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Protein
Submitted name:

Estrogen receptor

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

GO - Biological processi

  1. androgen metabolic process Source: Ensembl
  2. antral ovarian follicle growth Source: Ensembl
  3. cellular response to estrogen stimulus Source: Ensembl
  4. epithelial cell development Source: Ensembl
  5. epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  6. male gonad development Source: Ensembl
  7. mammary gland alveolus development Source: Ensembl
  8. mammary gland branching involved in pregnancy Source: Ensembl
  9. positive regulation of fibroblast proliferation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  12. prostate epithelial cord elongation Source: Ensembl
  13. regulation of apoptotic process Source: Ensembl
  14. regulation of branching involved in prostate gland morphogenesis Source: Ensembl
  15. uterus development Source: Ensembl
  16. vagina development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptorImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA156.

Expressioni

Gene expression databases

BgeeiQ9UBT1.
ExpressionAtlasiQ9UBT1. baseline and differential.

Family & Domainsi

Phylogenomic databases

KOiK08550.

Sequencei

Sequence statusi: Fragment.

Q9UBT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MTMTLHTKAS GMALLHQIQG NEL
Length:23
Mass (Da):2,526
Last modified:May 1, 2000 - v1
Checksum:i4A678094301081FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei23 – 231Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68067 mRNA. Translation: AAC51874.1.
U68068 mRNA. Translation: AAC51875.1.
RefSeqiNP_001116212.1. NM_001122740.1.
UniGeneiHs.208124.
Hs.744830.

Genome annotation databases

GeneIDi2099.
KEGGihsa:2099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68067 mRNA. Translation: AAC51874.1.
U68068 mRNA. Translation: AAC51875.1.
RefSeqiNP_001116212.1. NM_001122740.1.
UniGeneiHs.208124.
Hs.744830.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi2099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2099.
KEGGihsa:2099.

Organism-specific databases

CTDi2099.
PharmGKBiPA156.

Phylogenomic databases

KOiK08550.

Miscellaneous databases

GenomeRNAii2099.
NextBioi8491.

Gene expression databases

BgeeiQ9UBT1.
ExpressionAtlasiQ9UBT1. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A."
    Green S., Walter P., Kumar V., Krust A., Bornert J.M., Argos P., Chambon P.
    Nature 320:134-139(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  2. "Sequence and expression of human estrogen receptor complementary DNA."
    Greene G.L., Gilna P., Waterfield M., Baker A., Hort Y., Shine J.
    Science 231:1150-1154(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  3. "Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene."
    Keaveney M., Klug J., Dawson M.T., Nestor P.V., Neilan J.G., Forde R.C., Gannon F.
    J. Mol. Endocrinol. 6:111-115(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  4. "Analysis of upstream sequences of the human estrogen receptor gene."
    Piva R., Gambari R., Zorzato F., Kumar L., del Senno L.
    Biochem. Biophys. Res. Commun. 183:996-1002(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  5. "Sequence analysis of the 5' flanking region of the human estrogen receptor gene."
    Keaveney M., Klug J., Gannon F.
    DNA Seq. 2:347-358(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  6. "Sequencing of an RNA transcript of the human estrogen receptor gene: evidence for a new transcriptional event."
    Piva R., Bianchi N., Aguiari G.L., Gambari R., del Senno L.
    J. Steroid Biochem. Mol. Biol. 46:531-538(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  7. "Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoform."
    Grandien K.
    Mol. Cell. Endocrinol. 116:207-212(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-17.
    Tissue: Breast adenocarcinomaImported.
  8. "Identification of two estrogen receptor transcripts with novel 5' exons isolated from a MCF7 cDNA library."
    Thompson D.A., McPherson L.A., Carmeci C., deConinck E.C., Weigel R.J.
    J. Steroid Biochem. Mol. Biol. 62:143-153(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Breast adenocarcinomaImported.

Entry informationi

Entry nameiQ9UBT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBT1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.