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Q9UBI6

- GBG12_HUMAN

UniProt

Q9UBI6 - GBG12_HUMAN

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene
GNG12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. PDZ domain binding Source: MGI
  2. phosphate ion binding Source: Ensembl
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to glucagon stimulus Source: Reactome
  2. cerebral cortex development Source: Ensembl
  3. energy reserve metabolic process Source: Reactome
  4. G-protein coupled receptor signaling pathway Source: InterPro
  5. response to lipopolysaccharide Source: Ensembl
  6. signal transduction Source: ProtInc
  7. small molecule metabolic process Source: Reactome
  8. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinkiQ9UBI6.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene namesi
Name:GNG12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19663. GNG12.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. heterotrimeric G-protein complex Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 6968Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12PRO_0000012667Add
BLAST
Propeptidei70 – 723Removed in mature form By similarityPRO_0000012668

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei26 – 261Phosphoserine By similarity
Modified residuei69 – 691Cysteine methyl ester1 Publication
Lipidationi69 – 691S-geranylgeranyl cysteine1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ9UBI6.
PaxDbiQ9UBI6.
PeptideAtlasiQ9UBI6.
PRIDEiQ9UBI6.

PTM databases

PhosphoSiteiQ9UBI6.

Expressioni

Gene expression databases

ArrayExpressiQ9UBI6.
BgeeiQ9UBI6.
CleanExiHS_GNG12.
GenevestigatoriQ9UBI6.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi121016. 16 interactions.
IntActiQ9UBI6. 5 interactions.
MINTiMINT-1143633.
STRINGi9606.ENSP00000360021.

Structurei

3D structure databases

ProteinModelPortaliQ9UBI6.
SMRiQ9UBI6. Positions 10-53.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG265454.
HOVERGENiHBG014983.
InParanoidiQ9UBI6.
KOiK04347.
OMAiREWEDTQ.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9UBI6.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBI6-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD   50
PLLIGIPTSE NPFKDKKTCI IL 72
Length:72
Mass (Da):8,006
Last modified:January 23, 2007 - v3
Checksum:iA4C489A61697FAA9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291R → G in AAH05940. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF188181 Genomic DNA. Translation: AAF04571.1.
AF123766 mRNA. Translation: AAP97245.1.
AF119663 mRNA. Translation: AAF17220.1.
AF365871 mRNA. Translation: AAK53385.1.
AF493879 mRNA. Translation: AAM12593.1.
AK293101 mRNA. Translation: BAF85790.1.
AL832431 mRNA. Translation: CAH10645.1.
CH471059 Genomic DNA. Translation: EAX06484.1.
CH471059 Genomic DNA. Translation: EAX06485.1.
CH471059 Genomic DNA. Translation: EAX06486.1.
BC005940 mRNA. Translation: AAH05940.1.
CCDSiCCDS30749.1.
RefSeqiNP_061329.3. NM_018841.5.
UniGeneiHs.431101.

Genome annotation databases

EnsembliENST00000370982; ENSP00000360021; ENSG00000172380.
GeneIDi55970.
KEGGihsa:55970.
UCSCiuc001dea.2. human.

Polymorphism databases

DMDMi12229817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF188181 Genomic DNA. Translation: AAF04571.1 .
AF123766 mRNA. Translation: AAP97245.1 .
AF119663 mRNA. Translation: AAF17220.1 .
AF365871 mRNA. Translation: AAK53385.1 .
AF493879 mRNA. Translation: AAM12593.1 .
AK293101 mRNA. Translation: BAF85790.1 .
AL832431 mRNA. Translation: CAH10645.1 .
CH471059 Genomic DNA. Translation: EAX06484.1 .
CH471059 Genomic DNA. Translation: EAX06485.1 .
CH471059 Genomic DNA. Translation: EAX06486.1 .
BC005940 mRNA. Translation: AAH05940.1 .
CCDSi CCDS30749.1.
RefSeqi NP_061329.3. NM_018841.5.
UniGenei Hs.431101.

3D structure databases

ProteinModelPortali Q9UBI6.
SMRi Q9UBI6. Positions 10-53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121016. 16 interactions.
IntActi Q9UBI6. 5 interactions.
MINTi MINT-1143633.
STRINGi 9606.ENSP00000360021.

PTM databases

PhosphoSitei Q9UBI6.

Polymorphism databases

DMDMi 12229817.

Proteomic databases

MaxQBi Q9UBI6.
PaxDbi Q9UBI6.
PeptideAtlasi Q9UBI6.
PRIDEi Q9UBI6.

Protocols and materials databases

DNASUi 55970.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370982 ; ENSP00000360021 ; ENSG00000172380 .
GeneIDi 55970.
KEGGi hsa:55970.
UCSCi uc001dea.2. human.

Organism-specific databases

CTDi 55970.
GeneCardsi GC01M068167.
HGNCi HGNC:19663. GNG12.
MIMi 615405. gene.
neXtProti NX_Q9UBI6.
PharmGKBi PA134956700.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265454.
HOVERGENi HBG014983.
InParanoidi Q9UBI6.
KOi K04347.
OMAi REWEDTQ.
OrthoDBi EOG7H1JP7.
PhylomeDBi Q9UBI6.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.
SignaLinki Q9UBI6.

Miscellaneous databases

GeneWikii GNG12.
GenomeRNAii 55970.
NextBioi 61403.
PROi Q9UBI6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UBI6.
Bgeei Q9UBI6.
CleanExi HS_GNG12.
Genevestigatori Q9UBI6.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
    Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
    DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and characterizing a novel human cDNA homologous to Bos taurus G-protein gamma-12 subunit mRNA."
    Yang L., Yu L., Zhao S.Y.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  4. "Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms."
    Cook L.A., Schey K.L., Cleator J.H., Wilcox M.D., Dingus J., Hildebrandt J.D.
    Protein Sci. 10:2548-2555(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  13. "Large-scale top down proteomics of the human proteome: membrane proteins, mitochondria, and senescence."
    Catherman A.D., Durbin K.R., Ahlf D.R., Early B.P., Fellers R.T., Tran J.C., Thomas P.M., Kelleher N.L.
    Mol. Cell. Proteomics 12:3465-3473(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOPRENYLATION AT CYS-69, METHYLATION AT CYS-69, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGBG12_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI6
Secondary accession number(s): Q69YP5, Q9BRV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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