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Protein

Peflin

Gene

PEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi127 – 1381PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi194 – 2052PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • calcium ion binding Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • proteolysis Source: GO_Central
  • response to calcium ion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162517-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peflin
Alternative name(s):
PEF protein with a long N-terminal hydrophobic domain
Penta-EF hand domain-containing protein 1
Gene namesi
Name:PEF1
Synonyms:ABP32
ORF Names:UNQ1845/PRO3573
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30009. PEF1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162517.
PharmGKBiPA142671184.

Polymorphism and mutation databases

BioMutaiPEF1.
DMDMi74761895.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002470451 – 284PeflinAdd BLAST284

Proteomic databases

EPDiQ9UBV8.
MaxQBiQ9UBV8.
PaxDbiQ9UBV8.
PeptideAtlasiQ9UBV8.
PRIDEiQ9UBV8.

2D gel databases

REPRODUCTION-2DPAGEIPI00018235.

PTM databases

iPTMnetiQ9UBV8.
PhosphoSitePlusiQ9UBV8.

Expressioni

Gene expression databases

BgeeiENSG00000162517.
CleanExiHS_PEF1.
GenevisibleiQ9UBV8. HS.

Organism-specific databases

HPAiHPA061608.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with PDCD6. Dissociates from PDCD6 in presence of Ca2+.

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131374EBI-724639,EBI-739580
CEP55D3DR373EBI-724639,EBI-10173536
DAZAP2Q150383EBI-724639,EBI-724310
EWSR1Q018443EBI-724639,EBI-739737
FOXR2Q6PJQ53EBI-724639,EBI-8468543
HGSO149643EBI-724639,EBI-740220
KLHL12Q53G597EBI-724639,EBI-740929
PDCD6O7534011EBI-724639,EBI-352915
TFGQ927343EBI-724639,EBI-357061

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi139275. 28 interactors.
IntActiQ9UBV8. 23 interactors.
MINTiMINT-5003645.
STRINGi9606.ENSP00000362807.

Structurei

3D structure databases

ProteinModelPortaliQ9UBV8.
SMRiQ9UBV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 2919
Repeati31 – 3929
Repeati41 – 4939
Repeati50 – 5849
Repeati59 – 6759
Repeati76 – 8469
Repeati85 – 9278
Repeati93 – 10088
Repeati101 – 10999
Domaini114 – 149EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini155 – 183EF-hand 2PROSITE-ProRule annotationAdd BLAST29
Domaini181 – 216EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini217 – 253EF-hand 4PROSITE-ProRule annotationAdd BLAST37
Domaini254 – 283EF-hand 5PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 1099 X 9 AA approximate tandem repeat of [AP]-P-G-G-P-Y-G-G-P-PAdd BLAST89
Regioni204 – 284Required for interaction with PDCD6Add BLAST81

Sequence similaritiesi

Contains 5 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231983.
HOVERGENiHBG004492.
InParanoidiQ9UBV8.
OMAiPSMQLDR.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ9UBV8.
TreeFamiTF314682.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASYPYRQGC PGAAGQAPGA PPGSYYPGPP NSGGQYGSGL PPGGGYGGPA
60 70 80 90 100
PGGPYGPPAG GGPYGHPNPG MFPSGTPGGP YGGAAPGGPY GQPPPSSYGA
110 120 130 140 150
QQPGLYGQGG APPNVDPEAY SWFQSVDSDH SGYISMKELK QALVNCNWSS
160 170 180 190 200
FNDETCLMMI NMFDKTKSGR IDVYGFSALW KFIQQWKNLF QQYDRDRSGS
210 220 230 240 250
ISYTELQQAL SQMGYNLSPQ FTQLLVSRYC PRSANPAMQL DRFIQVCTQL
260 270 280
QVLTEAFREK DTAVQGNIRL SFEDFVTMTA SRML
Length:284
Mass (Da):30,381
Last modified:May 1, 2000 - v1
Checksum:i2E9AA5750CB7A68A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026628 mRNA. Translation: BAA85163.1.
AB018357 mRNA. Translation: BAA84922.1.
AY359011 mRNA. Translation: AAQ89370.1.
AK001420 mRNA. Translation: BAA91680.1.
CR542139 mRNA. Translation: CAG46936.1.
BC002773 mRNA. Translation: AAH02773.1.
BC012561 mRNA. Translation: AAH12561.1.
CCDSiCCDS345.1.
RefSeqiNP_036524.1. NM_012392.3.
UniGeneiHs.470417.

Genome annotation databases

EnsembliENST00000373703; ENSP00000362807; ENSG00000162517.
GeneIDi553115.
KEGGihsa:553115.
UCSCiuc001bth.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026628 mRNA. Translation: BAA85163.1.
AB018357 mRNA. Translation: BAA84922.1.
AY359011 mRNA. Translation: AAQ89370.1.
AK001420 mRNA. Translation: BAA91680.1.
CR542139 mRNA. Translation: CAG46936.1.
BC002773 mRNA. Translation: AAH02773.1.
BC012561 mRNA. Translation: AAH12561.1.
CCDSiCCDS345.1.
RefSeqiNP_036524.1. NM_012392.3.
UniGeneiHs.470417.

3D structure databases

ProteinModelPortaliQ9UBV8.
SMRiQ9UBV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139275. 28 interactors.
IntActiQ9UBV8. 23 interactors.
MINTiMINT-5003645.
STRINGi9606.ENSP00000362807.

PTM databases

iPTMnetiQ9UBV8.
PhosphoSitePlusiQ9UBV8.

Polymorphism and mutation databases

BioMutaiPEF1.
DMDMi74761895.

2D gel databases

REPRODUCTION-2DPAGEIPI00018235.

Proteomic databases

EPDiQ9UBV8.
MaxQBiQ9UBV8.
PaxDbiQ9UBV8.
PeptideAtlasiQ9UBV8.
PRIDEiQ9UBV8.

Protocols and materials databases

DNASUi553115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373703; ENSP00000362807; ENSG00000162517.
GeneIDi553115.
KEGGihsa:553115.
UCSCiuc001bth.3. human.

Organism-specific databases

CTDi553115.
GeneCardsiPEF1.
HGNCiHGNC:30009. PEF1.
HPAiHPA061608.
MIMi610033. gene.
neXtProtiNX_Q9UBV8.
OpenTargetsiENSG00000162517.
PharmGKBiPA142671184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231983.
HOVERGENiHBG004492.
InParanoidiQ9UBV8.
OMAiPSMQLDR.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ9UBV8.
TreeFamiTF314682.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162517-MONOMER.

Miscellaneous databases

GeneWikiiPEF1.
GenomeRNAii553115.
PROiQ9UBV8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162517.
CleanExiHS_PEF1.
GenevisibleiQ9UBV8. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEF1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.