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Q9UBN6 (TR10D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 10D
Alternative name(s):
Decoy receptor 2
Short name=DcR2
TNF-related apoptosis-inducing ligand receptor 4
Short name=TRAIL receptor 4
Short name=TRAIL-R4
TRAIL receptor with a truncated death domain
CD_antigen=CD264
Gene names
Name:TNFRSF10D
Synonyms:DCR2, TRAILR4, TRUNDD
ORF Names:UNQ251/PRO288
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to Ref.1, it cannot but according to Ref.2, it can induce the NF-kappa-B pathway.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Sequence similarities

Contains 1 death domain.

Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of apoptotic process

Traceable author statement Ref.2. Source: ProtInc

signal transduction

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransmembrane signaling receptor activity

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5555 Ref.1 Ref.7
Chain56 – 386331Tumor necrosis factor receptor superfamily member 10D
PRO_0000034584

Regions

Topological domain56 – 211156Extracellular Potential
Transmembrane212 – 23221Helical; Potential
Topological domain233 – 386154Cytoplasmic Potential
Repeat58 – 9740TNFR-Cys 1
Repeat98 – 13942TNFR-Cys 2
Repeat140 – 18041TNFR-Cys 3
Domain340 – 36627Death; truncated
Compositional bias225 – 2284Poly-Val
Compositional bias246 – 2505Poly-Gly

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 96 By similarity
Disulfide bond99 ↔ 115 By similarity
Disulfide bond118 ↔ 131 By similarity
Disulfide bond121 ↔ 139 By similarity
Disulfide bond141 ↔ 155 By similarity
Disulfide bond158 ↔ 172 By similarity
Disulfide bond162 ↔ 180 By similarity

Natural variations

Natural variant351P → S in TRAIL-R4-B. Ref.2
Corresponds to variant rs11135703 [ dbSNP | Ensembl ].
VAR_011417
Natural variant2761R → H.
Corresponds to variant rs55636833 [ dbSNP | Ensembl ].
VAR_061854
Natural variant3101S → L in TRAIL-R4-B. Ref.2
Corresponds to variant rs1133782 [ dbSNP | Ensembl ].
VAR_011418
Natural variant3451T → P.
Corresponds to variant rs34622674 [ dbSNP | Ensembl ].
VAR_057288

Sequences

Sequence LengthMass (Da)Tools
Q9UBN6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 77A93577CAAF2632

FASTA38641,823
        10         20         30         40         50         60 
MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR 

        70         80         90        100        110        120 
QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV 

       130        140        150        160        170        180 
CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC 

       190        200        210        220        230        240 
KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL 

       250        260        270        280        290        300 
KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL 

       310        320        330        340        350        360 
AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE 

       370        380 
TIQDQLVGSE KLFYEEDEAG SATSCL 

« Hide

References

« Hide 'large scale' references
[1]"A novel receptor for Apo2L/TRAIL contains a truncated death domain."
Marsters S.A., Sheridan J.P., Pitti R.M., Huang A., Skubatch M., Baldwin D., Yuan J., Gurney A., Goddard A.D., Godowski P., Ashkenazi A.
Curr. Biol. 7:1003-1006(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
Tissue: Fetal lung.
[2]"The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain."
Degli-Esposti M.A., Dougall W.C., Smolak P.J., Waugh J.Y., Smith C.A., Goodwin R.G.
Immunity 7:813-820(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS SER-35 AND LEU-310.
Tissue: Foreskin fibroblast and Peripheral blood lymphocyte.
[3]"TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling."
Pan G., Ni J., Yu G.-L., Wei Y.-F., Dixit V.M.
FEBS Lett. 424:41-45(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 56-70.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF029761 mRNA. Translation: AAD03477.1.
AF021232 mRNA. Translation: AAC32765.1.
AF021233 mRNA. Translation: AAC32766.1.
AF023849 mRNA. Translation: AAC52053.1.
AY358285 mRNA. Translation: AAQ88652.1.
AK313528 mRNA. Translation: BAG36307.1.
BC052270 mRNA. Translation: AAH52270.1.
RefSeqNP_003831.2. NM_003840.4.
UniGeneHs.213467.

3D structure databases

ProteinModelPortalQ9UBN6.
SMRQ9UBN6. Positions 83-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114321. 7 interactions.
DIPDIP-6231N.
IntActQ9UBN6. 1 interaction.
MINTMINT-4657998.
STRING9606.ENSP00000310263.

PTM databases

PhosphoSiteQ9UBN6.

Polymorphism databases

DMDM18203495.

Proteomic databases

PaxDbQ9UBN6.
PRIDEQ9UBN6.

Protocols and materials databases

DNASU8793.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312584; ENSP00000310263; ENSG00000173530.
GeneID8793.
KEGGhsa:8793.
UCSCuc003xcz.2. human.

Organism-specific databases

CTD8793.
GeneCardsGC08M022993.
H-InvDBHIX0025539.
HGNCHGNC:11907. TNFRSF10D.
MIM603614. gene.
neXtProtNX_Q9UBN6.
PharmGKBPA36600.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80202.
HOGENOMHOG000142423.
HOVERGENHBG061626.
InParanoidQ9UBN6.
KOK04722.
OrthoDBEOG71VSSN.
PhylomeDBQ9UBN6.
TreeFamTF333916.

Enzyme and pathway databases

SignaLinkQ9UBN6.

Gene expression databases

BgeeQ9UBN6.
CleanExHS_TNFRSF10D.
GenevestigatorQ9UBN6.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view]
PfamPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSPR01956. TNFACTORR10.
SMARTSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTNFRSF10D.
GenomeRNAi8793.
NextBio32976.
PROQ9UBN6.
SOURCESearch...

Entry information

Entry nameTR10D_HUMAN
AccessionPrimary (citable) accession number: Q9UBN6
Secondary accession number(s): B2R8W0, Q9Y6Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries