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Protein

Protein UXT

Gene

UXT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in gene transcription regulation (PubMed:28106301, PubMed:21730289). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584).9 Publications
Isoform 1: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.1 Publication

GO - Molecular functioni

  • beta-tubulin binding Source: HGNC
  • chromatin binding Source: UniProtKB
  • microtubule binding Source: HGNC
  • RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • centrosome cycle Source: HGNC
  • microtubule cytoskeleton organization Source: HGNC
  • mitochondrion transport along microtubule Source: HGNC
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chaperone, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8953750. Transcriptional Regulation by E2F6.
SIGNORiQ9UBK9.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UXT
Alternative name(s):
Androgen receptor trapped clone 27 protein1 Publication
Short name:
ART-271 Publication
Ubiquitously expressed transcript protein
Gene namesi
Name:UXT
ORF Names:HSPC024
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126756.11.
HGNCiHGNC:12641. UXT.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi50L → P: Causes dislocation from the centrosome; when associated with L-59. 1 Publication1
Mutagenesisi59L → P: Causes dislocation from the centrosome; when associated with L-50. 1 Publication1

Organism-specific databases

DisGeNETi8409.
OpenTargetsiENSG00000126756.
PharmGKBiPA37265.

Polymorphism and mutation databases

BioMutaiUXT.
DMDMi8928445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657511 – 157Protein UXTAdd BLAST157

Proteomic databases

EPDiQ9UBK9.
MaxQBiQ9UBK9.
PaxDbiQ9UBK9.
PeptideAtlasiQ9UBK9.
PRIDEiQ9UBK9.

PTM databases

iPTMnetiQ9UBK9.
PhosphoSitePlusiQ9UBK9.

Expressioni

Tissue specificityi

Ubiquitous (PubMed:10087202, PubMed:11854421, PubMed:17635584, PubMed:11827465). Expressed in prostate epithelial cells (PubMed:21730289). Expressed in mammary epithelial cells (PubMed:28106301). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus (PubMed:11854421, PubMed:17635584, PubMed:11827465). Overexpressed in a number of tumor tissues (PubMed:11854421, PubMed:16221885, PubMed:28106301).7 Publications

Gene expression databases

BgeeiENSG00000126756.
CleanExiHS_UXT.
ExpressionAtlasiQ9UBK9. baseline and differential.
GenevisibleiQ9UBK9. HS.

Organism-specific databases

HPAiHPA050499.
HPA058400.

Interactioni

Subunit structurei

Homohexamer (PubMed:16221885). Interacts with LRPPRC (PubMed:11827465, PubMed:17554592). Interacts with androgen receptor AR (via N-terminus) (PubMed:11854421). Interacts with estrogen receptor ESR1; the interaction relocalizes ESR1 from the nucleus to the cytoplasm (PubMed:28106301). In the nucleus, interacts specifically with RELA (via RHD domain) and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation (PubMed:17620405). Interacts with MECOM (PubMed:17635584). Interacts with URI1 (PubMed:21730289). Isoform 1 is part of complex I composed of TNF-alpha receptor TNFRSF1A, TRADD, TRAF2 and RIPK1 formed in response to TNF-alpha stimulation. Within the complex, interacts (via TPQE motif) with TRAF2; the interaction prevents the recruitment of FADD and CASP8/caspase 8 to complex I (PubMed:21307340).9 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • beta-tubulin binding Source: HGNC
  • microtubule binding Source: HGNC

Protein-protein interaction databases

BioGridi113997. 61 interactors.
IntActiQ9UBK9. 56 interactors.
MINTiMINT-1143575.
STRINGi9606.ENSP00000337393.

Structurei

3D structure databases

ProteinModelPortaliQ9UBK9.
SMRiQ9UBK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UXT family.Curated

Phylogenomic databases

eggNOGiKOG3047. Eukaryota.
ENOG4111Q3P. LUCA.
GeneTreeiENSGT00390000018078.
HOGENOMiHOG000005748.
HOVERGENiHBG001087.
InParanoidiQ9UBK9.
PhylomeDBiQ9UBK9.
TreeFamiTF323827.

Family and domain databases

InterProiView protein in InterPro
IPR004127. Prefoldin_subunit_alpha.
IPR003994. UXT.
PfamiView protein in Pfam
PF02996. Prefoldin. 1 hit.
PRINTSiPR01502. UXTPROTEIN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9UBK9-1) [UniParc]FASTAAdd to basket
Also known as: UXT-V21 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPPKRRAV EATGEKVLRY ETFISDVLQR DLRKVLDHRD KVYEQLAKYL
60 70 80 90 100
QLRNVIERLQ EAKHSELYMQ VDLGCNFFVD TVVPDTSRIY VALGYGFFLE
110 120 130 140 150
LTLAEALKFI DRKSSLLTEL SNSLTKDSMN IKAHIHMLLE GLRELQGLQN

FPEKPHH
Length:157
Mass (Da):18,246
Last modified:May 1, 2000 - v1
Checksum:i94CE14C462DEE308
GO
Isoform 1 (identifier: Q9UBK9-2) [UniParc]FASTAAdd to basket
Also known as: UXT-V11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVFPLPTPQEPIM

Show »
Length:169
Mass (Da):19,597
Checksum:i9CF9D541236BDC79
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0590811M → MVFPLPTPQEPIM in isoform 1. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092737 mRNA. Translation: AAD28698.1.
AF083241 mRNA. Translation: AAD39839.1.
AF083242 mRNA. Translation: AAD39840.1.
AK312072 mRNA. Translation: BAG35008.1.
AL009172 Genomic DNA. No translation available.
CH471164 Genomic DNA. Translation: EAW59325.1.
CH471164 Genomic DNA. Translation: EAW59326.1.
BC000720 mRNA. Translation: AAH00720.1.
BC008890 mRNA. Translation: AAH08890.1.
CCDSiCCDS14284.1. [Q9UBK9-2]
CCDS14285.1. [Q9UBK9-1]
RefSeqiNP_004173.1. NM_004182.3. [Q9UBK9-1]
NP_705582.1. NM_153477.2. [Q9UBK9-2]
UniGeneiHs.172791.
Hs.735566.

Genome annotation databases

EnsembliENST00000333119; ENSP00000327797; ENSG00000126756. [Q9UBK9-1]
ENST00000335890; ENSP00000337393; ENSG00000126756. [Q9UBK9-2]
GeneIDi8409.
KEGGihsa:8409.
UCSCiuc004dim.4. human. [Q9UBK9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUXT_HUMAN
AccessioniPrimary (citable) accession number: Q9UBK9
Secondary accession number(s): A0A0C4DFR8
, B2R561, Q5JZG3, Q9Y6E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families