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Protein

Kidney-associated antigen 1

Gene

KAAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kidney-associated antigen 1
Alternative name(s):
RU2 antisense gene protein
Gene namesi
Name:KAAG1
Synonyms:RU2AS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21031. KAAG1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915618.

Polymorphism and mutation databases

BioMutaiKAAG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8484Kidney-associated antigen 1PRO_0000274669Add
BLAST

Proteomic databases

PaxDbiQ9UBP8.
PRIDEiQ9UBP8.

Expressioni

Tissue specificityi

Expressed in testis and kidney, and, at lower levels, in urinary bladder and liver. Expressed by a high proportion of tumors of various histologic origin, including melanomas, sarcomas and colorectal carcinomas.1 Publication

Gene expression databases

BgeeiQ9UBP8.
CleanExiHS_KAAG1.
GenevisibleiQ9UBP8. HS.

Organism-specific databases

HPAiHPA036021.

Interactioni

Protein-protein interaction databases

BioGridi131666. 1 interaction.
STRINGi9606.ENSP00000274766.

Structurei

3D structure databases

ProteinModelPortaliQ9UBP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 364Poly-Ala

Phylogenomic databases

eggNOGiENOG410JGC7. Eukaryota.
ENOG41118AS. LUCA.
GeneTreeiENSGT00390000011791.
HOGENOMiHOG000113188.
InParanoidiQ9UBP8.
OMAiAAPCEEG.
OrthoDBiEOG7D85ZZ.
PhylomeDBiQ9UBP8.
TreeFamiTF340885.

Family and domain databases

InterProiIPR029407. KAAG1.
[Graphical view]
PfamiPF15354. KAAG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDAAPRVE GVPVAVHKHA LHDGLRQVAG PGAAAAHLPR WPPPQLAASR
60 70 80
REAPPLSQRP HRTQGAGSPP ETNEKLTNPQ VKEK
Length:84
Mass (Da):8,969
Last modified:May 1, 2000 - v1
Checksum:i70B739F173A9E560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181720 Genomic DNA. Translation: AAF23611.1.
AF181722 mRNA. Translation: AAF23613.1.
AL359713 Genomic DNA. Translation: CAI17106.1.
CCDSiCCDS4551.1.
RefSeqiNP_851854.1. NM_181337.3.
UniGeneiHs.697888.

Genome annotation databases

EnsembliENST00000274766; ENSP00000274766; ENSG00000146049.
GeneIDi353219.
KEGGihsa:353219.
UCSCiuc003ndz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181720 Genomic DNA. Translation: AAF23611.1.
AF181722 mRNA. Translation: AAF23613.1.
AL359713 Genomic DNA. Translation: CAI17106.1.
CCDSiCCDS4551.1.
RefSeqiNP_851854.1. NM_181337.3.
UniGeneiHs.697888.

3D structure databases

ProteinModelPortaliQ9UBP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131666. 1 interaction.
STRINGi9606.ENSP00000274766.

Polymorphism and mutation databases

BioMutaiKAAG1.

Proteomic databases

PaxDbiQ9UBP8.
PRIDEiQ9UBP8.

Protocols and materials databases

DNASUi353219.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274766; ENSP00000274766; ENSG00000146049.
GeneIDi353219.
KEGGihsa:353219.
UCSCiuc003ndz.1. human.

Organism-specific databases

CTDi353219.
GeneCardsiKAAG1.
H-InvDBHIX0005620.
HGNCiHGNC:21031. KAAG1.
HPAiHPA036021.
MIMi608211. gene.
neXtProtiNX_Q9UBP8.
PharmGKBiPA134915618.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JGC7. Eukaryota.
ENOG41118AS. LUCA.
GeneTreeiENSGT00390000011791.
HOGENOMiHOG000113188.
InParanoidiQ9UBP8.
OMAiAAPCEEG.
OrthoDBiEOG7D85ZZ.
PhylomeDBiQ9UBP8.
TreeFamiTF340885.

Miscellaneous databases

GenomeRNAii353219.
PROiQ9UBP8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBP8.
CleanExiHS_KAAG1.
GenevisibleiQ9UBP8. HS.

Family and domain databases

InterProiIPR029407. KAAG1.
[Graphical view]
PfamiPF15354. KAAG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription."
    Van den Eynde B.J., Gaugler B., Probst-Kepper M., Michaux L., Devuyst O., Lorge F., Weynants P., Boon T.
    J. Exp. Med. 190:1793-1800(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKAAG1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.