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Q9UBT7 (CTNL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-catulin
Alternative name(s):
Alpha-catenin-related protein
Short name=ACRP
Catenin alpha-like protein 1
Gene names
Name:CTNNAL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length734 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

Subunit structure

Interacts with ARHGEF1. Ref.12

Subcellular location

Cytoplasmcytoskeleton. Cell membrane; Peripheral membrane protein Ref.12.

Tissue specificity

Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland. Ref.1 Ref.2 Ref.12

Induction

Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis. Ref.1

Sequence similarities

Belongs to the vinculin/alpha-catenin family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UBT7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UBT7-2)

Also known as: Alpha2-catulin;

The sequence of this isoform differs from the canonical sequence as follows:
     714-734: LQMENNGWVSVTNKDTMDSKT → SETRY
Isoform 3 (identifier: Q9UBT7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     397-480: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 734734Alpha-catulin
PRO_0000064268

Amino acid modifications

Modified residue5381Phosphoserine Ref.13

Natural variations

Alternative sequence397 – 48084Missing in isoform 3.
VSP_012582
Alternative sequence714 – 73421LQMEN…MDSKT → SETRY in isoform 2.
VSP_012583
Natural variant911N → T. Ref.6
Corresponds to variant rs28361109 [ dbSNP | Ensembl ].
VAR_020924
Natural variant2031E → K. Ref.6
Corresponds to variant rs28361118 [ dbSNP | Ensembl ].
VAR_020925
Natural variant4241T → S.
Corresponds to variant rs16913734 [ dbSNP | Ensembl ].
VAR_033845
Natural variant5271E → Q. Ref.6
Corresponds to variant rs7021366 [ dbSNP | Ensembl ].
VAR_020926
Natural variant5551D → E.
Corresponds to variant rs34922868 [ dbSNP | Ensembl ].
VAR_053370
Natural variant5931I → N. Ref.6
Corresponds to variant rs28361167 [ dbSNP | Ensembl ].
VAR_020927
Natural variant7161M → R. Ref.6
Corresponds to variant rs28361182 [ dbSNP | Ensembl ].
VAR_020928

Experimental info

Sequence conflict5041F → S in BAD96950. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 8756237C73AAEA31

FASTA73481,896
        10         20         30         40         50         60 
MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 

        70         80         90        100        110        120 
SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 

       130        140        150        160        170        180 
TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 

       190        200        210        220        230        240 
LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 

       250        260        270        280        290        300 
ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 

       310        320        330        340        350        360 
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 

       370        380        390        400        410        420 
ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 

       430        440        450        460        470        480 
LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 

       490        500        510        520        530        540 
IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 

       550        560        570        580        590        600 
KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 

       610        620        630        640        650        660 
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 

       670        680        690        700        710        720 
NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG 

       730 
WVSVTNKDTM DSKT 

« Hide

Isoform 2 (Alpha2-catulin) [UniParc].

Checksum: 3FDAAE7A79BBB43E
Show »

FASTA71880,152
Isoform 3 [UniParc].

Checksum: F71E1D06CBF61593
Show »

FASTA65072,616

References

« Hide 'large scale' references
[1]"Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin."
Zhang J.-S., Nelson M., Wang L., Liu W., Qian C.-P., Shridhar V., Urrutia R., Smith D.I.
Genomics 54:149-154(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
Tissue: Pancreatic cancer.
[2]"Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing."
Janssens B., Staes K., van Roy F.M.
Biochim. Biophys. Acta 1447:341-347(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[3]Kishi M., Nagafuchi A., Tsukita S.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Isolation of a novel alpha-catenin-like gene from the familial dysautonomia candidate region on 9q31."
Slaugenhaupt S.A., Liebert C.B., Leyne M., Mull J., Gill S., Chadwick B.P., Maayan C., Axelrod F.B., Blumenfeld A., Gusella J.F.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Gastric mucosa.
[6]NIEHS SNPs program
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-91; LYS-203; GLN-527; ASN-593 AND ARG-716.
[7]"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. expand/collapse author list , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[11]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-734 (ISOFORM 3).
Tissue: Brain.
[12]"Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation."
Park B., Nguyen N.T., Dutt P., Merdek K.D., Bashar M., Sterpetti P., Tosolini A., Testa J.R., Toksoz D.
J. Biol. Chem. 277:45361-45370(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ARHGEF1.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030233 mRNA. Translation: AAC83460.1.
U97067 mRNA. Translation: AAC27693.1.
AF134888 expand/collapse EMBL AC list , AF134871, AF134873, AF134874, AF134872, AF134875, AF134877, AF134879, AF134881, AF134887, AF134886, AF134885, AF134884, AF134883, AF134882, AF134880, AF134878, AF134876 Genomic DNA. Translation: AAF07820.1.
AF134888 expand/collapse EMBL AC list , AF134871, AF134872, AF134874, AF134876, AF134878, AF134880, AF134882, AF134884, AF134887, AF134886, AF134885, AF134883, AF134881, AF134879, AF134877, AF134875, AF134873 Genomic DNA. Translation: AAF07821.1.
AF135021 mRNA. Translation: AAF07819.1.
AF006070 mRNA. Translation: AAC26011.1.
AF080071 mRNA. Translation: AAC69576.1.
AK223230 mRNA. Translation: BAD96950.1.
AY523969 Genomic DNA. Translation: AAR92479.1.
AB451283 mRNA. Translation: BAG70097.1.
AB451415 mRNA. Translation: BAG70229.1.
AL354797 Genomic DNA. Translation: CAI39471.1.
AL354797 Genomic DNA. Translation: CAI39472.1.
CH471105 Genomic DNA. Translation: EAW59036.1.
BC117208 mRNA. Translation: AAI17209.1.
BC117234 mRNA. Translation: AAI17235.1.
AL050016 mRNA. Translation: CAB43238.1.
CCDSCCDS6775.1. [Q9UBT7-1]
CCDS69638.1. [Q9UBT7-2]
PIRT08703.
RefSeqNP_001273903.1. NM_001286974.1. [Q9UBT7-2]
NP_003789.1. NM_003798.3. [Q9UBT7-1]
UniGeneHs.58488.

3D structure databases

ProteinModelPortalQ9UBT7.
SMRQ9UBT7. Positions 71-715.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114266. 5 interactions.
IntActQ9UBT7. 5 interactions.
MINTMINT-3002286.
STRING9606.ENSP00000320434.

PTM databases

PhosphoSiteQ9UBT7.

Polymorphism databases

DMDM62901512.

Proteomic databases

MaxQBQ9UBT7.
PaxDbQ9UBT7.
PRIDEQ9UBT7.

Protocols and materials databases

DNASU8727.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325551; ENSP00000320434; ENSG00000119326. [Q9UBT7-1]
ENST00000325580; ENSP00000323351; ENSG00000119326. [Q9UBT7-3]
ENST00000374595; ENSP00000363723; ENSG00000119326. [Q9UBT7-2]
GeneID8727.
KEGGhsa:8727.
UCSCuc004bdo.1. human. [Q9UBT7-1]
uc004bdp.1. human. [Q9UBT7-2]
uc010mts.1. human. [Q9UBT7-3]

Organism-specific databases

CTD8727.
GeneCardsGC09M111704.
HGNCHGNC:2512. CTNNAL1.
MIM604785. gene.
neXtProtNX_Q9UBT7.
PharmGKBPA27011.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304997.
HOVERGENHBG051219.
InParanoidQ9UBT7.
OMAITCIHAE.
OrthoDBEOG74BJRF.
PhylomeDBQ9UBT7.
TreeFamTF313686.

Gene expression databases

ArrayExpressQ9UBT7.
BgeeQ9UBT7.
CleanExHS_CTNNAL1.
GenevestigatorQ9UBT7.

Family and domain databases

InterProIPR001033. Alpha_catenin.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERPTHR18914. PTHR18914. 1 hit.
PfamPF01044. Vinculin. 3 hits.
[Graphical view]
PRINTSPR00805. ALPHACATENIN.
SUPFAMSSF47220. SSF47220. 3 hits.
ProtoNetSearch...

Other

ChiTaRSCTNNAL1. human.
GeneWikiCTNNAL1.
GenomeRNAi8727.
NextBio32739.
PROQ9UBT7.
SOURCESearch...

Entry information

Entry nameCTNL1_HUMAN
AccessionPrimary (citable) accession number: Q9UBT7
Secondary accession number(s): B5BU47 expand/collapse secondary AC list , O76084, Q53FQ2, Q5JTQ7, Q5JTQ8, Q9Y401
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM