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Protein

Cathepsin Z

Gene

CTSZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.

Catalytic activityi

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei921
Active sitei2411
Active sitei2611

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciZFISH:HS02205-MONOMER.
BRENDAi3.4.18.1. 2681.
ReactomeiR-HSA-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiC01.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin Z (EC:3.4.18.1)
Alternative name(s):
Cathepsin P
Cathepsin X
Gene namesi
Name:CTSZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:2547. CTSZ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1522.
OpenTargetsiENSG00000101160.
PharmGKBiPA27043.

Chemistry databases

ChEMBLiCHEMBL4160.
GuidetoPHARMACOLOGYi2354.

Polymorphism and mutation databases

BioMutaiCTSZ.
DMDMi12643324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002628524 – 61Activation peptideAdd BLAST38
ChainiPRO_000002628662 – 303Cathepsin ZAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 132
Disulfide bondi126 ↔ 164
Disulfide bondi154 ↔ 170
Disulfide bondi173 ↔ 179
Glycosylationi184N-linked (GlcNAc...)1 Publication1
Disulfide bondi214 ↔ 296
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiQ9UBR2.
MaxQBiQ9UBR2.
PaxDbiQ9UBR2.
PeptideAtlasiQ9UBR2.
PRIDEiQ9UBR2.

PTM databases

PhosphoSitePlusiQ9UBR2.
SwissPalmiQ9UBR2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000101160.
CleanExiHS_CTSZ.
GenevisibleiQ9UBR2. HS.

Organism-specific databases

HPAiCAB025114.
HPA049876.
HPA053504.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-8636823,EBI-10171697
KRTAP5-9P263716EBI-8636823,EBI-3958099
MID2Q9UJV3-25EBI-8636823,EBI-10172526
MTUS2Q5JR593EBI-8636823,EBI-742948
NOTCH2NLQ7Z3S95EBI-8636823,EBI-945833
PLSCR1O151623EBI-8636823,EBI-740019

Protein-protein interaction databases

BioGridi107902. 14 interactors.
IntActiQ9UBR2. 20 interactors.
MINTiMINT-3079312.
STRINGi9606.ENSP00000217131.

Chemistry databases

BindingDBiQ9UBR2.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 42Combined sources3
Helixi59 – 61Combined sources3
Beta strandi85 – 87Combined sources3
Helixi92 – 108Combined sources17
Turni109 – 111Combined sources3
Helixi120 – 126Combined sources7
Beta strandi127 – 131Combined sources5
Beta strandi133 – 135Combined sources3
Helixi137 – 146Combined sources10
Beta strandi149 – 151Combined sources3
Helixi152 – 154Combined sources3
Helixi166 – 169Combined sources4
Beta strandi170 – 175Combined sources6
Beta strandi178 – 181Combined sources4
Beta strandi190 – 196Combined sources7
Helixi199 – 209Combined sources11
Beta strandi212 – 216Combined sources5
Helixi220 – 223Combined sources4
Beta strandi227 – 230Combined sources4
Beta strandi241 – 251Combined sources11
Beta strandi254 – 260Combined sources7
Beta strandi272 – 276Combined sources5
Helixi280 – 283Combined sources4
Helixi285 – 287Combined sources3
Turni290 – 293Combined sources4
Beta strandi296 – 301Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEUX-ray1.70A/B27-303[»]
1EF7X-ray2.67A/B62-303[»]
ProteinModelPortaliQ9UBR2.
SMRiQ9UBR2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UBR2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000264454.
HOVERGENiHBG004456.
InParanoidiQ9UBR2.
KOiK08568.
OMAiQCGTCTE.
OrthoDBiEOG091G0BNT.
PhylomeDBiQ9UBR2.
TreeFamiTF313225.

Family and domain databases

InterProiIPR033157. Cathepsin_X.
IPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF377. PTHR12411:SF377. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY
60 70 80 90 100
PRPHEYLSPA DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA
110 120 130 140 150
MADRINIKRK GAWPSTLLSV QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP
160 170 180 190 200
DETCNNYQAK DQECDKFNQC GTCNEFKECH AIRNYTLWRV GDYGSLSGRE
210 220 230 240 250
KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN HVVSVAGWGI
260 270 280 290 300
SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD

PIV
Length:303
Mass (Da):33,868
Last modified:May 1, 2000 - v1
Checksum:i6274FD1974D0EBDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48S → T in AAC39839 (PubMed:9642240).Curated1
Sequence conflicti150P → S in AAC61477 (PubMed:9738465).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01025436P → S.1 PublicationCorresponds to variant rs778998634dbSNPEnsembl.1
Natural variantiVAR_010255129A → R Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_033719286A → T.Corresponds to variant rs34069356dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073890 mRNA. Translation: AAC61477.1.
AF032906 mRNA. Translation: AAC39839.1.
AF136273 mRNA. Translation: AAF13145.1.
AF136276, AF136274, AF136275 Genomic DNA. Translation: AAF13148.1.
AK314931 mRNA. Translation: BAG37437.1.
AL109840 Genomic DNA. Translation: CAC09370.1.
CH471077 Genomic DNA. Translation: EAW75448.1.
BC042168 mRNA. Translation: AAH42168.1.
AF009923 mRNA. Translation: AAC63141.1.
CCDSiCCDS13474.1.
RefSeqiNP_001327.2. NM_001336.3.
UniGeneiHs.252549.

Genome annotation databases

EnsembliENST00000217131; ENSP00000217131; ENSG00000101160.
GeneIDi1522.
KEGGihsa:1522.
UCSCiuc002yai.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073890 mRNA. Translation: AAC61477.1.
AF032906 mRNA. Translation: AAC39839.1.
AF136273 mRNA. Translation: AAF13145.1.
AF136276, AF136274, AF136275 Genomic DNA. Translation: AAF13148.1.
AK314931 mRNA. Translation: BAG37437.1.
AL109840 Genomic DNA. Translation: CAC09370.1.
CH471077 Genomic DNA. Translation: EAW75448.1.
BC042168 mRNA. Translation: AAH42168.1.
AF009923 mRNA. Translation: AAC63141.1.
CCDSiCCDS13474.1.
RefSeqiNP_001327.2. NM_001336.3.
UniGeneiHs.252549.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEUX-ray1.70A/B27-303[»]
1EF7X-ray2.67A/B62-303[»]
ProteinModelPortaliQ9UBR2.
SMRiQ9UBR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107902. 14 interactors.
IntActiQ9UBR2. 20 interactors.
MINTiMINT-3079312.
STRINGi9606.ENSP00000217131.

Chemistry databases

BindingDBiQ9UBR2.
ChEMBLiCHEMBL4160.
GuidetoPHARMACOLOGYi2354.

Protein family/group databases

MEROPSiC01.013.

PTM databases

PhosphoSitePlusiQ9UBR2.
SwissPalmiQ9UBR2.

Polymorphism and mutation databases

BioMutaiCTSZ.
DMDMi12643324.

Proteomic databases

EPDiQ9UBR2.
MaxQBiQ9UBR2.
PaxDbiQ9UBR2.
PeptideAtlasiQ9UBR2.
PRIDEiQ9UBR2.

Protocols and materials databases

DNASUi1522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217131; ENSP00000217131; ENSG00000101160.
GeneIDi1522.
KEGGihsa:1522.
UCSCiuc002yai.3. human.

Organism-specific databases

CTDi1522.
DisGeNETi1522.
GeneCardsiCTSZ.
HGNCiHGNC:2547. CTSZ.
HPAiCAB025114.
HPA049876.
HPA053504.
MIMi603169. gene.
neXtProtiNX_Q9UBR2.
OpenTargetsiENSG00000101160.
PharmGKBiPA27043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000264454.
HOVERGENiHBG004456.
InParanoidiQ9UBR2.
KOiK08568.
OMAiQCGTCTE.
OrthoDBiEOG091G0BNT.
PhylomeDBiQ9UBR2.
TreeFamiTF313225.

Enzyme and pathway databases

BioCyciZFISH:HS02205-MONOMER.
BRENDAi3.4.18.1. 2681.
ReactomeiR-HSA-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-5694530. Cargo concentration in the ER.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiCTSZ. human.
EvolutionaryTraceiQ9UBR2.
GeneWikiiCathepsin_Z.
GenomeRNAii1522.
PROiQ9UBR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101160.
CleanExiHS_CTSZ.
GenevisibleiQ9UBR2. HS.

Family and domain databases

InterProiIPR033157. Cathepsin_X.
IPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF377. PTHR12411:SF377. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATZ_HUMAN
AccessioniPrimary (citable) accession number: Q9UBR2
Secondary accession number(s): B2RC40
, O75331, Q9UQV5, Q9UQV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.