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Protein

Short transient receptor potential channel 4

Gene

TRPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.2 Publications

GO - Molecular functioni

  • beta-catenin binding Source: BHF-UCL
  • cadherin binding Source: BHF-UCL
  • calcium channel activity Source: Reactome
  • inositol 1,4,5 trisphosphate binding Source: Ensembl
  • store-operated calcium channel activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133107-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Protein family/group databases

TCDBi1.A.4.1.12. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 4
Short name:
TrpC4
Alternative name(s):
Trp-related protein 4
Short name:
hTrp-4
Short name:
hTrp4
Gene namesi
Name:TRPC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:12336. TRPC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 329CytoplasmicSequence analysisAdd BLAST329
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 362ExtracellularSequence analysisAdd BLAST12
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 436CytoplasmicSequence analysisAdd BLAST53
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 469ExtracellularSequence analysisAdd BLAST12
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 511CytoplasmicSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Topological domaini533 – 599ExtracellularSequence analysisAdd BLAST67
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 977CytoplasmicSequence analysisAdd BLAST357

GO - Cellular componenti

  • basolateral plasma membrane Source: BHF-UCL
  • calcium channel complex Source: UniProtKB
  • caveola Source: Ensembl
  • cell surface Source: BHF-UCL
  • cortical cytoskeleton Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi959Y → F: Reduced EGF-induced phosphorylation and decreased association with SLC9A3R1/NHERF. Loss of EGF-induced phosphorylation and decreased association with SLC9A3R1/NHERF; when associated with F-972. 1 Publication1
Mutagenesisi972Y → F: Reduced EGF-induced phosphorylation and decreased association with SLC9A3R1/NHERF. Loss of EGF-induced phosphorylation and decreased association with SLC9A3R1/NHERF; when associated with F-959. 1 Publication1
Mutagenesisi975 – 977Missing : Loss of interaction with SLC9A3R1/NHERF. 1 Publication3

Organism-specific databases

DisGeNETi7223.
OpenTargetsiENSG00000133107.
PharmGKBiPA37009.

Chemistry databases

GuidetoPHARMACOLOGYi489.

Polymorphism and mutation databases

BioMutaiTRPC4.
DMDMi13633994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153141 – 977Short transient receptor potential channel 4Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei959Phosphotyrosine; by FYN1 Publication1
Modified residuei972Phosphotyrosine; by FYN1 Publication1

Post-translational modificationi

Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBN4.
PaxDbiQ9UBN4.
PeptideAtlasiQ9UBN4.
PRIDEiQ9UBN4.

PTM databases

iPTMnetiQ9UBN4.
PhosphoSitePlusiQ9UBN4.

Expressioni

Tissue specificityi

Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.1 Publication

Gene expression databases

BgeeiENSG00000133107.
CleanExiHS_TRPC4.
ExpressionAtlasiQ9UBN4. baseline and differential.
GenevisibleiQ9UBN4. HS.

Interactioni

Subunit structurei

Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF. Interacts with MX1 and RNF24. Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat). Interacts with CDH5 and CTNNB1. Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus). Interacts (via protein 4.1-binding domain) with EPB41L2.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MX1P205912EBI-929504,EBI-929476

GO - Molecular functioni

  • beta-catenin binding Source: BHF-UCL
  • cadherin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi113074. 12 interactors.
IntActiQ9UBN4. 2 interactors.
MINTiMINT-157838.
STRINGi9606.ENSP00000369003.

Structurei

3D structure databases

ProteinModelPortaliQ9UBN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 60ANK 1Add BLAST30
Repeati69 – 97ANK 2Add BLAST29
Repeati98 – 124ANK 3Add BLAST27
Repeati141 – 170ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 172Multimerization domainBy similarityAdd BLAST86
Regioni254 – 304Multimerization domainBy similarityAdd BLAST51
Regioni615 – 977Binds to ITPR1, ITPR2 and ITPR3Add BLAST363
Regioni975 – 977PDZ-binding domain3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili223 – 260Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi377 – 382Poly-Leu6

Domaini

The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1.
The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5.

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000151279.
HOVERGENiHBG068337.
InParanoidiQ9UBN4.
KOiK04967.
OMAiCILVDHR.
OrthoDBiEOG091G029I.
PhylomeDBiQ9UBN4.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005460. TRPC4_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF25. PTHR10117:SF25. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01645. TRPCHANNEL4.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9UBN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK
60 70 80 90 100
SLEEAEIYFK ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL
110 120 130 140 150
LHAIRKEVVG AVELLLNHKK PSGEKQVPPI LLDKQFSEFT PDITPIILAA
160 170 180 190 200
HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE CVSSSDVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE YEELSRQCKQ
260 270 280 290 300
FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF
310 320 330 340 350
VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA
360 370 380 390 400
PKSPLGLFIR KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT
410 420 430 440 450
IVEWMILPWV LGFIWGEIKQ MWDGGLQDYI HDWWNLMDFV MNSLYLATIS
460 470 480 490 500
LKIVAFVKYS ALNPRESWDM WHPTLVAEAL FAIANIFSSL RLISLFTANS
510 520 530 540 550
HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY YEETKGLTCK
560 570 580 590 600
GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM
610 620 630 640 650
FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG
660 670 680 690 700
GTLPTPFNVI PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL
710 720 730 740 750
RRHHQYQEVM RNLVKRYVAA MIRDAKTEEG LTEENFKELK QDISSFRFEV
760 770 780 790 800
LGLLRGSKLS TIQSANASKE SSNSADSDEK SDSEGNSKDK KKNFSLFDLT
810 820 830 840 850
TLIHPRSAAI ASERHNISNG SALVVQEPPR EKQRKVNFVT DIKNFGLFHR
860 870 880 890 900
RSKQNAAEQN ANQIFSVSEE VARQQAAGPL ERNIQLESRG LASRGDLSIP
910 920 930 940 950
GLSEQCVLVD HRERNTDTLG LQVGKRVCPF KSEKVVVEDT VPIIPKEKHA
960 970
KEEDSSIDYD LNLPDTVTHE DYVTTRL
Length:977
Mass (Da):112,101
Last modified:May 1, 2000 - v1
Checksum:i77E4D27C374D660E
GO
Isoform Beta (identifier: Q9UBN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     785-868: Missing.

Show »
Length:893
Mass (Da):102,640
Checksum:i20E5FE3C93B47BB5
GO
Isoform Delta (identifier: Q9UBN4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     730-870: Missing.

Show »
Length:836
Mass (Da):96,389
Checksum:i1BAE1CA946ED6DAF
GO
Isoform Gamma (identifier: Q9UBN4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     629-693: Missing.
     785-868: Missing.

Show »
Length:828
Mass (Da):94,859
Checksum:iC01141A15CCA516C
GO
Isoform Epsilon (identifier: Q9UBN4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     693-693: G → GVRTQH

Show »
Length:982
Mass (Da):112,723
Checksum:i7F4500A57F38B8BD
GO
Isoform Zeta (identifier: Q9UBN4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-299: Missing.

Show »
Length:804
Mass (Da):92,221
Checksum:i30F8E11810A76888
GO
Isoform Eta (identifier: Q9UBN4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-323: FVAQPNCQQLLASRWYDEFPGWRR → ASYGEKLNRCGMADFRTTSMIGGI
     324-977: Missing.

Show »
Length:323
Mass (Da):36,759
Checksum:i39B4E28D03534CDD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036452138E → K in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041439127 – 299Missing in isoform Zeta. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_047747300 – 323FVAQP…PGWRR → ASYGEKLNRCGMADFRTTSM IGGI in isoform Eta. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_047748324 – 977Missing in isoform Eta. 1 PublicationAdd BLAST654
Alternative sequenceiVSP_006567629 – 693Missing in isoform Gamma. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_041262693G → GVRTQH in isoform Epsilon. 1 Publication1
Alternative sequenceiVSP_006568730 – 870Missing in isoform Delta. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_006569785 – 868Missing in isoform Beta and isoform Gamma. 2 PublicationsAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063822 mRNA. Translation: AAF22927.1.
AF063823 mRNA. Translation: AAF22928.1.
AF063824 mRNA. Translation: AAF22929.1.
AF063825 mRNA. Translation: AAF22930.1.
AF175406 mRNA. Translation: AAD51736.1.
AF421358 mRNA. Translation: AAL24549.1.
AF421359 mRNA. Translation: AAL24550.1.
AF421360 mRNA. Translation: AAL24551.1.
AF421361 mRNA. Translation: AAL24552.1.
AF421362 mRNA. Translation: AAL24553.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70109.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70110.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70111.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70114.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15556.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15557.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15558.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15560.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70112.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15561.1.
CH471075 Genomic DNA. Translation: EAX08595.1.
CH471075 Genomic DNA. Translation: EAX08596.1.
CH471075 Genomic DNA. Translation: EAX08597.1.
CH471075 Genomic DNA. Translation: EAX08598.1.
CH471075 Genomic DNA. Translation: EAX08600.1.
CH471075 Genomic DNA. Translation: EAX08601.1.
BC104725 mRNA. Translation: AAI04726.1.
U40983 mRNA. Translation: AAC50630.1.
CCDSiCCDS45035.1. [Q9UBN4-6]
CCDS45036.1. [Q9UBN4-4]
CCDS45037.1. [Q9UBN4-5]
CCDS45038.1. [Q9UBN4-2]
CCDS45039.1. [Q9UBN4-3]
CCDS9365.1. [Q9UBN4-1]
RefSeqiNP_001129427.1. NM_001135955.1. [Q9UBN4-2]
NP_001129428.1. NM_001135956.1. [Q9UBN4-4]
NP_001129429.1. NM_001135957.1. [Q9UBN4-3]
NP_001129430.1. NM_001135958.1. [Q9UBN4-6]
NP_003297.1. NM_003306.1. [Q9UBN4-5]
NP_057263.1. NM_016179.2. [Q9UBN4-1]
UniGeneiHs.262960.

Genome annotation databases

EnsembliENST00000338947; ENSP00000342580; ENSG00000133107. [Q9UBN4-6]
ENST00000355779; ENSP00000348025; ENSG00000133107. [Q9UBN4-3]
ENST00000358477; ENSP00000351264; ENSG00000133107. [Q9UBN4-2]
ENST00000379673; ENSP00000368995; ENSG00000133107. [Q9UBN4-4]
ENST00000379679; ENSP00000369001; ENSG00000133107. [Q9UBN4-6]
ENST00000379705; ENSP00000369027; ENSG00000133107. [Q9UBN4-1]
ENST00000488717; ENSP00000435969; ENSG00000133107. [Q9UBN4-7]
ENST00000625583; ENSP00000486109; ENSG00000133107. [Q9UBN4-5]
GeneIDi7223.
KEGGihsa:7223.
UCSCiuc001uws.4. human. [Q9UBN4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063822 mRNA. Translation: AAF22927.1.
AF063823 mRNA. Translation: AAF22928.1.
AF063824 mRNA. Translation: AAF22929.1.
AF063825 mRNA. Translation: AAF22930.1.
AF175406 mRNA. Translation: AAD51736.1.
AF421358 mRNA. Translation: AAL24549.1.
AF421359 mRNA. Translation: AAL24550.1.
AF421360 mRNA. Translation: AAL24551.1.
AF421361 mRNA. Translation: AAL24552.1.
AF421362 mRNA. Translation: AAL24553.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70109.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70110.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70111.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70114.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15556.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15557.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15558.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15560.1.
AL138679, AL354802 Genomic DNA. Translation: CAH70112.1.
AL354802, AL138679 Genomic DNA. Translation: CAI15561.1.
CH471075 Genomic DNA. Translation: EAX08595.1.
CH471075 Genomic DNA. Translation: EAX08596.1.
CH471075 Genomic DNA. Translation: EAX08597.1.
CH471075 Genomic DNA. Translation: EAX08598.1.
CH471075 Genomic DNA. Translation: EAX08600.1.
CH471075 Genomic DNA. Translation: EAX08601.1.
BC104725 mRNA. Translation: AAI04726.1.
U40983 mRNA. Translation: AAC50630.1.
CCDSiCCDS45035.1. [Q9UBN4-6]
CCDS45036.1. [Q9UBN4-4]
CCDS45037.1. [Q9UBN4-5]
CCDS45038.1. [Q9UBN4-2]
CCDS45039.1. [Q9UBN4-3]
CCDS9365.1. [Q9UBN4-1]
RefSeqiNP_001129427.1. NM_001135955.1. [Q9UBN4-2]
NP_001129428.1. NM_001135956.1. [Q9UBN4-4]
NP_001129429.1. NM_001135957.1. [Q9UBN4-3]
NP_001129430.1. NM_001135958.1. [Q9UBN4-6]
NP_003297.1. NM_003306.1. [Q9UBN4-5]
NP_057263.1. NM_016179.2. [Q9UBN4-1]
UniGeneiHs.262960.

3D structure databases

ProteinModelPortaliQ9UBN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113074. 12 interactors.
IntActiQ9UBN4. 2 interactors.
MINTiMINT-157838.
STRINGi9606.ENSP00000369003.

Chemistry databases

GuidetoPHARMACOLOGYi489.

Protein family/group databases

TCDBi1.A.4.1.12. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9UBN4.
PhosphoSitePlusiQ9UBN4.

Polymorphism and mutation databases

BioMutaiTRPC4.
DMDMi13633994.

Proteomic databases

EPDiQ9UBN4.
PaxDbiQ9UBN4.
PeptideAtlasiQ9UBN4.
PRIDEiQ9UBN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338947; ENSP00000342580; ENSG00000133107. [Q9UBN4-6]
ENST00000355779; ENSP00000348025; ENSG00000133107. [Q9UBN4-3]
ENST00000358477; ENSP00000351264; ENSG00000133107. [Q9UBN4-2]
ENST00000379673; ENSP00000368995; ENSG00000133107. [Q9UBN4-4]
ENST00000379679; ENSP00000369001; ENSG00000133107. [Q9UBN4-6]
ENST00000379705; ENSP00000369027; ENSG00000133107. [Q9UBN4-1]
ENST00000488717; ENSP00000435969; ENSG00000133107. [Q9UBN4-7]
ENST00000625583; ENSP00000486109; ENSG00000133107. [Q9UBN4-5]
GeneIDi7223.
KEGGihsa:7223.
UCSCiuc001uws.4. human. [Q9UBN4-1]

Organism-specific databases

CTDi7223.
DisGeNETi7223.
GeneCardsiTRPC4.
HGNCiHGNC:12336. TRPC4.
MIMi603651. gene.
neXtProtiNX_Q9UBN4.
OpenTargetsiENSG00000133107.
PharmGKBiPA37009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000151279.
HOVERGENiHBG068337.
InParanoidiQ9UBN4.
KOiK04967.
OMAiCILVDHR.
OrthoDBiEOG091G029I.
PhylomeDBiQ9UBN4.
TreeFamiTF313147.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133107-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiTRPC4. human.
GeneWikiiTRPC4.
GenomeRNAii7223.
PROiQ9UBN4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133107.
CleanExiHS_TRPC4.
ExpressionAtlasiQ9UBN4. baseline and differential.
GenevisibleiQ9UBN4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005460. TRPC4_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF25. PTHR10117:SF25. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01645. TRPCHANNEL4.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC4_HUMAN
AccessioniPrimary (citable) accession number: Q9UBN4
Secondary accession number(s): B1ALE0
, B1ALE1, B1ALE2, Q15721, Q3SWS6, Q96P03, Q96P04, Q96P05, Q9UIB0, Q9UIB1, Q9UIB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation.
The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.