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Q9UBN1 (CCG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name=TARP gamma-4
Gene names
Name:CACNG4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Ref.6

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Voltage-dependent calcium channel gamma-4 subunit
PRO_0000164678

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 10777Extracellular Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 1368Cytoplasmic Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 18629Extracellular Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 327120Cytoplasmic Potential

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation451N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9UBN1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 79630ACC03B1DAE6

FASTA32736,579
        10         20         30         40         50         60 
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD GPPPRRARGD 

        70         80         90        100        110        120 
LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL LRIVRASSVF PILSTILLLL 

       130        140        150        160        170        180 
GGLCIGAGRI YSRKNNIVLS AGILFVAAGL SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN 

       190        200        210        220        230        240 
YGWSFYFGAL SFIVAETVGV LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR 

       250        260        270        280        290        300 
RRSRSSSRST EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF 

       310        320 
LQVHDFFQQD LKEGFHVSML NRRTTPV 

« Hide

References

« Hide 'large scale' references
[1]"Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of the Homo sapiens putative voltage-gated calcium channel gamma-4 subunit."
Black J.L. III, Lennon V.A.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Caudate nucleus.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF142625 expand/collapse EMBL AC list , AF142622, AF142623, AF142624 Genomic DNA. Translation: AAF03090.1.
AF162692 mRNA. Translation: AAF14538.1.
AK315149 mRNA. Translation: BAG37597.1.
CH471099 Genomic DNA. Translation: EAW89020.1.
BC034532 mRNA. Translation: AAH34532.1.
CCDSCCDS11667.1.
RefSeqNP_055220.1. NM_014405.3.
UniGeneHs.514423.

3D structure databases

ProteinModelPortalQ9UBN1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117994. 1 interaction.
STRING9606.ENSP00000262138.

Chemistry

ChEMBLCHEMBL2363032.

Protein family/group databases

TCDB8.A.16.2.3. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSiteQ9UBN1.

Polymorphism databases

DMDM10719940.

Proteomic databases

PaxDbQ9UBN1.
PRIDEQ9UBN1.

Protocols and materials databases

DNASU27092.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262138; ENSP00000262138; ENSG00000075461.
GeneID27092.
KEGGhsa:27092.
UCSCuc002jft.2. human.

Organism-specific databases

CTD27092.
GeneCardsGC17P064961.
HGNCHGNC:1408. CACNG4.
HPAHPA060718.
MIM606404. gene.
neXtProtNX_Q9UBN1.
PharmGKBPA26018.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45952.
HOGENOMHOG000233440.
HOVERGENHBG003682.
InParanoidQ9UBN1.
KOK04869.
OMANCHINIK.
OrthoDBEOG7TQV1Q.
PhylomeDBQ9UBN1.
TreeFamTF327980.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ9UBN1.
CleanExHS_CACNG4.
GenevestigatorQ9UBN1.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.
ProtoNetSearch...

Other

GeneWikiCACNG4.
GenomeRNAi27092.
NextBio49721.
PROQ9UBN1.
SOURCESearch...

Entry information

Entry nameCCG4_HUMAN
AccessionPrimary (citable) accession number: Q9UBN1
Secondary accession number(s): B2RCK0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM