zinc finger	491 – 549	59	MYM-type 4
	Zinc finger	559 – 597	39	MYM-type 5
	Zinc finger	605 – 652	48	MYM-type 6
	Zinc finger	660 – 694	35	MYM-type 7
	Zinc finger	701 – 740	40	MYM-type 8
	Zinc finger	747 – 781	35	MYM-type 9
Sites
	Site	913 – 914	2	Breakpoint for translocation to form ZMYM2-FGFR1
Amino acid modifications
	Modified residue	305	1	Phosphoserine Ref.13
	Modified residue	362	1	Phosphoserine Ref.12
	Modified residue	838	1	Phosphoserine Ref.12 Ref.14
	Modified residue	1376	1	Phosphothreonine Ref.14
Experimental info
	Sequence conflict	102	1	S → P in CAH56193. Ref.4
	Sequence conflict	110	1	K → E in AAH36372. Ref.7
	Sequence conflict	388 – 416	29	VAQVD…KQNPT → GWLKWIQVSPSRNSVVTSCL ISLMKNNRILL in CAA73875. Ref.1
	Sequence conflict	657 – 659	3	NKV → ASL in CAH70133. Ref.5
	Sequence conflict	657 – 659	3	NKV → ASL in CAH71822. Ref.5
	Sequence conflict	736	1	K → G in CAA73875. Ref.1
	Sequence conflict	766 – 767	2	Missing in CAH70133. Ref.5
	Sequence conflict	766 – 767	2	Missing in CAH71822. Ref.5
	Sequence conflict	856	1	T → I in AAH36372. Ref.7
	Sequence conflict	967	1	Missing in AAB88464. Ref.9
	Sequence conflict	1009 – 1010	2	DF → IS in AAB88464. Ref.9
	Sequence conflict	1016	1	Missing in AAB88464. Ref.9
	Sequence conflict	1259	1	C → R in AAH36372. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9UBW7-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2652D4C766492FF9	FASTA	1,377	154,911
	10 20 30 40 50 60 MDTSSVGGLE LTDQTPVLLG STAMATSLTN VGNSFSGPAN PLVSRSNKFQ NSSVEDDDDV 70 80 90 100 110 120 VFIEPVQPPP PSVPVVADQR TITFTSSKNE ELQGNDSKIT PSSKELASQK GSVSETIVID 130 140 150 160 170 180 DEEDMETNQG QEKNSSNFIE RRPPETKNRT NDVDFSTSSF SRSKVNAGMG NSGITTEPDS 190 200 210 220 230 240 EIQIANVTTL ETGVSSVNDG QLENTDGRDM NLMITHVTSL QNTNLGDVSN GLQSSNFGVN 250 260 270 280 290 300 IQTYTPSLTS QTKTGVGPFN PGRMNVAGDV FQNGESATHH NPDSWISQSA SFPRNQKQPG 310 320 330 340 350 360 VDSLSPVASL PKQIFQPSVQ QQPTKPVKVT CANCKKPLQK GQTAYQRKGS AHLFCSTTCL 370 380 390 400 410 420 SSFSHKPAPK KLCVMCKKDI TTMKGTIVAQ VDSSESFQEF CSTSCLSLYE DKQNPTKGAL 430 440 450 460 470 480 NKSRCTICGK LTEIRHEVSF KNMTHKLCSD HCFNRYRMAN GLIMNCCEQC GEYLPSKGAG 490 500 510 520 530 540 NNVLVIDGQQ KRFCCQSCVS EYKQVGSHPS FLKEVRDHMQ DSFLMQPEKY GKLTTCTGCR 550 560 570 580 590 600 TQCRFFDMTQ CIGPNGYMEP YCSTACMNSH KTKYAKSQSL GIICHFCKRN SLPQYQATMP 610 620 630 640 650 660 DGKLYNFCNS SCVAKFQALS MQSSPNGQFV APSDIQLKCN YCKNSFCSKP EILEWENKVH 670 680 690 700 710 720 QFCSKTCSDD YKKLHCIVTY CEYCQEEKTL HETVNFSGVK RPFCSEGCKL LYKQDFARRL 730 740 750 760 770 780 GLRCVTCNYC SQLCKKGATK ELDGVVRDFC SEDCCKKFQD WYYKAARCDC CKSQGTLKER 790 800 810 820 830 840 VQWRGEMKHF CDQHCLLRFY CQQNEPNMTT QKGPENLHYD QGCQTSRTKM TGSAPPPSPT 850 860 870 880 890 900 PNKEMKNKAV LCKPLTMTKA TYCKPHMQTK SCQTDDTWRT EYVPVPIPVP VYIPVPMHMY 910 920 930 940 950 960 SQNIPVPTTV PVPVPVPVFL PAPLDSSEKI PAAIEELKSK VSSDALDTEL LTMTDMMSED 970 980 990 1000 1010 1020 EGKTETTNIN SVIIETDIIG SDLLKNSDPE TQSSMPDVPY EPDLDIEIDF PRAAEELDME 1030 1040 1050 1060 1070 1080 NEFLLPPVFG EEYEEQPRPR SKKKGAKRKA VSGYQSHDDS SDNSECSFPF KYTYGVNAWK 1090 1100 1110 1120 1130 1140 HWVKTRQLDE DLLVLDELKS SKSVKLKEDL LSHTTAELNY GLAHFVNEIR RPNGENYAPD 1150 1160 1170 1180 1190 1200 SIYYLCLGIQ EYLCGSNRKD NIFIDPGYQT FEQELNKILR SWQPSILPDG SIFSRVEEDY 1210 1220 1230 1240 1250 1260 LWRIKQLGSH SPVALLNTLF YFNTKYFGLK TVEQHLRLSF GTVFRHWKKN PLTMENKACL 1270 1280 1290 1300 1310 1320 RYQVSSLCGT DNEDKITTGK RKHEDDEPVF EQIENTANPS RCPVKMFECY LSKSPQNLNQ 1330 1340 1350 1360 1370 RMDVFYLQPE CSSSTDSPVW YTSTSLDRNT LENMLVRVLL VKDIYDKDNY ELDEDTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)." Popovici C., Adelaide J., Ollendorff V., Chaffanet M., Guasch G., Jacrot M., Leroux D., Birnbaum D., Pebusque M.-J. Proc. Natl. Acad. Sci. U.S.A. 95:5712-5717(1998) [PubMed: 9576949] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome." Reiter A., Sohal J., Kulkarni S., Chase A., Macdonald D.H.C., Aguiar R.C.T., Goncalves C., Hernandez J.M., Jennings B.A., Goldman J.M., Cross N.C.P. Blood 92:1735-1742(1998) [PubMed: 9716603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome." Kulkarni S., Reiter A.J., Smedley D., Goldman J.M., Cross N.C.P. Genomics 55:118-121(1999) [PubMed: 9889006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Endometrial tumor.
[5]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[8]	"The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13." Still I.H., Cowell J.K. Blood 92:1456-1458(1998) [PubMed: 9694738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-1377.
[9]	"The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP." Smedley D., Hamoudi R., Clark J., Warren W., Abdul-Rauf M., Somers G., Venter D., Fagan K., Cooper C., Shipley J. Hum. Mol. Genet. 7:637-642(1998) [PubMed: 9499416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-1020.
[10]	"FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome." Xiao S., Nalabolu S.R., Aster J.C., Ma J., Abruzzo L., Jaffe E.S., Stone R., Weissman S.M., Hudson T.J., Fletcher J.A. Nat. Genet. 18:84-87(1998) [PubMed: 9425908] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 621-1377.
[11]	"A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes." Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R. J. Biol. Chem. 278:7234-7239(2003) [PubMed: 12493763] [Abstract] Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; AOF2; RCOR1; PHF21A; ZNF217; ZMYM3; KIAA0182 AND GTF2I.
[12]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362 AND SER-838, MASS SPECTROMETRY. Tissue: Epithelium.
[13]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, MASS SPECTROMETRY. Tissue: Epithelium.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-838 AND THR-1376, MASS SPECTROMETRY.
[15]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13472 mRNA. Translation: CAA73875.1. AJ224901 mRNA. Translation: CAA12204.1. AJ007676 , AJ007677, AJ007678, AJ007679, AJ007680, AJ007681, AJ007682, AJ007683, AJ007684, AJ007685, AJ007686, AJ007687, AJ007688, AJ007689, AJ007690, AJ007691, AJ007692, AJ007693, AJ007694, AJ007695, AJ007696 Genomic DNA. Translation: CAA07604.1. BX647944 mRNA. Translation: CAH56193.1. AL137119, AL138688 Genomic DNA. Translation: CAH70133.1. AL138688, AL137119 Genomic DNA. Translation: CAH71822.1. CH471075 Genomic DNA. Translation: EAX08244.1. BC036372 mRNA. Translation: AAH36372.1. AF060181 mRNA. Translation: AAC23591.1. Frameshift. AF035374 mRNA. Translation: AAB88464.1. Frameshift. AF012126 mRNA. Translation: AAC01561.1.
IPI	IPI00294603.
PIR	T45119.
RefSeq	NP_003444.1. NP_932072.1.
UniGene	Hs.644041
3D structure databases
SMR	Q9UBW7. Positions 316-360.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UBW7.
PTM databases
PhosphoSite	Q9UBW7.
Proteomic databases
PRIDE	Q9UBW7.
Genome annotation databases
Ensembl	ENST00000382869; ENSP00000372322; ENSG00000121741; Homo sapiens. [Genome view] ENST00000382870; ENSP00000372323; ENSG00000121741; Homo sapiens. [Genome view] ENST00000382871; ENSP00000372324; ENSG00000121741; Homo sapiens. [Genome view] ENST00000382874; ENSP00000372327; ENSG00000121741; Homo sapiens. [Genome view] ENST00000382881; ENSP00000372334; ENSG00000121741; Homo sapiens. [Genome view] ENST00000382883; ENSP00000372336; ENSG00000121741; Homo sapiens. [Genome view] ENST00000418722; ENSP00000401434; ENSG00000121741; Homo sapiens. [Genome view] ENST00000456228; ENSP00000413744; ENSG00000121741; Homo sapiens. [Genome view]
GeneID	7750.
KEGG	hsa:7750.
UCSC	uc001umr.1. human.
Organism-specific databases
CTD	7750.
GeneCards	GC13P019431.
HGNC	HGNC:12989. ZMYM2.
MIM	602221. gene.
Orphanet	86832. Adult myelodysplastic/myeloproliferative disease.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9UBW7.
OMA	FLMQPEK.
Gene expression databases
ArrayExpress	Q9UBW7.
Bgee	Q9UBW7.
Genevestigator	Q9UBW7.
GermOnline	ENSG00000121741. Homo sapiens.
Family and domain databases
InterPro	IPR011017. TRASH. IPR010507. Znf_MYM. [Graphical view]
Pfam	PF06467. zf-FCS. 10 hits. [Graphical view]
SMART	SM00746. TRASH. 9 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29992.
SOURCE	Search...

Entry information

Entry name

ZMYM2_HUMAN

Accession

Primary (citable) accession number: Q9UBW7
Secondary accession number(s): A6NDG0 , A6NI02, O43212, O43434, O60898, Q5W0Q4, Q63HP0, Q8NE39, Q9H538, Q9UEU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.