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Protein

Alpha-catulin

Gene

CTNNAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

GO - Biological processi

  • cell adhesion Source: InterPro
  • Rho protein signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-catulin
Alternative name(s):
Alpha-catenin-related protein
Short name:
ACRP
Catenin alpha-like protein 1
Gene namesi
Name:CTNNAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2512. CTNNAL1.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8727.
OpenTargetsiENSG00000119326.
PharmGKBiPA27011.

Polymorphism and mutation databases

BioMutaiCTNNAL1.
DMDMi62901512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642681 – 734Alpha-catulinAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei374PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBT7.
PaxDbiQ9UBT7.
PeptideAtlasiQ9UBT7.
PRIDEiQ9UBT7.

PTM databases

iPTMnetiQ9UBT7.
PhosphoSitePlusiQ9UBT7.

Expressioni

Tissue specificityi

Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.3 Publications

Inductioni

Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.1 Publication

Gene expression databases

BgeeiENSG00000119326.
CleanExiHS_CTNNAL1.
ExpressionAtlasiQ9UBT7. baseline and differential.
GenevisibleiQ9UBT7. HS.

Organism-specific databases

HPAiHPA066188.

Interactioni

Subunit structurei

Interacts with ARHGEF1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C19orf57Q0VDD73EBI-514206,EBI-741210
DMDP115325EBI-514206,EBI-295827
RNF135Q8IUD65EBI-514206,EBI-9916363
SPERTQ8NA613EBI-514206,EBI-741724
USH1CQ9Y6N93EBI-514206,EBI-954308

Protein-protein interaction databases

BioGridi114266. 13 interactors.
IntActiQ9UBT7. 13 interactors.
MINTiMINT-3002286.
STRINGi9606.ENSP00000320434.

Structurei

3D structure databases

ProteinModelPortaliQ9UBT7.
SMRiQ9UBT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOVERGENiHBG051219.
InParanoidiQ9UBT7.
OMAiYHADHVV.
OrthoDBiEOG091G0BL2.
PhylomeDBiQ9UBT7.
TreeFamiTF313686.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030045. CTNNAL1.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PTHR18914:SF8. PTHR18914:SF8. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT
60 70 80 90 100
LINHKDNTKK SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI
110 120 130 140 150
NIACIEAKQA GETIAALTDI TNLNHLESDG QITIFTDKTG VIKAARLLLS
160 170 180 190 200
SVTKVLLLAD RVVIKQIITS RNKVLATMER LEKVNSFQEF VQIFSQFGNE
210 220 230 240 250
MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT ASKTCLRHPN
260 270 280 290 300
CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK
310 320 330 340 350
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS
360 370 380 390 400
TQARMELQQL ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST
410 420 430 440 450
ATQLAADLLK YHADHVVLKA LKLTGVEGNL EALAEYACKL SEQKEQLVET
460 470 480 490 500
CRLLRHISGT EPLEITCIHA EETFQVTGQQ IISAAETLTL HPSSKIAKEN
510 520 530 540 550
LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP KPMKNNANLK
560 570 580 590 600
SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM
610 620 630 640 650
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD
660 670 680 690 700
DDKLMLLLEI NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL
710 720 730
VQLLSLCYKL LKKLQMENNG WVSVTNKDTM DSKT
Length:734
Mass (Da):81,896
Last modified:February 1, 2005 - v2
Checksum:i8756237C73AAEA31
GO
Isoform 2 (identifier: Q9UBT7-2) [UniParc]FASTAAdd to basket
Also known as: Alpha2-catulin

The sequence of this isoform differs from the canonical sequence as follows:
     714-734: LQMENNGWVSVTNKDTMDSKT → SETRY

Show »
Length:718
Mass (Da):80,152
Checksum:i3FDAAE7A79BBB43E
GO
Isoform 3 (identifier: Q9UBT7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-480: Missing.

Show »
Length:650
Mass (Da):72,616
Checksum:iF71E1D06CBF61593
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti504F → S in BAD96950 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02092491N → T.1 PublicationCorresponds to variant rs28361109dbSNPEnsembl.1
Natural variantiVAR_020925203E → K.1 PublicationCorresponds to variant rs28361118dbSNPEnsembl.1
Natural variantiVAR_033845424T → S.Corresponds to variant rs16913734dbSNPEnsembl.1
Natural variantiVAR_020926527E → Q.1 PublicationCorresponds to variant rs7021366dbSNPEnsembl.1
Natural variantiVAR_053370555D → E.Corresponds to variant rs34922868dbSNPEnsembl.1
Natural variantiVAR_020927593I → N.1 PublicationCorresponds to variant rs28361167dbSNPEnsembl.1
Natural variantiVAR_020928716M → R.1 PublicationCorresponds to variant rs28361182dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012582397 – 480Missing in isoform 3. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_012583714 – 734LQMEN…MDSKT → SETRY in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030233 mRNA. Translation: AAC83460.1.
U97067 mRNA. Translation: AAC27693.1.
AF134888
, AF134871, AF134873, AF134874, AF134872, AF134875, AF134877, AF134879, AF134881, AF134887, AF134886, AF134885, AF134884, AF134883, AF134882, AF134880, AF134878, AF134876 Genomic DNA. Translation: AAF07820.1.
AF134888
, AF134871, AF134872, AF134874, AF134876, AF134878, AF134880, AF134882, AF134884, AF134887, AF134886, AF134885, AF134883, AF134881, AF134879, AF134877, AF134875, AF134873 Genomic DNA. Translation: AAF07821.1.
AF135021 mRNA. Translation: AAF07819.1.
AF006070 mRNA. Translation: AAC26011.1.
AF080071 mRNA. Translation: AAC69576.1.
AK223230 mRNA. Translation: BAD96950.1.
AY523969 Genomic DNA. Translation: AAR92479.1.
AB451283 mRNA. Translation: BAG70097.1.
AB451415 mRNA. Translation: BAG70229.1.
AL354797 Genomic DNA. Translation: CAI39471.1.
AL354797 Genomic DNA. Translation: CAI39472.1.
CH471105 Genomic DNA. Translation: EAW59036.1.
BC117208 mRNA. Translation: AAI17209.1.
BC117234 mRNA. Translation: AAI17235.1.
AL050016 mRNA. Translation: CAB43238.1.
CCDSiCCDS6775.1. [Q9UBT7-1]
CCDS69638.1. [Q9UBT7-2]
PIRiT08703.
RefSeqiNP_001273903.1. NM_001286974.1. [Q9UBT7-2]
NP_003789.1. NM_003798.3. [Q9UBT7-1]
UniGeneiHs.58488.

Genome annotation databases

EnsembliENST00000325551; ENSP00000320434; ENSG00000119326. [Q9UBT7-1]
ENST00000374595; ENSP00000363723; ENSG00000119326. [Q9UBT7-2]
GeneIDi8727.
KEGGihsa:8727.
UCSCiuc004bdo.3. human. [Q9UBT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030233 mRNA. Translation: AAC83460.1.
U97067 mRNA. Translation: AAC27693.1.
AF134888
, AF134871, AF134873, AF134874, AF134872, AF134875, AF134877, AF134879, AF134881, AF134887, AF134886, AF134885, AF134884, AF134883, AF134882, AF134880, AF134878, AF134876 Genomic DNA. Translation: AAF07820.1.
AF134888
, AF134871, AF134872, AF134874, AF134876, AF134878, AF134880, AF134882, AF134884, AF134887, AF134886, AF134885, AF134883, AF134881, AF134879, AF134877, AF134875, AF134873 Genomic DNA. Translation: AAF07821.1.
AF135021 mRNA. Translation: AAF07819.1.
AF006070 mRNA. Translation: AAC26011.1.
AF080071 mRNA. Translation: AAC69576.1.
AK223230 mRNA. Translation: BAD96950.1.
AY523969 Genomic DNA. Translation: AAR92479.1.
AB451283 mRNA. Translation: BAG70097.1.
AB451415 mRNA. Translation: BAG70229.1.
AL354797 Genomic DNA. Translation: CAI39471.1.
AL354797 Genomic DNA. Translation: CAI39472.1.
CH471105 Genomic DNA. Translation: EAW59036.1.
BC117208 mRNA. Translation: AAI17209.1.
BC117234 mRNA. Translation: AAI17235.1.
AL050016 mRNA. Translation: CAB43238.1.
CCDSiCCDS6775.1. [Q9UBT7-1]
CCDS69638.1. [Q9UBT7-2]
PIRiT08703.
RefSeqiNP_001273903.1. NM_001286974.1. [Q9UBT7-2]
NP_003789.1. NM_003798.3. [Q9UBT7-1]
UniGeneiHs.58488.

3D structure databases

ProteinModelPortaliQ9UBT7.
SMRiQ9UBT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114266. 13 interactors.
IntActiQ9UBT7. 13 interactors.
MINTiMINT-3002286.
STRINGi9606.ENSP00000320434.

PTM databases

iPTMnetiQ9UBT7.
PhosphoSitePlusiQ9UBT7.

Polymorphism and mutation databases

BioMutaiCTNNAL1.
DMDMi62901512.

Proteomic databases

EPDiQ9UBT7.
PaxDbiQ9UBT7.
PeptideAtlasiQ9UBT7.
PRIDEiQ9UBT7.

Protocols and materials databases

DNASUi8727.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325551; ENSP00000320434; ENSG00000119326. [Q9UBT7-1]
ENST00000374595; ENSP00000363723; ENSG00000119326. [Q9UBT7-2]
GeneIDi8727.
KEGGihsa:8727.
UCSCiuc004bdo.3. human. [Q9UBT7-1]

Organism-specific databases

CTDi8727.
DisGeNETi8727.
GeneCardsiCTNNAL1.
HGNCiHGNC:2512. CTNNAL1.
HPAiHPA066188.
MIMi604785. gene.
neXtProtiNX_Q9UBT7.
OpenTargetsiENSG00000119326.
PharmGKBiPA27011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOVERGENiHBG051219.
InParanoidiQ9UBT7.
OMAiYHADHVV.
OrthoDBiEOG091G0BL2.
PhylomeDBiQ9UBT7.
TreeFamiTF313686.

Miscellaneous databases

ChiTaRSiCTNNAL1. human.
GeneWikiiCTNNAL1.
GenomeRNAii8727.
PROiQ9UBT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119326.
CleanExiHS_CTNNAL1.
ExpressionAtlasiQ9UBT7. baseline and differential.
GenevisibleiQ9UBT7. HS.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030045. CTNNAL1.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 1 hit.
PTHR18914:SF8. PTHR18914:SF8. 1 hit.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCTNL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBT7
Secondary accession number(s): B5BU47
, O76084, Q53FQ2, Q5JTQ7, Q5JTQ8, Q9Y401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.