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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

GNG12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • PDZ domain binding Source: MGI
  • phosphate ion binding Source: Ensembl
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiQ9UBI6
SIGNORiQ9UBI6

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:GNG12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000172380.5
HGNCiHGNC:19663 GNG12
MIMi615405 gene
neXtProtiNX_Q9UBI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172380
PharmGKBiPA134956700

Polymorphism and mutation databases

BioMutaiGNG12
DMDMi12229817

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000126672 – 69Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Add BLAST68
PropeptideiPRO_000001266870 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Modified residuei42PhosphotyrosineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei69Cysteine methyl ester1 Publication1
Lipidationi69S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9UBI6
MaxQBiQ9UBI6
PaxDbiQ9UBI6
PeptideAtlasiQ9UBI6
PRIDEiQ9UBI6
TopDownProteomicsiQ9UBI6

PTM databases

iPTMnetiQ9UBI6
PhosphoSitePlusiQ9UBI6

Expressioni

Gene expression databases

BgeeiENSG00000172380
CleanExiHS_GNG12
GenevisibleiQ9UBI6 HS

Organism-specific databases

HPAiHPA057790
HPA062208

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL2Q141926EBI-358636,EBI-701903

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

BioGridi121016, 29 interactors
IntActiQ9UBI6, 17 interactors
STRINGi9606.ENSP00000360021

Structurei

3D structure databases

ProteinModelPortaliQ9UBI6
SMRiQ9UBI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiQ9UBI6
KOiK04347
OMAiDHESDDC
OrthoDBiEOG091G17J0
PhylomeDBiQ9UBI6
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD
60 70
PLLIGIPTSE NPFKDKKTCI IL
Length:72
Mass (Da):8,006
Last modified:January 23, 2007 - v3
Checksum:iA4C489A61697FAA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → G in AAH05940 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188181 Genomic DNA Translation: AAF04571.1
AF123766 mRNA Translation: AAP97245.1
AF119663 mRNA Translation: AAF17220.1
AF365871 mRNA Translation: AAK53385.1
AF493879 mRNA Translation: AAM12593.1
AK293101 mRNA Translation: BAF85790.1
AL832431 mRNA Translation: CAH10645.1
CH471059 Genomic DNA Translation: EAX06484.1
CH471059 Genomic DNA Translation: EAX06485.1
CH471059 Genomic DNA Translation: EAX06486.1
BC005940 mRNA Translation: AAH05940.1
CCDSiCCDS30749.1
RefSeqiNP_061329.3, NM_018841.5
XP_016857298.1, XM_017001809.1
XP_016857299.1, XM_017001810.1
XP_016857300.1, XM_017001811.1
UniGeneiHs.431101

Genome annotation databases

EnsembliENST00000370982; ENSP00000360021; ENSG00000172380
GeneIDi55970
KEGGihsa:55970
UCSCiuc001dea.3 human

Entry informationi

Entry nameiGBG12_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI6
Secondary accession number(s): Q69YP5, Q9BRV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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