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Protein

Xenotropic and polytropic retrovirus receptor 1

Gene

XPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses.By similarity2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. receptor activity Source: ProtInc
  3. transmembrane signaling receptor activity Source: ProtInc
  4. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Xenotropic and polytropic retrovirus receptor 1
Alternative name(s):
Protein SYG1 homolog
Xenotropic and polytropic murine leukemia virus receptor X3
Short name:
X-receptor
Gene namesi
Name:XPR1
Synonyms:SYG1, XR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12827. XPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 236236CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Topological domaini258 – 2647ExtracellularSequence Analysis
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Topological domaini286 – 31833CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence AnalysisAdd
BLAST
Topological domaini340 – 3456ExtracellularSequence Analysis
Transmembranei346 – 36823HelicalSequence AnalysisAdd
BLAST
Topological domaini369 – 3768CytoplasmicSequence Analysis
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST
Topological domaini398 – 4025ExtracellularSequence Analysis
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Topological domaini424 – 47350CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei474 – 49623HelicalSequence AnalysisAdd
BLAST
Topological domaini497 – 50711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence AnalysisAdd
BLAST
Topological domaini529 – 696168CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: GO_Central
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37420.

Polymorphism and mutation databases

BioMutaiXPR1.
DMDMi74753221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Xenotropic and polytropic retrovirus receptor 1PRO_0000315853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei668 – 6681Phosphoserine1 Publication
Modified residuei690 – 6901Phosphothreonine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UBH6.
PaxDbiQ9UBH6.
PRIDEiQ9UBH6.

PTM databases

PhosphoSiteiQ9UBH6.

Expressioni

Tissue specificityi

Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.2 Publications

Developmental stagei

Expressed in fetal liver.2 Publications

Gene expression databases

BgeeiQ9UBH6.
CleanExiHS_XPR1.
ExpressionAtlasiQ9UBH6. baseline and differential.
GenevestigatoriQ9UBH6.

Organism-specific databases

HPAiHPA016563.

Interactioni

Protein-protein interaction databases

BioGridi114647. 16 interactions.
IntActiQ9UBH6. 1 interaction.
STRINGi9606.ENSP00000356562.

Structurei

3D structure databases

ProteinModelPortaliQ9UBH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 177177SPXPROSITE-ProRule annotationAdd
BLAST
Domaini439 – 643205EXSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EXS domain.PROSITE-ProRule annotation
Contains 1 SPX domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5409.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000046196.
HOVERGENiHBG108684.
InParanoidiQ9UBH6.
OMAiCINTKHI.
OrthoDBiEOG7VQJCG.
PhylomeDBiQ9UBH6.
TreeFamiTF314643.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY
60 70 80 90 100
FAKFEEKFFQ TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE
110 120 130 140 150
STGVTTLRQR RKPVFHLSHE ERVQHRNIKD LKLAFSEFYL SLILLQNYQN
160 170 180 190 200
LNFTGFRKIL KKHDKILETS RGADWRVAHV EVAPFYTCKK INQLISETEA
210 220 230 240 250
VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF CGIFIVLNIT
260 270 280 290 300
LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV
310 320 330 340 350
LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA
360 370 380 390 400
LYGFMVFFLI NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL
410 420 430 440 450
NSLSVILMDL EYMICFYSLE LKWDESKGLL PNNSEESGIC HKYTYGVRAI
460 470 480 490 500
VQCIPAWLRF IQCLRRYRDT KRAFPHLVNA GKYSTTFFMV TFAALYSTHK
510 520 530 540 550
ERGHSDTMVF FYLWIVFYII SSCYTLIWDL KMDWGLFDKN AGENTFLREE
560 570 580 590 600
IVYPQKAYYY CAIIEDVILR FAWTIQISIT STTLLPHSGD IIATVFAPLE
610 620 630 640 650
VFRRFVWNFF RLENEHLNNC GEFRAVRDIS VAPLNADDQT LLEQMMDQDD
660 670 680 690
GVRNRQKNRS WKYNQSISLR RPRLASQSKA RDTKVLIEDT DDEANT
Length:696
Mass (Da):81,535
Last modified:May 1, 2000 - v1
Checksum:iB5B4BABF5CA2503A
GO
Isoform 2 (identifier: Q9UBH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-501: Missing.

Show »
Length:631
Mass (Da):73,919
Checksum:iEAFF4C1162AC29AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti491 – 4911T → A.1 Publication
Corresponds to variant rs1061012 [ dbSNP | Ensembl ].
VAR_038350

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei437 – 50165Missing in isoform 2. 1 PublicationVSP_030748Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115389 mRNA. Translation: AAD17211.1.
AF089744 mRNA. Translation: AAD10196.1.
AF099082 mRNA. Translation: AAD08928.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1.
CH471067 Genomic DNA. Translation: EAW91086.1.
BC041142 mRNA. Translation: AAH41142.1.
AL133058 mRNA. Translation: CAB61383.1.
AL137583 mRNA. Translation: CAB70825.1.
CCDSiCCDS1340.1. [Q9UBH6-1]
CCDS44284.1. [Q9UBH6-2]
PIRiT42660.
RefSeqiNP_001129141.1. NM_001135669.1. [Q9UBH6-2]
NP_004727.2. NM_004736.3. [Q9UBH6-1]
UniGeneiHs.227656.

Genome annotation databases

EnsembliENST00000367589; ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
ENST00000367590; ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
GeneIDi9213.
KEGGihsa:9213.
UCSCiuc001goi.3. human. [Q9UBH6-1]
uc009wxn.3. human. [Q9UBH6-2]

Polymorphism and mutation databases

BioMutaiXPR1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115389 mRNA. Translation: AAD17211.1.
AF089744 mRNA. Translation: AAD10196.1.
AF099082 mRNA. Translation: AAD08928.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1.
CH471067 Genomic DNA. Translation: EAW91086.1.
BC041142 mRNA. Translation: AAH41142.1.
AL133058 mRNA. Translation: CAB61383.1.
AL137583 mRNA. Translation: CAB70825.1.
CCDSiCCDS1340.1. [Q9UBH6-1]
CCDS44284.1. [Q9UBH6-2]
PIRiT42660.
RefSeqiNP_001129141.1. NM_001135669.1. [Q9UBH6-2]
NP_004727.2. NM_004736.3. [Q9UBH6-1]
UniGeneiHs.227656.

3D structure databases

ProteinModelPortaliQ9UBH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114647. 16 interactions.
IntActiQ9UBH6. 1 interaction.
STRINGi9606.ENSP00000356562.

PTM databases

PhosphoSiteiQ9UBH6.

Polymorphism and mutation databases

BioMutaiXPR1.
DMDMi74753221.

Proteomic databases

MaxQBiQ9UBH6.
PaxDbiQ9UBH6.
PRIDEiQ9UBH6.

Protocols and materials databases

DNASUi9213.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367589; ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
ENST00000367590; ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
GeneIDi9213.
KEGGihsa:9213.
UCSCiuc001goi.3. human. [Q9UBH6-1]
uc009wxn.3. human. [Q9UBH6-2]

Organism-specific databases

CTDi9213.
GeneCardsiGC01P180601.
H-InvDBHIX0001390.
HGNCiHGNC:12827. XPR1.
HPAiHPA016563.
MIMi605237. gene.
neXtProtiNX_Q9UBH6.
PharmGKBiPA37420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5409.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000046196.
HOVERGENiHBG108684.
InParanoidiQ9UBH6.
OMAiCINTKHI.
OrthoDBiEOG7VQJCG.
PhylomeDBiQ9UBH6.
TreeFamiTF314643.

Miscellaneous databases

GenomeRNAii9213.
NextBioi34539.
PROiQ9UBH6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBH6.
CleanExiHS_XPR1.
ExpressionAtlasiQ9UBH6. baseline and differential.
GenevestigatoriQ9UBH6.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1."
    Yang Y.-L., Guo L., Xu S., Holland C.A., Kitamura T., Hunter K., Cunningham J.M.
    Nat. Genet. 21:216-219(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES.
  2. "Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses."
    Tailor C.S., Nouri A., Lee C.G., Kozak C., Kabat D.
    Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Lymphocyte.
  3. "A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction."
    Battini J.-L., Rasko J.E.J., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-491.
    Tissue: Cervix carcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-696 (ISOFORM 1).
    Tissue: Testis.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiXPR1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBH6
Secondary accession number(s): O95719
, Q7L8K9, Q8IW20, Q9NT19, Q9UFB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.