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Q9UBI1 (COMD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COMM domain-containing protein 3
Alternative name(s):
Protein Bup
Protein PIL
Gene names
Name:COMMD3
Synonyms:BUP, C10orf8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May down-regulate activation of NF-kappa-B. Ref.1

Subunit structure

Interacts (via COMM domain) with COMMD1 (via COMM domain). Ref.1

Tissue specificity

Widely expressed with highest expression in thymus. Ref.1

Sequence similarities

Contains 1 COMM domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

COMMD1Q8N6683EBI-714979,EBI-1550112

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 195195COMM domain-containing protein 3
PRO_0000077389

Regions

Domain124 – 19370COMM

Natural variations

Natural variant181R → G.
Corresponds to variant rs11552445 [ dbSNP | Ensembl ].
VAR_061121

Sequences

Sequence LengthMass (Da)Tools
Q9UBI1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: AC757941FC17F757

FASTA19522,151
        10         20         30         40         50         60 
MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK 

        70         80         90        100        110        120 
HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGSIGR 

       130        140        150        160        170        180 
SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL VTLSVQNTDS PSYPEISFSC SMEQLQDLVG 

       190 
KLKDASKSLE RATQL 

« Hide

References

« Hide 'large scale' references
[1]"COMMD proteins, a novel family of structural and functional homologs of MURR1."
Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.
J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
[2]"Novel genes expressed in human dendritic cells."
Li Y., Li N., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Dendritic cell.
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY542159 mRNA. Translation: AAS22241.1.
AF201948 mRNA. Translation: AAF17240.1.
AF078848 mRNA. Translation: AAD44480.1.
AL158211 Genomic DNA. Translation: CAI15951.1.
CH471072 Genomic DNA. Translation: EAW86149.1.
CH471072 Genomic DNA. Translation: EAW86155.1.
BC022898 mRNA. Translation: AAH22898.1.
CCDSCCDS7137.1.
RefSeqNP_036203.1. NM_012071.3.
UniGeneHs.534398.

3D structure databases

ProteinModelPortalQ9UBI1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116984. 6 interactions.
IntActQ9UBI1. 6 interactions.
STRING9606.ENSP00000366032.

PTM databases

PhosphoSiteQ9UBI1.

Polymorphism databases

DMDM51316114.

Proteomic databases

MaxQBQ9UBI1.
PaxDbQ9UBI1.
PRIDEQ9UBI1.

Protocols and materials databases

DNASU23412.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376836; ENSP00000366032; ENSG00000148444.
GeneID23412.
KEGGhsa:23412.
UCSCuc001irf.3. human.

Organism-specific databases

CTD23412.
GeneCardsGC10P022604.
HGNCHGNC:23332. COMMD3.
HPAHPA036584.
neXtProtNX_Q9UBI1.
PharmGKBPA134864927.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43936.
HOGENOMHOG000231902.
HOVERGENHBG051068.
InParanoidQ9UBI1.
OMANQLHKMY.
OrthoDBEOG779P06.
PhylomeDBQ9UBI1.
TreeFamTF329267.

Gene expression databases

BgeeQ9UBI1.
CleanExHS_COMMD3.
GenevestigatorQ9UBI1.

Family and domain databases

InterProIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23412.
NextBio45607.
PROQ9UBI1.

Entry information

Entry nameCOMD3_HUMAN
AccessionPrimary (citable) accession number: Q9UBI1
Secondary accession number(s): D3DRU7, Q5T8Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM