Reviewed,
UniProtKB/Swiss-Prot Q9UBK2 (PRGC1_HUMAN)
Last modified
February 9, 2010.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Short name=PPAR-gamma coactivator 1-alpha Short name=PPARGC-1-alpha Short name=PGC-1-alpha Alternative name(s): Ligand effect modulator 6 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 798 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis By similarity. Ref.3 |
| Subunit structure | Binds MYBBP1A, which inhibits transcriptional activation by this protein By similarity. Interacts with PRDM16 By similarity. Interacts with LRPPRC. Homooligomer. Interacts with LPIN1 By similarity. Ref.3 Ref.4 |
| Subcellular location | |
| Tissue specificity | Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. Ref.3 Ref.1 Ref.2 |
| Sequence similarities | Contains 1 RRM (RNA recognition motif) domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 798 | 798 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | PRO_0000081732 | |||||||
Regions | |||||||||||
| Domain | 677 – 753 | 77 | RRM | ||||||||
| Region | 293 – 339 | 47 | Interaction with PPARG | ||||||||
| Motif | 144 – 148 | 5 | LXXLL motif | ||||||||
| Compositional bias | 566 – 599 | 34 | Arg/Ser-rich | ||||||||
| Compositional bias | 621 – 633 | 13 | Arg/Ser-rich | ||||||||
Natural variations | |||||||||||
| Natural variant | 482 | 1 | G → S: dbSNP rs8192678. Ref.2 | VAR_018450 | |||||||
| Natural variant | 612 | 1 | T → M: dbSNP rs3736265. | VAR_018451 | |||||||
Secondary structure | |||||||||||
Helix Strand Turn | |||||||||||
| Helix | 209 – 214 | 6 | |||||||||
Sequences
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References
| [1] | "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression." Esterbauer H., Oberkofler H., Krempler F., Patsch W. Genomics 62:98-102(1999) [PubMed: 10585775] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. |
| [2] | "Cloning and mRNA tissue distribution of human PPARgamma coactivator-1." Larrouy D., Vidal H., Andreelli F., Laville M., Langin D. Int. J. Obes. Relat. Metab. Disord. 23:1327-1332(1999) [PubMed: 10643692] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT SER-482. Tissue: Skeletal muscle. |
| [3] | "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen." Knutti D., Kaul A., Kralli A. Mol. Cell. Biol. 20:2411-2422(2000) [PubMed: 10713165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [4] | "Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex." Cooper M.P., Qu L., Rohas L.M., Lin J., Yang W., Erdjument-Bromage H., Tempst P., Spiegelman B.M. Genes Dev. 20:2996-3009(2006) [PubMed: 17050673] [Abstract] Cited for: INTERACTION WITH LRPPRC. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF108205 AF108204 Genomic DNA. Translation: AAF19083.1. AF106698 mRNA. Translation: AAF18573.1. AF159714 mRNA. Translation: AAD51615.1. AF186379 mRNA. Translation: AAD56250.1. | ||||||||||||||||||||||||
| IPI | IPI00033138. | ||||||||||||||||||||||||
| RefSeq | NP_037393.1. | ||||||||||||||||||||||||
| UniGene | Hs.527078 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||
| SMR | Q9UBK2. Positions 675-739. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | Q9UBK2. 2 interactions. | ||||||||||||||||||||||||
| STRING | Q9UBK2. | ||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||
| PhosphoSite | Q9UBK2. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PRIDE | Q9UBK2. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000264867; ENSP00000264867; ENSG00000109819; Homo sapiens. [Genome view] | ||||||||||||||||||||||||
| GeneID | 10891. | ||||||||||||||||||||||||
| KEGG | hsa:10891. | ||||||||||||||||||||||||
| UCSC | uc003gqs.1. human. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 10891. | ||||||||||||||||||||||||
| GeneCards | GC04M023469. | ||||||||||||||||||||||||
| H-InvDB | HIX0004134. | ||||||||||||||||||||||||
| HGNC | HGNC:9237. PPARGC1A. | ||||||||||||||||||||||||
| MIM | 604517. gene. | ||||||||||||||||||||||||
| PharmGKB | PA33558. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | HBG716332. | ||||||||||||||||||||||||
| HOVERGEN | Q9UBK2. | ||||||||||||||||||||||||
| InParanoid | Q9UBK2. | ||||||||||||||||||||||||
| OMA | RLFGDHD. | ||||||||||||||||||||||||
| OrthoDB | EOG9ZPHF4. | ||||||||||||||||||||||||
| PhylomeDB | Q9UBK2. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Pathway_Interaction_DB | hdac_classiii_pathway. Signaling events mediated by HDAC Class III. p38alphabetadownstreampathway. Signaling mediated by p38-alpha and p38-beta. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | Q9UBK2. | ||||||||||||||||||||||||
| Bgee | Q9UBK2. | ||||||||||||||||||||||||
| CleanEx | HS_PPARGC1A. | ||||||||||||||||||||||||
| Genevestigator | Q9UBK2. | ||||||||||||||||||||||||
| GermOnline | ENSG00000109819. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR012677. a_b_plait_nuc_bd. IPR000504. RRM_RNP1. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00076. RRM_1. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00360. RRM. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS50102. RRM. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 41353. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | PRGC1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UBK2 Secondary accession number(s): Q9UN32 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


