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Q9UBT1

- Q9UBT1_HUMAN

UniProt

Q9UBT1 - Q9UBT1_HUMAN

Protein
Submitted name:

Estrogen receptor

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

    GO - Biological processi

    1. androgen metabolic process Source: Ensembl
    2. antral ovarian follicle growth Source: Ensembl
    3. cellular response to estrogen stimulus Source: Ensembl
    4. epithelial cell development Source: Ensembl
    5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
    6. male gonad development Source: Ensembl
    7. mammary gland alveolus development Source: Ensembl
    8. mammary gland branching involved in pregnancy Source: Ensembl
    9. positive regulation of fibroblast proliferation Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    12. prostate epithelial cord elongation Source: Ensembl
    13. regulation of apoptotic process Source: Ensembl
    14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
    15. uterus development Source: Ensembl
    16. vagina development Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Estrogen receptorImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA156.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBT1.

    Family & Domainsi

    Phylogenomic databases

    KOiK08550.

    Sequencei

    Sequence statusi: Fragment.

    Q9UBT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMTLHTKAS GMALLHQIQG NEL                                23
    Length:23
    Mass (Da):2,526
    Last modified:May 1, 2000 - v1
    Checksum:i4A678094301081FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei23 – 231Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68067 mRNA. Translation: AAC51874.1.
    U68068 mRNA. Translation: AAC51875.1.
    RefSeqiNP_001116212.1. NM_001122740.1.
    UniGeneiHs.208124.
    Hs.744830.

    Genome annotation databases

    GeneIDi2099.
    KEGGihsa:2099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68067 mRNA. Translation: AAC51874.1 .
    U68068 mRNA. Translation: AAC51875.1 .
    RefSeqi NP_001116212.1. NM_001122740.1.
    UniGenei Hs.208124.
    Hs.744830.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 2099.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2099.
    KEGGi hsa:2099.

    Organism-specific databases

    CTDi 2099.
    PharmGKBi PA156.

    Phylogenomic databases

    KOi K08550.

    Miscellaneous databases

    GenomeRNAii 2099.
    NextBioi 8491.

    Gene expression databases

    ArrayExpressi Q9UBT1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A."
      Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., Chambon P.
      Nature 320:134-139(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    2. "Sequence and expression of human estrogen receptor complementary DNA."
      Greene G.L., Gilna P., Waterfield M., Baker A., Hort Y., Shine J.
      Science 231:1150-1154(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    3. "Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene."
      Keaveney M., Klug J., Dawson M.T., Nestor P.V., Neilan J.G., Forde R.C., Gannon F.
      J. Mol. Endocrinol. 6:111-115(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    4. "Analysis of upstream sequences of the human estrogen receptor gene."
      Piva R., Gambari R., Zorzato F., Kumar L., del Senno L.
      Biochem. Biophys. Res. Commun. 183:996-1002(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    5. "Sequence analysis of the 5' flanking region of the human estrogen receptor gene."
      Keaveney M., Klug J., Gannon F.
      DNA Seq. 2:347-358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    6. "Sequencing of an RNA transcript of the human estrogen receptor gene: evidence for a new transcriptional event."
      Piva R., Bianchi N., Aguiari G.L., Gambari R., del Senno L.
      J. Steroid Biochem. Mol. Biol. 46:531-538(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    7. "Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoform."
      Grandien K.
      Mol. Cell. Endocrinol. 116:207-212(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
      Tissue: Breast adenocarcinomaImported.
    8. "Identification of two estrogen receptor transcripts with novel 5' exons isolated from a MCF7 cDNA library."
      Thompson D.A., McPherson L.A., Carmeci C., deConinck E.C., Weigel R.J.
      J. Steroid Biochem. Mol. Biol. 62:143-153(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Breast adenocarcinomaImported.

    Entry informationi

    Entry nameiQ9UBT1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBT1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.