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Protein

Headcase protein homolog

Gene

HECA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.1 Publication

GO - Biological processi

  • negative regulation of mitotic cell cycle Source: HGNC
  • respiratory tube development Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Headcase protein homolog
Short name:
hHDC
Gene namesi
Name:HECA
Synonyms:HDC
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112406.4
HGNCiHGNC:21041 HECA
MIMi607977 gene
neXtProtiNX_Q9UBI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi51696
OpenTargetsiENSG00000112406
PharmGKBiPA134977625

Polymorphism and mutation databases

BioMutaiHECA
DMDMi44887986

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839341 – 543Headcase protein homologAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBI9
MaxQBiQ9UBI9
PaxDbiQ9UBI9
PeptideAtlasiQ9UBI9
PRIDEiQ9UBI9

PTM databases

iPTMnetiQ9UBI9
PhosphoSitePlusiQ9UBI9

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000112406
CleanExiHS_HDC
HS_HECA
GenevisibleiQ9UBI9 HS

Organism-specific databases

HPAiHPA042313

Interactioni

Protein-protein interaction databases

BioGridi119682, 1 interactor
STRINGi9606.ENSP00000356630

Structurei

3D structure databases

ProteinModelPortaliQ9UBI9
SMRiQ9UBI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 95Ala/Gly-richAdd BLAST87

Phylogenomic databases

eggNOGiKOG3816 Eukaryota
ENOG410XREE LUCA
GeneTreeiENSGT00500000044928
HOGENOMiHOG000112873
HOVERGENiHBG049012
InParanoidiQ9UBI9
OMAiQKGLNHD
OrthoDBiEOG091G054P
PhylomeDBiQ9UBI9
TreeFamiTF315512

Family and domain databases

InterProiView protein in InterPro
IPR026066 Headcase
IPR031947 Headcase_mid
PANTHERiPTHR13425 PTHR13425, 1 hit
PfamiView protein in Pfam
PF16002 Headcase, 1 hit
PF15353 HECA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UBI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNPKNSKGG RKNKRANSSG DEQENGAGAL AAAGAAGAAA GGALAAAAGC
60 70 80 90 100
GAAAAGAPGA GGAAGAGGAG TGAANAAAAA GAAAAGDAKN EAPCATPLIC
110 120 130 140 150
SFGRPVDLEK DDYQKVVCNN EHCPCSTWMH LQCFYEWESS ILVQFNCIGR
160 170 180 190 200
ARSWNEKQCR QNMWTKKGYD LAFRFCSCRC GQGHLKKDTD WYQVKRMQDE
210 220 230 240 250
KKKKSGSEKN TGRPPGEAAE EAKKCRPPNK PQKGPSHDLP RRHSMDRQNS
260 270 280 290 300
QEKAVGAAAY GARSPGGSPG QSPPTGYSIL SPAHFSGPRS SRYLGEFLKN
310 320 330 340 350
AIHLEPHKKA MAGGHVFRNA HFDYSPAGLA VHRGGHFDTP VQFLRRLDLS
360 370 380 390 400
ELLTHIPRHK LNTFHVRMED DAQVGQGEDL RKFILAALSA SHRNVVNCAL
410 420 430 440 450
CHRALPVFEQ FPLVDGTLFL SPSRHDEIEY DVPCHLQGRL MHLYAVCVDC
460 470 480 490 500
LEGVHKIICI KCKSRWDGSW HQLGTMYTYD ILAASPCCQA RLNCKHCGKP
510 520 530 540
VIDVRIGMQY FSEYSNVQQC PHCGNLDYHF VKPFSSFKVL EAY
Length:543
Mass (Da):58,837
Last modified:May 1, 2000 - v1
Checksum:iA161B7F4C57EF0D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033496 Genomic DNA Translation: BAA85333.1
AB033492 mRNA Translation: BAA85322.1
AL031772 Genomic DNA Translation: CAB94782.1
BC070068 mRNA Translation: AAH70068.1
CCDSiCCDS5194.1
RefSeqiNP_057301.1, NM_016217.2
UniGeneiHs.197644

Genome annotation databases

EnsembliENST00000367658; ENSP00000356630; ENSG00000112406
GeneIDi51696
KEGGihsa:51696
UCSCiuc003qin.4 human

Similar proteinsi

Entry informationi

Entry nameiHDC_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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