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Q9UBS3

- DNJB9_HUMAN

UniProt

Q9UBS3 - DNJB9_HUMAN

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Protein
DnaJ homolog subfamily B member 9
Gene
DNAJB9, MDG1, UNQ743/PRO1471
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein.1 Publication

GO - Molecular functioni

  1. misfolded protein binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. endoplasmic reticulum unfolded protein response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 9
Alternative name(s):
Endoplasmic reticulum DNA J domain-containing protein 4
Short name:
ER-resident protein ERdj4
Short name:
ERdj4
Microvascular endothelial differentiation gene 1 protein
Short name:
Mdg-1
Gene namesi
Name:DNAJB9
Synonyms:MDG1
ORF Names:UNQ743/PRO1471
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:6968. DNAJB9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum Source: LIFEdb
  3. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  4. endoplasmic reticulum membrane Source: Reactome
  5. extracellular vesicular exosome Source: UniProt
  6. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 223200DnaJ homolog subfamily B member 9
PRO_0000071031Add
BLAST

Proteomic databases

MaxQBiQ9UBS3.
PaxDbiQ9UBS3.
PRIDEiQ9UBS3.

PTM databases

PhosphoSiteiQ9UBS3.

Expressioni

Gene expression databases

ArrayExpressiQ9UBS3.
BgeeiQ9UBS3.
CleanExiHS_DNAJB9.
GenevestigatoriQ9UBS3.

Organism-specific databases

HPAiHPA040967.
HPA041553.

Interactioni

Subunit structurei

Interacts with DERL1 By similarity.

Protein-protein interaction databases

BioGridi110354. 16 interactions.
IntActiQ9UBS3. 8 interactions.
MINTiMINT-1375508.
STRINGi9606.ENSP00000249356.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi27 – 315
Helixi39 – 5214
Turni55 – 573
Helixi61 – 7818
Helixi81 – 888
Helixi91 – 944
Beta strandi97 – 993

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTRNMR-A26-100[»]
ProteinModelPortaliQ9UBS3.
SMRiQ9UBS3. Positions 27-105.

Miscellaneous databases

EvolutionaryTraceiQ9UBS3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9065J
Add
BLAST

Sequence similaritiesi

Contains 1 J domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0484.
HOGENOMiHOG000290187.
HOVERGENiHBG051372.
InParanoidiQ9UBS3.
KOiK09515.
OMAiATPQSIF.
OrthoDBiEOG71CFND.
PhylomeDBiQ9UBS3.
TreeFamiTF105143.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBS3-1 [UniParc]FASTAAdd to Basket

« Hide

MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA    50
MKYHPDKNKS PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ 100
RGSGSSFEQS FNFNFDDLFK DFGFFGQNQN TGSKKRFENH FQTRQDGGSS 150
RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS GFDSTNQHTV QTENRFHGSS 200
KHCRTVTQRR GNMVTTYTDC SGQ 223
Length:223
Mass (Da):25,518
Last modified:May 1, 2000 - v1
Checksum:i59E3E57FF8B378BC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361R → H.
Corresponds to variant rs17155937 [ dbSNP | Ensembl ].
VAR_048911

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026908 mRNA. Translation: BAA84703.1.
AF083247 mRNA. Translation: AAD39845.1.
AL080081 mRNA. Translation: CAB45701.1.
AY359045 mRNA. Translation: AAQ89404.1.
BC028912 mRNA. Translation: AAH28912.1.
CCDSiCCDS5752.1.
PIRiT12472.
RefSeqiNP_036460.1. NM_012328.2.
UniGeneiHs.732494.
Hs.741182.

Genome annotation databases

EnsembliENST00000249356; ENSP00000249356; ENSG00000128590.
GeneIDi4189.
KEGGihsa:4189.
UCSCiuc003vfn.3. human.

Polymorphism databases

DMDMi18203496.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026908 mRNA. Translation: BAA84703.1 .
AF083247 mRNA. Translation: AAD39845.1 .
AL080081 mRNA. Translation: CAB45701.1 .
AY359045 mRNA. Translation: AAQ89404.1 .
BC028912 mRNA. Translation: AAH28912.1 .
CCDSi CCDS5752.1.
PIRi T12472.
RefSeqi NP_036460.1. NM_012328.2.
UniGenei Hs.732494.
Hs.741182.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CTR NMR - A 26-100 [» ]
ProteinModelPortali Q9UBS3.
SMRi Q9UBS3. Positions 27-105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110354. 16 interactions.
IntActi Q9UBS3. 8 interactions.
MINTi MINT-1375508.
STRINGi 9606.ENSP00000249356.

PTM databases

PhosphoSitei Q9UBS3.

Polymorphism databases

DMDMi 18203496.

Proteomic databases

MaxQBi Q9UBS3.
PaxDbi Q9UBS3.
PRIDEi Q9UBS3.

Protocols and materials databases

DNASUi 4189.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249356 ; ENSP00000249356 ; ENSG00000128590 .
GeneIDi 4189.
KEGGi hsa:4189.
UCSCi uc003vfn.3. human.

Organism-specific databases

CTDi 4189.
GeneCardsi GC07P108210.
HGNCi HGNC:6968. DNAJB9.
HPAi HPA040967.
HPA041553.
MIMi 602634. gene.
neXtProti NX_Q9UBS3.
PharmGKBi PA27419.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0484.
HOGENOMi HOG000290187.
HOVERGENi HBG051372.
InParanoidi Q9UBS3.
KOi K09515.
OMAi ATPQSIF.
OrthoDBi EOG71CFND.
PhylomeDBi Q9UBS3.
TreeFami TF105143.

Enzyme and pathway databases

Reactomei REACT_18273. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSi DNAJB9. human.
EvolutionaryTracei Q9UBS3.
GeneWikii DNAJB9.
GenomeRNAii 4189.
NextBioi 16506.
PROi Q9UBS3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UBS3.
Bgeei Q9UBS3.
CleanExi HS_DNAJB9.
Genevestigatori Q9UBS3.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human microvascular endothelial differentiation gene 1."
    Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C."
    Dong M., Bridges J.P., Apsley K., Xu Y., Weaver T.E.
    Mol. Biol. Cell 19:2620-2630(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Solution structure of J-domain from human DnaJ subfamily B member 9."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 24-102.

Entry informationi

Entry nameiDNJB9_HUMAN
AccessioniPrimary (citable) accession number: Q9UBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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