Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UBW5

- BIN2_HUMAN

UniProt

Q9UBW5 - BIN2_HUMAN

Protein

Bridging integrator 2

Gene

BIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.1 Publication

    GO - Molecular functioni

    1. phospholipid binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell chemotaxis Source: UniProtKB
    2. membrane tubulation Source: UniProtKB
    3. phagocytosis, engulfment Source: UniProtKB
    4. podosome assembly Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bridging integrator 2
    Alternative name(s):
    Breast cancer-associated protein 1
    Gene namesi
    Name:BIN2
    Synonyms:BRAP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:1053. BIN2.

    Subcellular locationi

    Cytoplasm. Cell projectionpodosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcell cortex. Cell projectionphagocytic cup
    Note: Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. cell junction Source: UniProtKB-KW
    3. cell projection Source: UniProtKB-KW
    4. phagocytic cup Source: UniProtKB-SubCell
    5. podosome Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi13 – 131F → A: Strongly reduces binding to membranes. 1 Publication
    Mutagenesisi21 – 211F → A: Strongly reduces binding to membranes. 1 Publication
    Mutagenesisi81 – 811V → R: Abolishes dimerization and membrane binding; when associated with E-214. 1 Publication
    Mutagenesisi214 – 2141S → E: Abolishes dimerization and membrane binding; when associated with R-81. 1 Publication

    Organism-specific databases

    PharmGKBiPA25356.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Bridging integrator 2PRO_0000256140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731Phosphoserine1 Publication
    Modified residuei357 – 3571Phosphoserine1 Publication
    Modified residuei436 – 4361Phosphoserine1 Publication
    Modified residuei438 – 4381Phosphothreonine1 Publication
    Modified residuei444 – 4441Phosphoserine1 Publication
    Modified residuei447 – 4471Phosphoserine1 Publication
    Modified residuei458 – 4581Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBW5.
    PaxDbiQ9UBW5.
    PRIDEiQ9UBW5.

    2D gel databases

    OGPiQ9UBW5.

    PTM databases

    PhosphoSiteiQ9UBW5.

    Expressioni

    Tissue specificityi

    Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.2 Publications

    Inductioni

    Up-regulated during monocytic differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ9UBW5.
    BgeeiQ9UBW5.
    CleanExiHS_BIN2.
    GenevestigatoriQ9UBW5.

    Organism-specific databases

    HPAiHPA038666.
    HPA038667.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BIN1O004992EBI-2042570,EBI-719094

    Protein-protein interaction databases

    BioGridi119528. 5 interactions.
    IntActiQ9UBW5. 3 interactions.
    STRINGi9606.ENSP00000267012.

    Structurei

    Secondary structure

    1
    565
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 3116
    Helixi41 – 8848
    Helixi96 – 12025
    Helixi122 – 1309
    Helixi132 – 16029
    Beta strandi161 – 1644
    Helixi167 – 20034
    Helixi202 – 24140

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AVMX-ray1.91A11-245[»]
    4I1QX-ray2.53A/B20-238[»]
    ProteinModelPortaliQ9UBW5.
    SMRiQ9UBW5. Positions 15-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 244217BARPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili304 – 32926Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi253 – 2564Poly-Ser
    Compositional biasi413 – 47967Pro-richAdd
    BLAST

    Domaini

    The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.1 Publication

    Sequence similaritiesi

    Contains 1 BAR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG264615.
    HOGENOMiHOG000252987.
    HOVERGENiHBG004224.
    InParanoidiQ9UBW5.
    OMAiQEEVLPC.
    OrthoDBiEOG7XWPND.
    PhylomeDBiQ9UBW5.
    TreeFamiTF313542.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR003005. Amphiphysin.
    IPR004148. BAR_dom.
    IPR028827. BIN2.
    [Graphical view]
    PANTHERiPTHR10321:SF11. PTHR10321:SF11. 1 hit.
    PfamiPF03114. BAR. 1 hit.
    [Graphical view]
    PRINTSiPR01251. AMPHIPHYSIN.
    SMARTiSM00721. BAR. 1 hit.
    [Graphical view]
    PROSITEiPS51021. BAR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBW5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGKAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKAVETKD ERFEQSASNF    50
    YQQQAEGHKL YKDLKNFLSA VKVMHESSKR VSETLQEIYS SEWDGHEELK 100
    AIVWNNDLLW EDYEEKLADQ AVRTMEIYVA QFSEIKERIA KRGRKLVDYD 150
    SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA QTVFEDLNQE LLEELPILYN 200
    SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK QHSNKVFVVK 250
    GLSSSSRRSL VISPPVRTAT VSSPLTSPTS PSTLSLKSES ESVSATEDLA 300
    PDAAQGEDNS EIKELLEEEE IEKEGSEASS SEEDEPLPAC NGPAQAQPSP 350
    TTERAKSQEE VLPSSTTPSP GGALSPSGQP SSSATEVVLR TRTASEGSEQ 400
    PKKRASIQRT SAPPSRPPPP RATASPRPSS GNIPSSPTAS GGGSPTSPRA 450
    SLGTGTASPR TSLEVSPNPE PPEKPVRTPE AKENENIHNQ NPEELCTSPT 500
    LMTSQVASEP GEAKKMEDKE KDNKLISANS SEGQDQLQVS MVPENNNLTA 550
    PEPQEEVSTS ENPQL 565
    Length:565
    Mass (Da):61,874
    Last modified:April 3, 2007 - v3
    Checksum:iB1D1FB89A97E9E43
    GO
    Isoform 2 (identifier: Q9UBW5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-136: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:533
    Mass (Da):58,030
    Checksum:iE549F6F418F01E02
    GO

    Sequence cautioni

    The sequence BAA91376.1 differs from that shown. Reason: Frameshift at position 156.
    The sequence BAA91376.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631Missing in AAD54227. (PubMed:10903846)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481S → N.1 Publication
    Corresponds to variant rs7312857 [ dbSNP | Ensembl ].
    VAR_028883
    Natural varianti529 – 5291N → D.4 Publications
    Corresponds to variant rs7954976 [ dbSNP | Ensembl ].
    VAR_028884

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 13632Missing in isoform 2. 1 PublicationVSP_021328Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146531 mRNA. Translation: AAD54227.1.
    AB032698 mRNA. Translation: BAA88108.1.
    AB032710 Genomic DNA. Translation: BAA88125.1.
    AK000783 mRNA. Translation: BAA91376.1. Sequence problems.
    AC046135 Genomic DNA. No translation available.
    BC047686 mRNA. Translation: AAH47686.1.
    RefSeqiNP_001276936.1. NM_001290007.1.
    NP_001276937.1. NM_001290008.1.
    NP_001276938.1. NM_001290009.1.
    NP_057377.3. NM_016293.3.
    UniGeneiHs.14770.

    Genome annotation databases

    EnsembliENST00000267012; ENSP00000267012; ENSG00000110934. [Q9UBW5-1]
    ENST00000452142; ENSP00000410217; ENSG00000110934. [Q9UBW5-2]
    GeneIDi51411.
    KEGGihsa:51411.
    UCSCiuc001ryg.3. human. [Q9UBW5-1]
    uc009zlz.3. human. [Q9UBW5-2]

    Polymorphism databases

    DMDMi143811367.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146531 mRNA. Translation: AAD54227.1 .
    AB032698 mRNA. Translation: BAA88108.1 .
    AB032710 Genomic DNA. Translation: BAA88125.1 .
    AK000783 mRNA. Translation: BAA91376.1 . Sequence problems.
    AC046135 Genomic DNA. No translation available.
    BC047686 mRNA. Translation: AAH47686.1 .
    RefSeqi NP_001276936.1. NM_001290007.1.
    NP_001276937.1. NM_001290008.1.
    NP_001276938.1. NM_001290009.1.
    NP_057377.3. NM_016293.3.
    UniGenei Hs.14770.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AVM X-ray 1.91 A 11-245 [» ]
    4I1Q X-ray 2.53 A/B 20-238 [» ]
    ProteinModelPortali Q9UBW5.
    SMRi Q9UBW5. Positions 15-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119528. 5 interactions.
    IntActi Q9UBW5. 3 interactions.
    STRINGi 9606.ENSP00000267012.

    PTM databases

    PhosphoSitei Q9UBW5.

    Polymorphism databases

    DMDMi 143811367.

    2D gel databases

    OGPi Q9UBW5.

    Proteomic databases

    MaxQBi Q9UBW5.
    PaxDbi Q9UBW5.
    PRIDEi Q9UBW5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267012 ; ENSP00000267012 ; ENSG00000110934 . [Q9UBW5-1 ]
    ENST00000452142 ; ENSP00000410217 ; ENSG00000110934 . [Q9UBW5-2 ]
    GeneIDi 51411.
    KEGGi hsa:51411.
    UCSCi uc001ryg.3. human. [Q9UBW5-1 ]
    uc009zlz.3. human. [Q9UBW5-2 ]

    Organism-specific databases

    CTDi 51411.
    GeneCardsi GC12M051697.
    H-InvDB HIX0201823.
    HGNCi HGNC:1053. BIN2.
    HPAi HPA038666.
    HPA038667.
    MIMi 605936. gene.
    neXtProti NX_Q9UBW5.
    PharmGKBi PA25356.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264615.
    HOGENOMi HOG000252987.
    HOVERGENi HBG004224.
    InParanoidi Q9UBW5.
    OMAi QEEVLPC.
    OrthoDBi EOG7XWPND.
    PhylomeDBi Q9UBW5.
    TreeFami TF313542.

    Miscellaneous databases

    ChiTaRSi BIN2. human.
    GenomeRNAii 51411.
    NextBioi 54957.
    PROi Q9UBW5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBW5.
    Bgeei Q9UBW5.
    CleanExi HS_BIN2.
    Genevestigatori Q9UBW5.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR003005. Amphiphysin.
    IPR004148. BAR_dom.
    IPR028827. BIN2.
    [Graphical view ]
    PANTHERi PTHR10321:SF11. PTHR10321:SF11. 1 hit.
    Pfami PF03114. BAR. 1 hit.
    [Graphical view ]
    PRINTSi PR01251. AMPHIPHYSIN.
    SMARTi SM00721. BAR. 1 hit.
    [Graphical view ]
    PROSITEi PS51021. BAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bin2, a functionally nonredundant member of the BAR adaptor gene family."
      Ge K., Prendergast G.C.
      Genomics 67:210-220(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-529, INDUCTION, INTERACTION WITH BIN2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Genomic structure and chromosome location of the BRAP1 gene."
      Miki Y., Saito H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANTS ASN-48 AND ASP-529.
      Tissue: Mammary gland.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-529.
      Tissue: Colon.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-529.
      Tissue: Ovary.
    6. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-357; SER-436; THR-438; SER-444; SER-447 AND SER-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
      Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
      PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) OF 1-238, FUNCTION, DOMAIN, SUBUNIT, INTERACTION WITH ARHGEF6; ARHGEF7; SH3GL1; SH3GL2; SH3GL3, IDENTIFICATION IN A COMPLEX WITH GIT2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF PHE-13; PHE-21; VAL-81 AND SER-214.

    Entry informationi

    Entry nameiBIN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBW5
    Secondary accession number(s): Q86VV0, Q9NWK4, Q9UKN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3