ID   DNJB9_HUMAN             Reviewed;         223 AA.
AC   Q9UBS3;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-JAN-2012, entry version 97.
DE   RecName: Full=DnaJ homolog subfamily B member 9;
DE   AltName: Full=Microvascular endothelial differentiation gene 1 protein;
DE            Short=Mdg-1;
GN   Name=DNAJB9; Synonyms=MDG1; ORFNames=UNQ743/PRO1471;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T.;
RT   "Human microvascular endothelial differentiation gene 1.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200;
RA   Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA   Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA   Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT   "Cloning and functional analysis of cDNAs with open reading frames for
RT   300 previously undefined genes expressed in CD34+ hematopoietic
RT   stem/progenitor cells.";
RL   Genome Res. 10:1546-1560(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=21154917; PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA   Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA   Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA   Wambutt R., Korn B., Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and
RT   analysis of 500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   STRUCTURE BY NMR OF 24-102.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of J-domain from human DnaJ subfamily B menber
RT   9.";
RL   Submitted (NOV-2005) to the PDB data bank.
CC   -!- FUNCTION: Acts as a co-chaperone with an Hsp70 protein (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity). Note=Stress induces its translocation to the nucleus
CC       (By similarity).
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AB026908; BAA84703.1; -; mRNA.
DR   EMBL; AF083247; AAD39845.1; -; mRNA.
DR   EMBL; AL080081; CAB45701.1; -; mRNA.
DR   EMBL; AY359045; AAQ89404.1; -; mRNA.
DR   EMBL; BC028912; AAH28912.1; -; mRNA.
DR   IPI; IPI00017608; -.
DR   PIR; T12472; T12472.
DR   RefSeq; NP_036460.1; NM_012328.2.
DR   UniGene; Hs.6790; -.
DR   PDB; 2CTR; NMR; -; A=26-100.
DR   PDBsum; 2CTR; -.
DR   ProteinModelPortal; Q9UBS3; -.
DR   SMR; Q9UBS3; 27-105.
DR   IntAct; Q9UBS3; 8.
DR   MINT; MINT-1375508; -.
DR   STRING; Q9UBS3; -.
DR   PhosphoSite; Q9UBS3; -.
DR   DMDM; 18203496; -.
DR   PRIDE; Q9UBS3; -.
DR   Ensembl; ENST00000249356; ENSP00000249356; ENSG00000128590.
DR   GeneID; 4189; -.
DR   KEGG; hsa:4189; -.
DR   UCSC; uc003vfn.1; human.
DR   CTD; 4189; -.
DR   GeneCards; GC07P108210; -.
DR   H-InvDB; HIX0006998; -.
DR   HGNC; HGNC:6968; DNAJB9.
DR   HPA; HPA040967; -.
DR   HPA; HPA041553; -.
DR   MIM; 602634; gene.
DR   neXtProt; NX_Q9UBS3; -.
DR   GeneTree; ENSGT00600000084291; -.
DR   HOGENOM; HBG278661; -.
DR   HOVERGEN; HBG051372; -.
DR   InParanoid; Q9UBS3; -.
DR   OMA; FNFDDLF; -.
DR   OrthoDB; EOG4B2SZB; -.
DR   PhylomeDB; Q9UBS3; -.
DR   Reactome; REACT_15380; Diabetes pathways.
DR   NextBio; 16506; -.
DR   ArrayExpress; Q9UBS3; -.
DR   Bgee; Q9UBS3; -.
DR   CleanEx; HS_DNAJB9; -.
DR   Genevestigator; Q9UBS3; -.
DR   GermOnline; ENSG00000128590; Homo sapiens.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0051787; F:misfolded protein binding; IDA:UniProtKB.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0030433; P:ER-associated protein catabolic process; IMP:UniProtKB.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR018253; Heat_shock_DnaJ_CS.
DR   InterPro; IPR003095; Hsp_DnaJ.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   KO; K09515; -.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; DnaJ_N; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Complete proteome; Cytoplasm; Nucleus;
KW   Polymorphism; Reference proteome.
FT   CHAIN         1    223       DnaJ homolog subfamily B member 9.
FT                                /FTId=PRO_0000071031.
FT   DOMAIN       26     90       J.
FT   VARIANT     136    136       R -> H (in dbSNP:rs17155937).
FT                                /FTId=VAR_048911.
FT   HELIX        27     31
FT   HELIX        39     52
FT   TURN         55     57
FT   HELIX        61     78
FT   HELIX        81     88
FT   HELIX        91     94
FT   STRAND       97     99
SQ   SEQUENCE   223 AA;  25518 MW;  59E3E57FF8B378BC CRC64;
     MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS
     PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK
     DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS
     GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ
//