Q9UBT7 (CTNL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-catulin

Alternative name(s):
Alpha-catenin-related protein
Short name=ACRP
Catenin alpha-like protein 1

Gene names

Name:

CTNNAL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	734 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Subunit structure	Interacts with ARHGEF1. Ref.12
Subcellular location	Cytoplasm › cytoskeleton. Cell membrane; Peripheral membrane protein Ref.12.
Tissue specificity	Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland. Ref.1 Ref.2 Ref.12
Induction	Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis. Ref.1
Sequence similarities	Belongs to the vinculin/alpha-catenin family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Inferred from direct assay Ref.12. Source: MGI cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytosol Inferred from direct assay Ref.12. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UBT7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UBT7-2)

Also known as: Alpha2-catulin;

The sequence of this isoform differs from the canonical sequence as follows:
     714-734: LQMENNGWVSVTNKDTMDSKT → SETRY

Isoform 3 (identifier: Q9UBT7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     397-480: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 734	734	Alpha-catulin		PRO_0000064268
Amino acid modifications
	Modified residue	538	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	397 – 480	84	Missing in isoform 3.		VSP_012582
	Alternative sequence	714 – 734	21	LQMEN…MDSKT → SETRY in isoform 2.		VSP_012583
	Natural variant	91	1	N → T. Ref.6 Corresponds to variant rs28361109 [ dbSNP | Ensembl ].		VAR_020924
	Natural variant	203	1	E → K. Ref.6 Corresponds to variant rs28361118 [ dbSNP | Ensembl ].		VAR_020925
	Natural variant	424	1	T → S. Corresponds to variant rs16913734 [ dbSNP | Ensembl ].		VAR_033845
	Natural variant	527	1	E → Q. Ref.6 Corresponds to variant rs7021366 [ dbSNP | Ensembl ].		VAR_020926
	Natural variant	555	1	D → E. Corresponds to variant rs34922868 [ dbSNP | Ensembl ].		VAR_053370
	Natural variant	593	1	I → N. Ref.6 Corresponds to variant rs28361167 [ dbSNP | Ensembl ].		VAR_020927
	Natural variant	716	1	M → R. Ref.6 Corresponds to variant rs28361182 [ dbSNP | Ensembl ].		VAR_020928
Experimental info
	Sequence conflict	504	1	F → S in BAD96950. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 8756237C73AAEA31	FASTA	734	81,896
	10 20 30 40 50 60 MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 70 80 90 100 110 120 SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 130 140 150 160 170 180 TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 190 200 210 220 230 240 LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 250 260 270 280 290 300 ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 310 320 330 340 350 360 MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 370 380 390 400 410 420 ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 430 440 450 460 470 480 LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 490 500 510 520 530 540 IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 550 560 570 580 590 600 KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 610 620 630 640 650 660 SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 670 680 690 700 710 720 NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG 730 WVSVTNKDTM DSKT
	Isoform 2 (Alpha2-catulin) [UniParc]. Checksum: 3FDAAE7A79BBB43E	FASTA	718	80,152
	10 20 30 40 50 60 MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 70 80 90 100 110 120 SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 130 140 150 160 170 180 TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 190 200 210 220 230 240 LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 250 260 270 280 290 300 ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 310 320 330 340 350 360 MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 370 380 390 400 410 420 ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA 430 440 450 460 470 480 LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ 490 500 510 520 530 540 IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP 550 560 570 580 590 600 KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM 610 620 630 640 650 660 SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI 670 680 690 700 710 NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKSETRY
	Isoform 3 [UniParc]. Checksum: F71E1D06CBF61593	FASTA	650	72,616
	10 20 30 40 50 60 MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK 70 80 90 100 110 120 SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI 130 140 150 160 170 180 TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER 190 200 210 220 230 240 LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT 250 260 270 280 290 300 ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK 310 320 330 340 350 360 MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL 370 380 390 400 410 420 ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKEIISA AETLTLHPSS KIAKENLDVF 430 440 450 460 470 480 CEAWESQISD MSTLLREIND VFEGRRGEKY GYLSLPKPMK NNANLKSLKP DKPDSEEQAK 490 500 510 520 530 540 IAKLGLKLGL LTSDADCEIE KWEDQENEIV QYGRNMSSMA YSLYLFTRGE GPLKTSQDLI 550 560 570 580 590 600 HQLEVFAAEG LKLTSSVQAF SKQLKDDDKL MLLLEINKLI PLCHQLQTVT KTSLQNKVFL 610 620 630 640 650 KVDKCITKTR SMMALLVQLL SLCYKLLKKL QMENNGWVSV TNKDTMDSKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin." Zhang J.-S., Nelson M., Wang L., Liu W., Qian C.-P., Shridhar V., Urrutia R., Smith D.I. Genomics 54:149-154(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION. Tissue: Pancreatic cancer.
[2]	"Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing." Janssens B., Staes K., van Roy F.M. Biochim. Biophys. Acta 1447:341-347(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[3]	Kishi M., Nagafuchi A., Tsukita S. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Isolation of a novel alpha-catenin-like gene from the familial dysautonomia candidate region on 9q31." Slaugenhaupt S.A., Liebert C.B., Leyne M., Mull J., Gill S., Chadwick B.P., Maayan C., Axelrod F.B., Blumenfeld A., Gusella J.F. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Gastric mucosa.
[6]	NIEHS SNPs program Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-91; LYS-203; GLN-527; ASN-593 AND ARG-716.
[7]	"Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N. Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[11]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-734 (ISOFORM 3). Tissue: Brain.
[12]	"Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation." Park B., Nguyen N.T., Dutt P., Merdek K.D., Bashar M., Sterpetti P., Tosolini A., Testa J.R., Toksoz D. J. Biol. Chem. 277:45361-45370(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ARHGEF1.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF030233 mRNA. Translation: AAC83460.1. U97067 mRNA. Translation: AAC27693.1. AF134888 , AF134871, AF134873, AF134874, AF134872, AF134875, AF134877, AF134879, AF134881, AF134887, AF134886, AF134885, AF134884, AF134883, AF134882, AF134880, AF134878, AF134876 Genomic DNA. Translation: AAF07820.1. AF134888 , AF134871, AF134872, AF134874, AF134876, AF134878, AF134880, AF134882, AF134884, AF134887, AF134886, AF134885, AF134883, AF134881, AF134879, AF134877, AF134875, AF134873 Genomic DNA. Translation: AAF07821.1. AF135021 mRNA. Translation: AAF07819.1. AF006070 mRNA. Translation: AAC26011.1. AF080071 mRNA. Translation: AAC69576.1. AK223230 mRNA. Translation: BAD96950.1. AY523969 Genomic DNA. Translation: AAR92479.1. AB451283 mRNA. Translation: BAG70097.1. AB451415 mRNA. Translation: BAG70229.1. AL354797 Genomic DNA. Translation: CAI39471.1. AL354797 Genomic DNA. Translation: CAI39472.1. CH471105 Genomic DNA. Translation: EAW59036.1. BC117208 mRNA. Translation: AAI17209.1. BC117234 mRNA. Translation: AAI17235.1. AL050016 mRNA. Translation: CAB43238.1.
IPI	IPI00000163. IPI00179328. IPI00549924.
PIR	T08703.
RefSeq	NP_003789.1. NM_003798.2.
UniGene	Hs.58488.
3D structure databases
ProteinModelPortal	Q9UBT7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UBT7. 4 interactions.
STRING	9606.ENSP00000320434.
PTM databases
PhosphoSite	Q9UBT7.
Polymorphism databases
DMDM	62901512.
Proteomic databases
PaxDb	Q9UBT7.
PRIDE	Q9UBT7.
Protocols and materials databases
DNASU	8727.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325551; ENSP00000320434; ENSG00000119326. ENST00000325580; ENSP00000323351; ENSG00000119326. ENST00000374595; ENSP00000363723; ENSG00000119326.
GeneID	8727.
KEGG	hsa:8727.
UCSC	uc004bdo.1. human. uc004bdp.1. human. uc010mts.1. human.
Organism-specific databases
CTD	8727.
GeneCards	GC09M111704.
HGNC	HGNC:2512. CTNNAL1.
MIM	604785. gene.
neXtProt	NX_Q9UBT7.
PharmGKB	PA27011.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG304997.
HOVERGEN	HBG051219.
InParanoid	Q9UBT7.
OMA	EITCIHA.
OrthoDB	EOG46HG98.
PhylomeDB	Q9UBT7.
Gene expression databases
ArrayExpress	Q9UBT7.
Bgee	Q9UBT7.
CleanEx	HS_CTNNAL1.
Genevestigator	Q9UBT7.
GermOnline	ENSG00000119326. Homo sapiens.
Family and domain databases
InterPro	IPR001033. Alpha_catenin. IPR006077. Vinculin/catenin. [Graphical view]
Pfam	PF01044. Vinculin. 3 hits. [Graphical view]
PRINTS	PR00805. ALPHACATENIN.
SUPFAM	SSF47220. Vinculin/catenin. 3 hits.
ProtoNet	Search...
Other
ChiTaRS	CTNNAL1. human.
GenomeRNAi	8727.
NextBio	32739.
SOURCE	Search...

Entry information

Entry name

CTNL1_HUMAN

Accession

Primary (citable) accession number: Q9UBT7
Secondary accession number(s): B5BU47 , O76084, Q53FQ2, Q5JTQ7, Q5JTQ8, Q9Y401

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.