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Protein

Ribosomal protein S6 kinase beta-2

Gene

RPS6KB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates specifically ribosomal protein S6.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 81ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • peptide binding Source: Ensembl
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: ProtInc
  • ribosomal protein S6 kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • positive regulation of translational initiation Source: UniProtKB
  • protein kinase B signaling Source: Ensembl
  • signal transduction Source: ProtInc
  • translation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10964-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-198693. AKT phosphorylates targets in the nucleus.
R-HSA-5674400. Constitutive Signaling by AKT1 E17K in Cancer.
SignaLinkiQ9UBS0.
SIGNORiQ9UBS0.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinase beta-2 (EC:2.7.11.1)
Short name:
S6K-beta-2
Short name:
S6K2
Alternative name(s):
70 kDa ribosomal protein S6 kinase 2
Short name:
P70S6K2
Short name:
p70-S6K 2
S6 kinase-related kinase
Short name:
SRK
Serine/threonine-protein kinase 14B
p70 ribosomal S6 kinase beta
Short name:
S6K-beta
Short name:
p70 S6 kinase beta
Short name:
p70 S6K-beta
Short name:
p70 S6KB
Short name:
p70-beta
Gene namesi
Name:RPS6KB2
Synonyms:STK14B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10437. RPS6KB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6199.
OpenTargetsiENSG00000175634.
PharmGKBiPA34852.

Chemistry databases

ChEMBLiCHEMBL3111.
GuidetoPHARMACOLOGYi1526.

Polymorphism and mutation databases

BioMutaiRPS6KB2.
DMDMi296434560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862141 – 482Ribosomal protein S6 kinase beta-2Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei473Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBS0.
PaxDbiQ9UBS0.
PeptideAtlasiQ9UBS0.
PRIDEiQ9UBS0.

PTM databases

iPTMnetiQ9UBS0.
PhosphoSitePlusiQ9UBS0.

Expressioni

Gene expression databases

BgeeiENSG00000175634.
CleanExiHS_RPS6KB2.
ExpressionAtlasiQ9UBS0. baseline and differential.
GenevisibleiQ9UBS0. HS.

Organism-specific databases

HPAiCAB019404.
HPA010010.

Interactioni

Protein-protein interaction databases

BioGridi112113. 193 interactors.
IntActiQ9UBS0. 8 interactors.
MINTiMINT-207158.
STRINGi9606.ENSP00000308413.

Chemistry databases

BindingDBiQ9UBS0.

Structurei

3D structure databases

ProteinModelPortaliQ9UBS0.
SMRiQ9UBS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 328Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini329 – 399AGC-kinase C-terminalAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi471 – 477Nuclear localization signal1 Publication7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi411 – 482Pro-richAdd BLAST72

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133668.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ9UBS0.
KOiK04688.
OMAiETSVNLC.
OrthoDBiEOG091G05Z7.
PhylomeDBiQ9UBS0.
TreeFamiTF313438.

Family and domain databases

CDDicd05584. STKc_p70S6K. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016238. Ribosomal_S6_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000605. Ribsml_S6_kin_1. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVFDLDLE TEEGSEGEGE PELSPADACP LAELRAAGLE PVGHYEEVEL
60 70 80 90 100
TETSVNVGPE RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV
110 120 130 140 150
LRKAKIVRNA KDTAHTRAER NILESVKHPF IVELAYAFQT GGKLYLILEC
160 170 180 190 200
LSGGELFTHL EREGIFLEDT ACFYLAEITL ALGHLHSQGI IYRDLKPENI
210 220 230 240 250
MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI LVRSGHNRAV
260 270 280 290 300
DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIRGKLALPP YLTPDARDLV
310 320 330 340 350
KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ
360 370 380 390 400
SEEDVSQFDT RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE
410 420 430 440 450
GFSFQPKLRS PRRLNSSPRA PVSPLKFSPF EGFRPSPSLP EPTELPLPPL
460 470 480
LPPPPPSTTA PLPIRPPSGT KKSKRGRGRP GR
Length:482
Mass (Da):53,455
Last modified:May 18, 2010 - v2
Checksum:i5D33660D24A2C7BE
GO
Isoform 2 (identifier: Q9UBS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-154: GG → VD
     155-482: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):16,868
Checksum:iB556CDA0AE062FBC
GO

Sequence cautioni

The sequence BAA34402 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90Missing in BAA37145 (PubMed:9878560).Curated1
Sequence conflicti409R → C in BAA37145 (PubMed:9878560).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040643267P → L.1 PublicationCorresponds to variant rs55987642dbSNPEnsembl.1
Natural variantiVAR_040644368V → M.1 PublicationCorresponds to variant rs55642995dbSNPEnsembl.1
Natural variantiVAR_040645420A → V.Combined sources5 PublicationsCorresponds to variant rs13859dbSNPEnsembl.1
Natural variantiVAR_040646443T → M in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs374535834dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056441153 – 154GG → VD in isoform 2. 1 Publication2
Alternative sequenceiVSP_056442155 – 482Missing in isoform 2. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016869 mRNA. Translation: BAA34402.1. Different initiation.
AB019245 mRNA. Translation: BAA37145.1.
AF076931 mRNA. Translation: AAD46063.1.
AF099739 mRNA. Translation: AAD20990.1.
AK297527 mRNA. Translation: BAG59930.1.
AP003419 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74621.1.
BC000094 mRNA. Translation: AAH00094.3.
BC136564 mRNA. Translation: AAI36565.1.
CCDSiCCDS41677.1. [Q9UBS0-1]
PIRiJE0377.
RefSeqiNP_003943.2. NM_003952.2. [Q9UBS0-1]
UniGeneiHs.534345.

Genome annotation databases

EnsembliENST00000312629; ENSP00000308413; ENSG00000175634. [Q9UBS0-1]
ENST00000528964; ENSP00000432847; ENSG00000175634. [Q9UBS0-2]
GeneIDi6199.
KEGGihsa:6199.
UCSCiuc001old.4. human. [Q9UBS0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016869 mRNA. Translation: BAA34402.1. Different initiation.
AB019245 mRNA. Translation: BAA37145.1.
AF076931 mRNA. Translation: AAD46063.1.
AF099739 mRNA. Translation: AAD20990.1.
AK297527 mRNA. Translation: BAG59930.1.
AP003419 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74621.1.
BC000094 mRNA. Translation: AAH00094.3.
BC136564 mRNA. Translation: AAI36565.1.
CCDSiCCDS41677.1. [Q9UBS0-1]
PIRiJE0377.
RefSeqiNP_003943.2. NM_003952.2. [Q9UBS0-1]
UniGeneiHs.534345.

3D structure databases

ProteinModelPortaliQ9UBS0.
SMRiQ9UBS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112113. 193 interactors.
IntActiQ9UBS0. 8 interactors.
MINTiMINT-207158.
STRINGi9606.ENSP00000308413.

Chemistry databases

BindingDBiQ9UBS0.
ChEMBLiCHEMBL3111.
GuidetoPHARMACOLOGYi1526.

PTM databases

iPTMnetiQ9UBS0.
PhosphoSitePlusiQ9UBS0.

Polymorphism and mutation databases

BioMutaiRPS6KB2.
DMDMi296434560.

Proteomic databases

EPDiQ9UBS0.
PaxDbiQ9UBS0.
PeptideAtlasiQ9UBS0.
PRIDEiQ9UBS0.

Protocols and materials databases

DNASUi6199.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312629; ENSP00000308413; ENSG00000175634. [Q9UBS0-1]
ENST00000528964; ENSP00000432847; ENSG00000175634. [Q9UBS0-2]
GeneIDi6199.
KEGGihsa:6199.
UCSCiuc001old.4. human. [Q9UBS0-1]

Organism-specific databases

CTDi6199.
DisGeNETi6199.
GeneCardsiRPS6KB2.
H-InvDBHIX0009859.
HGNCiHGNC:10437. RPS6KB2.
HPAiCAB019404.
HPA010010.
MIMi608939. gene.
neXtProtiNX_Q9UBS0.
OpenTargetsiENSG00000175634.
PharmGKBiPA34852.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133668.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ9UBS0.
KOiK04688.
OMAiETSVNLC.
OrthoDBiEOG091G05Z7.
PhylomeDBiQ9UBS0.
TreeFamiTF313438.

Enzyme and pathway databases

BioCyciZFISH:HS10964-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-198693. AKT phosphorylates targets in the nucleus.
R-HSA-5674400. Constitutive Signaling by AKT1 E17K in Cancer.
SignaLinkiQ9UBS0.
SIGNORiQ9UBS0.

Miscellaneous databases

GeneWikiiRPS6KB2.
GenomeRNAii6199.
PROiQ9UBS0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175634.
CleanExiHS_RPS6KB2.
ExpressionAtlasiQ9UBS0. baseline and differential.
GenevisibleiQ9UBS0. HS.

Family and domain databases

CDDicd05584. STKc_p70S6K. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016238. Ribosomal_S6_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000605. Ribsml_S6_kin_1. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKS6B2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBS0
Secondary accession number(s): B2RMZ9
, B4DML8, O94809, Q9UEC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.