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Q9UBI1

- COMD3_HUMAN

UniProt

Q9UBI1 - COMD3_HUMAN

Protein

COMM domain-containing protein 3

Gene

COMMD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May down-regulate activation of NF-kappa-B.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMM domain-containing protein 3
    Alternative name(s):
    Protein Bup
    Protein PIL
    Gene namesi
    Name:COMMD3
    Synonyms:BUP, C10orf8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23332. COMMD3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864927.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 195195COMM domain-containing protein 3PRO_0000077389Add
    BLAST

    Proteomic databases

    MaxQBiQ9UBI1.
    PaxDbiQ9UBI1.
    PRIDEiQ9UBI1.

    PTM databases

    PhosphoSiteiQ9UBI1.

    Expressioni

    Tissue specificityi

    Widely expressed with highest expression in thymus.1 Publication

    Gene expression databases

    BgeeiQ9UBI1.
    CleanExiHS_COMMD3.
    GenevestigatoriQ9UBI1.

    Organism-specific databases

    HPAiHPA036584.

    Interactioni

    Subunit structurei

    Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COMMD1Q8N6683EBI-714979,EBI-1550112

    Protein-protein interaction databases

    BioGridi116984. 6 interactions.
    IntActiQ9UBI1. 6 interactions.
    STRINGi9606.ENSP00000366032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBI1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini124 – 19370COMMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 COMM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43936.
    HOGENOMiHOG000231902.
    HOVERGENiHBG051068.
    InParanoidiQ9UBI1.
    OMAiNQLHKMY.
    OrthoDBiEOG779P06.
    PhylomeDBiQ9UBI1.
    TreeFamiTF329267.

    Family and domain databases

    InterProiIPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view]
    PfamiPF07258. HCaRG. 1 hit.
    [Graphical view]
    PROSITEiPS51269. COMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UBI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD    50
    LKHIDPVVLK HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF 100
    CTEYQNNKNS LEILLGSIGR SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL 150
    VTLSVQNTDS PSYPEISFSC SMEQLQDLVG KLKDASKSLE RATQL 195
    Length:195
    Mass (Da):22,151
    Last modified:May 1, 2000 - v1
    Checksum:iAC757941FC17F757
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181R → G.
    Corresponds to variant rs11552445 [ dbSNP | Ensembl ].
    VAR_061121

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542159 mRNA. Translation: AAS22241.1.
    AF201948 mRNA. Translation: AAF17240.1.
    AF078848 mRNA. Translation: AAD44480.1.
    AL158211 Genomic DNA. Translation: CAI15951.1.
    CH471072 Genomic DNA. Translation: EAW86149.1.
    CH471072 Genomic DNA. Translation: EAW86155.1.
    BC022898 mRNA. Translation: AAH22898.1.
    CCDSiCCDS7137.1.
    RefSeqiNP_036203.1. NM_012071.3.
    UniGeneiHs.534398.

    Genome annotation databases

    EnsembliENST00000376836; ENSP00000366032; ENSG00000148444.
    GeneIDi23412.
    KEGGihsa:23412.
    UCSCiuc001irf.3. human.

    Polymorphism databases

    DMDMi51316114.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542159 mRNA. Translation: AAS22241.1 .
    AF201948 mRNA. Translation: AAF17240.1 .
    AF078848 mRNA. Translation: AAD44480.1 .
    AL158211 Genomic DNA. Translation: CAI15951.1 .
    CH471072 Genomic DNA. Translation: EAW86149.1 .
    CH471072 Genomic DNA. Translation: EAW86155.1 .
    BC022898 mRNA. Translation: AAH22898.1 .
    CCDSi CCDS7137.1.
    RefSeqi NP_036203.1. NM_012071.3.
    UniGenei Hs.534398.

    3D structure databases

    ProteinModelPortali Q9UBI1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116984. 6 interactions.
    IntActi Q9UBI1. 6 interactions.
    STRINGi 9606.ENSP00000366032.

    PTM databases

    PhosphoSitei Q9UBI1.

    Polymorphism databases

    DMDMi 51316114.

    Proteomic databases

    MaxQBi Q9UBI1.
    PaxDbi Q9UBI1.
    PRIDEi Q9UBI1.

    Protocols and materials databases

    DNASUi 23412.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376836 ; ENSP00000366032 ; ENSG00000148444 .
    GeneIDi 23412.
    KEGGi hsa:23412.
    UCSCi uc001irf.3. human.

    Organism-specific databases

    CTDi 23412.
    GeneCardsi GC10P022604.
    HGNCi HGNC:23332. COMMD3.
    HPAi HPA036584.
    neXtProti NX_Q9UBI1.
    PharmGKBi PA134864927.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43936.
    HOGENOMi HOG000231902.
    HOVERGENi HBG051068.
    InParanoidi Q9UBI1.
    OMAi NQLHKMY.
    OrthoDBi EOG779P06.
    PhylomeDBi Q9UBI1.
    TreeFami TF329267.

    Miscellaneous databases

    GenomeRNAii 23412.
    NextBioi 45607.
    PROi Q9UBI1.

    Gene expression databases

    Bgeei Q9UBI1.
    CleanExi HS_COMMD3.
    Genevestigatori Q9UBI1.

    Family and domain databases

    InterProi IPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view ]
    Pfami PF07258. HCaRG. 1 hit.
    [Graphical view ]
    PROSITEi PS51269. COMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
    2. "Novel genes expressed in human dendritic cells."
      Li Y., Li N., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMD3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBI1
    Secondary accession number(s): D3DRU7, Q5T8Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3