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Q9UBS3

- DNJB9_HUMAN

UniProt

Q9UBS3 - DNJB9_HUMAN

Protein

DnaJ homolog subfamily B member 9

Gene

DNAJB9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.1 Publication

    GO - Molecular functioni

    1. misfolded protein binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. endoplasmic reticulum unfolded protein response Source: Reactome
    4. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily B member 9
    Alternative name(s):
    Endoplasmic reticulum DNA J domain-containing protein 4
    Short name:
    ER-resident protein ERdj4
    Short name:
    ERdj4
    Microvascular endothelial differentiation gene 1 protein
    Short name:
    Mdg-1
    Gene namesi
    Name:DNAJB9
    Synonyms:MDG1
    ORF Names:UNQ743/PRO1471
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:6968. DNAJB9.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum Source: LIFEdb
    3. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    4. endoplasmic reticulum membrane Source: Reactome
    5. extracellular vesicular exosome Source: UniProt
    6. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27419.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 223200DnaJ homolog subfamily B member 9PRO_0000071031Add
    BLAST

    Proteomic databases

    MaxQBiQ9UBS3.
    PaxDbiQ9UBS3.
    PRIDEiQ9UBS3.

    PTM databases

    PhosphoSiteiQ9UBS3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBS3.
    BgeeiQ9UBS3.
    CleanExiHS_DNAJB9.
    GenevestigatoriQ9UBS3.

    Organism-specific databases

    HPAiHPA040967.
    HPA041553.

    Interactioni

    Subunit structurei

    Interacts with DERL1.By similarity

    Protein-protein interaction databases

    BioGridi110354. 16 interactions.
    IntActiQ9UBS3. 8 interactions.
    MINTiMINT-1375508.
    STRINGi9606.ENSP00000249356.

    Structurei

    Secondary structure

    1
    223
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi27 – 315
    Helixi39 – 5214
    Turni55 – 573
    Helixi61 – 7818
    Helixi81 – 888
    Helixi91 – 944
    Beta strandi97 – 993

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CTRNMR-A26-100[»]
    ProteinModelPortaliQ9UBS3.
    SMRiQ9UBS3. Positions 27-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UBS3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 9065JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0484.
    HOGENOMiHOG000290187.
    HOVERGENiHBG051372.
    InParanoidiQ9UBS3.
    KOiK09515.
    OMAiATPQSIF.
    OrthoDBiEOG71CFND.
    PhylomeDBiQ9UBS3.
    TreeFamiTF105143.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UBS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA    50
    MKYHPDKNKS PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ 100
    RGSGSSFEQS FNFNFDDLFK DFGFFGQNQN TGSKKRFENH FQTRQDGGSS 150
    RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS GFDSTNQHTV QTENRFHGSS 200
    KHCRTVTQRR GNMVTTYTDC SGQ 223
    Length:223
    Mass (Da):25,518
    Last modified:May 1, 2000 - v1
    Checksum:i59E3E57FF8B378BC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361R → H.
    Corresponds to variant rs17155937 [ dbSNP | Ensembl ].
    VAR_048911

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026908 mRNA. Translation: BAA84703.1.
    AF083247 mRNA. Translation: AAD39845.1.
    AL080081 mRNA. Translation: CAB45701.1.
    AY359045 mRNA. Translation: AAQ89404.1.
    BC028912 mRNA. Translation: AAH28912.1.
    CCDSiCCDS5752.1.
    PIRiT12472.
    RefSeqiNP_036460.1. NM_012328.2.
    UniGeneiHs.732494.
    Hs.741182.

    Genome annotation databases

    EnsembliENST00000249356; ENSP00000249356; ENSG00000128590.
    GeneIDi4189.
    KEGGihsa:4189.
    UCSCiuc003vfn.3. human.

    Polymorphism databases

    DMDMi18203496.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026908 mRNA. Translation: BAA84703.1 .
    AF083247 mRNA. Translation: AAD39845.1 .
    AL080081 mRNA. Translation: CAB45701.1 .
    AY359045 mRNA. Translation: AAQ89404.1 .
    BC028912 mRNA. Translation: AAH28912.1 .
    CCDSi CCDS5752.1.
    PIRi T12472.
    RefSeqi NP_036460.1. NM_012328.2.
    UniGenei Hs.732494.
    Hs.741182.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CTR NMR - A 26-100 [» ]
    ProteinModelPortali Q9UBS3.
    SMRi Q9UBS3. Positions 27-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110354. 16 interactions.
    IntActi Q9UBS3. 8 interactions.
    MINTi MINT-1375508.
    STRINGi 9606.ENSP00000249356.

    PTM databases

    PhosphoSitei Q9UBS3.

    Polymorphism databases

    DMDMi 18203496.

    Proteomic databases

    MaxQBi Q9UBS3.
    PaxDbi Q9UBS3.
    PRIDEi Q9UBS3.

    Protocols and materials databases

    DNASUi 4189.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249356 ; ENSP00000249356 ; ENSG00000128590 .
    GeneIDi 4189.
    KEGGi hsa:4189.
    UCSCi uc003vfn.3. human.

    Organism-specific databases

    CTDi 4189.
    GeneCardsi GC07P108210.
    HGNCi HGNC:6968. DNAJB9.
    HPAi HPA040967.
    HPA041553.
    MIMi 602634. gene.
    neXtProti NX_Q9UBS3.
    PharmGKBi PA27419.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOGENOMi HOG000290187.
    HOVERGENi HBG051372.
    InParanoidi Q9UBS3.
    KOi K09515.
    OMAi ATPQSIF.
    OrthoDBi EOG71CFND.
    PhylomeDBi Q9UBS3.
    TreeFami TF105143.

    Enzyme and pathway databases

    Reactomei REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi DNAJB9. human.
    EvolutionaryTracei Q9UBS3.
    GeneWikii DNAJB9.
    GenomeRNAii 4189.
    NextBioi 16506.
    PROi Q9UBS3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBS3.
    Bgeei Q9UBS3.
    CleanExi HS_DNAJB9.
    Genevestigatori Q9UBS3.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human microvascular endothelial differentiation gene 1."
      Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C."
      Dong M., Bridges J.P., Apsley K., Xu Y., Weaver T.E.
      Mol. Biol. Cell 19:2620-2630(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Solution structure of J-domain from human DnaJ subfamily B member 9."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 24-102.

    Entry informationi

    Entry nameiDNJB9_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3