SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UBN1

- CCG4_HUMAN

UniProt

Q9UBN1 - CCG4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene
CACNG4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

  1. membrane depolarization Source: Reactome
  2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  3. synaptic transmission Source: Reactome
  4. transmission of nerve impulse Source: Ensembl
  5. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
REACT_18307. Trafficking of AMPA receptors.

Protein family/group databases

TCDBi8.A.16.2.3. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-4 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-4 subunit
Transmembrane AMPAR regulatory protein gamma-4
Short name:
TARP gamma-4
Gene namesi
Name:CACNG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1408. CACNG4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99Cytoplasmic Reviewed prediction
Transmembranei10 – 3021Helical; Reviewed predictionAdd
BLAST
Topological domaini31 – 10777Extracellular Reviewed predictionAdd
BLAST
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST
Topological domaini129 – 1368Cytoplasmic Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed predictionAdd
BLAST
Topological domaini158 – 18629Extracellular Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Topological domaini208 – 327120Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. endocytic vesicle membrane Source: Reactome
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Voltage-dependent calcium channel gamma-4 subunitPRO_0000164678Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi45 – 451N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UBN1.
PRIDEiQ9UBN1.

PTM databases

PhosphoSiteiQ9UBN1.

Expressioni

Gene expression databases

BgeeiQ9UBN1.
CleanExiHS_CACNG4.
GenevestigatoriQ9UBN1.

Organism-specific databases

HPAiHPA060718.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.

Protein-protein interaction databases

BioGridi117994. 1 interaction.
STRINGi9606.ENSP00000262138.

Structurei

3D structure databases

ProteinModelPortaliQ9UBN1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45952.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ9UBN1.
KOiK04869.
OMAiNCHINIK.
OrthoDBiEOG7TQV1Q.
PhylomeDBiQ9UBN1.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.

Sequencei

Sequence statusi: Complete.

Q9UBN1-1 [UniParc]FASTAAdd to Basket

« Hide

MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD    50
GPPPRRARGD LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL 100
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL 150
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV 200
LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST 250
EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF 300
LQVHDFFQQD LKEGFHVSML NRRTTPV 327
Length:327
Mass (Da):36,579
Last modified:May 1, 2000 - v1
Checksum:i79630ACC03B1DAE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF142625
, AF142622, AF142623, AF142624 Genomic DNA. Translation: AAF03090.1.
AF162692 mRNA. Translation: AAF14538.1.
AK315149 mRNA. Translation: BAG37597.1.
CH471099 Genomic DNA. Translation: EAW89020.1.
BC034532 mRNA. Translation: AAH34532.1.
CCDSiCCDS11667.1.
RefSeqiNP_055220.1. NM_014405.3.
UniGeneiHs.514423.

Genome annotation databases

EnsembliENST00000262138; ENSP00000262138; ENSG00000075461.
GeneIDi27092.
KEGGihsa:27092.
UCSCiuc002jft.2. human.

Polymorphism databases

DMDMi10719940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF142625
, AF142622 , AF142623 , AF142624 Genomic DNA. Translation: AAF03090.1 .
AF162692 mRNA. Translation: AAF14538.1 .
AK315149 mRNA. Translation: BAG37597.1 .
CH471099 Genomic DNA. Translation: EAW89020.1 .
BC034532 mRNA. Translation: AAH34532.1 .
CCDSi CCDS11667.1.
RefSeqi NP_055220.1. NM_014405.3.
UniGenei Hs.514423.

3D structure databases

ProteinModelPortali Q9UBN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117994. 1 interaction.
STRINGi 9606.ENSP00000262138.

Chemistry

ChEMBLi CHEMBL2363032.

Protein family/group databases

TCDBi 8.A.16.2.3. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSitei Q9UBN1.

Polymorphism databases

DMDMi 10719940.

Proteomic databases

PaxDbi Q9UBN1.
PRIDEi Q9UBN1.

Protocols and materials databases

DNASUi 27092.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262138 ; ENSP00000262138 ; ENSG00000075461 .
GeneIDi 27092.
KEGGi hsa:27092.
UCSCi uc002jft.2. human.

Organism-specific databases

CTDi 27092.
GeneCardsi GC17P064961.
HGNCi HGNC:1408. CACNG4.
HPAi HPA060718.
MIMi 606404. gene.
neXtProti NX_Q9UBN1.
PharmGKBi PA26018.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45952.
HOGENOMi HOG000233440.
HOVERGENi HBG003682.
InParanoidi Q9UBN1.
KOi K04869.
OMAi NCHINIK.
OrthoDBi EOG7TQV1Q.
PhylomeDBi Q9UBN1.
TreeFami TF327980.

Enzyme and pathway databases

Reactomei REACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
REACT_18307. Trafficking of AMPA receptors.

Miscellaneous databases

GeneWikii CACNG4.
GenomeRNAii 27092.
NextBioi 49721.
PROi Q9UBN1.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBN1.
CleanExi HS_CACNG4.
Genevestigatori Q9UBN1.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
    Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
    Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of the Homo sapiens putative voltage-gated calcium channel gamma-4 subunit."
    Black J.L. III, Lennon V.A.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Caudate nucleus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
    Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
    Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCCG4_HUMAN
AccessioniPrimary (citable) accession number: Q9UBN1
Secondary accession number(s): B2RCK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi