Reviewed,
UniProtKB/Swiss-Prot Q9UBS3 (DNJB9_HUMAN)
Last modified
January 19, 2010.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DnaJ homolog subfamily B member 9 Alternative name(s): Microvascular endothelial differentiation gene 1 protein Short name=Mdg-1 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 223 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Polymorphism |
| Molecular function | Chaperone |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: InterPro |
| Cellular component | endoplasmic reticulum Inferred from direct assay. Source: LIFEdb nucleolusInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||
Molecule processing | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 223 | 223 | DnaJ homolog subfamily B member 9 | PRO_0000071031 | |||||||||||||||||||
Regions | |||||||||||||||||||||||
| Domain | 26 – 90 | 65 | J | ||||||||||||||||||||
Natural variations | |||||||||||||||||||||||
| Natural variant | 136 | 1 | R → H: dbSNP rs17155937. | VAR_048911 | |||||||||||||||||||
Secondary structure | |||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||
| Helix | 27 – 31 | 5 | |||||||||||||||||||||
| Helix | 39 – 52 | 14 | |||||||||||||||||||||
| Turn | 55 – 57 | 3 | |||||||||||||||||||||
| Helix | 61 – 78 | 18 | |||||||||||||||||||||
| Helix | 81 – 88 | 8 | |||||||||||||||||||||
| Helix | 91 – 94 | 4 | |||||||||||||||||||||
| Beta strand | 97 – 99 | 3 | |||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human MDG1 gene, complete cds." Ye M., Zhang Q., Fu G., Huang Q., Zhou J., Shen Y., Xu S., He K., Chen S., Mao M., Chen Z. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Human microvascular endothelial differentiation gene 1." Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A.Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Solution structure of J-domain from human DnaJ subfamily B menber 9." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 24-102. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF083247 mRNA. Translation: AAD39845.1. AB026908 mRNA. Translation: BAA84703.1. AL080081 mRNA. Translation: CAB45701.1. AY359045 mRNA. Translation: AAQ89404.1. BC028912 mRNA. Translation: AAH28912.1. | ||||||||||||
| IPI | IPI00017608. | ||||||||||||
| PIR | T12472. | ||||||||||||
| RefSeq | NP_036460.1. | ||||||||||||
| UniGene | Hs.6790 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q9UBS3. 7 interactions. | ||||||||||||
| STRING | Q9UBS3. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q9UBS3. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000249356; ENSP00000249356; ENSG00000128590; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 4189. | ||||||||||||
| KEGG | hsa:4189. | ||||||||||||
| UCSC | uc003vfn.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 4189. | ||||||||||||
| GeneCards | GC07P107997. | ||||||||||||
| H-InvDB | HIX0006998. | ||||||||||||
| HGNC | HGNC:6968. DNAJB9. | ||||||||||||
| MIM | 602634. gene. | ||||||||||||
| PharmGKB | PA27419. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | HBG278661. | ||||||||||||
| HOVERGEN | Q9UBS3. | ||||||||||||
| InParanoid | Q9UBS3. | ||||||||||||
| OMA | FNFDDLF. | ||||||||||||
| OrthoDB | EOG9G4K9D. | ||||||||||||
| PhylomeDB | Q9UBS3. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Reactome | REACT_15380. Diabetes pathways. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q9UBS3. | ||||||||||||
| Bgee | Q9UBS3. | ||||||||||||
| CleanEx | HS_DNAJB9. | ||||||||||||
| Genevestigator | Q9UBS3. | ||||||||||||
| GermOnline | ENSG00000128590. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. IPR003095. Hsp_DnaJ. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:1.10.287.110. DnaJ_N. 1 hit. | ||||||||||||
| PANTHER | PTHR11821. Hsp40/DnaJ_Rel. 1 hit. | ||||||||||||
| Pfam | PF00226. DnaJ. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00625. DNAJPROTEIN. | ||||||||||||
| SMART | SM00271. DnaJ. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 16506. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | DNJB9_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UBS3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


