Q9UBL9 (P2RX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
P2X purinoceptor 2
Short name=P2X2

Alternative name(s):
ATP receptor
Purinergic receptor

Gene names

Name:	P2RX2
Synonyms:	P2X2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle.
Subunit structure	Functional P2XRs are organized as homomeric and heteromeric trimers.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the P2X receptor family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to pain Inferred from electronic annotation. Source: Compara detection of hypoxic conditions in blood by carotid body chemoreceptor signaling Inferred from electronic annotation. Source: Compara neuromuscular junction development Inferred from electronic annotation. Source: Compara neuromuscular synaptic transmission Inferred from electronic annotation. Source: Compara peristalsis Inferred from electronic annotation. Source: Compara positive regulation of calcium ion transport into cytosol Non-traceable author statement PubMed 17895406. Source: BHF-UCL positive regulation of calcium-mediated signaling Non-traceable author statement PubMed 17895406. Source: BHF-UCL protein heterooligomerization Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from physical interaction PubMed 15313628. Source: BHF-UCL regulation of action potential in neuron Inferred from electronic annotation. Source: Compara response to ATP Inferred from electronic annotation. Source: Compara response to carbohydrate stimulus Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara sensory perception of taste Inferred from electronic annotation. Source: Compara urinary bladder smooth muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from Biological aspect of Ancestor. Source: RefGenome neuronal cell body Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara presynaptic membrane Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Non-traceable author statement PubMed 17895406. Source: BHF-UCL cadmium ion binding Inferred from electronic annotation. Source: Compara cobalt ion binding Inferred from electronic annotation. Source: Compara copper ion binding Inferred from electronic annotation. Source: Compara drug binding Inferred from electronic annotation. Source: Compara extracellular ATP-gated cation channel activity Non-traceable author statement PubMed 17895406. Source: BHF-UCL mercury ion binding Inferred from electronic annotation. Source: Compara nickel cation binding Inferred from electronic annotation. Source: Compara phosphatidylinositol binding Inferred from electronic annotation. Source: Compara purinergic nucleotide receptor activity Non-traceable author statement PubMed 17895406. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9UBL9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9UBL9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     381-447: Missing.

Isoform C (identifier: Q9UBL9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     104-127: Missing.

Isoform D (identifier: Q9UBL9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     354-354: V → VVRNPLWGPSGCGGSTRPLHTGLCWPQ

Isoform H (identifier: Q9UBL9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     36-127: Missing.

Isoform I (identifier: Q9UBL9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     38-152: NRRLGVLYRA...VAGELDMLGN → IHRAEKLPGE...GRGGVREAPR

Isoform K (identifier: Q9UBL9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     104-127: Missing.
     154-258: LRTGRCVPYY...GESFTELAHK → ALQDLRGVRL...ELHRARTQGR
     381-447: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	P2X purinoceptor 2		PRO_0000161549
Regions
	Topological domain	1 – 42	42	Cytoplasmic Potential
	Transmembrane	43 – 63	21	Helical; Name=1; Potential
	Topological domain	64 – 337	274	Extracellular Potential
	Transmembrane	338 – 358	21	Helical; Name=2; Potential
	Topological domain	359 – 471	113	Cytoplasmic Potential
	Region	320 – 333	14	Pore-forming motif Potential
Amino acid modifications
	Glycosylation	133	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
	Disulfide bond	21 ↔ 439		By similarity
	Disulfide bond	125 ↔ 176		By similarity
	Disulfide bond	136 ↔ 159		By similarity
	Disulfide bond	142 ↔ 170		By similarity
	Disulfide bond	226 ↔ 236		By similarity
	Disulfide bond	270 ↔ 279		By similarity
Natural variations
	Alternative sequence	36 – 127	92	Missing in isoform H.		VSP_004495
	Alternative sequence	38 – 152	115	NRRLG…DMLGN → IHRAEKLPGERDGPRELHHH QGQGDHHVRAQSVGRGGVRE APR in isoform I.		VSP_004496
	Alternative sequence	104 – 127	24	Missing in isoform C and isoform K.		VSP_004497
	Alternative sequence	154 – 258	105	LRTGR…ELAHK → ALQDLRGVRLVPGGRWGLCQ PISGYDGPKFHHPHQEQHPL PQIPLLQGQHRRPHRRVPEA LHVPRGLRPLLPHLQAGLYR GEGWGELHRARTQGR in isoform K.		VSP_014135
	Alternative sequence	354	1	V → VVRNPLWGPSGCGGSTRPLH TGLCWPQ in isoform D.		VSP_004498
	Alternative sequence	381 – 447	67	Missing in isoform B and isoform K.		VSP_004499
Experimental info
	Sequence conflict	1 – 14	14	MAAAQ…AGATA → MV in AAD42947. Ref.3
	Sequence conflict	1 – 14	14	MAAAQ…AGATA → MV in AAD42948. Ref.3
	Sequence conflict	48	1	V → A in AAQ54329. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 84CD61DA136EF420	FASTA	471	51,754
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 70 80 90 100 110 120 FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPEGGSVFSI ITRVEATHSQ 130 140 150 160 170 180 TQGTCPESIR VHNATCLSDA DCVAGELDML GNGLRTGRCV PYYQGPSKTC EVFGWCPVED 190 200 210 220 230 240 GASVSQFLGT MAPNFTILIK NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK 250 260 270 280 290 300 LGFIVEKAGE SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 310 320 330 340 350 360 FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT SVGVGSFLCD 370 380 390 400 410 420 WILLTFMNKN KVYSHKKFDK VCTPSHPSGS WPVTLARVLG QAPPEPGHRS EDQHPSPPSG 430 440 450 460 470 QEGQQGAECG PAFPPLRPCP ISAPSEQMVD TPASEPAQAS TPTDPKGLAQ L
	Isoform B [UniParc]. Checksum: 695AC6C1655DB952	FASTA	404	44,842
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 70 80 90 100 110 120 FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPEGGSVFSI ITRVEATHSQ 130 140 150 160 170 180 TQGTCPESIR VHNATCLSDA DCVAGELDML GNGLRTGRCV PYYQGPSKTC EVFGWCPVED 190 200 210 220 230 240 GASVSQFLGT MAPNFTILIK NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK 250 260 270 280 290 300 LGFIVEKAGE SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 310 320 330 340 350 360 FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT SVGVGSFLCD 370 380 390 400 WILLTFMNKN KVYSHKKFDK MVDTPASEPA QASTPTDPKG LAQL
	Isoform C [UniParc]. Checksum: BAF5513A27314D1D	FASTA	447	49,266
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 70 80 90 100 110 120 FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPESIRVHNA TCLSDADCVA 130 140 150 160 170 180 GELDMLGNGL RTGRCVPYYQ GPSKTCEVFG WCPVEDGASV SQFLGTMAPN FTILIKNSIH 190 200 210 220 230 240 YPKFHFSKGN IADRTDGYLK RCTFHEASDL YCPIFKLGFI VEKAGESFTE LAHKGGVIGV 250 260 270 280 290 300 IINWDCDLDL PASECNPKYS FRRLDPKHVP ASSGYNFRFA KYYKINGTTT RTLIKAYGIR 310 320 330 340 350 360 IDVIVHGQAG KFSLIPTIIN LATALTSVGV GSFLCDWILL TFMNKNKVYS HKKFDKVCTP 370 380 390 400 410 420 SHPSGSWPVT LARVLGQAPP EPGHRSEDQH PSPPSGQEGQ QGAECGPAFP PLRPCPISAP 430 440 SEQMVDTPAS EPAQASTPTD PKGLAQL
	Isoform D [UniParc]. Checksum: FC4007F5BDD46E0E	FASTA	497	54,513
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 70 80 90 100 110 120 FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPEGGSVFSI ITRVEATHSQ 130 140 150 160 170 180 TQGTCPESIR VHNATCLSDA DCVAGELDML GNGLRTGRCV PYYQGPSKTC EVFGWCPVED 190 200 210 220 230 240 GASVSQFLGT MAPNFTILIK NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK 250 260 270 280 290 300 LGFIVEKAGE SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 310 320 330 340 350 360 FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT SVGVVRNPLW 370 380 390 400 410 420 GPSGCGGSTR PLHTGLCWPQ GSFLCDWILL TFMNKNKVYS HKKFDKVCTP SHPSGSWPVT 430 440 450 460 470 480 LARVLGQAPP EPGHRSEDQH PSPPSGQEGQ QGAECGPAFP PLRPCPISAP SEQMVDTPAS 490 EPAQASTPTD PKGLAQL
	Isoform H [UniParc]. Checksum: 8D1AA9A069D7F008	FASTA	379	41,254
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVSIRVH NATCLSDADC VAGELDMLGN 70 80 90 100 110 120 GLRTGRCVPY YQGPSKTCEV FGWCPVEDGA SVSQFLGTMA PNFTILIKNS IHYPKFHFSK 130 140 150 160 170 180 GNIADRTDGY LKRCTFHEAS DLYCPIFKLG FIVEKAGESF TELAHKGGVI GVIINWDCDL 190 200 210 220 230 240 DLPASECNPK YSFRRLDPKH VPASSGYNFR FAKYYKINGT TTRTLIKAYG IRIDVIVHGQ 250 260 270 280 290 300 AGKFSLIPTI INLATALTSV GVGSFLCDWI LLTFMNKNKV YSHKKFDKVC TPSHPSGSWP 310 320 330 340 350 360 VTLARVLGQA PPEPGHRSED QHPSPPSGQE GQQGAECGPA FPPLRPCPIS APSEQMVDTP 370 ASEPAQASTP TDPKGLAQL
	Isoform I [UniParc]. Checksum: 8B55562C9BAEAE5E	FASTA	399	43,726
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRIHR AEKLPGERDG PRELHHHQGQ 70 80 90 100 110 120 GDHHVRAQSV GRGGVREAPR GLRTGRCVPY YQGPSKTCEV FGWCPVEDGA SVSQFLGTMA 130 140 150 160 170 180 PNFTILIKNS IHYPKFHFSK GNIADRTDGY LKRCTFHEAS DLYCPIFKLG FIVEKAGESF 190 200 210 220 230 240 TELAHKGGVI GVIINWDCDL DLPASECNPK YSFRRLDPKH VPASSGYNFR FAKYYKINGT 250 260 270 280 290 300 TTRTLIKAYG IRIDVIVHGQ AGKFSLIPTI INLATALTSV GVGSFLCDWI LLTFMNKNKV 310 320 330 340 350 360 YSHKKFDKVC TPSHPSGSWP VTLARVLGQA PPEPGHRSED QHPSPPSGQE GQQGAECGPA 370 380 390 FPPLRPCPIS APSEQMVDTP ASEPAQASTP TDPKGLAQL
	Isoform K [UniParc]. Checksum: 36FC1F15D45624DC	FASTA	370	41,370
	10 20 30 40 50 60 MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 70 80 90 100 110 120 FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPESIRVHNA TCLSDADCVA 130 140 150 160 170 180 GELDMLGNGA LQDLRGVRLV PGGRWGLCQP ISGYDGPKFH HPHQEQHPLP QIPLLQGQHR 190 200 210 220 230 240 RPHRRVPEAL HVPRGLRPLL PHLQAGLYRG EGWGELHRAR TQGRGGVIGV IINWDCDLDL 250 260 270 280 290 300 PASECNPKYS FRRLDPKHVP ASSGYNFRFA KYYKINGTTT RTLIKAYGIR IDVIVHGQAG 310 320 330 340 350 360 KFSLIPTIIN LATALTSVGV GSFLCDWILL TFMNKNKVYS HKKFDKMVDT PASEPAQAST 370 PTDPKGLAQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and functional characterization of human P2X(2) receptors." Lynch K.J., Touma E., Niforatos W., Kage K.L., Burgard E.C., van Biesen T., Kowaluk E.A., Jarvis M.F. Mol. Pharmacol. 56:1171-1181(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A; B; C AND D). Tissue: Pituitary.
[2]	"Cloning of the human P2X2 receptor cDNA and multiple splice variants." McMahon R.A., Egan T.M., Hurley P.T., Nelson A., Rogers M., Martin F. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Tissue: Placenta.
[3]	"Cloning and molecular characterization of human P2X2 and its splice variants." Chang T.K., Kosaka A.H., Oglesby I.B., Gever J.R., Lachnit W.G., Ford A.P.D.W., Chang D.J. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; H AND I). Tissue: Prostate.
[4]	Lin L., Zheng G., Yu R., Li H., Shen C., Zhou G., Zhong G., Li M., Xiao W., Ke R., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM K).
[5]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

P2X receptor entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF190822 mRNA. Translation: AAF19170.1. AF190823 mRNA. Translation: AAF19171.1. AF190824 mRNA. Translation: AAF19172.1. AF190825 mRNA. Translation: AAF19173.1. AF190826 Genomic DNA. Translation: AAF19174.1. AF109387 mRNA. Translation: AAD42947.1. AF109388 mRNA. Translation: AAD42948.1. AF260426 mRNA. Translation: AAF74201.1. AF260427 mRNA. Translation: AAF74202.1. AF260428 mRNA. Translation: AAF74203.1. AF260429 mRNA. Translation: AAF74204.1. AY346374 mRNA. Translation: AAQ54329.1. AC131212 Genomic DNA. No translation available.
IPI	IPI00219278. IPI00219279. IPI00219280. IPI00219281. IPI00298586. IPI00329494. IPI00433338.
RefSeq	NP_036358.2. NM_012226.3. NP_057402.1. NM_016318.2. NP_733782.1. NM_170682.2. NP_733783.1. NM_170683.2. NP_777361.1. NM_174872.1. NP_777362.1. NM_174873.1.
UniGene	Hs.258580.
3D structure databases
ProteinModelPortal	Q9UBL9.
ModBase	Search...
PTM databases
PhosphoSite	Q9UBL9.
Polymorphism databases
DMDM	12643353.
Proteomic databases
PaxDb	Q9UBL9.
PRIDE	Q9UBL9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343948; ENSP00000343339; ENSG00000187848. ENST00000348800; ENSP00000345095; ENSG00000187848. ENST00000350048; ENSP00000343904; ENSG00000187848. ENST00000351222; ENSP00000344502; ENSG00000187848. ENST00000352418; ENSP00000341419; ENSG00000187848. ENST00000389110; ENSP00000373762; ENSG00000187848. ENST00000449132; ENSP00000405531; ENSG00000187848.
GeneID	22953.
KEGG	hsa:22953.
UCSC	uc001uki.1. human. uc001ukj.1. human. uc001ukk.1. human. uc001ukl.1. human. uc001ukm.1. human. uc001ukn.1. human. uc001uko.1. human.
Organism-specific databases
CTD	22953.
GeneCards	GC12P133195.
HGNC	HGNC:15459. P2RX2.
HPA	HPA014025.
MIM	600844. gene.
neXtProt	NX_Q9UBL9.
PharmGKB	PA32862.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG68669.
HOVERGEN	HBG053086.
KO	K05216.
OMA	ILLYFVW.
Gene expression databases
Bgee	Q9UBL9.
Genevestigator	Q9UBL9.
GermOnline	ENSG00000187848. Homo sapiens.
Family and domain databases
Gene3D	2.60.490.10. 1 hit.
InterPro	IPR003045. P2X2_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor. [Graphical view]
PANTHER	PTHR10125. PTHR10125. 1 hit. PTHR10125:SF4. PTHR10125:SF4. 1 hit.
Pfam	PF00864. P2X_receptor. 1 hit. [Graphical view]
PRINTS	PR01309. P2X2RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMs	TIGR00863. P2X. 1 hit.
PROSITE	PS01212. P2X_RECEPTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9UBL9.
ChEMBL	CHEMBL2531.
GenomeRNAi	22953.
NextBio	43725.
SOURCE	Search...

Entry information

Entry name

P2RX2_HUMAN

Accession

Primary (citable) accession number: Q9UBL9
Secondary accession number(s): A6NGB4 , A6NH93, A6NHC2, A6NHU3, A6NIG9, Q6V9R6, Q9NR37, Q9NR38, Q9UHD5, Q9UHD6, Q9UHD7, Q9Y637, Q9Y638

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.