Reviewed, UniProtKB/Swiss-Prot Q9UBI1 (COMD3_HUMAN)

Names and origin

Protein names

Recommended name:
    COMM domain-containing protein 3
Alternative name(s):
    Protein Bup
    Protein PIL

Gene names

Name:	COMMD3
Synonyms:	BUP, C10orf8

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Widely expressed with highest expression in thymus. Ref.1
Sequence similarities	Contains 1 COMM domain.

Ontologies

Keywords
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COMMD1	Q8N668	2	EBI-714979,EBI-1550112

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	COMM domain-containing protein 3		PRO_0000077389
Regions
	Domain	124 – 193	70	COMM
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine

Sequences

	Sequence		Length	Mass (Da)
	Q9UBI1-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: AC757941FC17F757	FASTA	195	22,151
	10 20 30 40 50 60 MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK 70 80 90 100 110 120 HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGSIGR 130 140 150 160 170 180 SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL VTLSVQNTDS PSYPEISFSC SMEQLQDLVG 190 KLKDASKSLE RATQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Novel genes expressed in human dendritic cells." Li Y., Li N., Tu Y., Gu W., Wang Y., Han Z., Chen Z. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Dendritic cell.
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY542159 mRNA. Translation: AAS22241.1. AF201948 mRNA. Translation: AAF17240.1. AF078848 mRNA. Translation: AAD44480.1. AL158211 Genomic DNA. Translation: CAI15951.1. CH471072 Genomic DNA. Translation: EAW86149.1. BC022898 mRNA. Translation: AAH22898.1.
IPI	IPI00015773.
RefSeq	NP_036203.1.
UniGene	Hs.534398
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UBI1. 4 interactions.
STRING	Q9UBI1.
Proteomic databases
PRIDE	Q9UBI1.
Genome annotation databases
Ensembl	ENST00000376836; ENSP00000366032; ENSG00000148444; Homo sapiens. [Genome view]
GeneID	23412.
KEGG	hsa:23412.
UCSC	uc001irf.1. human.
Organism-specific databases
CTD	23412.
GeneCards	GC10P022645.
H-InvDB	HIX0008700.
HGNC	HGNC:23332. COMMD3.
PharmGKB	PA134864927.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UBI1.
HOVERGEN	Q9UBI1.
OMA	ELSEYVQ
OrthoDB	EOG96X1VH
Gene expression databases
ArrayExpress	Q9UBI1.
Bgee	Q9UBI1.
CleanEx	HS_COMMD3.
Genevestigator	Q9UBI1.
GermOnline	ENSG00000148444. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	45607.

Entry information

Entry name

COMD3_HUMAN

Accession

Primary (citable) accession number: Q9UBI1
Secondary accession number(s): Q5T8Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	May 1, 2000
Last modified:	November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.