UniProtKB - Q9UBS3 (DNJB9_HUMAN)
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Protein
DnaJ homolog subfamily B member 9
Gene
DNAJB9
Organism
Homo sapiens (Human)
Status
Functioni
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).By similarity1 Publication
GO - Molecular functioni
- chaperone binding Source: UniProtKB
- Hsp70 protein binding Source: Ensembl
- misfolded protein binding Source: UniProtKB
GO - Biological processi
- B cell differentiation Source: UniProtKB
- immunoglobulin production Source: UniProtKB
- IRE1-mediated unfolded protein response Source: Reactome
- negative regulation of IRE1-mediated unfolded protein response Source: UniProtKB
- response to endoplasmic reticulum stress Source: UniProtKB
- ubiquitin-dependent ERAD pathway Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Biological process | Unfolded protein response |
Enzyme and pathway databases
Reactomei | R-HSA-381038. XBP1(S) activates chaperone genes. |
Names & Taxonomyi
Protein namesi | Recommended name: DnaJ homolog subfamily B member 9CuratedAlternative name(s): Endoplasmic reticulum DNA J domain-containing protein 41 Publication Short name: ER-resident protein ERdj41 Publication Short name: ERdj41 Publication Microvascular endothelial differentiation gene 1 protein1 Publication Short name: Mdg-11 Publication |
Gene namesi | Name:DNAJB9 Synonyms:MDG11 Publication ORF Names:UNQ743/PRO14711 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128590.4. |
HGNCi | HGNC:6968. DNAJB9. |
MIMi | 602634. gene. |
neXtProti | NX_Q9UBS3. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 4189. |
OpenTargetsi | ENSG00000128590. |
PharmGKBi | PA27419. |
Polymorphism and mutation databases
BioMutai | DNAJB9. |
DMDMi | 18203496. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000071031 | 24 – 223 | DnaJ homolog subfamily B member 9Add BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 133 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UBS3. |
MaxQBi | Q9UBS3. |
PaxDbi | Q9UBS3. |
PeptideAtlasi | Q9UBS3. |
PRIDEi | Q9UBS3. |
PTM databases
iPTMneti | Q9UBS3. |
PhosphoSitePlusi | Q9UBS3. |
Expressioni
Tissue specificityi
Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248).1 Publication
Gene expression databases
Bgeei | ENSG00000128590. |
CleanExi | HS_DNAJB9. |
ExpressionAtlasi | Q9UBS3. baseline and differential. |
Genevisiblei | Q9UBS3. HS. |
Organism-specific databases
HPAi | HPA040967. HPA041553. |
Interactioni
Subunit structurei
Interacts with HSPA5/BiP; interaction is direct (By similarity). Interacts with ERN1/IRE1 (via the luminal region) (By similarity). Interacts with DERL1 (By similarity).By similarity
GO - Molecular functioni
- chaperone binding Source: UniProtKB
- Hsp70 protein binding Source: Ensembl
- misfolded protein binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 110354. 59 interactors. |
IntActi | Q9UBS3. 9 interactors. |
MINTi | Q9UBS3. |
STRINGi | 9606.ENSP00000249356. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 27 – 31 | Combined sources | 5 | |
Helixi | 39 – 52 | Combined sources | 14 | |
Turni | 55 – 57 | Combined sources | 3 | |
Helixi | 61 – 78 | Combined sources | 18 | |
Helixi | 81 – 88 | Combined sources | 8 | |
Helixi | 91 – 94 | Combined sources | 4 | |
Beta strandi | 97 – 99 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CTR | NMR | - | A | 26-100 | [»] | |
ProteinModelPortali | Q9UBS3. | |||||
SMRi | Q9UBS3. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UBS3. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 90 | JPROSITE-ProRule annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 223 | Divergent targeting domainBy similarityAdd BLAST | 133 |
Domaini
The J domain stimulates the ATPase activity of HSPA5/BiP, while the divergent targeting domain is required for efficient substrate recognition by HSPA5/BiP. The divergent targeting domain specifically recognizes and binds to aggregation-prone sequences.By similarity
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0714. Eukaryota. COG0484. LUCA. |
GeneTreei | ENSGT00760000118947. |
HOGENOMi | HOG000290187. |
HOVERGENi | HBG051372. |
InParanoidi | Q9UBS3. |
KOi | K09515. |
OMAi | ATPQSIF. |
OrthoDBi | EOG091G15JG. |
PhylomeDBi | Q9UBS3. |
TreeFami | TF105143. |
Family and domain databases
CDDi | cd06257. DnaJ. 1 hit. |
Gene3Di | 1.10.287.110. 1 hit. |
InterProi | View protein in InterPro IPR001623. DnaJ_domain. IPR018253. DnaJ_domain_CS. IPR036869. J_dom_sf. |
Pfami | View protein in Pfam PF00226. DnaJ. 1 hit. |
PRINTSi | PR00625. JDOMAIN. |
SMARTi | View protein in SMART SM00271. DnaJ. 1 hit. |
SUPFAMi | SSF46565. SSF46565. 1 hit. |
PROSITEi | View protein in PROSITE PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9UBS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA
60 70 80 90 100
MKYHPDKNKS PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ
110 120 130 140 150
RGSGSSFEQS FNFNFDDLFK DFGFFGQNQN TGSKKRFENH FQTRQDGGSS
160 170 180 190 200
RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS GFDSTNQHTV QTENRFHGSS
210 220
KHCRTVTQRR GNMVTTYTDC SGQ
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048911 | 136 | R → H. Corresponds to variant dbSNP:rs17155937Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB026908 mRNA. Translation: BAA84703.1. AF083247 mRNA. Translation: AAD39845.1. AL080081 mRNA. Translation: CAB45701.1. AY359045 mRNA. Translation: AAQ89404.1. BC028912 mRNA. Translation: AAH28912.1. |
CCDSi | CCDS5752.1. |
PIRi | T12472. |
RefSeqi | NP_036460.1. NM_012328.2. |
UniGenei | Hs.732494. Hs.741182. |
Genome annotation databases
Ensembli | ENST00000249356; ENSP00000249356; ENSG00000128590. |
GeneIDi | 4189. |
KEGGi | hsa:4189. |
UCSCi | uc003vfn.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | DNJB9_HUMAN | |
Accessioni | Q9UBS3Primary (citable) accession number: Q9UBS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |