DnaJ homolog subfamily B member 9 - Homo sapiens (Human)

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Q9UBS3 (DNJB9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily B member 9

Alternative name(s):
Microvascular endothelial differentiation gene 1 protein
Short name=Mdg-1

Gene names

Name:	DNAJB9
Synonyms:	MDG1
ORF Names:	UNQ743/PRO1471

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a co-chaperone with an Hsp70 protein By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Stress induces its translocation to the nucleus By similarity.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER-associated protein catabolic process Inferred from mutant phenotype PubMed 18400946. Source: UniProtKB activation of signaling protein activity involved in unfolded protein response Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	misfolded protein binding Inferred from direct assay PubMed 18400946. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 223

223

DnaJ homolog subfamily B member 9

PRO_0000071031

Regions

Domain

26 – 90

Natural variations

Natural variant

136

R → H.
Corresponds to variant rs17155937 [ dbSNP | Ensembl ].

VAR_048911

Secondary structure

223

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UBS3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 59E3E57FF8B378BC
Show »

FASTA

223

25,518

        10         20         30         40         50         60 
MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS 

        70         80         90        100        110        120 
PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK 

       130        140        150        160        170        180 
DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS 

       190        200        210        220 
GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human microvascular endothelial differentiation gene 1." Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Solution structure of J-domain from human DnaJ subfamily B member 9." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 24-102.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB026908 mRNA. Translation: BAA84703.1.
AF083247 mRNA. Translation: AAD39845.1.
AL080081 mRNA. Translation: CAB45701.1.
AY359045 mRNA. Translation: AAQ89404.1.
BC028912 mRNA. Translation: AAH28912.1.

IPI

IPI00017608.

PIR

T12472.

RefSeq

NP_036460.1. NM_012328.2.

UniGene

Hs.732494.
Hs.741182.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CTR	NMR	-	A	26-100	[»]

ProteinModelPortal

Q9UBS3.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UBS3. 8 interactions.

MINT

MINT-1375508.

STRING

9606.ENSP00000249356.

PTM databases

PhosphoSite

Q9UBS3.

Polymorphism databases

DMDM

18203496.

Proteomic databases

PaxDb

Q9UBS3.

PRIDE

Q9UBS3.

Protocols and materials databases

DNASU

4189.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000249356; ENSP00000249356; ENSG00000128590.

GeneID

4189.

KEGG

hsa:4189.

UCSC

uc003vfn.3. human.

Organism-specific databases

CTD

4189.

GeneCards

GC07P108210.

HGNC

HGNC:6968. DNAJB9.

HPA

HPA040967.
HPA041553.

MIM

602634. gene.

neXtProt

NX_Q9UBS3.

PharmGKB

PA27419.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0484.

HOGENOM

HOG000290187.

HOVERGEN

HBG051372.

InParanoid

Q9UBS3.

K09515.

OMA

GLFDDMF.

OrthoDB

EOG4B2SZB.

PhylomeDB

Q9UBS3.

Enzyme and pathway databases

Reactome

REACT_116125. Disease.

Gene expression databases

ArrayExpress

Q9UBS3.

Bgee

Q9UBS3.

CleanEx

HS_DNAJB9.

Genevestigator

Q9UBS3.

GermOnline

ENSG00000128590. Homo sapiens.

Family and domain databases

Gene3D

1.10.287.110. 1 hit.

InterPro

IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]

Pfam

PF00226. DnaJ. 1 hit.
[Graphical view]

PRINTS

PR00625. JDOMAIN.

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

SUPFAM

SSF46565. DnaJ_N. 1 hit.

PROSITE

PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

DNAJB9. human.

EvolutionaryTrace

Q9UBS3.

GenomeRNAi

4189.

NextBio

16506.

SOURCE

Search...

Entry information

Entry name

DNJB9_HUMAN

Accession

Primary (citable) accession number: Q9UBS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents