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Q9UBN6

- TR10D_HUMAN

UniProt

Q9UBN6 - TR10D_HUMAN

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Protein
Tumor necrosis factor receptor superfamily member 10D
Gene
TNFRSF10D, DCR2, TRAILR4, TRUNDD, UNQ251/PRO288
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to 1 Publication, it cannot but according to 1 Publication, it can induce the NF-kappa-B pathway.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: ProtInc
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ9UBN6.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10D
Alternative name(s):
Decoy receptor 2
Short name:
DcR2
TNF-related apoptosis-inducing ligand receptor 4
Short name:
TRAIL receptor 4
Short name:
TRAIL-R4
TRAIL receptor with a truncated death domain
CD_antigen: CD264
Gene namesi
Synonyms:DCR2, TRAILR4, TRUNDD
ORF Names:UNQ251/PRO288
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:11907. TNFRSF10D.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini56 – 211156Extracellular Reviewed prediction
Add
BLAST
Transmembranei212 – 23221Helical; Reviewed prediction
Add
BLAST
Topological domaini233 – 386154Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 55552 Publications
Add
BLAST
Chaini56 – 386331Tumor necrosis factor receptor superfamily member 10D
PRO_0000034584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 96 By similarity
Disulfide bondi99 ↔ 115 By similarity
Disulfide bondi118 ↔ 131 By similarity
Disulfide bondi121 ↔ 139 By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi141 ↔ 155 By similarity
Disulfide bondi158 ↔ 172 By similarity
Disulfide bondi162 ↔ 180 By similarity
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UBN6.
PaxDbiQ9UBN6.
PRIDEiQ9UBN6.

PTM databases

PhosphoSiteiQ9UBN6.

Expressioni

Tissue specificityi

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Gene expression databases

BgeeiQ9UBN6.
CleanExiHS_TNFRSF10D.
GenevestigatoriQ9UBN6.

Interactioni

Protein-protein interaction databases

BioGridi114321. 7 interactions.
DIPiDIP-6231N.
IntActiQ9UBN6. 1 interaction.
MINTiMINT-4657998.
STRINGi9606.ENSP00000310263.

Structurei

3D structure databases

ProteinModelPortaliQ9UBN6.
SMRiQ9UBN6. Positions 81-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 9740TNFR-Cys 1
Add
BLAST
Repeati98 – 13942TNFR-Cys 2
Add
BLAST
Repeati140 – 18041TNFR-Cys 3
Add
BLAST
Domaini340 – 36627Death; truncated
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 2284Poly-Val
Compositional biasi246 – 2505Poly-Gly

Sequence similaritiesi

Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80202.
HOGENOMiHOG000142423.
HOVERGENiHBG061626.
InParanoidiQ9UBN6.
KOiK04722.
OrthoDBiEOG71VSSN.
PhylomeDBiQ9UBN6.
TreeFamiTF333916.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01956. TNFACTORR10.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBN6-1 [UniParc]FASTAAdd to Basket

« Hide

MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP    50
VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT 100
EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN 150
SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT 200
TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG 250
PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL 300
AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS 350
ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL 386
Length:386
Mass (Da):41,823
Last modified:May 1, 2000 - v1
Checksum:i77A93577CAAF2632
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → S in TRAIL-R4-B. 1 Publication
Corresponds to variant rs11135703 [ dbSNP | Ensembl ].
VAR_011417
Natural varianti276 – 2761R → H.
Corresponds to variant rs55636833 [ dbSNP | Ensembl ].
VAR_061854
Natural varianti310 – 3101S → L in TRAIL-R4-B. 1 Publication
Corresponds to variant rs1133782 [ dbSNP | Ensembl ].
VAR_011418
Natural varianti345 – 3451T → P.
Corresponds to variant rs34622674 [ dbSNP | Ensembl ].
VAR_057288

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029761 mRNA. Translation: AAD03477.1.
AF021232 mRNA. Translation: AAC32765.1.
AF021233 mRNA. Translation: AAC32766.1.
AF023849 mRNA. Translation: AAC52053.1.
AY358285 mRNA. Translation: AAQ88652.1.
AK313528 mRNA. Translation: BAG36307.1.
BC052270 mRNA. Translation: AAH52270.1.
CCDSiCCDS6038.1.
RefSeqiNP_003831.2. NM_003840.4.
UniGeneiHs.213467.

Genome annotation databases

EnsembliENST00000312584; ENSP00000310263; ENSG00000173530.
GeneIDi8793.
KEGGihsa:8793.
UCSCiuc003xcz.2. human.

Polymorphism databases

DMDMi18203495.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029761 mRNA. Translation: AAD03477.1 .
AF021232 mRNA. Translation: AAC32765.1 .
AF021233 mRNA. Translation: AAC32766.1 .
AF023849 mRNA. Translation: AAC52053.1 .
AY358285 mRNA. Translation: AAQ88652.1 .
AK313528 mRNA. Translation: BAG36307.1 .
BC052270 mRNA. Translation: AAH52270.1 .
CCDSi CCDS6038.1.
RefSeqi NP_003831.2. NM_003840.4.
UniGenei Hs.213467.

3D structure databases

ProteinModelPortali Q9UBN6.
SMRi Q9UBN6. Positions 81-206.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114321. 7 interactions.
DIPi DIP-6231N.
IntActi Q9UBN6. 1 interaction.
MINTi MINT-4657998.
STRINGi 9606.ENSP00000310263.

PTM databases

PhosphoSitei Q9UBN6.

Polymorphism databases

DMDMi 18203495.

Proteomic databases

MaxQBi Q9UBN6.
PaxDbi Q9UBN6.
PRIDEi Q9UBN6.

Protocols and materials databases

DNASUi 8793.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312584 ; ENSP00000310263 ; ENSG00000173530 .
GeneIDi 8793.
KEGGi hsa:8793.
UCSCi uc003xcz.2. human.

Organism-specific databases

CTDi 8793.
GeneCardsi GC08M022993.
H-InvDB HIX0025539.
HGNCi HGNC:11907. TNFRSF10D.
MIMi 603614. gene.
neXtProti NX_Q9UBN6.
PharmGKBi PA36600.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80202.
HOGENOMi HOG000142423.
HOVERGENi HBG061626.
InParanoidi Q9UBN6.
KOi K04722.
OrthoDBi EOG71VSSN.
PhylomeDBi Q9UBN6.
TreeFami TF333916.

Enzyme and pathway databases

SignaLinki Q9UBN6.

Miscellaneous databases

GeneWikii TNFRSF10D.
GenomeRNAii 8793.
NextBioi 32976.
PROi Q9UBN6.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBN6.
CleanExi HS_TNFRSF10D.
Genevestigatori Q9UBN6.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01956. TNFACTORR10.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Tissue: Fetal lung.
  2. "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain."
    Degli-Esposti M.A., Dougall W.C., Smolak P.J., Waugh J.Y., Smith C.A., Goodwin R.G.
    Immunity 7:813-820(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS SER-35 AND LEU-310.
    Tissue: Foreskin fibroblast and Peripheral blood lymphocyte.
  3. "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling."
    Pan G., Ni J., Yu G.-L., Wei Y.-F., Dixit V.M.
    FEBS Lett. 424:41-45(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 56-70.

Entry informationi

Entry nameiTR10D_HUMAN
AccessioniPrimary (citable) accession number: Q9UBN6
Secondary accession number(s): B2R8W0, Q9Y6Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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