##gff-version 3 Q9UBR1 UniProtKB Chain 1 384 . . . ID=PRO_0000204051;Note=Beta-ureidopropionase Q9UBR1 UniProtKB Domain 72 344 . . . Note=CN hydrolase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00054 Q9UBR1 UniProtKB Active site 119 119 . . . Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00054 Q9UBR1 UniProtKB Active site 196 196 . . . Note=Proton donor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00054 Q9UBR1 UniProtKB Active site 233 233 . . . Note=Nucleophile;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00054,ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Modified residue 378 378 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q03248 Q9UBR1 UniProtKB Natural variant 13 13 . . . ID=VAR_081207;Note=In UPB1D%3B strongly reduced activity%3B reduced formation of higher oligomers. L->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22525402,ECO:0000269|PubMed:24526388;Dbxref=dbSNP:rs200688546,PMID:22525402,PMID:24526388 Q9UBR1 UniProtKB Natural variant 85 85 . . . ID=VAR_026752;Note=In UPB1D%3B complete loss of activity. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15385443;Dbxref=dbSNP:rs34035085,PMID:15385443 Q9UBR1 UniProtKB Natural variant 235 235 . . . ID=VAR_081208;Note=In UPB1D%3B complete loss of activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22525402;Dbxref=dbSNP:rs766196011,PMID:22525402 Q9UBR1 UniProtKB Natural variant 236 236 . . . ID=VAR_081209;Note=In UPB1D%3B complete loss of activity. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22525402;Dbxref=dbSNP:rs144135211,PMID:22525402 Q9UBR1 UniProtKB Natural variant 264 264 . . . ID=VAR_081210;Note=In UPB1D%3B complete loss of activity. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22525402;Dbxref=PMID:22525402 Q9UBR1 UniProtKB Natural variant 271 271 . . . ID=VAR_081211;Note=In UPB1D%3B complete loss of activity%3B abolishes formation of higher oligomers. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24526388;Dbxref=dbSNP:rs747454154,PMID:24526388 Q9UBR1 UniProtKB Natural variant 286 286 . . . ID=VAR_081212;Note=In UPB1D%3B uncertain significance%3B mildly reduced enzyme activity%3B no effect on formation of higher oligomers. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24526388;Dbxref=dbSNP:rs200034079,PMID:24526388 Q9UBR1 UniProtKB Natural variant 326 326 . . . ID=VAR_081213;Note=In UPB1D%3B complete loss of activity%3B abolishes formation of higher oligomers. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22525402,ECO:0000269|PubMed:24526388;Dbxref=dbSNP:rs118163237,PMID:22525402,PMID:24526388 Q9UBR1 UniProtKB Natural variant 340 340 . . . ID=VAR_050280;Note=A->D;Dbxref=dbSNP:rs34110964 Q9UBR1 UniProtKB Natural variant 359 359 . . . ID=VAR_081214;Note=In UPB1D%3B complete loss of activity. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22525402;Dbxref=dbSNP:rs369879221,PMID:22525402 Q9UBR1 UniProtKB Mutagenesis 130 130 . . . Note=Loss of catalytic activity. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Mutagenesis 132 132 . . . Note=Loss of catalytic activity. Forms dimers%2C but no higher oligomers. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Mutagenesis 208 208 . . . Note=Loss of catalytic activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Mutagenesis 208 208 . . . Note=Loss of catalytic activity. Forms dimers%2C but no higher oligomers. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Mutagenesis 208 208 . . . Note=Loss of catalytic activity. Forms dimers%2C but no higher oligomers. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Mutagenesis 233 233 . . . Note=Loss of catalytic activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Mutagenesis 299 299 . . . Note=Loss of catalytic activity. Forms dimers%2C but no higher oligomers. T->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29976570;Dbxref=PMID:29976570 Q9UBR1 UniProtKB Sequence conflict 263 263 . . . Note=L->LRSL;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9UBR1 UniProtKB Helix 41 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 53 59 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 71 78 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 89 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 113 116 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Turn 119 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 135 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Turn 142 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 146 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 161 169 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 171 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 177 184 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 190 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 221 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 226 230 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 233 237 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 239 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 251 257 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 262 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 281 287 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 289 291 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 296 298 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 318 320 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 332 334 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Beta strand 336 343 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 346 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Turn 351 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 356 359 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ Q9UBR1 UniProtKB Helix 362 373 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6FTQ