Reviewed, UniProtKB/Swiss-Prot Q9UBT3 (DKK4_HUMAN)

Names and origin

Protein names

Recommended name:
    Dickkopf-related protein 4
      Short name=Dickkopf-4
      Short name=Dkk-4
      Short name=hDkk-4
Cleaved into the following chain:
    1- Recommended name:
            Dickkopf-related protein 4 short form

Gene names

Name:

DKK4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibitor of Wnt signaling pathway.
Subcellular location	Secreted.
Tissue specificity	Expressed in cerebellum, T-cells, esophagus and lung.
Post-translational modification	Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease.
Sequence similarities	Belongs to the dickkopf family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Cleavage on pair of basic residues
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of Wnt receptor signaling pathway Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Ref.1 Ref.4
	Chain	19 – 224	206	Dickkopf-related protein 4		PRO_0000007225
	Chain	134 – 224	91	Dickkopf-related protein 4 short form		PRO_0000007226
Regions
	Region	41 – 90	50	DKK-type Cys-1
	Region	145 – 218	74	DKK-type Cys-2
Experimental info
	Sequence conflict	93	1	M → L in BAA33438. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UBT3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 45F8EBC476961357	FASTA	224	24,876
	10 20 30 40 50 60 MVAAVLLGLS WLCSPLGALV LDFNNIRSSA DLHGARKGSQ CLSDTDCNTR KFCLQPRDEK 70 80 90 100 110 120 PFCATCRGLR RRCQRDAMCC PGTLCVNDVC TTMEDATPIL ERQLDEQDGT HAEGTTGHPV 130 140 150 160 170 180 QENQPKRKPS IKKSQGRKGQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG 190 200 210 220 HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional and structural diversity of the human Dickkopf gene family." Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A. Gene 238:301-313(1999) [PubMed: 10570958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-28 AND 134-144, PROTEOLYTIC PROCESSING.
[2]	"Human Dickkopf as well as DAN family members, Cerberus and Gremlin, are preferentially expressed in the epithelial malignant cell lines." Tate G., Mitsuya T. J. Biochem. Mol. Biol. Biophys. 3:239-242(1999) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-33.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF177397 mRNA. Translation: AAF02677.1. AB018005 Genomic DNA. Translation: BAA33475.1. AB017788 mRNA. Translation: BAA33438.1. BC107046 mRNA. Translation: AAI07047.1. BC107047 mRNA. Translation: AAI07048.1.
IPI	IPI00002771.
RefSeq	NP_055235.1.
UniGene	Hs.159311
3D structure databases
HSSP	HSSP built from PDB template 1IMT based on UniProtKB P25687.
ModBase	Search...
Proteomic databases
PRIDE	Q9UBT3.
Genome annotation databases
Ensembl	ENSG00000104371. Homo sapiens. [Contig view]
GeneID	27121.
KEGG	hsa:27121.
Organism-specific databases
GeneCards	GC08M042350.
H-InvDB	HIX0034234.
HGNC	HGNC:2894. DKK4.
MIM	605417. gene.
PharmGKB	PA27348.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UBT3.
HOVERGEN	Q9UBT3.
OMA	Q9UBT3. GSQCLSD.
Gene expression databases
ArrayExpress	Q9UBT3.
Bgee	Q9UBT3.
CleanEx	HS_DKK4.
GermOnline	ENSG00000104371. Homo sapiens.
Family and domain databases
InterPro	IPR006796. Dickkopf_N. IPR009523. Prokineticin. [Graphical view]
Pfam	PF04706. Dickkopf_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	49808.
SOURCE	Search...

Entry information

Entry name

DKK4_HUMAN

Accession

Primary (citable) accession number: Q9UBT3
Secondary accession number(s): Q3KNX0, Q9Y4C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)