Reviewed, UniProtKB/Swiss-Prot Q9UBN6 (TR10D_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor necrosis factor receptor superfamily member 10D
Alternative name(s):
    Decoy receptor 2
      Short name=DcR2
    TNF-related apoptosis-inducing ligand receptor 4
      Short name=TRAIL receptor 4
      Short name=TRAIL-R4
    TRAIL receptor with a truncated death domain
    CD_antigen=CD264

Gene names

Name:	TNFRSF10D
Synonyms:	DCR2, TRAILR4, TRUNDD
ORF Names:	UNQ251/PRO288

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway (According to Ref.1 it cannot but according to Ref.2 it can induce the NF-kappa-B pathway).
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Sequence similarities	Contains 1 death domain. Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	anti-apoptosis Ref.2 Traceable author statement. Source: ProtInc apoptosis Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Ref.2 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transmembrane receptor activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LRPPRC	P42704	1	EBI-1044859,EBI-1050853
MIF	P14174	1	EBI-1044859,EBI-372712
MYH10	P35580	1	EBI-1044859,EBI-351758
PFAS	O15067	1	EBI-1044859,EBI-1052653
SF3B3	Q15393	1	EBI-1044859,EBI-346977
TRIM28	Q13263	1	EBI-1044859,EBI-78139

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 55	55	Ref.7
	Chain	56 – 386	331	Tumor necrosis factor receptor superfamily member 10D		PRO_0000034584
Regions
	Topological domain	56 – 211	156	Extracellular Potential
	Transmembrane	212 – 232	21	Potential
	Topological domain	233 – 386	154	Cytoplasmic Potential
	Repeat	58 – 97	40	TNFR-Cys 1
	Repeat	98 – 139	42	TNFR-Cys 2
	Repeat	140 – 180	41	TNFR-Cys 3
	Domain	340 – 366	27	Death; truncated
	Compositional bias	225 – 228	4	Poly-Val
	Compositional bias	246 – 250	5	Poly-Gly
Amino acid modifications
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	182	1	N-linked (GlcNAc...) Potential
	Disulfide bond	83 ↔ 96		By similarity
	Disulfide bond	99 ↔ 115		By similarity
	Disulfide bond	118 ↔ 131		By similarity
	Disulfide bond	121 ↔ 139		By similarity
	Disulfide bond	141 ↔ 155		By similarity
	Disulfide bond	158 ↔ 172		By similarity
	Disulfide bond	162 ↔ 180		By similarity
Natural variations
	Natural variant	35	1	P → S in TRAIL-R4-B.		VAR_011417
	Natural variant	310	1	S → L in TRAIL-R4-B.		VAR_011418
	Natural variant	345	1	T → P: dbSNP rs34622674.		VAR_057288

Sequences

	Sequence		Length	Mass (Da)
	Q9UBN6-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 77A93577CAAF2632	FASTA	386	41,823
	10 20 30 40 50 60 MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR 70 80 90 100 110 120 QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV 130 140 150 160 170 180 CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC 190 200 210 220 230 240 KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL 250 260 270 280 290 300 KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL 310 320 330 340 350 360 AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE 370 380 TIQDQLVGSE KLFYEEDEAG SATSCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel receptor for Apo2L/TRAIL contains a truncated death domain." Marsters S.A., Sheridan J.P., Pitti R.M., Huang A., Skubatch M., Baldwin D., Yuan J., Gurney A., Goddard A.D., Godowski P., Ashkenazi A. Curr. Biol. 7:1003-1006(1997) [PubMed: 9382840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Fetal lung.
[2]	"The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain." Degli-Esposti M.A., Dougall W.C., Smolak P.J., Waugh J.Y., Smith C.A., Goodwin R.G. Immunity 7:813-820(1997) [PubMed: 9430226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS SER-35 AND LEU-310. Tissue: Foreskin fibroblast and Peripheral blood lymphocyte.
[3]	"TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling." Pan G., Ni J., Yu G.-L., Wei Y.-F., Dixit V.M. FEBS Lett. 424:41-45(1998) [PubMed: 9537512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 56-70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF029761 mRNA. Translation: AAD03477.1. AF021232 mRNA. Translation: AAC32765.1. AF021233 mRNA. Translation: AAC32766.1. AF023849 mRNA. Translation: AAC52053.1. AY358285 mRNA. Translation: AAQ88652.1. AK313528 mRNA. Translation: BAG36307.1. BC052270 mRNA. Translation: AAH52270.1.
IPI	IPI00294516.
RefSeq	NP_003831.2.
UniGene	Hs.213467
3D structure databases
HSSP	HSSP built from PDB template 1D4V based on UniProtKB O14763.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UBN6. 47 interactions.
PTM databases
PhosphoSite	Q9UBN6.
Proteomic databases
PRIDE	Q9UBN6.
Genome annotation databases
Ensembl	ENSG00000173530. Homo sapiens. [Contig view]
GeneID	8793.
KEGG	hsa:8793.
Organism-specific databases
GeneCards	GC08M023049.
H-InvDB	HIX0025539.
HGNC	HGNC:11907. TNFRSF10D.
MIM	603614. gene.
PharmGKB	PA36600.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UBN6.
HOVERGEN	Q9UBN6.
Enzyme and pathway databases
Pathway_Interaction_DB	trail_pathway. TRAIL signaling pathway.
Gene expression databases
ArrayExpress	Q9UBN6.
Bgee	Q9UBN6.
CleanEx	HS_TNFRSF10D.
GermOnline	ENSG00000173530. Homo sapiens.
Family and domain databases
InterPro	IPR001368. TNFR_Cys_rich_reg. [Graphical view]
Pfam	PF00020. TNFR_c6. 2 hits. [Graphical view]
SMART	SM00208. TNFR. 2 hits. [Graphical view]
PROSITE	PS50017. DEATH_DOMAIN. False negative. PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32976.
SOURCE	Search...

Entry information

Entry name

TR10D_HUMAN

Accession

Primary (citable) accession number: Q9UBN6
Secondary accession number(s): B2R8W0, Q9Y6Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)