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Protein
Submitted name:

C-C chemokine receptor 5

Gene

CCR5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: InterPro
  2. immune response Source: InterPro
  3. inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
C-C chemokine receptor 5Imported
Gene namesi
Name:CCR5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ9UBT9.
ExpressionAtlasiQ9UBT9. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9UBT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG106917.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UBT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PIYDINYYTS EPCQKINVKQ IAARLLPPLY SLVFIFGFVG NMLVILILIN
60 70 80 90 100
CKRLKSMTDI YLLNLAISDL FFLLTVPFWA HYAAAQWDFG NTMCQLLTGL
110 120 130 140 150
YFIGFFSGIF FIILLTIDRY LAVVHAVFAL KARTVTFGVV TSVITWVVAV
160 170 180 190 200
FASLPGIIFT RSQKEGLHYT CSSHFPYSQY QFWKNFQTLK IVILGLVLPL
210 220 230 240 250
LVMVICYSGI LKTLLRCRNE KKRHRAVRLI FTIMIVYFLF WAPYNIVLLL
260 270 280 290 300
NTFQEFFGLN NCSSSNRLDQ AMQVTETLGM THCCINPIIY AFVGEKFRNY
310 320 330
LLVFFQKHIA KRFCKCCSIF QQEAPERASS VYTRSTGEQ
Length:339
Mass (Da):39,114
Last modified:May 1, 2000 - v1
Checksum:i3C6369F92C29F4A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei339 – 3391Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161909 Genomic DNA. Translation: AAD47666.1.
AF161910 Genomic DNA. Translation: AAD47667.1.
AF161911 Genomic DNA. Translation: AAD47668.1.
AF161912 Genomic DNA. Translation: AAD47669.1.
AF161915 Genomic DNA. Translation: AAD47672.1.
UniGeneiHs.450802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161909 Genomic DNA. Translation: AAD47666.1.
AF161910 Genomic DNA. Translation: AAD47667.1.
AF161911 Genomic DNA. Translation: AAD47668.1.
AF161912 Genomic DNA. Translation: AAD47669.1.
AF161915 Genomic DNA. Translation: AAD47672.1.
UniGeneiHs.450802.

3D structure databases

ProteinModelPortaliQ9UBT9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9UBT9.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106917.

Gene expression databases

BgeeiQ9UBT9.
ExpressionAtlasiQ9UBT9. baseline and differential.

Family and domain databases

InterProiIPR002240. Chemokine_CCR5.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01110. CHEMOKINER5.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences of the CCR5 genes from diverse simian and prosimian species."
    Kunstman K., Chen Z., Korber B., Oprondek J., Stanton J., Agy M., Shibata R., Yoder A., Pillai S., Kuiken C., Marx P., Wolinksy S.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure and function of CC-chemokine receptor 5 homologues derived from representative primate species and subspecies of the taxonomic suborders Prosimii and Anthropoidea."
    Kunstman K.J., Puffer B., Korber B.T., Kuiken C., Smith U.R., Kunstman J., Stanton J., Agy M., Shibata R., Yoder A.D., Pillai S., Doms R.W., Marx P., Wolinsky S.M.
    J. Virol. 77:12310-12318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UBT9_HUMAN
AccessioniPrimary (citable) accession number: Q9UBT9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.