Reviewed, UniProtKB/Swiss-Prot Q9UBS3 (DNJB9_HUMAN)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily B member 9
Alternative name(s):
    Microvascular endothelial differentiation gene 1 protein
      Short name=Mdg-1

Gene names

Name:	DNAJB9
Synonyms:	MDG1
ORF Names:	UNQ743/PRO1471

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a co-chaperone with an Hsp70 protein By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Stress induces its translocation to the nucleus By similarity.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: LIFEdb nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 223

223

DnaJ homolog subfamily B member 9

PRO_0000071031

Regions

Domain

26 – 90

65

J

Natural variations

Natural variant

136

1

R → H: dbSNP rs17155937.

VAR_048911

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

223

Helix Strand Turn

Details...

Helix

27 – 31

5

Helix

39 – 52

14

Turn

55 – 57

3

Helix

61 – 78

18

Helix

81 – 88

8

Helix

91 – 94

4

Beta strand

97 – 99

3

Sequences

	Sequence		Length	Mass (Da)
	Q9UBS3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 59E3E57FF8B378BC	FASTA	223	25,518
	10 20 30 40 50 60 MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS 70 80 90 100 110 120 PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK 130 140 150 160 170 180 DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS 190 200 210 220 GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human MDG1 gene, complete cds." Ye M., Zhang Q., Fu G., Huang Q., Zhou J., Shen Y., Xu S., He K., Chen S., Mao M., Chen Z. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human microvascular endothelial differentiation gene 1." Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Solution structure of J-domain from human DnaJ subfamily B menber 9." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 24-102.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF083247 mRNA. Translation: AAD39845.1.
AB026908 mRNA. Translation: BAA84703.1.
AL080081 mRNA. Translation: CAB45701.1.
AY359045 mRNA. Translation: AAQ89404.1.
BC028912 mRNA. Translation: AAH28912.1.

IPI

IPI00017608.

PIR

T12472.

RefSeq

NP_036460.1.

UniGene

Hs.6790

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CTR	NMR	-	A	26-100	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UBS3. 7 interactions.

STRING

Q9UBS3.

Proteomic databases

PRIDE

Q9UBS3.

Genome annotation databases

Ensembl

ENST00000249356; ENSP00000249356; ENSG00000128590; Homo sapiens. [Genome view]

GeneID

4189.

KEGG

hsa:4189.

UCSC

uc003vfn.1. human.

Organism-specific databases

CTD

4189.

GeneCards

GC07P107997.

H-InvDB

HIX0006998.

HGNC

HGNC:6968. DNAJB9.

MIM

602634. gene.

PharmGKB

PA27419.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG278661.

HOVERGEN

Q9UBS3.

InParanoid

Q9UBS3.

OMA

FNFDDLF.

OrthoDB

EOG9G4K9D.

PhylomeDB

Q9UBS3.

Enzyme and pathway databases

Reactome

REACT_15380. Diabetes pathways.

Gene expression databases

ArrayExpress

Q9UBS3.

Bgee

Q9UBS3.

CleanEx

HS_DNAJB9.

Genevestigator

Q9UBS3.

GermOnline

ENSG00000128590. Homo sapiens.

Family and domain databases

InterPro

IPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR015609. Hsp40/DnaJ_Rel.
IPR003095. Hsp_DnaJ.
[Graphical view]

Gene3D

G3DSA:1.10.287.110. DnaJ_N. 1 hit.

PANTHER

PTHR11821. Hsp40/DnaJ_Rel. 1 hit.

Pfam

PF00226. DnaJ. 1 hit.
[Graphical view]

PRINTS

PR00625. DNAJPROTEIN.

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

PROSITE

PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

16506.

SOURCE

Search...

Entry information

Entry name

DNJB9_HUMAN

Accession

Primary (citable) accession number: Q9UBS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.