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Q9UBP5

- HEY2_HUMAN

UniProt

Q9UBP5 - HEY2_HUMAN

Protein

Hairy/enhancer-of-split related with YRPW motif protein 2

Gene

HEY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.4 Publications

    GO - Molecular functioni

    1. histone deacetylase binding Source: BHF-UCL
    2. microsatellite binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein binding transcription factor activity Source: UniProtKB
    5. RNA polymerase II activating transcription factor binding Source: BHF-UCL
    6. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: UniProtKB
    7. sequence-specific DNA binding Source: BHF-UCL
    8. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior axis specification Source: Ensembl
    2. arterial endothelial cell differentiation Source: BHF-UCL
    3. ascending aorta morphogenesis Source: BHF-UCL
    4. atrial septum morphogenesis Source: BHF-UCL
    5. atrioventricular valve development Source: Ensembl
    6. cardiac epithelial to mesenchymal transition Source: BHF-UCL
    7. cardiac left ventricle morphogenesis Source: BHF-UCL
    8. cardiac muscle hypertrophy in response to stress Source: Ensembl
    9. cardiac right ventricle morphogenesis Source: BHF-UCL
    10. cardiac septum morphogenesis Source: BHF-UCL
    11. cardiac vascular smooth muscle cell development Source: Ensembl
    12. cardiac ventricle morphogenesis Source: UniProtKB
    13. cell fate commitment Source: Ensembl
    14. cochlea development Source: Ensembl
    15. coronary vasculature morphogenesis Source: Ensembl
    16. dorsal aorta morphogenesis Source: BHF-UCL
    17. endocardial cushion to mesenchymal transition involved in heart valve formation Source: Ensembl
    18. heart trabecula formation Source: Ensembl
    19. labyrinthine layer blood vessel development Source: BHF-UCL
    20. mesenchymal cell development Source: BHF-UCL
    21. muscular septum morphogenesis Source: BHF-UCL
    22. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    23. negative regulation of cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
    24. negative regulation of gene expression Source: UniProtKB
    25. negative regulation of Notch signaling pathway Source: Ensembl
    26. negative regulation of transcription, DNA-templated Source: UniProtKB
    27. negative regulation of transcription by transcription factor localization Source: BHF-UCL
    28. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    29. negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
    30. negative regulation of transcription initiation from RNA polymerase II promoter Source: BHF-UCL
    31. negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
    32. Notch signaling involved in heart development Source: BHF-UCL
    33. Notch signaling pathway Source: UniProtKB
    34. outflow tract morphogenesis Source: BHF-UCL
    35. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    36. positive regulation of heart rate Source: Ensembl
    37. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    38. protein-DNA complex assembly Source: Ensembl
    39. pulmonary artery morphogenesis Source: BHF-UCL
    40. pulmonary valve morphogenesis Source: BHF-UCL
    41. regulation of auditory receptor cell differentiation Source: Ensembl
    42. regulation of vasculogenesis Source: BHF-UCL
    43. smooth muscle cell differentiation Source: BHF-UCL
    44. transcription from RNA polymerase II promoter Source: GOC
    45. tricuspid valve formation Source: Ensembl
    46. tricuspid valve morphogenesis Source: BHF-UCL
    47. umbilical cord morphogenesis Source: BHF-UCL
    48. vascular smooth muscle cell development Source: UniProtKB
    49. vasculogenesis Source: BHF-UCL
    50. ventricular cardiac muscle cell development Source: UniProtKB
    51. ventricular septum morphogenesis Source: BHF-UCL
    52. ventricular trabecula myocardium morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Notch signaling pathway, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hairy/enhancer-of-split related with YRPW motif protein 2
    Alternative name(s):
    Cardiovascular helix-loop-helix factor 1
    Short name:
    hCHF1
    Class B basic helix-loop-helix protein 32
    Short name:
    bHLHb32
    HES-related repressor protein 2
    Hairy and enhancer of split-related protein 2
    Short name:
    HESR-2
    Hairy-related transcription factor 2
    Short name:
    HRT-2
    Short name:
    hHRT2
    Protein gridlock homolog
    Gene namesi
    Name:HEY2
    Synonyms:BHLHB32, CHF1, GRL, HERP, HERP1, HRT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4881. HEY2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB
    4. transcriptional repressor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541G → P: Impairs transcriptional repression. 1 Publication

    Organism-specific databases

    PharmGKBiPA29259.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Hairy/enhancer-of-split related with YRPW motif protein 2PRO_0000245515Add
    BLAST

    Proteomic databases

    PaxDbiQ9UBP5.
    PRIDEiQ9UBP5.

    PTM databases

    PhosphoSiteiQ9UBP5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBP5.
    BgeeiQ9UBP5.
    CleanExiHS_HEY2.
    GenevestigatoriQ9UBP5.

    Organism-specific databases

    HPAiHPA030205.

    Interactioni

    Subunit structurei

    May self-associate By similarity. Interacts with GATA4, HES1 and HEYL By similarity. Interacts with HDAC1, NCOR1 and SIN3A By similarity. Interacts with ARNT and GATA6.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428582EBI-750630,EBI-466029
    SIRT1Q96EB63EBI-750630,EBI-1802965

    Protein-protein interaction databases

    BioGridi117045. 18 interactions.
    IntActiQ9UBP5. 5 interactions.
    MINTiMINT-1469894.
    STRINGi9606.ENSP00000357348.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBP5.
    SMRiQ9UBP5. Positions 40-104, 110-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 10356bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini122 – 15736OrangePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni47 – 11670Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi327 – 3304YRPW motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi175 – 19117His-richAdd
    BLAST
    Compositional biasi262 – 30241Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HEY family.Curated
    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 1 Orange domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG324798.
    HOGENOMiHOG000286035.
    HOVERGENiHBG003275.
    InParanoidiQ9UBP5.
    KOiK09091.
    OMAiSTCASQR.
    PhylomeDBiQ9UBP5.
    TreeFamiTF323617.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003650. Orange.
    IPR018352. Orange_subgr.
    [Graphical view]
    PfamiPF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    SM00511. ORANGE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UBP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRPCEETTS ESDMDETIDV GSENNYSGQS TSSVIRLNSP TTTSQIMARK    50
    KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL 100
    KMLQATGGKG YFDAHALAMD FMSIGFRECL TEVARYLSSV EGLDSSDPLR 150
    VRLVSHLSTC ATQREAAAMT SSMAHHHHPL HPHHWAAAFH HLPAALLQPN 200
    GLHASESTPC RLSTTSEVPP AHGSALLTAT FAHADSALRM PSTGSVAPCV 250
    PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP PNAAAAVAAA 300
    TAISPPLSVS ATSSPQQTSS GTNNKPYRPW GTEVGAF 337
    Length:337
    Mass (Da):35,808
    Last modified:May 1, 2000 - v1
    Checksum:i71B7B1AA69BA88D2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961T → A in a patient with atrioventricular septal defects. 1 Publication
    VAR_026974
    Natural varianti98 – 981D → A in a patient with atrioventricular septal defects. 1 Publication
    VAR_026975
    Natural varianti100 – 1001L → S in a patient with atrioventricular septal defects. 1 Publication
    VAR_026976
    Natural varianti140 – 1401V → M.
    Corresponds to variant rs3734638 [ dbSNP | Ensembl ].
    VAR_026977

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249545 mRNA. Translation: CAB56839.1.
    AF237949 mRNA. Translation: AAF44781.1.
    AF173901 mRNA. Translation: AAF20173.1.
    AF311884 mRNA. Translation: AAG31157.1.
    AF232238 mRNA. Translation: AAF37296.1.
    AB044755 mRNA. Translation: BAA96781.1.
    BT020067 mRNA. Translation: AAV38870.1.
    BT020068 mRNA. Translation: AAV38871.1.
    AL078594 Genomic DNA. Translation: CAB87581.1.
    BC007707 mRNA. Translation: AAH07707.1.
    CCDSiCCDS5131.1.
    RefSeqiNP_036391.1. NM_012259.2.
    UniGeneiHs.144287.

    Genome annotation databases

    EnsembliENST00000368364; ENSP00000357348; ENSG00000135547.
    GeneIDi23493.
    KEGGihsa:23493.
    UCSCiuc003qad.3. human.

    Polymorphism databases

    DMDMi74762767.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249545 mRNA. Translation: CAB56839.1 .
    AF237949 mRNA. Translation: AAF44781.1 .
    AF173901 mRNA. Translation: AAF20173.1 .
    AF311884 mRNA. Translation: AAG31157.1 .
    AF232238 mRNA. Translation: AAF37296.1 .
    AB044755 mRNA. Translation: BAA96781.1 .
    BT020067 mRNA. Translation: AAV38870.1 .
    BT020068 mRNA. Translation: AAV38871.1 .
    AL078594 Genomic DNA. Translation: CAB87581.1 .
    BC007707 mRNA. Translation: AAH07707.1 .
    CCDSi CCDS5131.1.
    RefSeqi NP_036391.1. NM_012259.2.
    UniGenei Hs.144287.

    3D structure databases

    ProteinModelPortali Q9UBP5.
    SMRi Q9UBP5. Positions 40-104, 110-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117045. 18 interactions.
    IntActi Q9UBP5. 5 interactions.
    MINTi MINT-1469894.
    STRINGi 9606.ENSP00000357348.

    PTM databases

    PhosphoSitei Q9UBP5.

    Polymorphism databases

    DMDMi 74762767.

    Proteomic databases

    PaxDbi Q9UBP5.
    PRIDEi Q9UBP5.

    Protocols and materials databases

    DNASUi 23493.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368364 ; ENSP00000357348 ; ENSG00000135547 .
    GeneIDi 23493.
    KEGGi hsa:23493.
    UCSCi uc003qad.3. human.

    Organism-specific databases

    CTDi 23493.
    GeneCardsi GC06P126068.
    HGNCi HGNC:4881. HEY2.
    HPAi HPA030205.
    MIMi 604674. gene.
    neXtProti NX_Q9UBP5.
    PharmGKBi PA29259.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324798.
    HOGENOMi HOG000286035.
    HOVERGENi HBG003275.
    InParanoidi Q9UBP5.
    KOi K09091.
    OMAi STCASQR.
    PhylomeDBi Q9UBP5.
    TreeFami TF323617.

    Enzyme and pathway databases

    Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    GeneWikii HEY2.
    GenomeRNAii 23493.
    NextBioi 45859.
    PROi Q9UBP5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBP5.
    Bgeei Q9UBP5.
    CleanExi HS_HEY2.
    Genevestigatori Q9UBP5.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003650. Orange.
    IPR018352. Orange_subgr.
    [Graphical view ]
    Pfami PF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    SM00511. ORANGE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
      Leimeister C., Externbrinck A., Klamt B., Gessler M.
      Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gridlock, an HLH gene required for assembly of the aorta in zebrafish."
      Zhong T.P., Rosenberg M., Mohideen M.-A.P.K., Weinstein B., Fishman M.C.
      Science 287:1820-1824(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
      Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E.
      J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ARNT.
      Tissue: Heart.
    4. "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
      Nakagawa O., McFadden D.G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING.
    5. "HERP, a new primary target of Notch regulated by ligand binding."
      Iso T., Sartorelli V., Chung G., Shichinohe T., Kedes L., Hamamori Y.
      Mol. Cell. Biol. 21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    6. "Homo sapiens testis cDNA clone, basic-helix-loop-helix protein (Hey2)."
      Tanaka K., Miyata J., Ikeda J.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    10. "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
      Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
      J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6."
      Shirvani S., Xiang F., Koibuchi N., Chin M.T.
      Biochem. Biophys. Res. Commun. 339:151-156(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GATA6, MUTAGENESIS OF GLY-54.
    12. Cited for: VARIANTS ALA-96; ALA-98 AND SER-100.

    Entry informationi

    Entry nameiHEY2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3