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Q9UBL9

- P2RX2_HUMAN

UniProt

Q9UBL9 - P2RX2_HUMAN

Protein

P2X purinoceptor 2

Gene

P2RX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K+ recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: BHF-UCL
    2. cadmium ion binding Source: Ensembl
    3. cobalt ion binding Source: Ensembl
    4. copper ion binding Source: Ensembl
    5. drug binding Source: Ensembl
    6. extracellular ATP-gated cation channel activity Source: UniProtKB
    7. identical protein binding Source: BHF-UCL
    8. ligand-gated ion channel activity Source: ProtInc
    9. mercury ion binding Source: Ensembl
    10. nickel cation binding Source: Ensembl
    11. phosphatidylinositol binding Source: Ensembl
    12. purinergic nucleotide receptor activity Source: BHF-UCL
    13. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. behavioral response to pain Source: Ensembl
    2. cation transport Source: GOC
    3. detection of hypoxic conditions in blood by carotid body chemoreceptor signaling Source: Ensembl
    4. ion transmembrane transport Source: GOC
    5. neuromuscular junction development Source: Ensembl
    6. neuromuscular synaptic transmission Source: Ensembl
    7. neuronal action potential Source: Ensembl
    8. peristalsis Source: Ensembl
    9. positive regulation of calcium ion transport into cytosol Source: BHF-UCL
    10. positive regulation of calcium-mediated signaling Source: BHF-UCL
    11. protein heterooligomerization Source: Ensembl
    12. protein homooligomerization Source: BHF-UCL
    13. purinergic nucleotide receptor signaling pathway Source: GOC
    14. response to ATP Source: Ensembl
    15. response to carbohydrate Source: Ensembl
    16. response to hypoxia Source: Ensembl
    17. sensory perception of sound Source: UniProtKB
    18. sensory perception of taste Source: Ensembl
    19. skeletal muscle fiber development Source: Ensembl
    20. urinary bladder smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Hearing, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2X purinoceptor 2
    Short name:
    P2X2
    Alternative name(s):
    ATP receptor
    Purinergic receptor
    Gene namesi
    Name:P2RX2
    Synonyms:P2X2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:15459. P2RX2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localizes to the apical membranes of hair cells in the organ of Corti.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. cell surface Source: Ensembl
    3. dendritic spine Source: Ensembl
    4. integral component of nuclear inner membrane Source: RefGenome
    5. integral component of plasma membrane Source: UniProtKB
    6. neuronal cell body Source: Ensembl
    7. postsynaptic density Source: Ensembl
    8. presynaptic membrane Source: Ensembl
    9. receptor complex Source: MGI
    10. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal dominant, 41 (DFNA41) [MIM:608224]: A form of non-syndromic deafness characterized by onset of progressive sensorineural hearing loss usually in the second decade. The hearing loss is severe and ultimately affects all frequencies. Exposure to noise exacerbates the hearing loss, particularly at high frequencies.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601V → L in DFNA41; found in heterozygous status in patients; abolished ATP-stimulated permeability. 1 Publication
    VAR_070687
    Natural varianti353 – 3531G → R in DFNA41. 1 Publication
    VAR_070688

    Keywords - Diseasei

    Deafness, Disease mutation, Non-syndromic deafness

    Organism-specific databases

    MIMi608224. phenotype.
    Orphaneti90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.
    PharmGKBiPA32862.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471P2X purinoceptor 2PRO_0000161549Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi21 ↔ 439By similarity
    Disulfide bondi125 ↔ 176By similarity
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 159By similarity
    Disulfide bondi142 ↔ 170By similarity
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi226 ↔ 236By similarity
    Disulfide bondi270 ↔ 279By similarity
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UBL9.
    PRIDEiQ9UBL9.

    PTM databases

    PhosphoSiteiQ9UBL9.

    Expressioni

    Gene expression databases

    BgeeiQ9UBL9.
    GenevestigatoriQ9UBL9.

    Organism-specific databases

    HPAiHPA014025.

    Interactioni

    Subunit structurei

    Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBL9.
    SMRiQ9UBL9. Positions 42-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini64 – 337274ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 471113CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni320 – 33314Pore-forming motifSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the P2X receptor family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68669.
    HOVERGENiHBG053086.
    KOiK05216.
    OMAiLYFVWYV.
    PhylomeDBiQ9UBL9.
    TreeFamiTF328633.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003045. P2X2_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF4. PTHR10125:SF4. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01309. P2X2RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsiTIGR00863. P2X. 1 hit.
    PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9UBL9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL    50
    LILLYFVWYV FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK 100
    PPEGGSVFSI ITRVEATHSQ TQGTCPESIR VHNATCLSDA DCVAGELDML 150
    GNGLRTGRCV PYYQGPSKTC EVFGWCPVED GASVSQFLGT MAPNFTILIK 200
    NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK LGFIVEKAGE 250
    SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 300
    FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT 350
    SVGVGSFLCD WILLTFMNKN KVYSHKKFDK VCTPSHPSGS WPVTLARVLG 400
    QAPPEPGHRS EDQHPSPPSG QEGQQGAECG PAFPPLRPCP ISAPSEQMVD 450
    TPASEPAQAS TPTDPKGLAQ L 471
    Length:471
    Mass (Da):51,754
    Last modified:May 1, 2000 - v1
    Checksum:i84CD61DA136EF420
    GO
    Isoform B (identifier: Q9UBL9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         381-447: Missing.

    Show »
    Length:404
    Mass (Da):44,842
    Checksum:i695AC6C1655DB952
    GO
    Isoform C (identifier: Q9UBL9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-127: Missing.

    Show »
    Length:447
    Mass (Da):49,266
    Checksum:iBAF5513A27314D1D
    GO
    Isoform D (identifier: Q9UBL9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-354: V → VVRNPLWGPSGCGGSTRPLHTGLCWPQ

    Show »
    Length:497
    Mass (Da):54,513
    Checksum:iFC4007F5BDD46E0E
    GO
    Isoform H (identifier: Q9UBL9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-127: Missing.

    Show »
    Length:379
    Mass (Da):41,254
    Checksum:i8D1AA9A069D7F008
    GO
    Isoform I (identifier: Q9UBL9-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-152: NRRLGVLYRA...VAGELDMLGN → IHRAEKLPGE...GRGGVREAPR

    Show »
    Length:399
    Mass (Da):43,726
    Checksum:i8B55562C9BAEAE5E
    GO
    Isoform K (identifier: Q9UBL9-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-127: Missing.
         154-258: LRTGRCVPYY...GESFTELAHK → ALQDLRGVRL...ELHRARTQGR
         381-447: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:370
    Mass (Da):41,370
    Checksum:i36FC1F15D45624DC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 1414MAAAQ…AGATA → MV in AAD42947. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti1 – 1414MAAAQ…AGATA → MV in AAD42948. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti48 – 481V → A in AAQ54329. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601V → L in DFNA41; found in heterozygous status in patients; abolished ATP-stimulated permeability. 1 Publication
    VAR_070687
    Natural varianti353 – 3531G → R in DFNA41. 1 Publication
    VAR_070688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei36 – 12792Missing in isoform H. 1 PublicationVSP_004495Add
    BLAST
    Alternative sequencei38 – 152115NRRLG…DMLGN → IHRAEKLPGERDGPRELHHH QGQGDHHVRAQSVGRGGVRE APR in isoform I. 1 PublicationVSP_004496Add
    BLAST
    Alternative sequencei104 – 12724Missing in isoform C and isoform K. 3 PublicationsVSP_004497Add
    BLAST
    Alternative sequencei154 – 258105LRTGR…ELAHK → ALQDLRGVRLVPGGRWGLCQ PISGYDGPKFHHPHQEQHPL PQIPLLQGQHRRPHRRVPEA LHVPRGLRPLLPHLQAGLYR GEGWGELHRARTQGR in isoform K. 1 PublicationVSP_014135Add
    BLAST
    Alternative sequencei354 – 3541V → VVRNPLWGPSGCGGSTRPLH TGLCWPQ in isoform D. 1 PublicationVSP_004498
    Alternative sequencei381 – 44767Missing in isoform B and isoform K. 3 PublicationsVSP_004499Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190822 mRNA. Translation: AAF19170.1.
    AF190823 mRNA. Translation: AAF19171.1.
    AF190824 mRNA. Translation: AAF19172.1.
    AF190825 mRNA. Translation: AAF19173.1.
    AF190826 Genomic DNA. Translation: AAF19174.1.
    AF109387 mRNA. Translation: AAD42947.1.
    AF109388 mRNA. Translation: AAD42948.1.
    AF260426 mRNA. Translation: AAF74201.1.
    AF260427 mRNA. Translation: AAF74202.1.
    AF260428 mRNA. Translation: AAF74203.1.
    AF260429 mRNA. Translation: AAF74204.1.
    AY346374 mRNA. Translation: AAQ54329.1.
    AC131212 Genomic DNA. No translation available.
    CCDSiCCDS31930.1. [Q9UBL9-4]
    CCDS31931.1. [Q9UBL9-1]
    CCDS31932.1. [Q9UBL9-2]
    CCDS31933.1. [Q9UBL9-3]
    CCDS31934.1. [Q9UBL9-6]
    CCDS31935.1. [Q9UBL9-5]
    CCDS61286.1. [Q9UBL9-7]
    RefSeqiNP_001269093.1. NM_001282164.1. [Q9UBL9-7]
    NP_001269094.1. NM_001282165.1.
    NP_036358.2. NM_012226.4. [Q9UBL9-6]
    NP_057402.1. NM_016318.3. [Q9UBL9-3]
    NP_733782.1. NM_170682.3. [Q9UBL9-1]
    NP_733783.1. NM_170683.3. [Q9UBL9-4]
    NP_777361.1. NM_174872.2. [Q9UBL9-5]
    NP_777362.1. NM_174873.2. [Q9UBL9-2]
    UniGeneiHs.258580.

    Genome annotation databases

    EnsembliENST00000343948; ENSP00000343339; ENSG00000187848. [Q9UBL9-4]
    ENST00000348800; ENSP00000345095; ENSG00000187848. [Q9UBL9-2]
    ENST00000350048; ENSP00000343904; ENSG00000187848. [Q9UBL9-3]
    ENST00000351222; ENSP00000344502; ENSG00000187848. [Q9UBL9-5]
    ENST00000352418; ENSP00000341419; ENSG00000187848. [Q9UBL9-6]
    ENST00000389110; ENSP00000373762; ENSG00000187848. [Q9UBL9-1]
    ENST00000449132; ENSP00000405531; ENSG00000187848. [Q9UBL9-7]
    GeneIDi22953.
    KEGGihsa:22953.
    UCSCiuc001uki.1. human. [Q9UBL9-2]
    uc001ukj.1. human. [Q9UBL9-1]
    uc001ukk.1. human. [Q9UBL9-4]
    uc001ukl.1. human. [Q9UBL9-3]
    uc001ukm.1. human. [Q9UBL9-6]
    uc001ukn.1. human. [Q9UBL9-5]
    uc001uko.1. human. [Q9UBL9-7]

    Polymorphism databases

    DMDMi12643353.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    P2X receptor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190822 mRNA. Translation: AAF19170.1 .
    AF190823 mRNA. Translation: AAF19171.1 .
    AF190824 mRNA. Translation: AAF19172.1 .
    AF190825 mRNA. Translation: AAF19173.1 .
    AF190826 Genomic DNA. Translation: AAF19174.1 .
    AF109387 mRNA. Translation: AAD42947.1 .
    AF109388 mRNA. Translation: AAD42948.1 .
    AF260426 mRNA. Translation: AAF74201.1 .
    AF260427 mRNA. Translation: AAF74202.1 .
    AF260428 mRNA. Translation: AAF74203.1 .
    AF260429 mRNA. Translation: AAF74204.1 .
    AY346374 mRNA. Translation: AAQ54329.1 .
    AC131212 Genomic DNA. No translation available.
    CCDSi CCDS31930.1. [Q9UBL9-4 ]
    CCDS31931.1. [Q9UBL9-1 ]
    CCDS31932.1. [Q9UBL9-2 ]
    CCDS31933.1. [Q9UBL9-3 ]
    CCDS31934.1. [Q9UBL9-6 ]
    CCDS31935.1. [Q9UBL9-5 ]
    CCDS61286.1. [Q9UBL9-7 ]
    RefSeqi NP_001269093.1. NM_001282164.1. [Q9UBL9-7 ]
    NP_001269094.1. NM_001282165.1.
    NP_036358.2. NM_012226.4. [Q9UBL9-6 ]
    NP_057402.1. NM_016318.3. [Q9UBL9-3 ]
    NP_733782.1. NM_170682.3. [Q9UBL9-1 ]
    NP_733783.1. NM_170683.3. [Q9UBL9-4 ]
    NP_777361.1. NM_174872.2. [Q9UBL9-5 ]
    NP_777362.1. NM_174873.2. [Q9UBL9-2 ]
    UniGenei Hs.258580.

    3D structure databases

    ProteinModelPortali Q9UBL9.
    SMRi Q9UBL9. Positions 42-364.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9UBL9.
    ChEMBLi CHEMBL2531.
    GuidetoPHARMACOLOGYi 479.

    PTM databases

    PhosphoSitei Q9UBL9.

    Polymorphism databases

    DMDMi 12643353.

    Proteomic databases

    PaxDbi Q9UBL9.
    PRIDEi Q9UBL9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343948 ; ENSP00000343339 ; ENSG00000187848 . [Q9UBL9-4 ]
    ENST00000348800 ; ENSP00000345095 ; ENSG00000187848 . [Q9UBL9-2 ]
    ENST00000350048 ; ENSP00000343904 ; ENSG00000187848 . [Q9UBL9-3 ]
    ENST00000351222 ; ENSP00000344502 ; ENSG00000187848 . [Q9UBL9-5 ]
    ENST00000352418 ; ENSP00000341419 ; ENSG00000187848 . [Q9UBL9-6 ]
    ENST00000389110 ; ENSP00000373762 ; ENSG00000187848 . [Q9UBL9-1 ]
    ENST00000449132 ; ENSP00000405531 ; ENSG00000187848 . [Q9UBL9-7 ]
    GeneIDi 22953.
    KEGGi hsa:22953.
    UCSCi uc001uki.1. human. [Q9UBL9-2 ]
    uc001ukj.1. human. [Q9UBL9-1 ]
    uc001ukk.1. human. [Q9UBL9-4 ]
    uc001ukl.1. human. [Q9UBL9-3 ]
    uc001ukm.1. human. [Q9UBL9-6 ]
    uc001ukn.1. human. [Q9UBL9-5 ]
    uc001uko.1. human. [Q9UBL9-7 ]

    Organism-specific databases

    CTDi 22953.
    GeneCardsi GC12P133195.
    HGNCi HGNC:15459. P2RX2.
    HPAi HPA014025.
    MIMi 600844. gene.
    608224. phenotype.
    neXtProti NX_Q9UBL9.
    Orphaneti 90635. Autosomal dominant nonsyndromic sensorineural deafness type DFNA.
    PharmGKBi PA32862.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68669.
    HOVERGENi HBG053086.
    KOi K05216.
    OMAi LYFVWYV.
    PhylomeDBi Q9UBL9.
    TreeFami TF328633.

    Miscellaneous databases

    GeneWikii P2RX2.
    GenomeRNAii 22953.
    NextBioi 43725.
    PROi Q9UBL9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBL9.
    Genevestigatori Q9UBL9.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003045. P2X2_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF4. PTHR10125:SF4. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01309. P2X2RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsi TIGR00863. P2X. 1 hit.
    PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and functional characterization of human P2X(2) receptors."
      Lynch K.J., Touma E., Niforatos W., Kage K.L., Burgard E.C., van Biesen T., Kowaluk E.A., Jarvis M.F.
      Mol. Pharmacol. 56:1171-1181(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A; B; C AND D).
      Tissue: Pituitary.
    2. "Cloning of the human P2X2 receptor cDNA and multiple splice variants."
      McMahon R.A., Egan T.M., Hurley P.T., Nelson A., Rogers M., Martin F.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
      Tissue: Placenta.
    3. "Cloning and molecular characterization of human P2X2 and its splice variants."
      Chang T.K., Kosaka A.H., Oglesby I.B., Gever J.R., Lachnit W.G., Ford A.P.D.W., Chang D.J.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; C; H AND I).
      Tissue: Prostate.
    4. Lin L., Zheng G., Yu R., Li H., Shen C., Zhou G., Zhong G., Li M., Xiao W., Ke R., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM K).
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: VARIANT DFNA41 LEU-60, CHARACTERIZATION OF VARIANT DFNA41 LEU-60, FUNCTION, SUBCELLULAR LOCATION.
    7. "A novel P2RX2 mutation in an Italian family affected by autosomal dominant nonsyndromic hearing loss."
      Faletra F., Girotto G., D'Adamo A.P., Vozzi D., Morgan A., Gasparini P.
      Gene 534:236-239(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT DFNA41 ARG-353.

    Entry informationi

    Entry nameiP2RX2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBL9
    Secondary accession number(s): A6NGB4
    , A6NH93, A6NHC2, A6NHU3, A6NIG9, Q6V9R6, Q9NR37, Q9NR38, Q9UHD5, Q9UHD6, Q9UHD7, Q9Y637, Q9Y638
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3