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Q9UBS3 (DNJB9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily B member 9
Alternative name(s):
Endoplasmic reticulum DNA J domain-containing protein 4
Short name=ER-resident protein ERdj4
Short name=ERdj4
Microvascular endothelial differentiation gene 1 protein
Short name=Mdg-1
Gene names
Name:DNAJB9
Synonyms:MDG1
ORF Names:UNQ743/PRO1471
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein. Ref.6

Subunit structure

Interacts with DERL1 By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Contains 1 J domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 223200DnaJ homolog subfamily B member 9
PRO_0000071031

Regions

Domain26 – 9065J

Natural variations

Natural variant1361R → H.
Corresponds to variant rs17155937 [ dbSNP | Ensembl ].
VAR_048911

Secondary structure

............... 223
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9UBS3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 59E3E57FF8B378BC

FASTA22325,518
        10         20         30         40         50         60 
MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS 

        70         80         90        100        110        120 
PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK 

       130        140        150        160        170        180 
DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS 

       190        200        210        220 
GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ 

« Hide

References

« Hide 'large scale' references
[1]"Human microvascular endothelial differentiation gene 1."
Seki N., Hattori A., Muramatsu M., Miyajima N., Saito T.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C."
Dong M., Bridges J.P., Apsley K., Xu Y., Weaver T.E.
Mol. Biol. Cell 19:2620-2630(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Solution structure of J-domain from human DnaJ subfamily B member 9."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 24-102.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026908 mRNA. Translation: BAA84703.1.
AF083247 mRNA. Translation: AAD39845.1.
AL080081 mRNA. Translation: CAB45701.1.
AY359045 mRNA. Translation: AAQ89404.1.
BC028912 mRNA. Translation: AAH28912.1.
CCDSCCDS5752.1.
PIRT12472.
RefSeqNP_036460.1. NM_012328.2.
UniGeneHs.732494.
Hs.741182.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTRNMR-A26-100[»]
ProteinModelPortalQ9UBS3.
SMRQ9UBS3. Positions 27-105.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110354. 16 interactions.
IntActQ9UBS3. 8 interactions.
MINTMINT-1375508.
STRING9606.ENSP00000249356.

PTM databases

PhosphoSiteQ9UBS3.

Polymorphism databases

DMDM18203496.

Proteomic databases

MaxQBQ9UBS3.
PaxDbQ9UBS3.
PRIDEQ9UBS3.

Protocols and materials databases

DNASU4189.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249356; ENSP00000249356; ENSG00000128590.
GeneID4189.
KEGGhsa:4189.
UCSCuc003vfn.3. human.

Organism-specific databases

CTD4189.
GeneCardsGC07P108210.
HGNCHGNC:6968. DNAJB9.
HPAHPA040967.
HPA041553.
MIM602634. gene.
neXtProtNX_Q9UBS3.
PharmGKBPA27419.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0484.
HOGENOMHOG000290187.
HOVERGENHBG051372.
InParanoidQ9UBS3.
KOK09515.
OMAATPQSIF.
OrthoDBEOG71CFND.
PhylomeDBQ9UBS3.
TreeFamTF105143.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ9UBS3.
BgeeQ9UBS3.
CleanExHS_DNAJB9.
GenevestigatorQ9UBS3.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDNAJB9. human.
EvolutionaryTraceQ9UBS3.
GeneWikiDNAJB9.
GenomeRNAi4189.
NextBio16506.
PROQ9UBS3.
SOURCESearch...

Entry information

Entry nameDNJB9_HUMAN
AccessionPrimary (citable) accession number: Q9UBS3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM