Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Headcase protein homolog

Gene

HECA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs.1 Publication

GO - Biological processi

  • negative regulation of mitotic cell cycle Source: HGNC
  • respiratory tube development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Headcase protein homolog
Short name:
hHDC
Gene namesi
Name:HECA
Synonyms:HDC
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21041. HECA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • membrane Source: UniProtKB
  • nucleus Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977625.

Polymorphism and mutation databases

BioMutaiHECA.
DMDMi44887986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Headcase protein homologPRO_0000083934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641PhosphoserineCombined sources
Modified residuei268 – 2681PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBI9.
MaxQBiQ9UBI9.
PaxDbiQ9UBI9.
PRIDEiQ9UBI9.

PTM databases

iPTMnetiQ9UBI9.
PhosphoSiteiQ9UBI9.

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highest levels are in the spleen, thymus, peripheral blood and heart. Lowest in the kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ9UBI9.
CleanExiHS_HDC.
HS_HECA.
GenevisibleiQ9UBI9. HS.

Organism-specific databases

HPAiHPA042313.

Interactioni

Protein-protein interaction databases

BioGridi119682. 1 interaction.
STRINGi9606.ENSP00000356630.

Structurei

3D structure databases

ProteinModelPortaliQ9UBI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 9587Ala/Gly-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG3816. Eukaryota.
ENOG410XREE. LUCA.
GeneTreeiENSGT00500000044928.
HOGENOMiHOG000112873.
HOVERGENiHBG049012.
InParanoidiQ9UBI9.
OMAiMEDDAQM.
OrthoDBiEOG715Q4P.
PhylomeDBiQ9UBI9.
TreeFamiTF315512.

Family and domain databases

InterProiIPR026066. Headcase.
IPR031947. Headcase_mid.
[Graphical view]
PANTHERiPTHR13425. PTHR13425. 1 hit.
PfamiPF16002. Headcase. 1 hit.
PF15353. HECA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNPKNSKGG RKNKRANSSG DEQENGAGAL AAAGAAGAAA GGALAAAAGC
60 70 80 90 100
GAAAAGAPGA GGAAGAGGAG TGAANAAAAA GAAAAGDAKN EAPCATPLIC
110 120 130 140 150
SFGRPVDLEK DDYQKVVCNN EHCPCSTWMH LQCFYEWESS ILVQFNCIGR
160 170 180 190 200
ARSWNEKQCR QNMWTKKGYD LAFRFCSCRC GQGHLKKDTD WYQVKRMQDE
210 220 230 240 250
KKKKSGSEKN TGRPPGEAAE EAKKCRPPNK PQKGPSHDLP RRHSMDRQNS
260 270 280 290 300
QEKAVGAAAY GARSPGGSPG QSPPTGYSIL SPAHFSGPRS SRYLGEFLKN
310 320 330 340 350
AIHLEPHKKA MAGGHVFRNA HFDYSPAGLA VHRGGHFDTP VQFLRRLDLS
360 370 380 390 400
ELLTHIPRHK LNTFHVRMED DAQVGQGEDL RKFILAALSA SHRNVVNCAL
410 420 430 440 450
CHRALPVFEQ FPLVDGTLFL SPSRHDEIEY DVPCHLQGRL MHLYAVCVDC
460 470 480 490 500
LEGVHKIICI KCKSRWDGSW HQLGTMYTYD ILAASPCCQA RLNCKHCGKP
510 520 530 540
VIDVRIGMQY FSEYSNVQQC PHCGNLDYHF VKPFSSFKVL EAY
Length:543
Mass (Da):58,837
Last modified:May 1, 2000 - v1
Checksum:iA161B7F4C57EF0D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033496 Genomic DNA. Translation: BAA85333.1.
AB033492 mRNA. Translation: BAA85322.1.
AL031772 Genomic DNA. Translation: CAB94782.1.
BC070068 mRNA. Translation: AAH70068.1.
CCDSiCCDS5194.1.
RefSeqiNP_057301.1. NM_016217.2.
UniGeneiHs.197644.

Genome annotation databases

EnsembliENST00000367658; ENSP00000356630; ENSG00000112406.
GeneIDi51696.
KEGGihsa:51696.
UCSCiuc003qin.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033496 Genomic DNA. Translation: BAA85333.1.
AB033492 mRNA. Translation: BAA85322.1.
AL031772 Genomic DNA. Translation: CAB94782.1.
BC070068 mRNA. Translation: AAH70068.1.
CCDSiCCDS5194.1.
RefSeqiNP_057301.1. NM_016217.2.
UniGeneiHs.197644.

3D structure databases

ProteinModelPortaliQ9UBI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119682. 1 interaction.
STRINGi9606.ENSP00000356630.

PTM databases

iPTMnetiQ9UBI9.
PhosphoSiteiQ9UBI9.

Polymorphism and mutation databases

BioMutaiHECA.
DMDMi44887986.

Proteomic databases

EPDiQ9UBI9.
MaxQBiQ9UBI9.
PaxDbiQ9UBI9.
PRIDEiQ9UBI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367658; ENSP00000356630; ENSG00000112406.
GeneIDi51696.
KEGGihsa:51696.
UCSCiuc003qin.4. human.

Organism-specific databases

CTDi51696.
GeneCardsiHECA.
HGNCiHGNC:21041. HECA.
HPAiHPA042313.
MIMi607977. gene.
neXtProtiNX_Q9UBI9.
PharmGKBiPA134977625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3816. Eukaryota.
ENOG410XREE. LUCA.
GeneTreeiENSGT00500000044928.
HOGENOMiHOG000112873.
HOVERGENiHBG049012.
InParanoidiQ9UBI9.
OMAiMEDDAQM.
OrthoDBiEOG715Q4P.
PhylomeDBiQ9UBI9.
TreeFamiTF315512.

Miscellaneous databases

ChiTaRSiHECA. human.
GenomeRNAii51696.
PROiQ9UBI9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBI9.
CleanExiHS_HDC.
HS_HECA.
GenevisibleiQ9UBI9. HS.

Family and domain databases

InterProiIPR026066. Headcase.
IPR031947. Headcase_mid.
[Graphical view]
PANTHERiPTHR13425. PTHR13425. 1 hit.
PfamiPF16002. Headcase. 1 hit.
PF15353. HECA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer."
    Makino N., Yamato T., Inoue H., Furukawa T., Abe T., Yokoyama T., Yatsuoka T., Fukushige S., Orikasa S., Takahashi T., Horii A.
    DNA Seq. 11:547-553(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiHDC_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.