Q9UBI6 (GBG12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene names

Name:

GNG12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Acetylation Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro cellular response to glucagon stimulus Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome signal transduction Traceable author statement Ref.1. Source: ProtInc small molecule metabolic process Traceable author statement. Source: Reactome synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 69	68	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12		PRO_0000012667
	Propeptide	70 – 72	3	Removed in mature form By similarity		PRO_0000012668
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	26	1	Phosphoserine By similarity
	Modified residue	69	1	Cysteine methyl ester By similarity
	Lipidation	69	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	29	1	R → G in AAH05940. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9UBI6 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A4C489A61697FAA9	FASTA	72	8,006
	10 20 30 40 50 60 MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD PLLIGIPTSE 70 NPFKDKKTCI IL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes." Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H. DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[3]	"Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms." Cook L.A., Schey K.L., Cleator J.H., Wilcox M.D., Dingus J., Hildebrandt J.D. Protein Sci. 10:2548-2555(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF188181 Genomic DNA. Translation: AAF04571.1. AF119663 mRNA. Translation: AAF17220.1. AF365871 mRNA. Translation: AAK53385.1. AF493879 mRNA. Translation: AAM12593.1. BC005940 mRNA. Translation: AAH05940.1.
IPI	IPI00221232.
RefSeq	NP_061329.3. NM_018841.5.
UniGene	Hs.741259.
3D structure databases
ProteinModelPortal	Q9UBI6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UBI6. 5 interactions.
MINT	MINT-1143633.
STRING	9606.ENSP00000360021.
PTM databases
PhosphoSite	Q9UBI6.
Polymorphism databases
DMDM	12229817.
Proteomic databases
PaxDb	Q9UBI6.
PeptideAtlas	Q9UBI6.
PRIDE	Q9UBI6.
Protocols and materials databases
DNASU	55970.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370982; ENSP00000360021; ENSG00000172380.
GeneID	55970.
KEGG	hsa:55970.
UCSC	uc001dea.2. human.
Organism-specific databases
CTD	55970.
GeneCards	GC01M068167.
HGNC	HGNC:19663. GNG12.
neXtProt	NX_Q9UBI6.
PharmGKB	PA134956700.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG265454.
HOVERGEN	HBG014983.
InParanoid	Q9UBI6.
KO	K04347.
OMA	SADLMLY.
OrthoDB	EOG4ZGPF1.
PhylomeDB	Q9UBI6.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q9UBI6.
Bgee	Q9UBI6.
CleanEx	HS_GNG12.
Genevestigator	Q9UBI6.
GermOnline	ENSG00000172380. Homo sapiens.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55970.
NextBio	61403.

Entry information

Entry name

GBG12_HUMAN

Accession

Primary (citable) accession number: Q9UBI6
Secondary accession number(s): Q9BRV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 124 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.