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Q9UBW5

- BIN2_HUMAN

UniProt

Q9UBW5 - BIN2_HUMAN

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Protein

Bridging integrator 2

Gene

BIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.1 Publication

GO - Molecular functioni

  1. phospholipid binding Source: UniProtKB

GO - Biological processi

  1. cell chemotaxis Source: UniProtKB
  2. membrane tubulation Source: UniProtKB
  3. phagocytosis, engulfment Source: UniProtKB
  4. podosome assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Bridging integrator 2
Alternative name(s):
Breast cancer-associated protein 1
Gene namesi
Name:BIN2
Synonyms:BRAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:1053. BIN2.

Subcellular locationi

Cytoplasm. Cell projectionpodosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmcell cortex. Cell projectionphagocytic cup
Note: Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
  5. podosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi13 – 131F → A: Strongly reduces binding to membranes. 1 Publication
Mutagenesisi21 – 211F → A: Strongly reduces binding to membranes. 1 Publication
Mutagenesisi81 – 811V → R: Abolishes dimerization and membrane binding; when associated with E-214. 1 Publication
Mutagenesisi214 – 2141S → E: Abolishes dimerization and membrane binding; when associated with R-81. 1 Publication

Organism-specific databases

PharmGKBiPA25356.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Bridging integrator 2PRO_0000256140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731Phosphoserine1 Publication
Modified residuei357 – 3571Phosphoserine1 Publication
Modified residuei436 – 4361Phosphoserine1 Publication
Modified residuei438 – 4381Phosphothreonine1 Publication
Modified residuei444 – 4441Phosphoserine1 Publication
Modified residuei447 – 4471Phosphoserine1 Publication
Modified residuei458 – 4581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UBW5.
PaxDbiQ9UBW5.
PRIDEiQ9UBW5.

2D gel databases

OGPiQ9UBW5.

PTM databases

PhosphoSiteiQ9UBW5.

Expressioni

Tissue specificityi

Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.2 Publications

Inductioni

Up-regulated during monocytic differentiation.1 Publication

Gene expression databases

BgeeiQ9UBW5.
CleanExiHS_BIN2.
ExpressionAtlasiQ9UBW5. baseline and differential.
GenevestigatoriQ9UBW5.

Organism-specific databases

HPAiHPA038666.
HPA038667.

Interactioni

Subunit structurei

Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BIN1O004992EBI-2042570,EBI-719094

Protein-protein interaction databases

BioGridi119528. 5 interactions.
IntActiQ9UBW5. 3 interactions.
STRINGi9606.ENSP00000267012.

Structurei

Secondary structure

1
565
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 3116Combined sources
Helixi41 – 8848Combined sources
Helixi96 – 12025Combined sources
Helixi122 – 1309Combined sources
Helixi132 – 16029Combined sources
Beta strandi161 – 1644Combined sources
Helixi167 – 20034Combined sources
Helixi202 – 24140Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AVMX-ray1.91A11-245[»]
4I1QX-ray2.53A/B20-238[»]
ProteinModelPortaliQ9UBW5.
SMRiQ9UBW5. Positions 15-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 244217BARPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili304 – 32926Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi253 – 2564Poly-Ser
Compositional biasi413 – 47967Pro-richAdd
BLAST

Domaini

The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.1 Publication

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG264615.
GeneTreeiENSGT00390000017588.
HOGENOMiHOG000252987.
HOVERGENiHBG004224.
InParanoidiQ9UBW5.
OMAiQEEVLPC.
OrthoDBiEOG7XWPND.
PhylomeDBiQ9UBW5.
TreeFamiTF313542.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR003005. Amphiphysin.
IPR004148. BAR_dom.
IPR028827. BIN2.
[Graphical view]
PANTHERiPTHR10321:SF11. PTHR10321:SF11. 1 hit.
PfamiPF03114. BAR. 1 hit.
[Graphical view]
PRINTSiPR01251. AMPHIPHYSIN.
SMARTiSM00721. BAR. 1 hit.
[Graphical view]
PROSITEiPS51021. BAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBW5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGKAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKAVETKD ERFEQSASNF
60 70 80 90 100
YQQQAEGHKL YKDLKNFLSA VKVMHESSKR VSETLQEIYS SEWDGHEELK
110 120 130 140 150
AIVWNNDLLW EDYEEKLADQ AVRTMEIYVA QFSEIKERIA KRGRKLVDYD
160 170 180 190 200
SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA QTVFEDLNQE LLEELPILYN
210 220 230 240 250
SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK QHSNKVFVVK
260 270 280 290 300
GLSSSSRRSL VISPPVRTAT VSSPLTSPTS PSTLSLKSES ESVSATEDLA
310 320 330 340 350
PDAAQGEDNS EIKELLEEEE IEKEGSEASS SEEDEPLPAC NGPAQAQPSP
360 370 380 390 400
TTERAKSQEE VLPSSTTPSP GGALSPSGQP SSSATEVVLR TRTASEGSEQ
410 420 430 440 450
PKKRASIQRT SAPPSRPPPP RATASPRPSS GNIPSSPTAS GGGSPTSPRA
460 470 480 490 500
SLGTGTASPR TSLEVSPNPE PPEKPVRTPE AKENENIHNQ NPEELCTSPT
510 520 530 540 550
LMTSQVASEP GEAKKMEDKE KDNKLISANS SEGQDQLQVS MVPENNNLTA
560
PEPQEEVSTS ENPQL
Length:565
Mass (Da):61,874
Last modified:April 3, 2007 - v3
Checksum:iB1D1FB89A97E9E43
GO
Isoform 2 (identifier: Q9UBW5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-136: Missing.

Note: No experimental confirmation available.

Show »
Length:533
Mass (Da):58,030
Checksum:iE549F6F418F01E02
GO

Sequence cautioni

The sequence BAA91376.1 differs from that shown. Reason: Frameshift at position 156.
The sequence BAA91376.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631Missing in AAD54227. (PubMed:10903846)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481S → N.1 Publication
Corresponds to variant rs7312857 [ dbSNP | Ensembl ].
VAR_028883
Natural varianti529 – 5291N → D.4 Publications
Corresponds to variant rs7954976 [ dbSNP | Ensembl ].
VAR_028884

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 13632Missing in isoform 2. 1 PublicationVSP_021328Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF146531 mRNA. Translation: AAD54227.1.
AB032698 mRNA. Translation: BAA88108.1.
AB032710 Genomic DNA. Translation: BAA88125.1.
AK000783 mRNA. Translation: BAA91376.1. Sequence problems.
AC046135 Genomic DNA. No translation available.
BC047686 mRNA. Translation: AAH47686.1.
RefSeqiNP_001276936.1. NM_001290007.1.
NP_001276937.1. NM_001290008.1.
NP_001276938.1. NM_001290009.1.
NP_057377.3. NM_016293.3.
UniGeneiHs.14770.

Genome annotation databases

EnsembliENST00000267012; ENSP00000267012; ENSG00000110934. [Q9UBW5-1]
GeneIDi51411.
KEGGihsa:51411.
UCSCiuc001ryg.3. human. [Q9UBW5-1]
uc009zlz.3. human. [Q9UBW5-2]

Polymorphism databases

DMDMi143811367.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF146531 mRNA. Translation: AAD54227.1 .
AB032698 mRNA. Translation: BAA88108.1 .
AB032710 Genomic DNA. Translation: BAA88125.1 .
AK000783 mRNA. Translation: BAA91376.1 . Sequence problems.
AC046135 Genomic DNA. No translation available.
BC047686 mRNA. Translation: AAH47686.1 .
RefSeqi NP_001276936.1. NM_001290007.1.
NP_001276937.1. NM_001290008.1.
NP_001276938.1. NM_001290009.1.
NP_057377.3. NM_016293.3.
UniGenei Hs.14770.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AVM X-ray 1.91 A 11-245 [» ]
4I1Q X-ray 2.53 A/B 20-238 [» ]
ProteinModelPortali Q9UBW5.
SMRi Q9UBW5. Positions 15-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119528. 5 interactions.
IntActi Q9UBW5. 3 interactions.
STRINGi 9606.ENSP00000267012.

PTM databases

PhosphoSitei Q9UBW5.

Polymorphism databases

DMDMi 143811367.

2D gel databases

OGPi Q9UBW5.

Proteomic databases

MaxQBi Q9UBW5.
PaxDbi Q9UBW5.
PRIDEi Q9UBW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267012 ; ENSP00000267012 ; ENSG00000110934 . [Q9UBW5-1 ]
GeneIDi 51411.
KEGGi hsa:51411.
UCSCi uc001ryg.3. human. [Q9UBW5-1 ]
uc009zlz.3. human. [Q9UBW5-2 ]

Organism-specific databases

CTDi 51411.
GeneCardsi GC12M051674.
H-InvDB HIX0201823.
HGNCi HGNC:1053. BIN2.
HPAi HPA038666.
HPA038667.
MIMi 605936. gene.
neXtProti NX_Q9UBW5.
PharmGKBi PA25356.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG264615.
GeneTreei ENSGT00390000017588.
HOGENOMi HOG000252987.
HOVERGENi HBG004224.
InParanoidi Q9UBW5.
OMAi QEEVLPC.
OrthoDBi EOG7XWPND.
PhylomeDBi Q9UBW5.
TreeFami TF313542.

Miscellaneous databases

ChiTaRSi BIN2. human.
GenomeRNAii 51411.
NextBioi 54957.
PROi Q9UBW5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBW5.
CleanExi HS_BIN2.
ExpressionAtlasi Q9UBW5. baseline and differential.
Genevestigatori Q9UBW5.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR003005. Amphiphysin.
IPR004148. BAR_dom.
IPR028827. BIN2.
[Graphical view ]
PANTHERi PTHR10321:SF11. PTHR10321:SF11. 1 hit.
Pfami PF03114. BAR. 1 hit.
[Graphical view ]
PRINTSi PR01251. AMPHIPHYSIN.
SMARTi SM00721. BAR. 1 hit.
[Graphical view ]
PROSITEi PS51021. BAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bin2, a functionally nonredundant member of the BAR adaptor gene family."
    Ge K., Prendergast G.C.
    Genomics 67:210-220(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-529, INDUCTION, INTERACTION WITH BIN2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Genomic structure and chromosome location of the BRAP1 gene."
    Miki Y., Saito H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANTS ASN-48 AND ASP-529.
    Tissue: Mammary gland.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-529.
    Tissue: Colon.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-529.
    Tissue: Ovary.
  6. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-357; SER-436; THR-438; SER-444; SER-447 AND SER-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
    Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
    PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) OF 1-238, FUNCTION, DOMAIN, SUBUNIT, INTERACTION WITH ARHGEF6; ARHGEF7; SH3GL1; SH3GL2; SH3GL3, IDENTIFICATION IN A COMPLEX WITH GIT2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF PHE-13; PHE-21; VAL-81 AND SER-214.

Entry informationi

Entry nameiBIN2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBW5
Secondary accession number(s): Q86VV0, Q9NWK4, Q9UKN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3