Q9UBK7 (RBL2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rab-like protein 2A

Gene names

Name:

RABL2A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UBK7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UBK7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: D → DA

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9UBK7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     168-168: K → KVWLTAEVASK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Rab-like protein 2A		PRO_0000121263
Regions
	Nucleotide binding	28 – 35	8	GTP By similarity
	Nucleotide binding	76 – 80	5	GTP By similarity
	Nucleotide binding	133 – 136	4	GTP By similarity
Natural variations
	Alternative sequence	136	1	D → DA in isoform 2.		VSP_005531
	Alternative sequence	168	1	K → KVWLTAEVASK in isoform 3.		VSP_041060

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 96947DD254886B3C	FASTA	228	26,115
	10 20 30 40 50 60 MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 70 80 90 100 110 120 HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR 130 140 150 160 170 180 EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY 190 200 210 220 KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEVASPHS
	Isoform 2 [UniParc]. Checksum: 20148DE39EC474A5	FASTA	229	26,186
	10 20 30 40 50 60 MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 70 80 90 100 110 120 HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR 130 140 150 160 170 180 EFRPEIPCIV VANKIDADIN VTQKSFNFAK KFSLPLYFVS AADGTNVVKL FNDAIRLAVS 190 200 210 220 YKQNSQDFMD EIFQELENFS LEQEEEDVPD QEQSSSIETP SEEVASPHS
	Isoform 3 [UniParc]. Checksum: 974E9EE00BCE3854	FASTA	238	27,201
	10 20 30 40 50 60 MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 70 80 90 100 110 120 HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR 130 140 150 160 170 180 EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKVW LTAEVASKLF 190 200 210 220 230 NDAIRLAVSY KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEVASPHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13." Wong A.C., Shkolny D., Dorman A., Willingham D., Roe B.A., McDermid H.E. Genomics 59:326-334(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF095350 mRNA. Translation: AAD51377.1. AF095351 mRNA. Translation: AAD51378.1. AL078621 Genomic DNA. Translation: CAX11909.1.
IPI	IPI00002644. IPI00221207. IPI00917072.
RefSeq	NP_009013.1. NM_007082.3. NP_038198.1. NM_013412.2.
UniGene	Hs.446425.
3D structure databases
ProteinModelPortal	Q9UBK7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000376871.
PTM databases
PhosphoSite	Q9UBK7.
Polymorphism databases
DMDM	12643870.
Proteomic databases
PaxDb	Q9UBK7.
PRIDE	Q9UBK7.
Protocols and materials databases
DNASU	11159.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393165; ENSP00000376870; ENSG00000144134. ENST00000393166; ENSP00000376871; ENSG00000144134. ENST00000393167; ENSP00000376872; ENSG00000144134. ENST00000409875; ENSP00000387229; ENSG00000144134.
GeneID	11159.
KEGG	hsa:11159.
UCSC	uc002tkn.4. human.
Organism-specific databases
CTD	11159.
GeneCards	GC02P114384.
HGNC	HGNC:9799. RABL2A.
MIM	605412. gene.
neXtProt	NX_Q9UBK7.
PharmGKB	PA34159.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233971.
HOVERGEN	HBG106536.
KO	K07931.
OMA	CTVEASE.
OrthoDB	EOG4J1194.
PhylomeDB	Q9UBK7.
Gene expression databases
ArrayExpress	Q9UBK7.
Bgee	Q9UBK7.
CleanEx	HS_RABL2A.
Genevestigator	Q9UBK7.
GermOnline	ENSG00000144134. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11159.
NextBio	42445.
SOURCE	Search...

Entry information

Entry name

RBL2A_HUMAN

Accession

Primary (citable) accession number: Q9UBK7
Secondary accession number(s): B7ZBD6, Q9NU37

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.