ID   DKK4_HUMAN              Reviewed;         224 AA.
AC   Q9UBT3; Q3KNX0; Q9Y4C3;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   07-JUL-2009, entry version 68.
DE   RecName: Full=Dickkopf-related protein 4;
DE            Short=Dickkopf-4;
DE            Short=Dkk-4;
DE            Short=hDkk-4;
DE   Contains:
DE     RecName: Full=Dickkopf-related protein 4 short form;
DE   Flags: Precursor;
GN   Name=DKK4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-28 AND 134-144, AND
RP   PROTEOLYTIC PROCESSING.
RX   MEDLINE=20035735; PubMed=10570958; DOI=10.1016/S0378-1119(99)00365-0;
RA   Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W.,
RA   Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B.,
RA   Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A.;
RT   "Functional and structural diversity of the human Dickkopf gene
RT   family.";
RL   Gene 238:301-313(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Tate G., Mitsuya T.;
RT   "Human Dickkopf as well as DAN family members, Cerberus and Gremlin,
RT   are preferentially expressed in the epithelial malignant cell lines.";
RL   J. Biochem. Mol. Biol. Biophys. 3:239-242(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 19-33.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Inhibitor of Wnt signaling pathway.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in cerebellum, T-cells, esophagus
CC       and lung.
CC   -!- PTM: Appears to be not glycosylated.
CC   -!- PTM: Can be proteolytically processed by a furin-like protease.
CC   -!- SIMILARITY: Belongs to the dickkopf family.
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DR   EMBL; AF177397; AAF02677.1; -; mRNA.
DR   EMBL; AB018005; BAA33475.1; -; Genomic_DNA.
DR   EMBL; AB017788; BAA33438.1; -; mRNA.
DR   EMBL; BC107046; AAI07047.1; -; mRNA.
DR   EMBL; BC107047; AAI07048.1; -; mRNA.
DR   IPI; IPI00002771; -.
DR   RefSeq; NP_055235.1; -.
DR   UniGene; Hs.159311; -.
DR   HSSP; P25687; 1IMT.
DR   PRIDE; Q9UBT3; -.
DR   Ensembl; ENSG00000104371; Homo sapiens.
DR   GeneID; 27121; -.
DR   KEGG; hsa:27121; -.
DR   UCSC; uc003xpb.1; human.
DR   GeneCards; GC08M042350; -.
DR   H-InvDB; HIX0034234; -.
DR   HGNC; HGNC:2894; DKK4.
DR   MIM; 605417; gene.
DR   PharmGKB; PA27348; -.
DR   HOGENOM; Q9UBT3; -.
DR   HOVERGEN; Q9UBT3; -.
DR   OMA; Q9UBT3; GSQCLSD.
DR   NextBio; 49808; -.
DR   ArrayExpress; Q9UBT3; -.
DR   Bgee; Q9UBT3; -.
DR   CleanEx; HS_DKK4; -.
DR   GermOnline; ENSG00000104371; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   GO; GO:0030178; P:negative regulation of Wnt receptor signali...; NAS:UniProtKB.
DR   GO; GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR009523; Prokineticin.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Complete proteome;
KW   Developmental protein; Direct protein sequencing; Secreted; Signal;
KW   Wnt signaling pathway.
FT   SIGNAL        1     18
FT   CHAIN        19    224       Dickkopf-related protein 4.
FT                                /FTId=PRO_0000007225.
FT   CHAIN       134    224       Dickkopf-related protein 4 short form.
FT                                /FTId=PRO_0000007226.
FT   REGION       41     90       DKK-type Cys-1.
FT   REGION      145    218       DKK-type Cys-2.
FT   CONFLICT     93     93       M -> L (in Ref. 2; BAA33438).
SQ   SEQUENCE   224 AA;  24876 MW;  45F8EBC476961357 CRC64;
     MVAAVLLGLS WLCSPLGALV LDFNNIRSSA DLHGARKGSQ CLSDTDCNTR KFCLQPRDEK
     PFCATCRGLR RRCQRDAMCC PGTLCVNDVC TTMEDATPIL ERQLDEQDGT HAEGTTGHPV
     QENQPKRKPS IKKSQGRKGQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG
     HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL
//