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Q9UBU6

- FA8A1_HUMAN

UniProt

Q9UBU6 - FA8A1_HUMAN

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Protein

Protein FAM8A1

Gene

FAM8A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi9.B.45.1.4. the arg/asp/asp (rdd) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM8A1
Alternative name(s):
Autosomal highly conserved protein
Gene namesi
Name:FAM8A1
Synonyms:AHCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:16372. FAM8A1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Protein FAM8A1PRO_0000087167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UBU6.
PaxDbiQ9UBU6.
PeptideAtlasiQ9UBU6.
PRIDEiQ9UBU6.

PTM databases

PhosphoSiteiQ9UBU6.

Expressioni

Tissue specificityi

Ubiquitously expressed, with a higher level of expression in testis.1 Publication

Gene expression databases

BgeeiQ9UBU6.
CleanExiHS_FAM8A1.
ExpressionAtlasiQ9UBU6. baseline and differential.
GenevestigatoriQ9UBU6.

Interactioni

Protein-protein interaction databases

BioGridi119541. 8 interactions.
IntActiQ9UBU6. 1 interaction.
STRINGi9606.ENSP00000259963.

Structurei

3D structure databases

ProteinModelPortaliQ9UBU6.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini242 – 408167RDDAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 646Poly-Ala
Compositional biasi164 – 1674Poly-Pro

Sequence similaritiesi

Contains 1 RDD domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263349.
GeneTreeiENSGT00390000007346.
HOGENOMiHOG000220846.
HOVERGENiHBG054566.
InParanoidiQ9UBU6.
OMAiAAFPAYC.
OrthoDBiEOG7QZGDK.
PhylomeDBiQ9UBU6.
TreeFamiTF314024.

Family and domain databases

InterProiIPR010432. RDD.
[Graphical view]
PfamiPF06271. RDD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEGPEEARG HPPGQDDGGG DHEPVPSLRG PPTTAVPCPR DDPQAEPQAP
60 70 80 90 100
GRPTAPGLAA AAAADKLEPP RELRKRGEAA SGSGAELQEQ AGCEAPEAAA
110 120 130 140 150
PRERPARLSA REYSRQVHEW LWQSYCGYLT WHSGLAAFPA YCSPQPSPQS
160 170 180 190 200
FPSGGAAVPQ AAAPPPPQLG YYNPFYFLSP GAAGPDPRTA AGISTPAPVA
210 220 230 240 250
GLGPRAPHVQ ASVRATPVTR VGSAAPSRSP SETGRQAGRE YVIPSLAHRF
260 270 280 290 300
MAEMVDFFIL FFIKATIVLS IMHLSGIKDI SKFAMHYIIE EIDEDTSMED
310 320 330 340 350
LQKMMVVALI YRLLVCFYEI ICIWGAGGAT PGKFLLGLRV VTCDTSVLIA
360 370 380 390 400
PSRVLVIPSS NVSITTSTIR ALIKNFSIAS FFPAFITLLF FQHNRTAYDI
410
VAGTIVVKRN GVR
Length:413
Mass (Da):44,123
Last modified:May 1, 2000 - v1
Checksum:i35B92497907CCD2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097027 mRNA. Translation: AAF07850.1.
AK312814 mRNA. Translation: BAG35672.1.
AL138824 Genomic DNA. Translation: CAI12251.1.
AF097026 Genomic DNA. Translation: AAF07849.1.
CH471087 Genomic DNA. Translation: EAW55382.1.
BC047881 mRNA. Translation: AAH47881.1.
CCDSiCCDS4540.1.
RefSeqiNP_057339.1. NM_016255.2.
UniGeneiHs.95260.

Genome annotation databases

EnsembliENST00000259963; ENSP00000259963; ENSG00000137414.
GeneIDi51439.
KEGGihsa:51439.
UCSCiuc003ncc.3. human.

Polymorphism databases

DMDMi74753230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097027 mRNA. Translation: AAF07850.1 .
AK312814 mRNA. Translation: BAG35672.1 .
AL138824 Genomic DNA. Translation: CAI12251.1 .
AF097026 Genomic DNA. Translation: AAF07849.1 .
CH471087 Genomic DNA. Translation: EAW55382.1 .
BC047881 mRNA. Translation: AAH47881.1 .
CCDSi CCDS4540.1.
RefSeqi NP_057339.1. NM_016255.2.
UniGenei Hs.95260.

3D structure databases

ProteinModelPortali Q9UBU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119541. 8 interactions.
IntActi Q9UBU6. 1 interaction.
STRINGi 9606.ENSP00000259963.

Protein family/group databases

TCDBi 9.B.45.1.4. the arg/asp/asp (rdd) family.

PTM databases

PhosphoSitei Q9UBU6.

Polymorphism databases

DMDMi 74753230.

Proteomic databases

MaxQBi Q9UBU6.
PaxDbi Q9UBU6.
PeptideAtlasi Q9UBU6.
PRIDEi Q9UBU6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259963 ; ENSP00000259963 ; ENSG00000137414 .
GeneIDi 51439.
KEGGi hsa:51439.
UCSCi uc003ncc.3. human.

Organism-specific databases

CTDi 51439.
GeneCardsi GC06P017600.
HGNCi HGNC:16372. FAM8A1.
neXtProti NX_Q9UBU6.
PharmGKBi PA27986.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263349.
GeneTreei ENSGT00390000007346.
HOGENOMi HOG000220846.
HOVERGENi HBG054566.
InParanoidi Q9UBU6.
OMAi AAFPAYC.
OrthoDBi EOG7QZGDK.
PhylomeDBi Q9UBU6.
TreeFami TF314024.

Miscellaneous databases

GenomeRNAii 51439.
NextBioi 55019.
PROi Q9UBU6.

Gene expression databases

Bgeei Q9UBU6.
CleanExi HS_FAM8A1.
ExpressionAtlasi Q9UBU6. baseline and differential.
Genevestigatori Q9UBU6.

Family and domain databases

InterProi IPR010432. RDD.
[Graphical view ]
Pfami PF06271. RDD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transduction of the human gene FAM8A1 by endogenous retrovirus during primate evolution."
    Jamain S., Girondot M., Leroy P., Clergue M., Quach H., Fellous M., Bourgeron T.
    Genomics 78:38-45(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFA8A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBU6
Secondary accession number(s): B2R725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3