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Q9UBN6

- TR10D_HUMAN

UniProt

Q9UBN6 - TR10D_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 10D

Gene

TNFRSF10D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of apoptotic process Source: ProtInc
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    SignaLinkiQ9UBN6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10D
    Alternative name(s):
    Decoy receptor 2
    Short name:
    DcR2
    TNF-related apoptosis-inducing ligand receptor 4
    Short name:
    TRAIL receptor 4
    Short name:
    TRAIL-R4
    TRAIL receptor with a truncated death domain
    CD_antigen: CD264
    Gene namesi
    Name:TNFRSF10D
    Synonyms:DCR2, TRAILR4, TRUNDD
    ORF Names:UNQ251/PRO288
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11907. TNFRSF10D.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36600.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 55552 PublicationsAdd
    BLAST
    Chaini56 – 386331Tumor necrosis factor receptor superfamily member 10DPRO_0000034584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
    Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi141 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi158 ↔ 172PROSITE-ProRule annotation
    Disulfide bondi162 ↔ 180PROSITE-ProRule annotation
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UBN6.
    PaxDbiQ9UBN6.
    PRIDEiQ9UBN6.

    PTM databases

    PhosphoSiteiQ9UBN6.

    Expressioni

    Tissue specificityi

    Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

    Gene expression databases

    BgeeiQ9UBN6.
    CleanExiHS_TNFRSF10D.
    GenevestigatoriQ9UBN6.

    Interactioni

    Protein-protein interaction databases

    BioGridi114321. 7 interactions.
    DIPiDIP-6231N.
    IntActiQ9UBN6. 1 interaction.
    MINTiMINT-4657998.
    STRINGi9606.ENSP00000310263.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBN6.
    SMRiQ9UBN6. Positions 81-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini56 – 211156ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini233 – 386154CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati58 – 9740TNFR-Cys 1Add
    BLAST
    Repeati98 – 13942TNFR-Cys 2Add
    BLAST
    Repeati140 – 18041TNFR-Cys 3Add
    BLAST
    Domaini340 – 36627Death; truncatedAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi225 – 2284Poly-Val
    Compositional biasi246 – 2505Poly-Gly

    Sequence similaritiesi

    Contains 1 death domain.Curated
    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80202.
    HOGENOMiHOG000142423.
    HOVERGENiHBG061626.
    InParanoidiQ9UBN6.
    KOiK04722.
    OrthoDBiEOG71VSSN.
    PhylomeDBiQ9UBN6.
    TreeFamiTF333916.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020465. TNFR_10.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PRINTSiPR01956. TNFACTORR10.
    SMARTiSM00208. TNFR. 2 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UBN6-1 [UniParc]FASTAAdd to Basket

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    MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP    50
    VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT 100
    EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN 150
    SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT 200
    TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG 250
    PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL 300
    AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS 350
    ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL 386
    Length:386
    Mass (Da):41,823
    Last modified:May 1, 2000 - v1
    Checksum:i77A93577CAAF2632
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351P → S in TRAIL-R4-B. 1 Publication
    Corresponds to variant rs11135703 [ dbSNP | Ensembl ].
    VAR_011417
    Natural varianti276 – 2761R → H.
    Corresponds to variant rs55636833 [ dbSNP | Ensembl ].
    VAR_061854
    Natural varianti310 – 3101S → L in TRAIL-R4-B. 1 Publication
    Corresponds to variant rs1133782 [ dbSNP | Ensembl ].
    VAR_011418
    Natural varianti345 – 3451T → P.
    Corresponds to variant rs34622674 [ dbSNP | Ensembl ].
    VAR_057288

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029761 mRNA. Translation: AAD03477.1.
    AF021232 mRNA. Translation: AAC32765.1.
    AF021233 mRNA. Translation: AAC32766.1.
    AF023849 mRNA. Translation: AAC52053.1.
    AY358285 mRNA. Translation: AAQ88652.1.
    AK313528 mRNA. Translation: BAG36307.1.
    BC052270 mRNA. Translation: AAH52270.1.
    CCDSiCCDS6038.1.
    RefSeqiNP_003831.2. NM_003840.4.
    UniGeneiHs.213467.

    Genome annotation databases

    EnsembliENST00000312584; ENSP00000310263; ENSG00000173530.
    GeneIDi8793.
    KEGGihsa:8793.
    UCSCiuc003xcz.2. human.

    Polymorphism databases

    DMDMi18203495.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029761 mRNA. Translation: AAD03477.1 .
    AF021232 mRNA. Translation: AAC32765.1 .
    AF021233 mRNA. Translation: AAC32766.1 .
    AF023849 mRNA. Translation: AAC52053.1 .
    AY358285 mRNA. Translation: AAQ88652.1 .
    AK313528 mRNA. Translation: BAG36307.1 .
    BC052270 mRNA. Translation: AAH52270.1 .
    CCDSi CCDS6038.1.
    RefSeqi NP_003831.2. NM_003840.4.
    UniGenei Hs.213467.

    3D structure databases

    ProteinModelPortali Q9UBN6.
    SMRi Q9UBN6. Positions 81-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114321. 7 interactions.
    DIPi DIP-6231N.
    IntActi Q9UBN6. 1 interaction.
    MINTi MINT-4657998.
    STRINGi 9606.ENSP00000310263.

    PTM databases

    PhosphoSitei Q9UBN6.

    Polymorphism databases

    DMDMi 18203495.

    Proteomic databases

    MaxQBi Q9UBN6.
    PaxDbi Q9UBN6.
    PRIDEi Q9UBN6.

    Protocols and materials databases

    DNASUi 8793.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312584 ; ENSP00000310263 ; ENSG00000173530 .
    GeneIDi 8793.
    KEGGi hsa:8793.
    UCSCi uc003xcz.2. human.

    Organism-specific databases

    CTDi 8793.
    GeneCardsi GC08M022993.
    H-InvDB HIX0025539.
    HGNCi HGNC:11907. TNFRSF10D.
    MIMi 603614. gene.
    neXtProti NX_Q9UBN6.
    PharmGKBi PA36600.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80202.
    HOGENOMi HOG000142423.
    HOVERGENi HBG061626.
    InParanoidi Q9UBN6.
    KOi K04722.
    OrthoDBi EOG71VSSN.
    PhylomeDBi Q9UBN6.
    TreeFami TF333916.

    Enzyme and pathway databases

    SignaLinki Q9UBN6.

    Miscellaneous databases

    GeneWikii TNFRSF10D.
    GenomeRNAii 8793.
    NextBioi 32976.
    PROi Q9UBN6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBN6.
    CleanExi HS_TNFRSF10D.
    Genevestigatori Q9UBN6.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020465. TNFR_10.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PRINTSi PR01956. TNFACTORR10.
    SMARTi SM00208. TNFR. 2 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
      Tissue: Fetal lung.
    2. "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain."
      Degli-Esposti M.A., Dougall W.C., Smolak P.J., Waugh J.Y., Smith C.A., Goodwin R.G.
      Immunity 7:813-820(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS SER-35 AND LEU-310.
      Tissue: Foreskin fibroblast and Peripheral blood lymphocyte.
    3. "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling."
      Pan G., Ni J., Yu G.-L., Wei Y.-F., Dixit V.M.
      FEBS Lett. 424:41-45(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 56-70.

    Entry informationi

    Entry nameiTR10D_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBN6
    Secondary accession number(s): B2R8W0, Q9Y6Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3