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Q9UBU7

- DBF4A_HUMAN

UniProt

Q9UBU7 - DBF4A_HUMAN

Protein

Protein DBF4 homolog A

Gene

DBF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri289 – 33749DBF4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. enzyme activator activity Source: ProtInc
    2. nucleic acid binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA replication Source: Reactome
    2. G1/S transition of mitotic cell cycle Source: Reactome
    3. mitotic cell cycle Source: Reactome
    4. positive regulation of catalytic activity Source: GOC

    Keywords - Biological processi

    Cell cycle, DNA replication

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1095. Activation of the pre-replicative complex.
    REACT_6769. Activation of ATR in response to replication stress.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein DBF4 homolog A
    Alternative name(s):
    Activator of S phase kinase
    Chiffon homolog A
    DBF4-type zinc finger-containing protein 1
    Gene namesi
    Name:DBF4
    Synonyms:ASK, DBF4A, ZDBF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17364. DBF4.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 674674Protein DBF4 homolog APRO_0000234061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731Phosphothreonine1 Publication
    Modified residuei345 – 3451Phosphothreonine1 Publication
    Modified residuei354 – 3541Phosphoserine1 Publication
    Modified residuei359 – 3591Phosphoserine2 Publications
    Modified residuei381 – 3811Phosphoserine1 Publication
    Modified residuei413 – 4131Phosphoserine1 Publication
    Modified residuei508 – 5081Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBU7.
    PaxDbiQ9UBU7.
    PRIDEiQ9UBU7.

    PTM databases

    PhosphoSiteiQ9UBU7.

    Expressioni

    Tissue specificityi

    Highly expressed in testis and thymus. Expressed also in most cancer cells lines.1 Publication

    Inductioni

    Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase.2 Publications

    Gene expression databases

    ArrayExpressiQ9UBU7.
    BgeeiQ9UBU7.
    CleanExiHS_DBF4.
    GenevestigatoriQ9UBU7.

    Organism-specific databases

    HPAiHPA051589.

    Interactioni

    Subunit structurei

    Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6.4 Publications

    Protein-protein interaction databases

    BioGridi116129. 18 interactions.
    DIPiDIP-31205N.
    IntActiQ9UBU7. 3 interactions.
    MINTiMINT-2842143.
    STRINGi9606.ENSP00000265728.

    Structurei

    Secondary structure

    1
    674
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi217 – 2259
    Beta strandi227 – 2293
    Beta strandi232 – 2354
    Beta strandi244 – 2463
    Turni297 – 3004
    Helixi306 – 3116
    Helixi313 – 3197
    Helixi322 – 3243
    Helixi325 – 3317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F99X-ray2.33B210-350[»]
    4F9AX-ray2.17B/D210-350[»]
    4F9BX-ray2.50B/D210-350[»]
    4F9CX-ray2.08B210-350[»]
    ProteinModelPortaliQ9UBU7.
    SMRiQ9UBU7. Positions 214-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 12889BRCT 1Add
    BLAST
    Domaini154 – 17926BRCT 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 BRCT domains.Curated
    Contains 1 DBF4-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri289 – 33749DBF4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG314450.
    HOVERGENiHBG063274.
    InParanoidiQ9UBU7.
    KOiK06629.
    OMAiDIWEEEN.
    OrthoDBiEOG7BGHK5.
    PhylomeDBiQ9UBU7.
    TreeFamiTF332790.

    Family and domain databases

    Gene3Di3.40.50.10190. 2 hits.
    InterProiIPR001357. BRCT_dom.
    IPR006572. Znf_DBF.
    [Graphical view]
    PfamiPF07535. zf-DBF. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    SM00586. ZnF_DBF. 1 hit.
    [Graphical view]
    PROSITEiPS51265. ZF_DBF4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBU7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSGAMRIHS KGHFQGGIQV KNEKNRPSLK SLKTDNRPEK SKCKPLWGKV    50
    FYLDLPSVTI SEKLQKDIKD LGGRVEEFLS KDISYLISNK KEAKFAQTLG 100
    RISPVPSPES AYTAETTSPH PSHDGSSFKS PDTVCLSRGK LLVEKAIKDH 150
    DFIPSNSILS NALSWGVKIL HIDDIRYYIE QKKKELYLLK KSSTSVRDGG 200
    KRVGSGAQKT RTGRLKKPFV KVEDMSQLYR PFYLQLTNMP FINYSIQKPC 250
    SPFDVDKPSS MQKQTQVKLR IQTDGDKYGG TSIQLQLKEK KKKGYCECCL 300
    QKYEDLETHL LSEQHRNFAQ SNQYQVVDDI VSKLVFDFVE YEKDTPKKKR 350
    IKYSVGSLSP VSASVLKKTE QKEKVELQHI SQKDCQEDDT TVKEQNFLYK 400
    ETQETEKKLL FISEPIPHPS NELRGLNEKM SNKCSMLSTA EDDIRQNFTQ 450
    LPLHKNKQEC ILDISEHTLS ENDLEELRVD HYKCNIQASV HVSDFSTDNS 500
    GSQPKQKSDT VLFPAKDLKE KDLHSIFTHD SGLITINSSQ EHLTVQAKAP 550
    FHTPPEEPNE CDFKNMDSLP SGKIHRKVKI ILGRNRKENL EPNAEFDKRT 600
    EFITQEENRI CSSPVQSLLD LFQTSEEKSE FLGFTSYTEK SGICNVLDIW 650
    EEENSDNLLT AFFSSPSTST FTGF 674
    Length:674
    Mass (Da):76,858
    Last modified:May 1, 2000 - v1
    Checksum:i353FEB7E85507E5C
    GO
    Isoform 2 (identifier: Q9UBU7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         228-234: LYRPFYL → SPAVHLM
         235-674: Missing.

    Show »
    Length:234
    Mass (Da):26,124
    Checksum:i50357B9FCF8472BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti581 – 5811I → L in EAL24170. (PubMed:12690205)Curated
    Sequence conflicti584 – 5841R → Q in EAL24170. (PubMed:12690205)Curated
    Sequence conflicti619 – 6191L → P in EAL24170. (PubMed:12690205)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121Y → N.
    Corresponds to variant rs1476703 [ dbSNP | Ensembl ].
    VAR_052970
    Natural varianti575 – 5751H → R.
    Corresponds to variant rs2041049 [ dbSNP | Ensembl ].
    VAR_052971

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei228 – 2347LYRPFYL → SPAVHLM in isoform 2. 1 PublicationVSP_018203
    Alternative sequencei235 – 674440Missing in isoform 2. 1 PublicationVSP_018204Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028069 mRNA. Translation: BAA78326.1.
    AB028070 mRNA. Translation: BAA78327.1.
    AF160249 mRNA. Translation: AAD41911.1.
    AF160876 mRNA. Translation: AAD45357.1.
    AK292569 mRNA. Translation: BAF85258.1.
    AC003083 Genomic DNA. Translation: AAS07442.1.
    AC005164 Genomic DNA. Translation: AAS07418.1.
    CH236949 Genomic DNA. Translation: EAL24170.1.
    CH471091 Genomic DNA. Translation: EAW76930.1.
    BC036045 mRNA. Translation: AAH36045.1.
    BC047693 mRNA. Translation: AAH47693.1.
    CCDSiCCDS5611.1. [Q9UBU7-1]
    PIRiT02633.
    RefSeqiNP_006707.1. NM_006716.3. [Q9UBU7-1]
    UniGeneiHs.485380.

    Genome annotation databases

    EnsembliENST00000265728; ENSP00000265728; ENSG00000006634. [Q9UBU7-1]
    ENST00000413643; ENSP00000414083; ENSG00000006634. [Q9UBU7-2]
    GeneIDi10926.
    KEGGihsa:10926.
    UCSCiuc003ujf.1. human. [Q9UBU7-1]

    Polymorphism databases

    DMDMi74753231.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028069 mRNA. Translation: BAA78326.1 .
    AB028070 mRNA. Translation: BAA78327.1 .
    AF160249 mRNA. Translation: AAD41911.1 .
    AF160876 mRNA. Translation: AAD45357.1 .
    AK292569 mRNA. Translation: BAF85258.1 .
    AC003083 Genomic DNA. Translation: AAS07442.1 .
    AC005164 Genomic DNA. Translation: AAS07418.1 .
    CH236949 Genomic DNA. Translation: EAL24170.1 .
    CH471091 Genomic DNA. Translation: EAW76930.1 .
    BC036045 mRNA. Translation: AAH36045.1 .
    BC047693 mRNA. Translation: AAH47693.1 .
    CCDSi CCDS5611.1. [Q9UBU7-1 ]
    PIRi T02633.
    RefSeqi NP_006707.1. NM_006716.3. [Q9UBU7-1 ]
    UniGenei Hs.485380.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F99 X-ray 2.33 B 210-350 [» ]
    4F9A X-ray 2.17 B/D 210-350 [» ]
    4F9B X-ray 2.50 B/D 210-350 [» ]
    4F9C X-ray 2.08 B 210-350 [» ]
    ProteinModelPortali Q9UBU7.
    SMRi Q9UBU7. Positions 214-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116129. 18 interactions.
    DIPi DIP-31205N.
    IntActi Q9UBU7. 3 interactions.
    MINTi MINT-2842143.
    STRINGi 9606.ENSP00000265728.

    Chemistry

    BindingDBi Q9UBU7.
    ChEMBLi CHEMBL2111377.

    PTM databases

    PhosphoSitei Q9UBU7.

    Polymorphism databases

    DMDMi 74753231.

    Proteomic databases

    MaxQBi Q9UBU7.
    PaxDbi Q9UBU7.
    PRIDEi Q9UBU7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265728 ; ENSP00000265728 ; ENSG00000006634 . [Q9UBU7-1 ]
    ENST00000413643 ; ENSP00000414083 ; ENSG00000006634 . [Q9UBU7-2 ]
    GeneIDi 10926.
    KEGGi hsa:10926.
    UCSCi uc003ujf.1. human. [Q9UBU7-1 ]

    Organism-specific databases

    CTDi 10926.
    GeneCardsi GC07P087505.
    HGNCi HGNC:17364. DBF4.
    HPAi HPA051589.
    MIMi 604281. gene.
    neXtProti NX_Q9UBU7.
    PharmGKBi PA142672016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314450.
    HOVERGENi HBG063274.
    InParanoidi Q9UBU7.
    KOi K06629.
    OMAi DIWEEEN.
    OrthoDBi EOG7BGHK5.
    PhylomeDBi Q9UBU7.
    TreeFami TF332790.

    Enzyme and pathway databases

    Reactomei REACT_1095. Activation of the pre-replicative complex.
    REACT_6769. Activation of ATR in response to replication stress.

    Miscellaneous databases

    GeneWikii DBF4.
    GenomeRNAii 10926.
    NextBioi 41507.
    PROi Q9UBU7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBU7.
    Bgeei Q9UBU7.
    CleanExi HS_DBF4.
    Genevestigatori Q9UBU7.

    Family and domain databases

    Gene3Di 3.40.50.10190. 2 hits.
    InterProi IPR001357. BRCT_dom.
    IPR006572. Znf_DBF.
    [Graphical view ]
    Pfami PF07535. zf-DBF. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    SM00586. ZnF_DBF. 1 hit.
    [Graphical view ]
    PROSITEi PS51265. ZF_DBF4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells."
      Kumagai H., Sato N., Yamada M., Mahony D., Seghezzi W., Lees E., Arai K., Masai H.
      Mol. Cell. Biol. 19:5083-5095(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH CDC7, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    2. "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication."
      Jiang W., McDonald D., Hope T.J., Hunter T.
      EMBO J. 18:5703-5713(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CDC7, INDUCTION.
    3. "Use of a semi-automated yeast two-hybrid system to identify proteins that interact with the human Cdc7 protein."
      Hollingsworth R.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Testis.
    9. "Functional interaction between tumor suppressor menin and activator of S-phase kinase."
      Schnepp R.W., Hou Z., Wang H., Petersen C., Silva A., Masai H., Hua X.
      Cancer Res. 64:6791-6796(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEN1.
    10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Cdc7 is an active kinase in human cancer cells undergoing replication stress."
      Tenca P., Brotherton D., Montagnoli A., Rainoldi S., Albanese C., Santocanale C.
      J. Biol. Chem. 282:208-215(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CDC7.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354 AND SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-273; THR-345; SER-381 AND SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDBF4A_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBU7
    Secondary accession number(s): A4D1D8
    , A8K954, O75226, Q75MS6, Q75N01, Q9Y2M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3