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Q9UBU6

- FA8A1_HUMAN

UniProt

Q9UBU6 - FA8A1_HUMAN

Protein

Protein FAM8A1

Gene

FAM8A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi9.B.45.1.4. the arg/asp/asp (rdd) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM8A1
    Alternative name(s):
    Autosomal highly conserved protein
    Gene namesi
    Name:FAM8A1
    Synonyms:AHCP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16372. FAM8A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27986.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Protein FAM8A1PRO_0000087167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei229 – 2291Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBU6.
    PaxDbiQ9UBU6.
    PeptideAtlasiQ9UBU6.
    PRIDEiQ9UBU6.

    PTM databases

    PhosphoSiteiQ9UBU6.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with a higher level of expression in testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9UBU6.
    BgeeiQ9UBU6.
    CleanExiHS_FAM8A1.
    GenevestigatoriQ9UBU6.

    Interactioni

    Protein-protein interaction databases

    BioGridi119541. 3 interactions.
    IntActiQ9UBU6. 1 interaction.
    STRINGi9606.ENSP00000259963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini242 – 408167RDDAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 646Poly-Ala
    Compositional biasi164 – 1674Poly-Pro

    Sequence similaritiesi

    Contains 1 RDD domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263349.
    HOGENOMiHOG000220846.
    HOVERGENiHBG054566.
    InParanoidiQ9UBU6.
    OMAiAAFPAYC.
    OrthoDBiEOG7QZGDK.
    PhylomeDBiQ9UBU6.
    TreeFamiTF314024.

    Family and domain databases

    InterProiIPR010432. RDD.
    [Graphical view]
    PfamiPF06271. RDD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UBU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEGPEEARG HPPGQDDGGG DHEPVPSLRG PPTTAVPCPR DDPQAEPQAP    50
    GRPTAPGLAA AAAADKLEPP RELRKRGEAA SGSGAELQEQ AGCEAPEAAA 100
    PRERPARLSA REYSRQVHEW LWQSYCGYLT WHSGLAAFPA YCSPQPSPQS 150
    FPSGGAAVPQ AAAPPPPQLG YYNPFYFLSP GAAGPDPRTA AGISTPAPVA 200
    GLGPRAPHVQ ASVRATPVTR VGSAAPSRSP SETGRQAGRE YVIPSLAHRF 250
    MAEMVDFFIL FFIKATIVLS IMHLSGIKDI SKFAMHYIIE EIDEDTSMED 300
    LQKMMVVALI YRLLVCFYEI ICIWGAGGAT PGKFLLGLRV VTCDTSVLIA 350
    PSRVLVIPSS NVSITTSTIR ALIKNFSIAS FFPAFITLLF FQHNRTAYDI 400
    VAGTIVVKRN GVR 413
    Length:413
    Mass (Da):44,123
    Last modified:May 1, 2000 - v1
    Checksum:i35B92497907CCD2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097027 mRNA. Translation: AAF07850.1.
    AK312814 mRNA. Translation: BAG35672.1.
    AL138824 Genomic DNA. Translation: CAI12251.1.
    AF097026 Genomic DNA. Translation: AAF07849.1.
    CH471087 Genomic DNA. Translation: EAW55382.1.
    BC047881 mRNA. Translation: AAH47881.1.
    CCDSiCCDS4540.1.
    RefSeqiNP_057339.1. NM_016255.2.
    UniGeneiHs.95260.

    Genome annotation databases

    EnsembliENST00000259963; ENSP00000259963; ENSG00000137414.
    GeneIDi51439.
    KEGGihsa:51439.
    UCSCiuc003ncc.3. human.

    Polymorphism databases

    DMDMi74753230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097027 mRNA. Translation: AAF07850.1 .
    AK312814 mRNA. Translation: BAG35672.1 .
    AL138824 Genomic DNA. Translation: CAI12251.1 .
    AF097026 Genomic DNA. Translation: AAF07849.1 .
    CH471087 Genomic DNA. Translation: EAW55382.1 .
    BC047881 mRNA. Translation: AAH47881.1 .
    CCDSi CCDS4540.1.
    RefSeqi NP_057339.1. NM_016255.2.
    UniGenei Hs.95260.

    3D structure databases

    ProteinModelPortali Q9UBU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119541. 3 interactions.
    IntActi Q9UBU6. 1 interaction.
    STRINGi 9606.ENSP00000259963.

    Protein family/group databases

    TCDBi 9.B.45.1.4. the arg/asp/asp (rdd) family.

    PTM databases

    PhosphoSitei Q9UBU6.

    Polymorphism databases

    DMDMi 74753230.

    Proteomic databases

    MaxQBi Q9UBU6.
    PaxDbi Q9UBU6.
    PeptideAtlasi Q9UBU6.
    PRIDEi Q9UBU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259963 ; ENSP00000259963 ; ENSG00000137414 .
    GeneIDi 51439.
    KEGGi hsa:51439.
    UCSCi uc003ncc.3. human.

    Organism-specific databases

    CTDi 51439.
    GeneCardsi GC06P017600.
    HGNCi HGNC:16372. FAM8A1.
    neXtProti NX_Q9UBU6.
    PharmGKBi PA27986.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263349.
    HOGENOMi HOG000220846.
    HOVERGENi HBG054566.
    InParanoidi Q9UBU6.
    OMAi AAFPAYC.
    OrthoDBi EOG7QZGDK.
    PhylomeDBi Q9UBU6.
    TreeFami TF314024.

    Miscellaneous databases

    GenomeRNAii 51439.
    NextBioi 55019.
    PROi Q9UBU6.

    Gene expression databases

    ArrayExpressi Q9UBU6.
    Bgeei Q9UBU6.
    CleanExi HS_FAM8A1.
    Genevestigatori Q9UBU6.

    Family and domain databases

    InterProi IPR010432. RDD.
    [Graphical view ]
    Pfami PF06271. RDD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transduction of the human gene FAM8A1 by endogenous retrovirus during primate evolution."
      Jamain S., Girondot M., Leroy P., Clergue M., Quach H., Fellous M., Bourgeron T.
      Genomics 78:38-45(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFA8A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBU6
    Secondary accession number(s): B2R725
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3