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Q9UBI6

- GBG12_HUMAN

UniProt

Q9UBI6 - GBG12_HUMAN

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene

GNG12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. PDZ domain binding Source: MGI
    2. phosphate ion binding Source: Ensembl
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to glucagon stimulus Source: Reactome
    2. cerebral cortex development Source: Ensembl
    3. energy reserve metabolic process Source: Reactome
    4. G-protein coupled receptor signaling pathway Source: InterPro
    5. response to lipopolysaccharide Source: Ensembl
    6. signal transduction Source: ProtInc
    7. small molecule metabolic process Source: Reactome
    8. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15457. G-protein activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.
    SignaLinkiQ9UBI6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
    Gene namesi
    Name:GNG12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19663. GNG12.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. heterotrimeric G-protein complex Source: InterPro
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134956700.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 6968Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12PRO_0000012667Add
    BLAST
    Propeptidei70 – 723Removed in mature formBy similarityPRO_0000012668

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei26 – 261PhosphoserineBy similarity
    Modified residuei69 – 691Cysteine methyl ester1 Publication
    Lipidationi69 – 691S-geranylgeranyl cysteine1 Publication

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ9UBI6.
    PaxDbiQ9UBI6.
    PeptideAtlasiQ9UBI6.
    PRIDEiQ9UBI6.

    PTM databases

    PhosphoSiteiQ9UBI6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBI6.
    BgeeiQ9UBI6.
    CleanExiHS_GNG12.
    GenevestigatoriQ9UBI6.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    BioGridi121016. 16 interactions.
    IntActiQ9UBI6. 5 interactions.
    MINTiMINT-1143633.
    STRINGi9606.ENSP00000360021.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBI6.
    SMRiQ9UBI6. Positions 10-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG265454.
    HOVERGENiHBG014983.
    InParanoidiQ9UBI6.
    KOiK04347.
    OMAiREWEDTQ.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ9UBI6.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UBI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD   50
    PLLIGIPTSE NPFKDKKTCI IL 72
    Length:72
    Mass (Da):8,006
    Last modified:January 23, 2007 - v3
    Checksum:iA4C489A61697FAA9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291R → G in AAH05940. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188181 Genomic DNA. Translation: AAF04571.1.
    AF123766 mRNA. Translation: AAP97245.1.
    AF119663 mRNA. Translation: AAF17220.1.
    AF365871 mRNA. Translation: AAK53385.1.
    AF493879 mRNA. Translation: AAM12593.1.
    AK293101 mRNA. Translation: BAF85790.1.
    AL832431 mRNA. Translation: CAH10645.1.
    CH471059 Genomic DNA. Translation: EAX06484.1.
    CH471059 Genomic DNA. Translation: EAX06485.1.
    CH471059 Genomic DNA. Translation: EAX06486.1.
    BC005940 mRNA. Translation: AAH05940.1.
    CCDSiCCDS30749.1.
    RefSeqiNP_061329.3. NM_018841.5.
    UniGeneiHs.431101.

    Genome annotation databases

    EnsembliENST00000370982; ENSP00000360021; ENSG00000172380.
    GeneIDi55970.
    KEGGihsa:55970.
    UCSCiuc001dea.2. human.

    Polymorphism databases

    DMDMi12229817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188181 Genomic DNA. Translation: AAF04571.1 .
    AF123766 mRNA. Translation: AAP97245.1 .
    AF119663 mRNA. Translation: AAF17220.1 .
    AF365871 mRNA. Translation: AAK53385.1 .
    AF493879 mRNA. Translation: AAM12593.1 .
    AK293101 mRNA. Translation: BAF85790.1 .
    AL832431 mRNA. Translation: CAH10645.1 .
    CH471059 Genomic DNA. Translation: EAX06484.1 .
    CH471059 Genomic DNA. Translation: EAX06485.1 .
    CH471059 Genomic DNA. Translation: EAX06486.1 .
    BC005940 mRNA. Translation: AAH05940.1 .
    CCDSi CCDS30749.1.
    RefSeqi NP_061329.3. NM_018841.5.
    UniGenei Hs.431101.

    3D structure databases

    ProteinModelPortali Q9UBI6.
    SMRi Q9UBI6. Positions 10-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121016. 16 interactions.
    IntActi Q9UBI6. 5 interactions.
    MINTi MINT-1143633.
    STRINGi 9606.ENSP00000360021.

    PTM databases

    PhosphoSitei Q9UBI6.

    Polymorphism databases

    DMDMi 12229817.

    Proteomic databases

    MaxQBi Q9UBI6.
    PaxDbi Q9UBI6.
    PeptideAtlasi Q9UBI6.
    PRIDEi Q9UBI6.

    Protocols and materials databases

    DNASUi 55970.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370982 ; ENSP00000360021 ; ENSG00000172380 .
    GeneIDi 55970.
    KEGGi hsa:55970.
    UCSCi uc001dea.2. human.

    Organism-specific databases

    CTDi 55970.
    GeneCardsi GC01M068167.
    HGNCi HGNC:19663. GNG12.
    MIMi 615405. gene.
    neXtProti NX_Q9UBI6.
    PharmGKBi PA134956700.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265454.
    HOVERGENi HBG014983.
    InParanoidi Q9UBI6.
    KOi K04347.
    OMAi REWEDTQ.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q9UBI6.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_15457. G-protein activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.
    SignaLinki Q9UBI6.

    Miscellaneous databases

    GeneWikii GNG12.
    GenomeRNAii 55970.
    NextBioi 61403.
    PROi Q9UBI6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UBI6.
    Bgeei Q9UBI6.
    CleanExi HS_GNG12.
    Genevestigatori Q9UBI6.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
      Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
      DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and characterizing a novel human cDNA homologous to Bos taurus G-protein gamma-12 subunit mRNA."
      Yang L., Yu L., Zhao S.Y.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    4. "Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms."
      Cook L.A., Schey K.L., Cleator J.H., Wilcox M.D., Dingus J., Hildebrandt J.D.
      Protein Sci. 10:2548-2555(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Melanoma.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    13. "Large-scale top down proteomics of the human proteome: membrane proteins, mitochondria, and senescence."
      Catherman A.D., Durbin K.R., Ahlf D.R., Early B.P., Fellers R.T., Tran J.C., Thomas P.M., Kelleher N.L.
      Mol. Cell. Proteomics 12:3465-3473(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-69, METHYLATION AT CYS-69, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiGBG12_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBI6
    Secondary accession number(s): Q69YP5, Q9BRV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3