Q9UBR6 (Q9UBR6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Telomerase reverse transcriptase EMBL AAD24464.1

Gene names

Name:

TERT EMBL AAD24464.1

Organism

Homo sapiens (Human) EMBL AAD24464.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	524 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Nucleotidyltransferase RNA-directed DNA polymerase EMBL AAD24464.1 Transferase
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	telomerase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	524	1	EMBL AAD24464.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UBR6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5F47DEFD01832B1B	FASTA	524	57,933
	10 20 30 40 50 60 MPRAPRCRAV RSLLRSHYRE VLPLATFVRR LGPQGWRLVQ RGDPAAFRAL VAQCLVCVPW 70 80 90 100 110 120 DARPPPAAPS FRQVSCLKEL VARVLQRLCE RGAKNVLAFG FALLDGARGG PPEAFTTSVR 130 140 150 160 170 180 SYLPNTVTDA LRGSGAWGLL LRRVGDDVLV HLLARCALFV LVAPSCAYQV CGPPLYQLGA 190 200 210 220 230 240 ATQARPPPHA SGPRRRLGCE RAWNHSVREA GVPLGLPAPG ARRRGGSASR SLPLPKRPRR 250 260 270 280 290 300 GAAPEPERTP VGQGSWAHPG RTRGPSDRGF CVVSPARPAE EATSLEGALS GTRHSHPSVG 310 320 330 340 350 360 RQHHAGPPST SRPPRPWDTP CPPVYAETKH FLYSSGDKEQ LRPSFLLSSL RPSLTGARRL 370 380 390 400 410 420 VETIFLGSRP WMPGTPRRLP RLPQRYWQMR PLFLELLGNH AQCPYGVLLK THCPLRAAVT 430 440 450 460 470 480 PAAGVCAREK PQGSVAAPEE EDTDPRRLVQ LLRQHSSPWQ VYGFVRACLR RLVPPGLWGS 490 500 510 520 RHNERRFLRN TKKFISLGKH AKLSLQELTW KMSVRDCAWL RRSP

References

[1]	"Identification of the human telomerase reverse transcriptase (hTERT) promoter." Ducrest A.-L., Amacker M., Reichenbach P., Nabholz M., Lingner J. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Direct activation of TERT transcription by c-MYC." Wu K.J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., Dalla-Favera R. Nat. Genet. 21:220-224(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation." Greenberg R.A., O'Hagan R.C., Deng H., Xiao Q., Hann S.R., Adams R.R., Lichtsteiner S., Chin L., Morin G.B., DePinho R.A. Oncogene 18:1219-1226(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas." Szutorisz H., Palmquist R., Roos G., Stenling R., Schorderet D., Reddel R., Lingner J., Nabholz M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF114847 Genomic DNA. Translation: AAD17210.1. AF121948 Genomic DNA. Translation: AAD24464.1.
IPI	IPI00963895.
UniGene	Hs.492203.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UBR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000148780.
HOVERGEN	HBG000460.
OrthoDB	EOG4J117F.
Gene expression databases
ArrayExpress	Q9UBR6.
Bgee	Q9UBR6.
Family and domain databases
InterPro	IPR021891. Telomerase_RBD. [Graphical view]
Pfam	PF12009. Telomerase_RBD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UBR6_HUMAN

Accession

Primary (citable) accession number: Q9UBR6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.