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Protein

Opticin

Gene

OPTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds collagen fibrils.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31578-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Opticin
Alternative name(s):
Oculoglycan
Gene namesi
Name:OPTC
Synonyms:OPT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8158. OPTC.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi26254.
OpenTargetsiENSG00000188770.
PharmGKBiPA31947.

Polymorphism and mutation databases

BioMutaiOPTC.
DMDMi8928250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003276520 – 332OpticinAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71SulfotyrosineSequence analysis1
Disulfide bondi289 ↔ 322By similarity
Glycosylationi312N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiQ9UBM4.
PeptideAtlasiQ9UBM4.
PRIDEiQ9UBM4.

PTM databases

iPTMnetiQ9UBM4.
PhosphoSitePlusiQ9UBM4.

Expressioni

Tissue specificityi

Retina, iris, ligament, skin and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000188770.
CleanExiHS_OPTC.
ExpressionAtlasiQ9UBM4. baseline and differential.
GenevisibleiQ9UBM4. HS.

Organism-specific databases

HPAiHPA034951.

Interactioni

Protein-protein interaction databases

IntActiQ9UBM4. 1 interactor.
STRINGi9606.ENSP00000356191.

Structurei

3D structure databases

ProteinModelPortaliQ9UBM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 153LRRNTAdd BLAST38
Repeati154 – 175LRR 1Add BLAST22
Repeati178 – 199LRR 2Add BLAST22
Repeati202 – 223LRR 3Add BLAST22
Repeati248 – 269LRR 4Add BLAST22
Repeati270 – 290LRR 5Add BLAST21
Repeati300 – 320LRR 6Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 112Ser/Thr-richAdd BLAST32
Compositional biasi128 – 140Cys-richAdd BLAST13

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ9UBM4.
KOiK08128.
OMAiFCDPEEH.
OrthoDBiEOG091G0E8Y.
PhylomeDBiQ9UBM4.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLAFLSLL ALVLQETGTA SLPRKERKRR EEQMPREGDS FEVLPLRNDV
60 70 80 90 100
LNPDNYGEVI DLSNYEELTD YGDQLPEVKV TSLAPATSIS PAKSTTAPGT
110 120 130 140 150
PSSNPTMTRP TTAGLLLSSQ PNHGLPTCLV CVCLGSSVYC DDIDLEDIPP
160 170 180 190 200
LPRRTAYLYA RFNRISRIRA EDFKGLTKLK RIDLSNNLIS SIDNDAFRLL
210 220 230 240 250
HALQDLILPE NQLEALPVLP SGIEFLDVRL NRLQSSGIQP AAFRAMEKLQ
260 270 280 290 300
FLYLSDNLLD SIPGPLPLSL RSVHLQNNLI ETMQRDVFCD PEEHKHTRRQ
310 320 330
LEDIRLDGNP INLSLFPSAY FCLPRLPIGR FT
Length:332
Mass (Da):37,261
Last modified:May 1, 2000 - v1
Checksum:i8060B4C46DF41C20
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055228182I → T.1 PublicationCorresponds to variant rs139024490dbSNPEnsembl.1
Natural variantiVAR_055229229R → C.1 PublicationCorresponds to variant rs150633473dbSNPEnsembl.1
Natural variantiVAR_055230325R → W.1 PublicationCorresponds to variant rs56219555dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133790 mRNA. Translation: CAB53459.1.
AF161702 mRNA. Translation: AAD45900.1.
AY077681 mRNA. Translation: AAL78286.1.
AL391817 Genomic DNA. Translation: CAI17035.1.
CH471067 Genomic DNA. Translation: EAW91482.1.
BC074942 mRNA. Translation: AAH74942.1.
BC074943 mRNA. Translation: AAH74943.1.
CCDSiCCDS1439.1.
RefSeqiNP_055174.1. NM_014359.3.
XP_011507708.1. XM_011509406.2.
UniGeneiHs.632468.

Genome annotation databases

EnsembliENST00000367222; ENSP00000356191; ENSG00000188770.
GeneIDi26254.
KEGGihsa:26254.
UCSCiuc001gzu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133790 mRNA. Translation: CAB53459.1.
AF161702 mRNA. Translation: AAD45900.1.
AY077681 mRNA. Translation: AAL78286.1.
AL391817 Genomic DNA. Translation: CAI17035.1.
CH471067 Genomic DNA. Translation: EAW91482.1.
BC074942 mRNA. Translation: AAH74942.1.
BC074943 mRNA. Translation: AAH74943.1.
CCDSiCCDS1439.1.
RefSeqiNP_055174.1. NM_014359.3.
XP_011507708.1. XM_011509406.2.
UniGeneiHs.632468.

3D structure databases

ProteinModelPortaliQ9UBM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UBM4. 1 interactor.
STRINGi9606.ENSP00000356191.

PTM databases

iPTMnetiQ9UBM4.
PhosphoSitePlusiQ9UBM4.

Polymorphism and mutation databases

BioMutaiOPTC.
DMDMi8928250.

Proteomic databases

PaxDbiQ9UBM4.
PeptideAtlasiQ9UBM4.
PRIDEiQ9UBM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367222; ENSP00000356191; ENSG00000188770.
GeneIDi26254.
KEGGihsa:26254.
UCSCiuc001gzu.2. human.

Organism-specific databases

CTDi26254.
DisGeNETi26254.
GeneCardsiOPTC.
HGNCiHGNC:8158. OPTC.
HPAiHPA034951.
MIMi605127. gene.
neXtProtiNX_Q9UBM4.
OpenTargetsiENSG00000188770.
PharmGKBiPA31947.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiQ9UBM4.
KOiK08128.
OMAiFCDPEEH.
OrthoDBiEOG091G0E8Y.
PhylomeDBiQ9UBM4.
TreeFamiTF351924.

Enzyme and pathway databases

BioCyciZFISH:G66-31578-MONOMER.

Miscellaneous databases

GeneWikiiOpticin.
GenomeRNAii26254.
PROiQ9UBM4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188770.
CleanExiHS_OPTC.
ExpressionAtlasiQ9UBM4. baseline and differential.
GenevisibleiQ9UBM4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPT_HUMAN
AccessioniPrimary (citable) accession number: Q9UBM4
Secondary accession number(s): Q5T2G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.