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Protein

Copine-7

Gene

CPNE7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

GO - Molecular functioni

  • transporter activity Source: ProtInc

GO - Biological processi

  • cellular response to calcium ion Source: UniProtKB
  • glycerophospholipid biosynthetic process Source: Reactome
  • lipid metabolic process Source: ProtInc
  • phospholipid metabolic process Source: Reactome
  • small molecule metabolic process Source: Reactome
  • transport Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1483206. Glycerophospholipid biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-7Curated
Alternative name(s):
Copine VII1 PublicationImported
Gene namesi
Name:CPNE7Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:2320. CPNE7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26837.

Polymorphism and mutation databases

BioMutaiCPNE7.
DMDMi10719954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Copine-7PRO_0000144848Add
BLAST

Proteomic databases

EPDiQ9UBL6.
MaxQBiQ9UBL6.
PaxDbiQ9UBL6.
PRIDEiQ9UBL6.

PTM databases

iPTMnetiQ9UBL6.
PhosphoSiteiQ9UBL6.

Expressioni

Tissue specificityi

Expressed in the brain, testis, thymus and small intestine (PubMed:10534407, PubMed:12949241).2 Publications

Gene expression databases

BgeeiQ9UBL6.
CleanExiHS_CPNE7.
ExpressionAtlasiQ9UBL6. baseline and differential.
GenevisibleiQ9UBL6. HS.

Organism-specific databases

HPAiHPA043359.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-744841,EBI-10173507

Protein-protein interaction databases

BioGridi118023. 26 interactions.
IntActiQ9UBL6. 6 interactions.
MINTiMINT-1450270.
STRINGi9606.ENSP00000268720.

Structurei

3D structure databases

ProteinModelPortaliQ9UBL6.
SMRiQ9UBL6. Positions 21-124, 216-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11487C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 32185C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini382 – 581200VWFAPROSITE-ProRule annotationAdd
BLAST

Domaini

The C2 domain 1 is not necessary for calcium-mediated translocation and association to the plasma membrane. The C2 domain 2 is necessary for calcium-mediated translocation and association to the plasma membrane.By similarity

Sequence similaritiesi

Belongs to the copine family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ9UBL6.
OMAiGNKVSWD.
OrthoDBiEOG77DJ57.
PhylomeDBiQ9UBL6.
TreeFamiTF316419.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGSERGAA ATPGGLPAPC ASKVELRLSC RHLLDRDPLT KSDPSVALLQ
60 70 80 90 100
QAQGQWVQVG RTEVVRSSLH PVFSKVFTVD YYFEEVQRLR FEVYDTHGPS
110 120 130 140 150
GFSCQEDDFL GGMECTLGQP AQKWLLQVVM RVSVDVLGPA GHCAKHFLCC
160 170 180 190 200
TESSHLARTG PSFLLRYDDL CLPWATAGAV RWWTCRGGHT QGWQIVAQKK
210 220 230 240 250
VTRPLLLKFG RNAGKSTITV IAEDISGNNG YVELSFRARK LDDKDLFSKS
260 270 280 290 300
DPFLELYRVN DDQGLQLVYR TEVVKNNLNP VWEAFKVSLS SLCSCEETRP
310 320 330 340 350
LKCLVWDYDS RGKHDFIGEF STTFEEMQKA FEEGQAQWDC VNPKYKQKRR
360 370 380 390 400
SYKNSGVVVL ADLKFHRVYS FLDYIMGGCQ IHFTVAIDFT ASNGDPRNSC
410 420 430 440 450
SLHYINPYQP NEYLKALVSV GEICQDYDSD KRFSALGFGA RIPPKYEVSH
460 470 480 490 500
DFAINFNPED DECEGIQGVV EAYQNCLPRV QLYGPTNVAP IISKVARVAA
510 520 530 540 550
AEESTGKASQ YYILLILTDG VVTDMADTRE AIVRASRLPM SIIIVGVGNA
560 570 580 590 600
DFTDMQVLDG DDGVLRSPRG EPALRDIVQF VPFRELKNAS PAALAKCVLA
610 620 630
EVPKQVVEYY SHRGLPPRSL GVPAGEASPG CTP
Length:633
Mass (Da):70,294
Last modified:May 1, 2000 - v1
Checksum:i8AF4B68D3EFC51BB
GO
Isoform 2 (identifier: Q9UBL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-194: Missing.

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):61,933
Checksum:iC77ADA4B60E7CFB6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771F → L.
Corresponds to variant rs455527 [ dbSNP | Ensembl ].
VAR_021955
Natural varianti397 – 3971R → Q.
Corresponds to variant rs28568523 [ dbSNP | Ensembl ].
VAR_033822
Natural varianti507 – 5071K → E.
Corresponds to variant rs35731090 [ dbSNP | Ensembl ].
VAR_048849
Natural varianti633 – 6331P → L.
Corresponds to variant rs3751682 [ dbSNP | Ensembl ].
VAR_021956

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 19475Missing in isoform 2. 1 PublicationVSP_001215Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133798 mRNA. Translation: CAB61431.1.
AJ133799
, AJ133800, AJ133801, AJ133802, AJ133803, AJ133804, AJ133805, AJ133806, AJ133807, AJ133808, AJ133809, AJ133810 Genomic DNA. Translation: CAB61446.1.
BC035334 mRNA. Translation: AAH35334.1.
BC064577 mRNA. Translation: AAH64577.1.
CCDSiCCDS10980.1. [Q9UBL6-1]
CCDS10981.1. [Q9UBL6-2]
RefSeqiNP_055242.1. NM_014427.4. [Q9UBL6-1]
NP_705900.1. NM_153636.2. [Q9UBL6-2]
UniGeneiHs.461775.

Genome annotation databases

EnsembliENST00000268720; ENSP00000268720; ENSG00000178773. [Q9UBL6-1]
ENST00000319518; ENSP00000317374; ENSG00000178773. [Q9UBL6-2]
GeneIDi27132.
KEGGihsa:27132.
UCSCiuc002fnp.3. human. [Q9UBL6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133798 mRNA. Translation: CAB61431.1.
AJ133799
, AJ133800, AJ133801, AJ133802, AJ133803, AJ133804, AJ133805, AJ133806, AJ133807, AJ133808, AJ133809, AJ133810 Genomic DNA. Translation: CAB61446.1.
BC035334 mRNA. Translation: AAH35334.1.
BC064577 mRNA. Translation: AAH64577.1.
CCDSiCCDS10980.1. [Q9UBL6-1]
CCDS10981.1. [Q9UBL6-2]
RefSeqiNP_055242.1. NM_014427.4. [Q9UBL6-1]
NP_705900.1. NM_153636.2. [Q9UBL6-2]
UniGeneiHs.461775.

3D structure databases

ProteinModelPortaliQ9UBL6.
SMRiQ9UBL6. Positions 21-124, 216-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118023. 26 interactions.
IntActiQ9UBL6. 6 interactions.
MINTiMINT-1450270.
STRINGi9606.ENSP00000268720.

PTM databases

iPTMnetiQ9UBL6.
PhosphoSiteiQ9UBL6.

Polymorphism and mutation databases

BioMutaiCPNE7.
DMDMi10719954.

Proteomic databases

EPDiQ9UBL6.
MaxQBiQ9UBL6.
PaxDbiQ9UBL6.
PRIDEiQ9UBL6.

Protocols and materials databases

DNASUi27132.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268720; ENSP00000268720; ENSG00000178773. [Q9UBL6-1]
ENST00000319518; ENSP00000317374; ENSG00000178773. [Q9UBL6-2]
GeneIDi27132.
KEGGihsa:27132.
UCSCiuc002fnp.3. human. [Q9UBL6-1]

Organism-specific databases

CTDi27132.
GeneCardsiCPNE7.
HGNCiHGNC:2320. CPNE7.
HPAiHPA043359.
MIMi605689. gene.
neXtProtiNX_Q9UBL6.
PharmGKBiPA26837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ9UBL6.
OMAiGNKVSWD.
OrthoDBiEOG77DJ57.
PhylomeDBiQ9UBL6.
TreeFamiTF316419.

Enzyme and pathway databases

ReactomeiR-HSA-1483206. Glycerophospholipid biosynthesis.

Miscellaneous databases

ChiTaRSiCPNE7. human.
GenomeRNAii27132.
NextBioi49860.
PROiQ9UBL6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBL6.
CleanExiHS_CPNE7.
ExpressionAtlasiQ9UBL6. baseline and differential.
GenevisibleiQ9UBL6. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3."
    Savino M., D'Apolito M., Centra M., van Beerendonk H.M., Cleton-Jansen A.-M., Whitmore S.A., Crawford J., Callen D.F., Zelante L., Savoia A.
    Genomics 61:219-226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils."
    Cowland J.B., Carter D., Bjerregaard M.D., Johnsen A.H., Borregaard N., Lollike K.
    J. Leukoc. Biol. 74:379-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting."
    Perestenko P.V., Pooler A.M., Noorbakhshnia M., Gray A., Bauccio C., Jeffrey McIlhinney R.A.
    FEBS J. 277:5174-5189(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCPNE7_HUMAN
AccessioniPrimary (citable) accession number: Q9UBL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 16, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.