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Q9UBI1

- COMD3_HUMAN

UniProt

Q9UBI1 - COMD3_HUMAN

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Protein
COMM domain-containing protein 3
Gene
COMMD3, BUP, C10orf8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May down-regulate activation of NF-kappa-B.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 3
Alternative name(s):
Protein Bup
Protein PIL
Gene namesi
Name:COMMD3
Synonyms:BUP, C10orf8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23332. COMMD3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195COMM domain-containing protein 3
PRO_0000077389Add
BLAST

Proteomic databases

MaxQBiQ9UBI1.
PaxDbiQ9UBI1.
PRIDEiQ9UBI1.

PTM databases

PhosphoSiteiQ9UBI1.

Expressioni

Tissue specificityi

Widely expressed with highest expression in thymus.1 Publication

Gene expression databases

BgeeiQ9UBI1.
CleanExiHS_COMMD3.
GenevestigatoriQ9UBI1.

Organism-specific databases

HPAiHPA036584.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
COMMD1Q8N6683EBI-714979,EBI-1550112

Protein-protein interaction databases

BioGridi116984. 6 interactions.
IntActiQ9UBI1. 6 interactions.
STRINGi9606.ENSP00000366032.

Structurei

3D structure databases

ProteinModelPortaliQ9UBI1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19370COMM
Add
BLAST

Sequence similaritiesi

Contains 1 COMM domain.

Phylogenomic databases

eggNOGiNOG43936.
HOGENOMiHOG000231902.
HOVERGENiHBG051068.
InParanoidiQ9UBI1.
OMAiNQLHKMY.
OrthoDBiEOG779P06.
PhylomeDBiQ9UBI1.
TreeFamiTF329267.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBI1-1 [UniParc]FASTAAdd to Basket

« Hide

MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD    50
LKHIDPVVLK HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF 100
CTEYQNNKNS LEILLGSIGR SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL 150
VTLSVQNTDS PSYPEISFSC SMEQLQDLVG KLKDASKSLE RATQL 195
Length:195
Mass (Da):22,151
Last modified:May 1, 2000 - v1
Checksum:iAC757941FC17F757
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181R → G.
Corresponds to variant rs11552445 [ dbSNP | Ensembl ].
VAR_061121

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542159 mRNA. Translation: AAS22241.1.
AF201948 mRNA. Translation: AAF17240.1.
AF078848 mRNA. Translation: AAD44480.1.
AL158211 Genomic DNA. Translation: CAI15951.1.
CH471072 Genomic DNA. Translation: EAW86149.1.
CH471072 Genomic DNA. Translation: EAW86155.1.
BC022898 mRNA. Translation: AAH22898.1.
CCDSiCCDS7137.1.
RefSeqiNP_036203.1. NM_012071.3.
UniGeneiHs.534398.

Genome annotation databases

EnsembliENST00000376836; ENSP00000366032; ENSG00000148444.
GeneIDi23412.
KEGGihsa:23412.
UCSCiuc001irf.3. human.

Polymorphism databases

DMDMi51316114.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542159 mRNA. Translation: AAS22241.1 .
AF201948 mRNA. Translation: AAF17240.1 .
AF078848 mRNA. Translation: AAD44480.1 .
AL158211 Genomic DNA. Translation: CAI15951.1 .
CH471072 Genomic DNA. Translation: EAW86149.1 .
CH471072 Genomic DNA. Translation: EAW86155.1 .
BC022898 mRNA. Translation: AAH22898.1 .
CCDSi CCDS7137.1.
RefSeqi NP_036203.1. NM_012071.3.
UniGenei Hs.534398.

3D structure databases

ProteinModelPortali Q9UBI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116984. 6 interactions.
IntActi Q9UBI1. 6 interactions.
STRINGi 9606.ENSP00000366032.

PTM databases

PhosphoSitei Q9UBI1.

Polymorphism databases

DMDMi 51316114.

Proteomic databases

MaxQBi Q9UBI1.
PaxDbi Q9UBI1.
PRIDEi Q9UBI1.

Protocols and materials databases

DNASUi 23412.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376836 ; ENSP00000366032 ; ENSG00000148444 .
GeneIDi 23412.
KEGGi hsa:23412.
UCSCi uc001irf.3. human.

Organism-specific databases

CTDi 23412.
GeneCardsi GC10P022604.
HGNCi HGNC:23332. COMMD3.
HPAi HPA036584.
neXtProti NX_Q9UBI1.
PharmGKBi PA134864927.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43936.
HOGENOMi HOG000231902.
HOVERGENi HBG051068.
InParanoidi Q9UBI1.
OMAi NQLHKMY.
OrthoDBi EOG779P06.
PhylomeDBi Q9UBI1.
TreeFami TF329267.

Miscellaneous databases

GenomeRNAii 23412.
NextBioi 45607.
PROi Q9UBI1.

Gene expression databases

Bgeei Q9UBI1.
CleanExi HS_COMMD3.
Genevestigatori Q9UBI1.

Family and domain databases

InterProi IPR017920. COMM.
IPR009886. HCaRG.
[Graphical view ]
Pfami PF07258. HCaRG. 1 hit.
[Graphical view ]
PROSITEi PS51269. COMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
  2. "Novel genes expressed in human dendritic cells."
    Li Y., Li N., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOMD3_HUMAN
AccessioniPrimary (citable) accession number: Q9UBI1
Secondary accession number(s): D3DRU7, Q5T8Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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