SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UBW7

- ZMYM2_HUMAN

UniProt

Q9UBW7 - ZMYM2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Zinc finger MYM-type protein 2
Gene
ZMYM2, FIM, RAMP, ZNF198
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei913 – 9142Breakpoint for translocation to form ZMYM2-FGFR1

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri352 – 38635MYM-type 1
Add
BLAST
Zinc fingeri398 – 43639MYM-type 2
Add
BLAST
Zinc fingeri445 – 48036MYM-type 3
Add
BLAST
Zinc fingeri491 – 54959MYM-type 4
Add
BLAST
Zinc fingeri559 – 59739MYM-type 5
Add
BLAST
Zinc fingeri605 – 65248MYM-type 6
Add
BLAST
Zinc fingeri660 – 69435MYM-type 7
Add
BLAST
Zinc fingeri701 – 74040MYM-type 8
Add
BLAST
Zinc fingeri747 – 78135MYM-type 9
Add
BLAST

GO - Molecular functioni

  1. ubiquitin conjugating enzyme binding Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_121141. Signaling by FGFR1 fusion mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 2
Alternative name(s):
Fused in myeloproliferative disorders protein
Rearranged in atypical myeloproliferative disorder protein
Zinc finger protein 198
Gene namesi
Name:ZMYM2
Synonyms:FIM, RAMP, ZNF198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:12989. ZMYM2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. PML body Source: UniProtKB
  2. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.

Organism-specific databases

PharmGKBiPA37569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13771377Zinc finger MYM-type protein 2
PRO_0000191382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei303 – 3031Phosphoserine1 Publication
Modified residuei305 – 3051Phosphoserine2 Publications
Modified residuei838 – 8381Phosphoserine2 Publications
Modified residuei958 – 9581Phosphoserine1 Publication
Modified residuei1376 – 13761Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UBW7.
PaxDbiQ9UBW7.
PRIDEiQ9UBW7.

PTM databases

PhosphoSiteiQ9UBW7.

Expressioni

Gene expression databases

ArrayExpressiQ9UBW7.
BgeeiQ9UBW7.
GenevestigatoriQ9UBW7.

Organism-specific databases

HPAiHPA031765.

Interactioni

Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.1 Publication

Protein-protein interaction databases

BioGridi113534. 36 interactions.
IntActiQ9UBW7. 16 interactions.
MINTiMINT-267007.

Structurei

3D structure databases

ProteinModelPortaliQ9UBW7.
SMRiQ9UBW7. Positions 316-360.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG86062.
HOVERGENiHBG058385.
InParanoidiQ9UBW7.
OMAiRRPNGES.
OrthoDBiEOG7JT6VN.
PhylomeDBiQ9UBW7.
TreeFamiTF336988.

Family and domain databases

InterProiIPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 9 hits.
[Graphical view]
SMARTiSM00746. TRASH. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDTSSVGGLE LTDQTPVLLG STAMATSLTN VGNSFSGPAN PLVSRSNKFQ     50
NSSVEDDDDV VFIEPVQPPP PSVPVVADQR TITFTSSKNE ELQGNDSKIT 100
PSSKELASQK GSVSETIVID DEEDMETNQG QEKNSSNFIE RRPPETKNRT 150
NDVDFSTSSF SRSKVNAGMG NSGITTEPDS EIQIANVTTL ETGVSSVNDG 200
QLENTDGRDM NLMITHVTSL QNTNLGDVSN GLQSSNFGVN IQTYTPSLTS 250
QTKTGVGPFN PGRMNVAGDV FQNGESATHH NPDSWISQSA SFPRNQKQPG 300
VDSLSPVASL PKQIFQPSVQ QQPTKPVKVT CANCKKPLQK GQTAYQRKGS 350
AHLFCSTTCL SSFSHKPAPK KLCVMCKKDI TTMKGTIVAQ VDSSESFQEF 400
CSTSCLSLYE DKQNPTKGAL NKSRCTICGK LTEIRHEVSF KNMTHKLCSD 450
HCFNRYRMAN GLIMNCCEQC GEYLPSKGAG NNVLVIDGQQ KRFCCQSCVS 500
EYKQVGSHPS FLKEVRDHMQ DSFLMQPEKY GKLTTCTGCR TQCRFFDMTQ 550
CIGPNGYMEP YCSTACMNSH KTKYAKSQSL GIICHFCKRN SLPQYQATMP 600
DGKLYNFCNS SCVAKFQALS MQSSPNGQFV APSDIQLKCN YCKNSFCSKP 650
EILEWENKVH QFCSKTCSDD YKKLHCIVTY CEYCQEEKTL HETVNFSGVK 700
RPFCSEGCKL LYKQDFARRL GLRCVTCNYC SQLCKKGATK ELDGVVRDFC 750
SEDCCKKFQD WYYKAARCDC CKSQGTLKER VQWRGEMKHF CDQHCLLRFY 800
CQQNEPNMTT QKGPENLHYD QGCQTSRTKM TGSAPPPSPT PNKEMKNKAV 850
LCKPLTMTKA TYCKPHMQTK SCQTDDTWRT EYVPVPIPVP VYIPVPMHMY 900
SQNIPVPTTV PVPVPVPVFL PAPLDSSEKI PAAIEELKSK VSSDALDTEL 950
LTMTDMMSED EGKTETTNIN SVIIETDIIG SDLLKNSDPE TQSSMPDVPY 1000
EPDLDIEIDF PRAAEELDME NEFLLPPVFG EEYEEQPRPR SKKKGAKRKA 1050
VSGYQSHDDS SDNSECSFPF KYTYGVNAWK HWVKTRQLDE DLLVLDELKS 1100
SKSVKLKEDL LSHTTAELNY GLAHFVNEIR RPNGENYAPD SIYYLCLGIQ 1150
EYLCGSNRKD NIFIDPGYQT FEQELNKILR SWQPSILPDG SIFSRVEEDY 1200
LWRIKQLGSH SPVALLNTLF YFNTKYFGLK TVEQHLRLSF GTVFRHWKKN 1250
PLTMENKACL RYQVSSLCGT DNEDKITTGK RKHEDDEPVF EQIENTANPS 1300
RCPVKMFECY LSKSPQNLNQ RMDVFYLQPE CSSSTDSPVW YTSTSLDRNT 1350
LENMLVRVLL VKDIYDKDNY ELDEDTD 1377
Length:1,377
Mass (Da):154,911
Last modified:May 1, 2000 - v1
Checksum:i2652D4C766492FF9
GO
Isoform 2 (identifier: Q9UBW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-251: Missing.
     529-549: KYGKLTTCTGCRTQCRFFDMT → VSRNVNGVQGLNIFEHCYYCH
     550-1377: Missing.

Show »
Length:462
Mass (Da):50,809
Checksum:iE906383363CB8D65
GO

Sequence cautioni

The sequence AAB88464.1 differs from that shown. Reason: Frameshift at positions 330, 966, 1009 and 1017.
The sequence AAC23591.1 differs from that shown. Reason: Frameshift at position 330.
The sequence CAA73875.1 differs from that shown. Reason: Frameshift at positions 388, 403, 406, 409 and 418.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei165 – 25187Missing in isoform 2.
VSP_039065Add
BLAST
Alternative sequencei529 – 54921KYGKL…FFDMT → VSRNVNGVQGLNIFEHCYYC H in isoform 2.
VSP_039066Add
BLAST
Alternative sequencei550 – 1377828Missing in isoform 2.
VSP_039067Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021S → P in CAH56193. 1 Publication
Sequence conflicti110 – 1101K → E in AAH36372. 1 Publication
Sequence conflicti304 – 3041L → V in CAB66556. 1 Publication
Sequence conflicti330 – 3301T → S in CAB66556. 1 Publication
Sequence conflicti411 – 4122DK → EQ in CAA73875. 1 Publication
Sequence conflicti424 – 4241R → G in CAB66556. 1 Publication
Sequence conflicti657 – 6593NKV → ASL in CAH70133. 1 Publication
Sequence conflicti657 – 6593NKV → ASL in CAH71822. 1 Publication
Sequence conflicti736 – 7361K → G in CAA73875. 1 Publication
Sequence conflicti766 – 7672Missing in CAH70133. 1 Publication
Sequence conflicti766 – 7672Missing in CAH71822. 1 Publication
Sequence conflicti856 – 8561T → I in AAH36372. 1 Publication
Sequence conflicti967 – 9671Missing in AAB88464. 1 Publication
Sequence conflicti1009 – 10102DF → IS in AAB88464. 1 Publication
Sequence conflicti1016 – 10161Missing in AAB88464. 1 Publication
Sequence conflicti1259 – 12591C → R in AAH36372. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13472 mRNA. Translation: CAA73875.1. Frameshift.
AJ224901 mRNA. Translation: CAA12204.1.
AJ007676
, AJ007677, AJ007678, AJ007679, AJ007680, AJ007681, AJ007682, AJ007683, AJ007684, AJ007685, AJ007686, AJ007687, AJ007688, AJ007689, AJ007690, AJ007691, AJ007692, AJ007693, AJ007694, AJ007695, AJ007696 Genomic DNA. Translation: CAA07604.1.
AL136621 mRNA. Translation: CAB66556.2.
BX647944 mRNA. Translation: CAH56193.1.
AL137119, AL138688 Genomic DNA. Translation: CAH70133.1.
AL137119 Genomic DNA. Translation: CAH70134.1.
AL138688, AL137119 Genomic DNA. Translation: CAH71822.1.
CH471075 Genomic DNA. Translation: EAX08244.1.
CH471075 Genomic DNA. Translation: EAX08247.1.
BC036372 mRNA. Translation: AAH36372.1.
AF060181 mRNA. Translation: AAC23591.1. Frameshift.
AF035374 mRNA. Translation: AAB88464.1. Frameshift.
AF012126 mRNA. Translation: AAC01561.1.
CCDSiCCDS45016.1. [Q9UBW7-1]
PIRiT45119.
RefSeqiNP_001177893.1. NM_001190964.2. [Q9UBW7-1]
NP_001177894.1. NM_001190965.2. [Q9UBW7-1]
NP_003444.1. NM_003453.4. [Q9UBW7-1]
NP_932072.1. NM_197968.3. [Q9UBW7-1]
XP_005266574.1. XM_005266517.1. [Q9UBW7-1]
XP_005266575.1. XM_005266518.1. [Q9UBW7-1]
XP_005266576.1. XM_005266519.1. [Q9UBW7-1]
XP_005266577.1. XM_005266520.1. [Q9UBW7-1]
UniGeneiHs.507433.

Genome annotation databases

EnsembliENST00000382869; ENSP00000372322; ENSG00000121741. [Q9UBW7-1]
ENST00000382871; ENSP00000372324; ENSG00000121741. [Q9UBW7-1]
ENST00000382874; ENSP00000372327; ENSG00000121741. [Q9UBW7-1]
ENST00000382881; ENSP00000372334; ENSG00000121741. [Q9UBW7-2]
GeneIDi7750.
KEGGihsa:7750.
UCSCiuc001umq.3. human. [Q9UBW7-2]
uc001umr.3. human. [Q9UBW7-1]

Polymorphism databases

DMDMi17369677.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13472 mRNA. Translation: CAA73875.1 . Frameshift.
AJ224901 mRNA. Translation: CAA12204.1 .
AJ007676
, AJ007677 , AJ007678 , AJ007679 , AJ007680 , AJ007681 , AJ007682 , AJ007683 , AJ007684 , AJ007685 , AJ007686 , AJ007687 , AJ007688 , AJ007689 , AJ007690 , AJ007691 , AJ007692 , AJ007693 , AJ007694 , AJ007695 , AJ007696 Genomic DNA. Translation: CAA07604.1 .
AL136621 mRNA. Translation: CAB66556.2 .
BX647944 mRNA. Translation: CAH56193.1 .
AL137119 , AL138688 Genomic DNA. Translation: CAH70133.1 .
AL137119 Genomic DNA. Translation: CAH70134.1 .
AL138688 , AL137119 Genomic DNA. Translation: CAH71822.1 .
CH471075 Genomic DNA. Translation: EAX08244.1 .
CH471075 Genomic DNA. Translation: EAX08247.1 .
BC036372 mRNA. Translation: AAH36372.1 .
AF060181 mRNA. Translation: AAC23591.1 . Frameshift.
AF035374 mRNA. Translation: AAB88464.1 . Frameshift.
AF012126 mRNA. Translation: AAC01561.1 .
CCDSi CCDS45016.1. [Q9UBW7-1 ]
PIRi T45119.
RefSeqi NP_001177893.1. NM_001190964.2. [Q9UBW7-1 ]
NP_001177894.1. NM_001190965.2. [Q9UBW7-1 ]
NP_003444.1. NM_003453.4. [Q9UBW7-1 ]
NP_932072.1. NM_197968.3. [Q9UBW7-1 ]
XP_005266574.1. XM_005266517.1. [Q9UBW7-1 ]
XP_005266575.1. XM_005266518.1. [Q9UBW7-1 ]
XP_005266576.1. XM_005266519.1. [Q9UBW7-1 ]
XP_005266577.1. XM_005266520.1. [Q9UBW7-1 ]
UniGenei Hs.507433.

3D structure databases

ProteinModelPortali Q9UBW7.
SMRi Q9UBW7. Positions 316-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113534. 36 interactions.
IntActi Q9UBW7. 16 interactions.
MINTi MINT-267007.

PTM databases

PhosphoSitei Q9UBW7.

Polymorphism databases

DMDMi 17369677.

Proteomic databases

MaxQBi Q9UBW7.
PaxDbi Q9UBW7.
PRIDEi Q9UBW7.

Protocols and materials databases

DNASUi 7750.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382869 ; ENSP00000372322 ; ENSG00000121741 . [Q9UBW7-1 ]
ENST00000382871 ; ENSP00000372324 ; ENSG00000121741 . [Q9UBW7-1 ]
ENST00000382874 ; ENSP00000372327 ; ENSG00000121741 . [Q9UBW7-1 ]
ENST00000382881 ; ENSP00000372334 ; ENSG00000121741 . [Q9UBW7-2 ]
GeneIDi 7750.
KEGGi hsa:7750.
UCSCi uc001umq.3. human. [Q9UBW7-2 ]
uc001umr.3. human. [Q9UBW7-1 ]

Organism-specific databases

CTDi 7750.
GeneCardsi GC13P020532.
HGNCi HGNC:12989. ZMYM2.
HPAi HPA031765.
MIMi 602221. gene.
neXtProti NX_Q9UBW7.
PharmGKBi PA37569.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86062.
HOVERGENi HBG058385.
InParanoidi Q9UBW7.
OMAi RRPNGES.
OrthoDBi EOG7JT6VN.
PhylomeDBi Q9UBW7.
TreeFami TF336988.

Enzyme and pathway databases

Reactomei REACT_121141. Signaling by FGFR1 fusion mutants.

Miscellaneous databases

ChiTaRSi ZMYM2. human.
GeneWikii ZMYM2.
GenomeRNAii 7750.
NextBioi 29992.
PROi Q9UBW7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UBW7.
Bgeei Q9UBW7.
Genevestigatori Q9UBW7.

Family and domain databases

InterProi IPR021893. DUF3504.
IPR011017. TRASH_dom.
IPR010507. Znf_MYM.
[Graphical view ]
Pfami PF12012. DUF3504. 1 hit.
PF06467. zf-FCS. 9 hits.
[Graphical view ]
SMARTi SM00746. TRASH. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)."
    Popovici C., Adelaide J., Ollendorff V., Chaffanet M., Guasch G., Jacrot M., Leroux D., Birnbaum D., Pebusque M.-J.
    Proc. Natl. Acad. Sci. U.S.A. 95:5712-5717(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome."
    Reiter A., Sohal J., Kulkarni S., Chase A., Macdonald D.H.C., Aguiar R.C.T., Goncalves C., Hernandez J.M., Jennings B.A., Goldman J.M., Cross N.C.P.
    Blood 92:1735-1742(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome."
    Kulkarni S., Reiter A.J., Smedley D., Goldman J.M., Cross N.C.P.
    Genomics 55:118-121(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endometrial tumor.
  6. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  9. "The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13."
    Still I.H., Cowell J.K.
    Blood 92:1456-1458(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-1377 (ISOFORM 1).
  10. "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP."
    Smedley D., Hamoudi R., Clark J., Warren W., Abdul-Rauf M., Somers G., Venter D., Fagan K., Cooper C., Shipley J.
    Hum. Mol. Genet. 7:637-642(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-1020 (ISOFORM 1).
  11. "FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome."
    Xiao S., Nalabolu S.R., Aster J.C., Ma J., Abruzzo L., Jaffe E.S., Stone R., Weissman S.M., Hudson T.J., Fletcher J.A.
    Nat. Genet. 18:84-87(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 621-1377 (ISOFORM 1).
  12. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."
    Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R.
    J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; KDM1A; RCOR1; PHF21A; ZNF217; ZMYM3; KIAA0182 AND GTF2I.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-838 AND THR-1376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND THR-1376, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303; SER-305; SER-838 AND SER-958, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZMYM2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBW7
Secondary accession number(s): A6NDG0
, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UEU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi