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Q9UBN1

- CCG4_HUMAN

UniProt

Q9UBN1 - CCG4_HUMAN

Protein

Voltage-dependent calcium channel gamma-4 subunit

Gene

CACNG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: ProtInc

    GO - Biological processi

    1. membrane depolarization Source: Reactome
    2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
    3. synaptic transmission Source: Reactome
    4. transmission of nerve impulse Source: Ensembl
    5. transport Source: ProtInc

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
    REACT_18307. Trafficking of AMPA receptors.

    Protein family/group databases

    TCDBi8.A.16.2.3. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-4 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-4 subunit
    Transmembrane AMPAR regulatory protein gamma-4
    Short name:
    TARP gamma-4
    Gene namesi
    Name:CACNG4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1408. CACNG4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. endocytic vesicle membrane Source: Reactome
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: Reactome
    5. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26018.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Voltage-dependent calcium channel gamma-4 subunitPRO_0000164678Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9UBN1.
    PRIDEiQ9UBN1.

    PTM databases

    PhosphoSiteiQ9UBN1.

    Expressioni

    Gene expression databases

    BgeeiQ9UBN1.
    CleanExiHS_CACNG4.
    GenevestigatoriQ9UBN1.

    Organism-specific databases

    HPAiHPA060718.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi117994. 1 interaction.
    STRINGi9606.ENSP00000262138.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 10777ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 1368CytoplasmicSequence Analysis
    Topological domaini158 – 18629ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 327120CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45952.
    HOGENOMiHOG000233440.
    HOVERGENiHBG003682.
    InParanoidiQ9UBN1.
    KOiK04869.
    OMAiNCHINIK.
    OrthoDBiEOG7TQV1Q.
    PhylomeDBiQ9UBN1.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR005423. VDCC_g4su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01603. VDCCGAMMA4.

    Sequencei

    Sequence statusi: Complete.

    Q9UBN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD    50
    GPPPRRARGD LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL 100
    LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL 150
    SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV 200
    LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST 250
    EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF 300
    LQVHDFFQQD LKEGFHVSML NRRTTPV 327
    Length:327
    Mass (Da):36,579
    Last modified:May 1, 2000 - v1
    Checksum:i79630ACC03B1DAE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142625
    , AF142622, AF142623, AF142624 Genomic DNA. Translation: AAF03090.1.
    AF162692 mRNA. Translation: AAF14538.1.
    AK315149 mRNA. Translation: BAG37597.1.
    CH471099 Genomic DNA. Translation: EAW89020.1.
    BC034532 mRNA. Translation: AAH34532.1.
    CCDSiCCDS11667.1.
    RefSeqiNP_055220.1. NM_014405.3.
    UniGeneiHs.514423.

    Genome annotation databases

    EnsembliENST00000262138; ENSP00000262138; ENSG00000075461.
    GeneIDi27092.
    KEGGihsa:27092.
    UCSCiuc002jft.2. human.

    Polymorphism databases

    DMDMi10719940.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142625
    , AF142622 , AF142623 , AF142624 Genomic DNA. Translation: AAF03090.1 .
    AF162692 mRNA. Translation: AAF14538.1 .
    AK315149 mRNA. Translation: BAG37597.1 .
    CH471099 Genomic DNA. Translation: EAW89020.1 .
    BC034532 mRNA. Translation: AAH34532.1 .
    CCDSi CCDS11667.1.
    RefSeqi NP_055220.1. NM_014405.3.
    UniGenei Hs.514423.

    3D structure databases

    ProteinModelPortali Q9UBN1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117994. 1 interaction.
    STRINGi 9606.ENSP00000262138.

    Chemistry

    ChEMBLi CHEMBL2363032.

    Protein family/group databases

    TCDBi 8.A.16.2.3. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    PTM databases

    PhosphoSitei Q9UBN1.

    Polymorphism databases

    DMDMi 10719940.

    Proteomic databases

    PaxDbi Q9UBN1.
    PRIDEi Q9UBN1.

    Protocols and materials databases

    DNASUi 27092.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262138 ; ENSP00000262138 ; ENSG00000075461 .
    GeneIDi 27092.
    KEGGi hsa:27092.
    UCSCi uc002jft.2. human.

    Organism-specific databases

    CTDi 27092.
    GeneCardsi GC17P064961.
    HGNCi HGNC:1408. CACNG4.
    HPAi HPA060718.
    MIMi 606404. gene.
    neXtProti NX_Q9UBN1.
    PharmGKBi PA26018.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45952.
    HOGENOMi HOG000233440.
    HOVERGENi HBG003682.
    InParanoidi Q9UBN1.
    KOi K04869.
    OMAi NCHINIK.
    OrthoDBi EOG7TQV1Q.
    PhylomeDBi Q9UBN1.
    TreeFami TF327980.

    Enzyme and pathway databases

    Reactomei REACT_13606. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
    REACT_18307. Trafficking of AMPA receptors.

    Miscellaneous databases

    GeneWikii CACNG4.
    GenomeRNAii 27092.
    NextBioi 49721.
    PROi Q9UBN1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBN1.
    CleanExi HS_CACNG4.
    Genevestigatori Q9UBN1.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR005423. VDCC_g4su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01603. VDCCGAMMA4.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
      Burgess D.L., Davis C.F., Gefrides L.A., Noebels J.L.
      Genome Res. 9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of the Homo sapiens putative voltage-gated calcium channel gamma-4 subunit."
      Black J.L. III, Lennon V.A.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Caudate nucleus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
      Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
      Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCCG4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBN1
    Secondary accession number(s): B2RCK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3