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Q9UBS8

- RNF14_HUMAN

UniProt

Q9UBS8 - RNF14_HUMAN

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Protein

E3 ubiquitin-protein ligase RNF14

Gene

RNF14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri220 – 27051RING-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 35062IBR-typeAdd
BLAST
Zinc fingeri404 – 43330RING-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. androgen receptor binding Source: UniProtKB
  2. small conjugating protein ligase activity Source: UniProtKB
  3. transcription coactivator activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. androgen receptor signaling pathway Source: UniProtKB
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. protein ubiquitination Source: UniProtKB
  4. regulation of androgen receptor signaling pathway Source: UniProtKB
  5. regulation of transcription, DNA-templated Source: UniProtKB
  6. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  7. response to estradiol Source: BHF-UCL
  8. signal transduction Source: UniProtKB
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF14 (EC:6.3.2.-)
Alternative name(s):
Androgen receptor-associated protein 54
HFB30
RING finger protein 14
Triad2 protein
Gene namesi
Name:RNF14
Synonyms:ARA54
ORF Names:HRIHFB2038
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:10058. RNF14.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi220 – 2201C → S: Loss of interaction with UBE2E2 and of autoubiquitination. 1 Publication

Organism-specific databases

PharmGKBiPA34423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474E3 ubiquitin-protein ligase RNF14PRO_0000056057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei348 – 3481Phosphoserine1 Publication

Post-translational modificationi

RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9UBS8.
PaxDbiQ9UBS8.
PRIDEiQ9UBS8.

PTM databases

PhosphoSiteiQ9UBS8.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9UBS8.
CleanExiHS_RNF14.
ExpressionAtlasiQ9UBS8. baseline and differential.
GenevestigatoriQ9UBS8.

Organism-specific databases

HPAiHPA008716.

Interactioni

Subunit structurei

Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor; testosterone- and RNF6-regulated it promotes AR transcriptional activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102752EBI-2130308,EBI-608057

Protein-protein interaction databases

BioGridi114968. 26 interactions.
IntActiQ9UBS8. 16 interactions.
MINTiMINT-1187964.
STRINGi9606.ENSP00000324956.

Structurei

3D structure databases

ProteinModelPortaliQ9UBS8.
SMRiQ9UBS8. Positions 188-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 137127RWDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni361 – 474114Interaction with androgen receptorAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili351 – 39545Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459D-box

Domaini

The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity
The RING-type zinc finger is essential for the interaction with UBE2E2.

Sequence similaritiesi

Belongs to the RBR family. RNF14 subfamily.Curated
Contains 1 IBR-type zinc finger.Curated
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 RWD domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri220 – 27051RING-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 35062IBR-typeAdd
BLAST
Zinc fingeri404 – 43330RING-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG266709.
GeneTreeiENSGT00750000117406.
HOVERGENiHBG057296.
InParanoidiQ9UBS8.
KOiK11971.
OMAiQYFCWLC.
PhylomeDBiQ9UBS8.
TreeFamiTF314401.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF01485. IBR. 2 hits.
PF05773. RWD. 1 hit.
[Graphical view]
SMARTiSM00647. IBR. 2 hits.
SM00184. RING. 1 hit.
SM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBS8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV
60 70 80 90 100
SGNSNECLQN SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP
110 120 130 140 150
TQLSALCKHL DNLWEEHRGS VVLFAWMQFL KEETLAYLNI VSPFELKIGS
160 170 180 190 200
QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE EIVDERAVQD VESLSNLIQE
210 220 230 240 250
ILDFDQAQQI KCFNSKLFLC SICFCEKLGS ECMYFLECRH VYCKACLKDY
260 270 280 290 300
FEIQIRDGQV QCLNCPEPKC PSVATPGQVK ELVEAELFAR YDRLLLQSSL
310 320 330 340 350
DLMADVVYCP RPCCQLPVMQ EPGCTMGICS SCNFAFCTLC RLTYHGVSPC
360 370 380 390 400
KVTAEKLMDL RNEYLQADEA NKRLLDQRYG KRVIQKALEE MESKEWLEKN
410 420 430 440 450
SKSCPCCGTP IEKLDGCNKM TCTGCMQYFC WICMGSLSRA NPYKHFNDPG
460 470
SPCFNRLFYA VDVDDDIWED EVED
Length:474
Mass (Da):53,837
Last modified:May 1, 2000 - v1
Checksum:i529E3F5AF38A5DAD
GO
Isoform 2 (identifier: Q9UBS8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.

Show »
Length:348
Mass (Da):39,634
Checksum:iC43770874596DD0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321Q → R in CAG32983. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 126126Missing in isoform 2. 1 PublicationVSP_045780Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022663 mRNA. Translation: BAA78677.1.
AF060544 mRNA. Translation: AAD21842.1.
AK023884 mRNA. Translation: BAG51234.1.
AK057868 mRNA. No translation available.
CR456702 mRNA. Translation: CAG32983.1.
AC005740 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61895.1.
CH471062 Genomic DNA. Translation: EAW61896.1.
CH471062 Genomic DNA. Translation: EAW61897.1.
BC126185 mRNA. Translation: AAI26186.1.
BC144061 mRNA. Translation: AAI44062.1.
AB015333 mRNA. Translation: BAA34792.1.
CCDSiCCDS4270.1. [Q9UBS8-1]
CCDS4271.1. [Q9UBS8-2]
RefSeqiNP_001188294.1. NM_001201365.1. [Q9UBS8-1]
NP_004281.1. NM_004290.4. [Q9UBS8-1]
NP_899645.1. NM_183398.2. [Q9UBS8-2]
NP_899646.1. NM_183399.2. [Q9UBS8-1]
NP_899647.1. NM_183400.2. [Q9UBS8-1]
NP_899648.1. NM_183401.2. [Q9UBS8-1]
XP_005268593.1. XM_005268536.1. [Q9UBS8-1]
XP_005268594.1. XM_005268537.1. [Q9UBS8-1]
XP_005268595.1. XM_005268538.1. [Q9UBS8-1]
XP_005268596.1. XM_005268539.1. [Q9UBS8-2]
XP_005268597.1. XM_005268540.1. [Q9UBS8-2]
XP_005268598.1. XM_005268541.1. [Q9UBS8-2]
UniGeneiHs.483616.

Genome annotation databases

EnsembliENST00000347642; ENSP00000324956; ENSG00000013561. [Q9UBS8-1]
ENST00000356143; ENSP00000348462; ENSG00000013561. [Q9UBS8-1]
ENST00000394514; ENSP00000378022; ENSG00000013561. [Q9UBS8-2]
ENST00000394519; ENSP00000378027; ENSG00000013561. [Q9UBS8-1]
ENST00000394520; ENSP00000378028; ENSG00000013561. [Q9UBS8-1]
GeneIDi9604.
KEGGihsa:9604.
UCSCiuc003lly.3. human. [Q9UBS8-1]

Polymorphism databases

DMDMi17380293.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022663 mRNA. Translation: BAA78677.1 .
AF060544 mRNA. Translation: AAD21842.1 .
AK023884 mRNA. Translation: BAG51234.1 .
AK057868 mRNA. No translation available.
CR456702 mRNA. Translation: CAG32983.1 .
AC005740 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61895.1 .
CH471062 Genomic DNA. Translation: EAW61896.1 .
CH471062 Genomic DNA. Translation: EAW61897.1 .
BC126185 mRNA. Translation: AAI26186.1 .
BC144061 mRNA. Translation: AAI44062.1 .
AB015333 mRNA. Translation: BAA34792.1 .
CCDSi CCDS4270.1. [Q9UBS8-1 ]
CCDS4271.1. [Q9UBS8-2 ]
RefSeqi NP_001188294.1. NM_001201365.1. [Q9UBS8-1 ]
NP_004281.1. NM_004290.4. [Q9UBS8-1 ]
NP_899645.1. NM_183398.2. [Q9UBS8-2 ]
NP_899646.1. NM_183399.2. [Q9UBS8-1 ]
NP_899647.1. NM_183400.2. [Q9UBS8-1 ]
NP_899648.1. NM_183401.2. [Q9UBS8-1 ]
XP_005268593.1. XM_005268536.1. [Q9UBS8-1 ]
XP_005268594.1. XM_005268537.1. [Q9UBS8-1 ]
XP_005268595.1. XM_005268538.1. [Q9UBS8-1 ]
XP_005268596.1. XM_005268539.1. [Q9UBS8-2 ]
XP_005268597.1. XM_005268540.1. [Q9UBS8-2 ]
XP_005268598.1. XM_005268541.1. [Q9UBS8-2 ]
UniGenei Hs.483616.

3D structure databases

ProteinModelPortali Q9UBS8.
SMRi Q9UBS8. Positions 188-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114968. 26 interactions.
IntActi Q9UBS8. 16 interactions.
MINTi MINT-1187964.
STRINGi 9606.ENSP00000324956.

PTM databases

PhosphoSitei Q9UBS8.

Polymorphism databases

DMDMi 17380293.

Proteomic databases

MaxQBi Q9UBS8.
PaxDbi Q9UBS8.
PRIDEi Q9UBS8.

Protocols and materials databases

DNASUi 9604.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347642 ; ENSP00000324956 ; ENSG00000013561 . [Q9UBS8-1 ]
ENST00000356143 ; ENSP00000348462 ; ENSG00000013561 . [Q9UBS8-1 ]
ENST00000394514 ; ENSP00000378022 ; ENSG00000013561 . [Q9UBS8-2 ]
ENST00000394519 ; ENSP00000378027 ; ENSG00000013561 . [Q9UBS8-1 ]
ENST00000394520 ; ENSP00000378028 ; ENSG00000013561 . [Q9UBS8-1 ]
GeneIDi 9604.
KEGGi hsa:9604.
UCSCi uc003lly.3. human. [Q9UBS8-1 ]

Organism-specific databases

CTDi 9604.
GeneCardsi GC05P141402.
HGNCi HGNC:10058. RNF14.
HPAi HPA008716.
MIMi 605675. gene.
neXtProti NX_Q9UBS8.
PharmGKBi PA34423.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG266709.
GeneTreei ENSGT00750000117406.
HOVERGENi HBG057296.
InParanoidi Q9UBS8.
KOi K11971.
OMAi QYFCWLC.
PhylomeDBi Q9UBS8.
TreeFami TF314401.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi RNF14. human.
GeneWikii RNF14.
GenomeRNAii 9604.
NextBioi 36027.
PROi Q9UBS8.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBS8.
CleanExi HS_RNF14.
ExpressionAtlasi Q9UBS8. baseline and differential.
Genevestigatori Q9UBS8.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR002867. Znf_C6HC.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF01485. IBR. 2 hits.
PF05773. RWD. 1 hit.
[Graphical view ]
SMARTi SM00647. IBR. 2 hits.
SM00184. RING. 1 hit.
SM00591. RWD. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50908. RWD. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif."
    Ueki N., Seki N., Yano K., Masuho Y., Saito T., Muramatsu M.-A.
    Biochim. Biophys. Acta 1445:232-236(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor."
    Kang H.-Y., Yeh S., Fujimoto N., Chang C.
    J. Biol. Chem. 274:8570-8576(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Prostate.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Thyroid.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-474 (ISOFORM 1), SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  9. "N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8."
    Ito K., Adachi S., Iwakami R., Yasuda H., Muto Y., Seki N., Okano Y.
    Eur. J. Biochem. 268:2725-2732(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-220.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-348, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination."
    Xu K., Shimelis H., Linn D.E., Jiang R., Yang X., Sun F., Guo Z., Chen H., Li W., Chen H., Kong X., Melamed J., Fang S., Xiao Z., Veenstra T.D., Qiu Y.
    Cancer Cell 15:270-282(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AR.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiRNF14_HUMAN
AccessioniPrimary (citable) accession number: Q9UBS8
Secondary accession number(s): A0AV26
, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3