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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

GNG12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • PDZ domain binding Source: MGI
  • phosphate ion binding Source: Ensembl
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172380-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiQ9UBI6.
SIGNORiQ9UBI6.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:GNG12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19663. GNG12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55970.
OpenTargetsiENSG00000172380.
PharmGKBiPA134956700.

Polymorphism and mutation databases

BioMutaiGNG12.
DMDMi12229817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000126672 – 69Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Add BLAST68
PropeptideiPRO_000001266870 – 72Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei26PhosphoserineBy similarity1
Modified residuei42PhosphotyrosineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei69Cysteine methyl ester1 Publication1
Lipidationi69S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9UBI6.
MaxQBiQ9UBI6.
PaxDbiQ9UBI6.
PeptideAtlasiQ9UBI6.
PRIDEiQ9UBI6.
TopDownProteomicsiQ9UBI6.

PTM databases

iPTMnetiQ9UBI6.
PhosphoSitePlusiQ9UBI6.

Expressioni

Gene expression databases

BgeeiENSG00000172380.
CleanExiHS_GNG12.
GenevisibleiQ9UBI6. HS.

Organism-specific databases

HPAiHPA057790.
HPA062208.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL2Q141924EBI-358636,EBI-701903

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

BioGridi121016. 29 interactors.
IntActiQ9UBI6. 14 interactors.
MINTiMINT-1143633.
STRINGi9606.ENSP00000360021.

Structurei

3D structure databases

ProteinModelPortaliQ9UBI6.
SMRiQ9UBI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiQ9UBI6.
KOiK04347.
OMAiNNITHAR.
OrthoDBiEOG091G17J0.
PhylomeDBiQ9UBI6.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD
60 70
PLLIGIPTSE NPFKDKKTCI IL
Length:72
Mass (Da):8,006
Last modified:January 23, 2007 - v3
Checksum:iA4C489A61697FAA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → G in AAH05940 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188181 Genomic DNA. Translation: AAF04571.1.
AF123766 mRNA. Translation: AAP97245.1.
AF119663 mRNA. Translation: AAF17220.1.
AF365871 mRNA. Translation: AAK53385.1.
AF493879 mRNA. Translation: AAM12593.1.
AK293101 mRNA. Translation: BAF85790.1.
AL832431 mRNA. Translation: CAH10645.1.
CH471059 Genomic DNA. Translation: EAX06484.1.
CH471059 Genomic DNA. Translation: EAX06485.1.
CH471059 Genomic DNA. Translation: EAX06486.1.
BC005940 mRNA. Translation: AAH05940.1.
CCDSiCCDS30749.1.
RefSeqiNP_061329.3. NM_018841.5.
XP_016857298.1. XM_017001809.1.
XP_016857299.1. XM_017001810.1.
XP_016857300.1. XM_017001811.1.
UniGeneiHs.431101.

Genome annotation databases

EnsembliENST00000370982; ENSP00000360021; ENSG00000172380.
GeneIDi55970.
KEGGihsa:55970.
UCSCiuc001dea.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188181 Genomic DNA. Translation: AAF04571.1.
AF123766 mRNA. Translation: AAP97245.1.
AF119663 mRNA. Translation: AAF17220.1.
AF365871 mRNA. Translation: AAK53385.1.
AF493879 mRNA. Translation: AAM12593.1.
AK293101 mRNA. Translation: BAF85790.1.
AL832431 mRNA. Translation: CAH10645.1.
CH471059 Genomic DNA. Translation: EAX06484.1.
CH471059 Genomic DNA. Translation: EAX06485.1.
CH471059 Genomic DNA. Translation: EAX06486.1.
BC005940 mRNA. Translation: AAH05940.1.
CCDSiCCDS30749.1.
RefSeqiNP_061329.3. NM_018841.5.
XP_016857298.1. XM_017001809.1.
XP_016857299.1. XM_017001810.1.
XP_016857300.1. XM_017001811.1.
UniGeneiHs.431101.

3D structure databases

ProteinModelPortaliQ9UBI6.
SMRiQ9UBI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121016. 29 interactors.
IntActiQ9UBI6. 14 interactors.
MINTiMINT-1143633.
STRINGi9606.ENSP00000360021.

PTM databases

iPTMnetiQ9UBI6.
PhosphoSitePlusiQ9UBI6.

Polymorphism and mutation databases

BioMutaiGNG12.
DMDMi12229817.

Proteomic databases

EPDiQ9UBI6.
MaxQBiQ9UBI6.
PaxDbiQ9UBI6.
PeptideAtlasiQ9UBI6.
PRIDEiQ9UBI6.
TopDownProteomicsiQ9UBI6.

Protocols and materials databases

DNASUi55970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370982; ENSP00000360021; ENSG00000172380.
GeneIDi55970.
KEGGihsa:55970.
UCSCiuc001dea.3. human.

Organism-specific databases

CTDi55970.
DisGeNETi55970.
GeneCardsiGNG12.
HGNCiHGNC:19663. GNG12.
HPAiHPA057790.
HPA062208.
MIMi615405. gene.
neXtProtiNX_Q9UBI6.
OpenTargetsiENSG00000172380.
PharmGKBiPA134956700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiQ9UBI6.
KOiK04347.
OMAiNNITHAR.
OrthoDBiEOG091G17J0.
PhylomeDBiQ9UBI6.
TreeFamiTF319909.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172380-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-163359. Glucagon signaling in metabolic regulation.
R-HSA-202040. G-protein activation.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-392170. ADP signalling through P2Y purinoceptor 12.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-418592. ADP signalling through P2Y purinoceptor 1.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-418597. G alpha (z) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
R-HSA-428930. Thromboxane signalling through TP receptor.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-500657. Presynaptic function of Kainate receptors.
R-HSA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SignaLinkiQ9UBI6.
SIGNORiQ9UBI6.

Miscellaneous databases

ChiTaRSiGNG12. human.
GeneWikiiGNG12.
GenomeRNAii55970.
PROiQ9UBI6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172380.
CleanExiHS_GNG12.
GenevisibleiQ9UBI6. HS.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG12_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI6
Secondary accession number(s): Q69YP5, Q9BRV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.