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Q9UBS9 (SUCO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SUN domain-containing ossification factor
Alternative name(s):
Membrane protein CH1
Protein osteopotentia homolog
SUN-like protein 1
Gene names
Name:SUCO
Synonyms:C1orf9, CH1, OPT, SLP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation By similarity.

Subcellular location

Rough endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Highly expressed in pancreas and testis and to a lower extent in prostate, ovary, heart, thymus, small intestine and spleen. Ref.1

Sequence similarities

Contains 1 SUN domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UBS9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UBS9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGFLARPFL...SGRGKKEEKM
     60-96: Missing.
     421-427: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 12541225SUN domain-containing ossification factor
PRO_5000065707

Regions

Transmembrane1011 – 103121Helical; Potential
Domain284 – 453170SUN
Coiled coil909 – 1009101 Potential

Amino acid modifications

Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Glycosylation9281N-linked (GlcNAc...) Potential
Glycosylation9551N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence11M → MRGFLARPFLSTNQHLAQWG SPLPQGKGLVQLPSQHTRHS RPFHELCSKEENSATVPKLI SLVVSSETIDFSNKTMDSRR DWEREKRILEGKLQLPKALA RTQRARDEGRAWTSRWLQRR RSPESCEAPLSAPLWGPQRG LPGREPLRSRSASAIALRTI GHILALLLRLLHLGLGSGGC REDVPPSGRGKKEEKM in isoform 2.
VSP_027921
Alternative sequence60 – 9637Missing in isoform 2.
VSP_027922
Alternative sequence421 – 4277Missing in isoform 2.
VSP_027923

Experimental info

Sequence conflict4521S → N in AAF04619. Ref.2
Sequence conflict8111V → M in AAF04619. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4EBA1ABCC27DAAB1

FASTA1,254139,430
        10         20         30         40         50         60 
MKKHRRALAL VSCLFLCSLV WLPSWRVCCK ESSSASASSY YSQDDNCALE NEDVQFQKKD 

        70         80         90        100        110        120 
EREGPINAES LGKSGSNLPI SPKEHKLKDD SIVDVQNTES KKLSPPVVET LPTVDLHEES 

       130        140        150        160        170        180 
SNAVVDSETV ENISSSSTSE ITPISKLDEI EKSGTIPIAK PSETEQSETD CDVGEALDAS 

       190        200        210        220        230        240 
APIEQPSFVS PPDSLVGQHI ENVSSSHGKG KITKSEFESK VSASEQGGGD PKSALNASDN 

       250        260        270        280        290        300 
LKNESSDYTK PGDIDPTSVA SPKDPEDIPT FDEWKKKVME VEKEKSQSMH ASSNGGSHAT 

       310        320        330        340        350        360 
KKVQKNRNNY ASVECGAKIL AANPEAKSTS AILIENMDLY MLNPCSTKIW FVIELCEPIQ 

       370        380        390        400        410        420 
VKQLDIANYE LFSSTPKDFL VSISDRYPTN KWIKLGTFHG RDERNVQSFP LDEQMYAKYV 

       430        440        450        460        470        480 
KMFIKYIKVE LLSHFGSEHF CPLSLIRVFG TSMVEEYEEI ADSQYHSERQ ELFDEDYDYP 

       490        500        510        520        530        540 
LDYNTGEDKS SKNLLGSATN AILNMVNIAA NILGAKTEDL TEGNKSISEN ATATAAPKMP 

       550        560        570        580        590        600 
ESTPVSTPVP SPEYVTTEVH THDMEPSTPD TPKESPIVQL VQEEEEEASP STVTLLGSGE 

       610        620        630        640        650        660 
QEDESSPWFE SETQIFCSEL TTICCISSFS EYIYKWCSVR VALYRQRSRT ALSKGKDYLV 

       670        680        690        700        710        720 
LAQPPLLLPA ESVDVSVLQP LSGELENTNI EREAETVVLG DLSSSMHQDD LVNHTVDAVE 

       730        740        750        760        770        780 
LEPSHSQTLS QSLLLDITPE INPLPKIEVS ESVEYEAGHI PSPVIPQESS VEIDNETEQK 

       790        800        810        820        830        840 
SESFSSIEKP SITYETNKVN ELMDNIIKED VNSMQIFTKL SETIVPPINT ATVPDNEDGE 

       850        860        870        880        890        900 
AKMNIADTAK QTLISVVDSS SLPEVKEEEQ SPEDALLRGL QRTATDFYAE LQNSTDLGYA 

       910        920        930        940        950        960 
NGNLVHGSNQ KESVFMRLNN RIKALEVNMS LSGRYLEELS QRYRKQMEEM QKAFNKTIVK 

       970        980        990       1000       1010       1020 
LQNTSRIAEE QDQRQTEAIQ LLQAQLTNMT QLVSNLSATV AELKREVSDR QSYLVISLVL 

      1030       1040       1050       1060       1070       1080 
CVVLGLMLCM QRCRNTSQFD GDYISKLPKS NQYPSPKRCF SSYDDMNLKR RTSFPLMRSK 

      1090       1100       1110       1120       1130       1140 
SLQLTGKEVD PNDLYIVEPL KFSPEKKKKR CKYKIEKIET IKPEEPLHPI ANGDIKGRKP 

      1150       1160       1170       1180       1190       1200 
FTNQRDFSNM GEVYHSSYKG PPSEGSSETS SQSEESYFCG ISACTSLCNG QSQKTKTEKR 

      1210       1220       1230       1240       1250 
ALKRRRSKVQ DQGKLIKTLI QTKSGSLPSL HDIIKGNKEI TVGTFGVTAV SGHI 

« Hide

Isoform 2 [UniParc].

Checksum: FA5EB6BA78F4A6DD
Show »

FASTA1,405156,418

References

« Hide 'large scale' references
[1]"The C1orf9 gene encodes a putative transmembrane member of a novel protein family."
Roesok O., Pedeutour F., Odeberg J., Lundeberg J., Aasheim H.-C.
Biochem. Biophys. Res. Commun. 267:855-862(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Cloning of an overexpressed gene on chromosome 1 in breast cancer defines a new gene family."
Chen L.-C., Cheung J., Moore D., Ljung B.-M., Kuo W.-L., Collins C., Gray J.W., Smith H.S.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Mammary gland.
[3]Rhodes S.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[7]"Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1."
Yu N., Zhao Z., Fu Y.-X., Sambuughin N., Ramsay M., Jenkins T., Leskinen E., Patthy L., Jorde L.B., Kuromori T., Li W.-H.
Mol. Biol. Evol. 18:214-222(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-244.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250075 mRNA. Translation: CAB57360.1.
AF097535 mRNA. Translation: AAF04619.1.
AL035291 mRNA. Translation: CAA22894.1.
Z96050, Z94054 Genomic DNA. Translation: CAI19034.1.
Z94054, Z96050 Genomic DNA. Translation: CAI19460.1.
BC137125 mRNA. Translation: AAI37126.1.
CH471067 Genomic DNA. Translation: EAW90931.1.
AF310265 Genomic DNA. Translation: AAK28742.1.
AF310266 Genomic DNA. Translation: AAK28743.1.
AF310267 Genomic DNA. Translation: AAK28744.1.
AF310268 Genomic DNA. Translation: AAK28745.1.
AF310269 Genomic DNA. Translation: AAK28746.1.
AF310270 Genomic DNA. Translation: AAK28747.1.
AF310271 Genomic DNA. Translation: AAK28748.1.
AF310272 Genomic DNA. Translation: AAK28749.1.
AF310273 Genomic DNA. Translation: AAK28750.1.
AF310274 Genomic DNA. Translation: AAK28751.1.
AF310275 Genomic DNA. Translation: AAK28752.1.
AF310276 Genomic DNA. Translation: AAK28753.1.
AF310277 Genomic DNA. Translation: AAK28754.1.
AF310278 Genomic DNA. Translation: AAK28755.1.
AF310279 Genomic DNA. Translation: AAK28756.1.
AF310280 Genomic DNA. Translation: AAK28757.1.
AF310281 Genomic DNA. Translation: AAK28758.1.
AF310282 Genomic DNA. Translation: AAK28759.1.
AF310283 Genomic DNA. Translation: AAK28760.1.
AF310284 Genomic DNA. Translation: AAK28761.1.
AF310285 Genomic DNA. Translation: AAK28762.1.
AF310286 Genomic DNA. Translation: AAK28763.1.
AF310287 Genomic DNA. Translation: AAK28764.1.
AF310288 Genomic DNA. Translation: AAK28765.1.
AF310289 Genomic DNA. Translation: AAK28766.1.
AF310290 Genomic DNA. Translation: AAK28767.1.
AF310291 Genomic DNA. Translation: AAK28768.1.
AF310292 Genomic DNA. Translation: AAK28769.1.
AF310293 Genomic DNA. Translation: AAK28770.1.
AF310294 Genomic DNA. Translation: AAK28771.1.
AF310295 Genomic DNA. Translation: AAK28772.1.
AF310296 Genomic DNA. Translation: AAK28773.1.
AF310297 Genomic DNA. Translation: AAK28774.1.
AF310298 Genomic DNA. Translation: AAK28775.1.
AF310299 Genomic DNA. Translation: AAK28776.1.
AF310300 Genomic DNA. Translation: AAK28777.1.
AF310301 Genomic DNA. Translation: AAK28778.1.
AF310302 Genomic DNA. Translation: AAK28779.1.
AF310303 Genomic DNA. Translation: AAK28780.1.
AF310304 Genomic DNA. Translation: AAK28781.1.
AF310305 Genomic DNA. Translation: AAK28782.1.
AF310306 Genomic DNA. Translation: AAK28783.1.
AF310307 Genomic DNA. Translation: AAK28784.1.
AF310308 Genomic DNA. Translation: AAK28785.1.
AF310309 Genomic DNA. Translation: AAK28786.1.
AF310310 Genomic DNA. Translation: AAK28787.1.
AF310311 Genomic DNA. Translation: AAK28788.1.
AF310312 Genomic DNA. Translation: AAK28789.1.
AF310313 Genomic DNA. Translation: AAK28790.1.
AF310314 Genomic DNA. Translation: AAK28791.1.
AF310315 Genomic DNA. Translation: AAK28792.1.
AF310316 Genomic DNA. Translation: AAK28793.1.
AF310317 Genomic DNA. Translation: AAK28794.1.
AF310318 Genomic DNA. Translation: AAK28795.1.
AF310319 Genomic DNA. Translation: AAK28796.1.
AF310320 Genomic DNA. Translation: AAK28797.1.
AF310321 Genomic DNA. Translation: AAK28798.1.
AF310322 Genomic DNA. Translation: AAK28799.1.
AF310323 Genomic DNA. Translation: AAK28800.1.
AF310324 Genomic DNA. Translation: AAK28801.1.
AF310325 Genomic DNA. Translation: AAK28802.1.
PIRJC7185.
RefSeqNP_001269679.1. NM_001282750.1.
NP_001269680.1. NM_001282751.1.
NP_055098.1. NM_014283.4.
NP_057311.3. NM_016227.3.
UniGeneHs.204559.

3D structure databases

ProteinModelPortalQ9UBS9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119536. 2 interactions.
STRING9606.ENSP00000263688.

Polymorphism databases

DMDM74761893.

Proteomic databases

PaxDbQ9UBS9.
PRIDEQ9UBS9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263688; ENSP00000263688; ENSG00000094975. [Q9UBS9-1]
ENST00000367723; ENSP00000356696; ENSG00000094975. [Q9UBS9-2]
GeneID51430.
KEGGhsa:51430.
UCSCuc001giq.4. human. [Q9UBS9-1]
uc009wwd.3. human. [Q9UBS9-2]

Organism-specific databases

CTD51430.
GeneCardsGC01P172502.
HGNCHGNC:1240. SUCO.
HPAHPA047251.
neXtProtNX_Q9UBS9.
PharmGKBPA25621.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314762.
HOGENOMHOG000070169.
HOVERGENHBG107549.
PhylomeDBQ9UBS9.
TreeFamTF105817.

Gene expression databases

ArrayExpressQ9UBS9.
BgeeQ9UBS9.
CleanExHS_C1orf9.
GenevestigatorQ9UBS9.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR012919. Sad1_UNC_C.
[Graphical view]
PfamPF07738. Sad1_UNC. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
PROSITEPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC1orf9. human.
GenomeRNAi51430.
NextBio54995.
PROQ9UBS9.

Entry information

Entry nameSUCO_HUMAN
AccessionPrimary (citable) accession number: Q9UBS9
Secondary accession number(s): B2RNU4 expand/collapse secondary AC list , Q9BQB9, Q9BXQ2, Q9UL04
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM