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Protein

Ribosomal protein S6 kinase beta-2

Gene

RPS6KB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates specifically ribosomal protein S6.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 81ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • peptide binding Source: Ensembl
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: ProtInc
  • ribosomal protein S6 kinase activity Source: Ensembl

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • positive regulation of translational initiation Source: UniProtKB
  • protein kinase B signaling Source: Ensembl
  • signal transduction Source: ProtInc
  • translation Source: ProtInc

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-198693 AKT phosphorylates targets in the nucleus
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
SignaLinkiQ9UBS0
SIGNORiQ9UBS0

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase beta-2 (EC:2.7.11.1)
Short name:
S6K-beta-2
Short name:
S6K2
Alternative name(s):
70 kDa ribosomal protein S6 kinase 2
Short name:
P70S6K2
Short name:
p70-S6K 2
S6 kinase-related kinase
Short name:
SRK
Serine/threonine-protein kinase 14B
p70 ribosomal S6 kinase beta
Short name:
S6K-beta
Short name:
p70 S6 kinase beta
Short name:
p70 S6K-beta
Short name:
p70 S6KB
Short name:
p70-beta
Gene namesi
Name:RPS6KB2
Synonyms:STK14B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175634.14
HGNCiHGNC:10437 RPS6KB2
MIMi608939 gene
neXtProtiNX_Q9UBS0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6199
OpenTargetsiENSG00000175634
PharmGKBiPA34852

Chemistry databases

ChEMBLiCHEMBL3111
GuidetoPHARMACOLOGYi1526

Polymorphism and mutation databases

BioMutaiRPS6KB2
DMDMi296434560

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862141 – 482Ribosomal protein S6 kinase beta-2Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei473Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBS0
PaxDbiQ9UBS0
PeptideAtlasiQ9UBS0
PRIDEiQ9UBS0

PTM databases

iPTMnetiQ9UBS0
PhosphoSitePlusiQ9UBS0

Expressioni

Gene expression databases

BgeeiENSG00000175634
CleanExiHS_RPS6KB2
ExpressionAtlasiQ9UBS0 baseline and differential
GenevisibleiQ9UBS0 HS

Organism-specific databases

HPAiCAB019404
HPA010010

Interactioni

Protein-protein interaction databases

BioGridi112113, 195 interactors
ELMiQ9UBS0
IntActiQ9UBS0, 8 interactors
MINTiQ9UBS0
STRINGi9606.ENSP00000308413

Chemistry databases

BindingDBiQ9UBS0

Structurei

3D structure databases

ProteinModelPortaliQ9UBS0
SMRiQ9UBS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 328Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini329 – 399AGC-kinase C-terminalAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi471 – 477Nuclear localization signal1 Publication7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi411 – 482Pro-richAdd BLAST72

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00890000139324
HOGENOMiHOG000233033
HOVERGENiHBG108317
InParanoidiQ9UBS0
KOiK04688
OMAiVQKHPFF
OrthoDBiEOG091G05Z7
PhylomeDBiQ9UBS0
TreeFamiTF313438

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016238 Ribosomal_S6_kinase
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000605 Ribsml_S6_kin_1, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL
60 70 80 90 100
TETSVNVGPE RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV
110 120 130 140 150
LRKAKIVRNA KDTAHTRAER NILESVKHPF IVELAYAFQT GGKLYLILEC
160 170 180 190 200
LSGGELFTHL EREGIFLEDT ACFYLAEITL ALGHLHSQGI IYRDLKPENI
210 220 230 240 250
MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI LVRSGHNRAV
260 270 280 290 300
DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLALPP YLTPDARDLV
310 320 330 340 350
KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ
360 370 380 390 400
SEEDVSQFDT RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE
410 420 430 440 450
GFSFQPKLRS PRRLNSSPRA PVSPLKFSPF EGFRPSPSLP EPTELPLPPL
460 470 480
LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP GR
Length:482
Mass (Da):53,455
Last modified:May 18, 2010 - v2
Checksum:i5D33660D24A2C7BE
GO
Isoform 2 (identifier: Q9UBS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-154: GG → VD
     155-482: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):16,868
Checksum:iB556CDA0AE062FBC
GO

Sequence cautioni

The sequence BAA34402 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90Missing in BAA37145 (PubMed:9878560).Curated1
Sequence conflicti409R → C in BAA37145 (PubMed:9878560).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040643267P → L1 PublicationCorresponds to variant dbSNP:rs55987642Ensembl.1
Natural variantiVAR_040644368V → M1 PublicationCorresponds to variant dbSNP:rs55642995Ensembl.1
Natural variantiVAR_040645420A → VCombined sources5 PublicationsCorresponds to variant dbSNP:rs13859Ensembl.1
Natural variantiVAR_040646443T → M in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs374535834Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056441153 – 154GG → VD in isoform 2. 1 Publication2
Alternative sequenceiVSP_056442155 – 482Missing in isoform 2. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016869 mRNA Translation: BAA34402.1 Different initiation.
AB019245 mRNA Translation: BAA37145.1
AF076931 mRNA Translation: AAD46063.1
AF099739 mRNA Translation: AAD20990.1
AK297527 mRNA Translation: BAG59930.1
AP003419 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74621.1
BC000094 mRNA Translation: AAH00094.3
BC136564 mRNA Translation: AAI36565.1
CCDSiCCDS41677.1 [Q9UBS0-1]
PIRiJE0377
RefSeqiNP_003943.2, NM_003952.2 [Q9UBS0-1]
UniGeneiHs.534345

Genome annotation databases

EnsembliENST00000312629; ENSP00000308413; ENSG00000175634 [Q9UBS0-1]
ENST00000528964; ENSP00000432847; ENSG00000175634 [Q9UBS0-2]
GeneIDi6199
KEGGihsa:6199
UCSCiuc001old.4 human [Q9UBS0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKS6B2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBS0
Secondary accession number(s): B2RMZ9
, B4DML8, O94809, Q9UEC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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