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Protein

Tumor necrosis factor receptor superfamily member 10D

Gene

TNFRSF10D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173530-MONOMER.
ReactomeiR-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
SignaLinkiQ9UBN6.
SIGNORiQ9UBN6.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10D
Alternative name(s):
Decoy receptor 2
Short name:
DcR2
TNF-related apoptosis-inducing ligand receptor 4
Short name:
TRAIL receptor 4
Short name:
TRAIL-R4
TRAIL receptor with a truncated death domain
CD_antigen: CD264
Gene namesi
Name:TNFRSF10D
Synonyms:DCR2, TRAILR4, TRUNDD
ORF Names:UNQ251/PRO288
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11907. TNFRSF10D.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini56 – 211ExtracellularSequence analysisAdd BLAST156
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 386CytoplasmicSequence analysisAdd BLAST154

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8793.
PharmGKBiPA36600.

Polymorphism and mutation databases

BioMutaiTNFRSF10D.
DMDMi18203495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 552 PublicationsAdd BLAST55
ChainiPRO_000003458456 – 386Tumor necrosis factor receptor superfamily member 10DAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi141 ↔ 155PROSITE-ProRule annotation
Disulfide bondi158 ↔ 172PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UBN6.
MaxQBiQ9UBN6.
PaxDbiQ9UBN6.
PeptideAtlasiQ9UBN6.
PRIDEiQ9UBN6.

PTM databases

iPTMnetiQ9UBN6.
PhosphoSitePlusiQ9UBN6.
SwissPalmiQ9UBN6.

Expressioni

Tissue specificityi

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Gene expression databases

BgeeiENSG00000173530.
CleanExiHS_TNFRSF10D.
GenevisibleiQ9UBN6. HS.

Interactioni

Protein-protein interaction databases

BioGridi114321. 6 interactors.
DIPiDIP-6231N.
IntActiQ9UBN6. 2 interactors.
MINTiMINT-4657998.
STRINGi9606.ENSP00000310263.

Structurei

3D structure databases

ProteinModelPortaliQ9UBN6.
SMRiQ9UBN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 97TNFR-Cys 1Add BLAST40
Repeati98 – 139TNFR-Cys 2Add BLAST42
Repeati140 – 180TNFR-Cys 3Add BLAST41
Domaini340 – 366Death; truncatedAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 228Poly-Val4
Compositional biasi246 – 250Poly-Gly5

Sequence similaritiesi

Contains 1 death domain.Curated
Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZX0. Eukaryota.
ENOG4111ZZM. LUCA.
HOGENOMiHOG000142423.
HOVERGENiHBG061626.
InParanoidiQ9UBN6.
KOiK04722.
OrthoDBiEOG091G0MOV.
PhylomeDBiQ9UBN6.
TreeFamiTF333916.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01956. TNFACTORR10.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP
60 70 80 90 100
VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT
110 120 130 140 150
EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN
160 170 180 190 200
SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT
210 220 230 240 250
TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG
260 270 280 290 300
PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL
310 320 330 340 350
AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS
360 370 380
ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL
Length:386
Mass (Da):41,823
Last modified:May 1, 2000 - v1
Checksum:i77A93577CAAF2632
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01141735P → S in TRAIL-R4-B. 1 PublicationCorresponds to variant rs11135703dbSNPEnsembl.1
Natural variantiVAR_061854276R → H.Corresponds to variant rs55636833dbSNPEnsembl.1
Natural variantiVAR_011418310S → L in TRAIL-R4-B. 1 PublicationCorresponds to variant rs1133782dbSNPEnsembl.1
Natural variantiVAR_057288345T → P.Corresponds to variant rs34622674dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029761 mRNA. Translation: AAD03477.1.
AF021232 mRNA. Translation: AAC32765.1.
AF021233 mRNA. Translation: AAC32766.1.
AF023849 mRNA. Translation: AAC52053.1.
AY358285 mRNA. Translation: AAQ88652.1.
AK313528 mRNA. Translation: BAG36307.1.
BC052270 mRNA. Translation: AAH52270.1.
CCDSiCCDS6038.1.
RefSeqiNP_003831.2. NM_003840.4.
UniGeneiHs.213467.

Genome annotation databases

EnsembliENST00000312584; ENSP00000310263; ENSG00000173530.
GeneIDi8793.
KEGGihsa:8793.
UCSCiuc003xcz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029761 mRNA. Translation: AAD03477.1.
AF021232 mRNA. Translation: AAC32765.1.
AF021233 mRNA. Translation: AAC32766.1.
AF023849 mRNA. Translation: AAC52053.1.
AY358285 mRNA. Translation: AAQ88652.1.
AK313528 mRNA. Translation: BAG36307.1.
BC052270 mRNA. Translation: AAH52270.1.
CCDSiCCDS6038.1.
RefSeqiNP_003831.2. NM_003840.4.
UniGeneiHs.213467.

3D structure databases

ProteinModelPortaliQ9UBN6.
SMRiQ9UBN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114321. 6 interactors.
DIPiDIP-6231N.
IntActiQ9UBN6. 2 interactors.
MINTiMINT-4657998.
STRINGi9606.ENSP00000310263.

PTM databases

iPTMnetiQ9UBN6.
PhosphoSitePlusiQ9UBN6.
SwissPalmiQ9UBN6.

Polymorphism and mutation databases

BioMutaiTNFRSF10D.
DMDMi18203495.

Proteomic databases

EPDiQ9UBN6.
MaxQBiQ9UBN6.
PaxDbiQ9UBN6.
PeptideAtlasiQ9UBN6.
PRIDEiQ9UBN6.

Protocols and materials databases

DNASUi8793.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312584; ENSP00000310263; ENSG00000173530.
GeneIDi8793.
KEGGihsa:8793.
UCSCiuc003xcz.4. human.

Organism-specific databases

CTDi8793.
DisGeNETi8793.
GeneCardsiTNFRSF10D.
H-InvDBHIX0025539.
HGNCiHGNC:11907. TNFRSF10D.
MIMi603614. gene.
neXtProtiNX_Q9UBN6.
PharmGKBiPA36600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZX0. Eukaryota.
ENOG4111ZZM. LUCA.
HOGENOMiHOG000142423.
HOVERGENiHBG061626.
InParanoidiQ9UBN6.
KOiK04722.
OrthoDBiEOG091G0MOV.
PhylomeDBiQ9UBN6.
TreeFamiTF333916.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173530-MONOMER.
ReactomeiR-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
SignaLinkiQ9UBN6.
SIGNORiQ9UBN6.

Miscellaneous databases

GeneWikiiTNFRSF10D.
GenomeRNAii8793.
PROiQ9UBN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173530.
CleanExiHS_TNFRSF10D.
GenevisibleiQ9UBN6. HS.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01956. TNFACTORR10.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTR10D_HUMAN
AccessioniPrimary (citable) accession number: Q9UBN6
Secondary accession number(s): B2R8W0, Q9Y6Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.