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Protein

Alpha-catulin

Gene

CTNNAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: InterPro
  • Rho protein signal transduction Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-catulin
Alternative name(s):
Alpha-catenin-related protein
Short name:
ACRP
Catenin alpha-like protein 1
Gene namesi
Name:CTNNAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000119326.14
HGNCiHGNC:2512 CTNNAL1
MIMi604785 gene
neXtProtiNX_Q9UBT7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8727
OpenTargetsiENSG00000119326
PharmGKBiPA27011

Polymorphism and mutation databases

BioMutaiCTNNAL1
DMDMi62901512

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642681 – 734Alpha-catulinAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei374PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBT7
PaxDbiQ9UBT7
PeptideAtlasiQ9UBT7
PRIDEiQ9UBT7

PTM databases

iPTMnetiQ9UBT7
PhosphoSitePlusiQ9UBT7

Expressioni

Tissue specificityi

Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.3 Publications

Inductioni

Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.1 Publication

Gene expression databases

BgeeiENSG00000119326
CleanExiHS_CTNNAL1
ExpressionAtlasiQ9UBT7 baseline and differential
GenevisibleiQ9UBT7 HS

Interactioni

Subunit structurei

Interacts with ARHGEF1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114266, 21 interactors
CORUMiQ9UBT7
DIPiDIP-33236N
IntActiQ9UBT7, 16 interactors
MINTiQ9UBT7
STRINGi9606.ENSP00000320434

Structurei

3D structure databases

ProteinModelPortaliQ9UBT7
SMRiQ9UBT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

eggNOGiKOG3681 Eukaryota
ENOG410XSRU LUCA
GeneTreeiENSGT00550000074411
HOVERGENiHBG051219
InParanoidiQ9UBT7
OMAiYHADHVV
OrthoDBiEOG091G0BL2
PhylomeDBiQ9UBT7
TreeFamiTF313686

Family and domain databases

InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR001033 Alpha_catenin
IPR030045 CTNNAL1
IPR006077 Vinculin/catenin
PANTHERiPTHR18914 PTHR18914, 1 hit
PTHR18914:SF8 PTHR18914:SF8, 1 hit
PfamiView protein in Pfam
PF01044 Vinculin, 2 hits
PRINTSiPR00805 ALPHACATENIN
SUPFAMiSSF47220 SSF47220, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT
60 70 80 90 100
LINHKDNTKK SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI
110 120 130 140 150
NIACIEAKQA GETIAALTDI TNLNHLESDG QITIFTDKTG VIKAARLLLS
160 170 180 190 200
SVTKVLLLAD RVVIKQIITS RNKVLATMER LEKVNSFQEF VQIFSQFGNE
210 220 230 240 250
MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT ASKTCLRHPN
260 270 280 290 300
CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK
310 320 330 340 350
MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS
360 370 380 390 400
TQARMELQQL ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST
410 420 430 440 450
ATQLAADLLK YHADHVVLKA LKLTGVEGNL EALAEYACKL SEQKEQLVET
460 470 480 490 500
CRLLRHISGT EPLEITCIHA EETFQVTGQQ IISAAETLTL HPSSKIAKEN
510 520 530 540 550
LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP KPMKNNANLK
560 570 580 590 600
SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM
610 620 630 640 650
SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD
660 670 680 690 700
DDKLMLLLEI NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL
710 720 730
VQLLSLCYKL LKKLQMENNG WVSVTNKDTM DSKT
Length:734
Mass (Da):81,896
Last modified:February 1, 2005 - v2
Checksum:i8756237C73AAEA31
GO
Isoform 2 (identifier: Q9UBT7-2) [UniParc]FASTAAdd to basket
Also known as: Alpha2-catulin

The sequence of this isoform differs from the canonical sequence as follows:
     714-734: LQMENNGWVSVTNKDTMDSKT → SETRY

Show »
Length:718
Mass (Da):80,152
Checksum:i3FDAAE7A79BBB43E
GO
Isoform 3 (identifier: Q9UBT7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-480: Missing.

Show »
Length:650
Mass (Da):72,616
Checksum:iF71E1D06CBF61593
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti504F → S in BAD96950 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02092491N → T1 PublicationCorresponds to variant dbSNP:rs28361109Ensembl.1
Natural variantiVAR_020925203E → K1 PublicationCorresponds to variant dbSNP:rs28361118Ensembl.1
Natural variantiVAR_033845424T → S. Corresponds to variant dbSNP:rs16913734Ensembl.1
Natural variantiVAR_020926527E → Q1 PublicationCorresponds to variant dbSNP:rs7021366Ensembl.1
Natural variantiVAR_053370555D → E. Corresponds to variant dbSNP:rs34922868Ensembl.1
Natural variantiVAR_020927593I → N1 PublicationCorresponds to variant dbSNP:rs28361167Ensembl.1
Natural variantiVAR_020928716M → R1 PublicationCorresponds to variant dbSNP:rs28361182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012582397 – 480Missing in isoform 3. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_012583714 – 734LQMEN…MDSKT → SETRY in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030233 mRNA Translation: AAC83460.1
U97067 mRNA Translation: AAC27693.1
AF134888
, AF134871, AF134873, AF134874, AF134872, AF134875, AF134877, AF134879, AF134881, AF134887, AF134886, AF134885, AF134884, AF134883, AF134882, AF134880, AF134878, AF134876 Genomic DNA Translation: AAF07820.1
AF134888
, AF134871, AF134872, AF134874, AF134876, AF134878, AF134880, AF134882, AF134884, AF134887, AF134886, AF134885, AF134883, AF134881, AF134879, AF134877, AF134875, AF134873 Genomic DNA Translation: AAF07821.1
AF135021 mRNA Translation: AAF07819.1
AF006070 mRNA Translation: AAC26011.1
AF080071 mRNA Translation: AAC69576.1
AK223230 mRNA Translation: BAD96950.1
AY523969 Genomic DNA Translation: AAR92479.1
AB451283 mRNA Translation: BAG70097.1
AB451415 mRNA Translation: BAG70229.1
AL354797 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59036.1
BC117208 mRNA Translation: AAI17209.1
BC117234 mRNA Translation: AAI17235.1
AL050016 mRNA Translation: CAB43238.1
CCDSiCCDS6775.1 [Q9UBT7-1]
CCDS69638.1 [Q9UBT7-2]
PIRiT08703
RefSeqiNP_001273903.1, NM_001286974.1 [Q9UBT7-2]
NP_003789.1, NM_003798.3 [Q9UBT7-1]
UniGeneiHs.58488

Genome annotation databases

EnsembliENST00000325551; ENSP00000320434; ENSG00000119326 [Q9UBT7-1]
ENST00000374595; ENSP00000363723; ENSG00000119326 [Q9UBT7-2]
GeneIDi8727
KEGGihsa:8727
UCSCiuc004bdo.3 human [Q9UBT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiCTNL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBT7
Secondary accession number(s): B5BU47
, O76084, Q53FQ2, Q5JTQ7, Q5JTQ8, Q9Y401
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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