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Protein

Xenotropic and polytropic retrovirus receptor 1

Gene

XPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106).By similarity3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei22 – 221Important for inositol polyphosphate binding1 Publication
Sitei26 – 261Important for inositol polyphosphate binding1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  • cellular phosphate ion homeostasis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Xenotropic and polytropic retrovirus receptor 1
Alternative name(s):
Protein SYG1 homolog
Xenotropic and polytropic murine leukemia virus receptor X3
Short name:
X-receptor
Gene namesi
Name:XPR1
Synonyms:SYG1, XR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12827. XPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 236236CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Topological domaini258 – 2647ExtracellularSequence analysis
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Topological domaini286 – 31833CytoplasmicSequence analysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence analysisAdd
BLAST
Topological domaini340 – 3456ExtracellularSequence analysis
Transmembranei346 – 36823HelicalSequence analysisAdd
BLAST
Topological domaini369 – 3768CytoplasmicSequence analysis
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Topological domaini398 – 4025ExtracellularSequence analysis
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Topological domaini424 – 47350CytoplasmicSequence analysisAdd
BLAST
Transmembranei474 – 49623HelicalSequence analysisAdd
BLAST
Topological domaini497 – 50711ExtracellularSequence analysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence analysisAdd
BLAST
Topological domaini529 – 696168CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: GO_Central
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Basal ganglia calcification, idiopathic, 6 (IBGC6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
See also OMIM:616413
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361S → N in IBGC6; phosphate efflux is impaired; present at the plasma membrane. 1 Publication
Corresponds to variant rs786205902 [ dbSNP | Ensembl ].
VAR_073840
Natural varianti140 – 1401L → P in IBGC6; phosphate efflux is impaired; present at the plasma membrane. 1 Publication
Corresponds to variant rs786205903 [ dbSNP | Ensembl ].
VAR_073841
Natural varianti145 – 1451L → P in IBGC6; dominant negative; phosphate efflux is impaired; loss of localization to the plasma membrane. 1 Publication
Corresponds to variant rs786205901 [ dbSNP | Ensembl ].
VAR_073842
Natural varianti218 – 2181L → S in IBGC6; present at the plasma membrane; phosphate efflux is impaired. 1 Publication
Corresponds to variant rs786205904 [ dbSNP | Ensembl ].
VAR_073843

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi616413. phenotype.
PharmGKBiPA37420.

Polymorphism and mutation databases

BioMutaiXPR1.
DMDMi74753221.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Xenotropic and polytropic retrovirus receptor 1PRO_0000315853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei668 – 6681PhosphoserineCombined sources
Modified residuei690 – 6901PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UBH6.
MaxQBiQ9UBH6.
PaxDbiQ9UBH6.
PeptideAtlasiQ9UBH6.
PRIDEiQ9UBH6.

PTM databases

iPTMnetiQ9UBH6.
PhosphoSiteiQ9UBH6.

Expressioni

Tissue specificityi

Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.2 Publications

Developmental stagei

Expressed in fetal liver.2 Publications

Gene expression databases

BgeeiQ9UBH6.
CleanExiHS_XPR1.
ExpressionAtlasiQ9UBH6. baseline and differential.
GenevisibleiQ9UBH6. HS.

Organism-specific databases

HPAiHPA016563.

Interactioni

Protein-protein interaction databases

BioGridi114647. 42 interactions.
IntActiQ9UBH6. 21 interactions.
STRINGi9606.ENSP00000356562.

Structurei

Secondary structure

1
696
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 108Combined sources
Helixi13 – 186Combined sources
Helixi22 – 3413Combined sources
Helixi44 – 9855Combined sources
Helixi119 – 1224Combined sources
Helixi125 – 16743Combined sources
Helixi171 – 1799Combined sources
Turni180 – 1823Combined sources
Turni184 – 1863Combined sources
Helixi191 – 20414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5IJHX-ray2.43A/B1-207[»]
ProteinModelPortaliQ9UBH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 177177SPXPROSITE-ProRule annotationAdd
BLAST
Domaini439 – 643205EXSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 1658Important for inositol polyphosphate bindingBy similarity

Domaini

The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower.1 Publication

Sequence similaritiesi

Contains 1 EXS domain.PROSITE-ProRule annotation
Contains 1 SPX domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1162. Eukaryota.
COG5409. LUCA.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000046196.
HOVERGENiHBG108684.
InParanoidiQ9UBH6.
OMAiVLYGFMV.
OrthoDBiEOG7VQJCG.
PhylomeDBiQ9UBH6.
TreeFamiTF314643.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_dom.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 3 hits.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY
60 70 80 90 100
FAKFEEKFFQ TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE
110 120 130 140 150
STGVTTLRQR RKPVFHLSHE ERVQHRNIKD LKLAFSEFYL SLILLQNYQN
160 170 180 190 200
LNFTGFRKIL KKHDKILETS RGADWRVAHV EVAPFYTCKK INQLISETEA
210 220 230 240 250
VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF CGIFIVLNIT
260 270 280 290 300
LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV
310 320 330 340 350
LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA
360 370 380 390 400
LYGFMVFFLI NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL
410 420 430 440 450
NSLSVILMDL EYMICFYSLE LKWDESKGLL PNNSEESGIC HKYTYGVRAI
460 470 480 490 500
VQCIPAWLRF IQCLRRYRDT KRAFPHLVNA GKYSTTFFMV TFAALYSTHK
510 520 530 540 550
ERGHSDTMVF FYLWIVFYII SSCYTLIWDL KMDWGLFDKN AGENTFLREE
560 570 580 590 600
IVYPQKAYYY CAIIEDVILR FAWTIQISIT STTLLPHSGD IIATVFAPLE
610 620 630 640 650
VFRRFVWNFF RLENEHLNNC GEFRAVRDIS VAPLNADDQT LLEQMMDQDD
660 670 680 690
GVRNRQKNRS WKYNQSISLR RPRLASQSKA RDTKVLIEDT DDEANT
Length:696
Mass (Da):81,535
Last modified:May 1, 2000 - v1
Checksum:iB5B4BABF5CA2503A
GO
Isoform 2 (identifier: Q9UBH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-501: Missing.

Show »
Length:631
Mass (Da):73,919
Checksum:iEAFF4C1162AC29AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361S → N in IBGC6; phosphate efflux is impaired; present at the plasma membrane. 1 Publication
Corresponds to variant rs786205902 [ dbSNP | Ensembl ].
VAR_073840
Natural varianti140 – 1401L → P in IBGC6; phosphate efflux is impaired; present at the plasma membrane. 1 Publication
Corresponds to variant rs786205903 [ dbSNP | Ensembl ].
VAR_073841
Natural varianti145 – 1451L → P in IBGC6; dominant negative; phosphate efflux is impaired; loss of localization to the plasma membrane. 1 Publication
Corresponds to variant rs786205901 [ dbSNP | Ensembl ].
VAR_073842
Natural varianti218 – 2181L → S in IBGC6; present at the plasma membrane; phosphate efflux is impaired. 1 Publication
Corresponds to variant rs786205904 [ dbSNP | Ensembl ].
VAR_073843
Natural varianti491 – 4911T → A.1 Publication
Corresponds to variant rs1061012 [ dbSNP | Ensembl ].
VAR_038350

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei437 – 50165Missing in isoform 2. 1 PublicationVSP_030748Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115389 mRNA. Translation: AAD17211.1.
AF089744 mRNA. Translation: AAD10196.1.
AF099082 mRNA. Translation: AAD08928.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1.
CH471067 Genomic DNA. Translation: EAW91086.1.
BC041142 mRNA. Translation: AAH41142.1.
AL133058 mRNA. Translation: CAB61383.1.
AL137583 mRNA. Translation: CAB70825.1.
CCDSiCCDS1340.1. [Q9UBH6-1]
CCDS44284.1. [Q9UBH6-2]
PIRiT42660.
RefSeqiNP_001129141.1. NM_001135669.1. [Q9UBH6-2]
NP_004727.2. NM_004736.3. [Q9UBH6-1]
UniGeneiHs.227656.

Genome annotation databases

EnsembliENST00000367589; ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
ENST00000367590; ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
GeneIDi9213.
KEGGihsa:9213.
UCSCiuc001goi.4. human. [Q9UBH6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115389 mRNA. Translation: AAD17211.1.
AF089744 mRNA. Translation: AAD10196.1.
AF099082 mRNA. Translation: AAD08928.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1.
CH471067 Genomic DNA. Translation: EAW91086.1.
BC041142 mRNA. Translation: AAH41142.1.
AL133058 mRNA. Translation: CAB61383.1.
AL137583 mRNA. Translation: CAB70825.1.
CCDSiCCDS1340.1. [Q9UBH6-1]
CCDS44284.1. [Q9UBH6-2]
PIRiT42660.
RefSeqiNP_001129141.1. NM_001135669.1. [Q9UBH6-2]
NP_004727.2. NM_004736.3. [Q9UBH6-1]
UniGeneiHs.227656.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5IJHX-ray2.43A/B1-207[»]
ProteinModelPortaliQ9UBH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114647. 42 interactions.
IntActiQ9UBH6. 21 interactions.
STRINGi9606.ENSP00000356562.

PTM databases

iPTMnetiQ9UBH6.
PhosphoSiteiQ9UBH6.

Polymorphism and mutation databases

BioMutaiXPR1.
DMDMi74753221.

Proteomic databases

EPDiQ9UBH6.
MaxQBiQ9UBH6.
PaxDbiQ9UBH6.
PeptideAtlasiQ9UBH6.
PRIDEiQ9UBH6.

Protocols and materials databases

DNASUi9213.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367589; ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
ENST00000367590; ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
GeneIDi9213.
KEGGihsa:9213.
UCSCiuc001goi.4. human. [Q9UBH6-1]

Organism-specific databases

CTDi9213.
GeneCardsiXPR1.
H-InvDBHIX0001390.
HGNCiHGNC:12827. XPR1.
HPAiHPA016563.
MIMi605237. gene.
616413. phenotype.
neXtProtiNX_Q9UBH6.
PharmGKBiPA37420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1162. Eukaryota.
COG5409. LUCA.
GeneTreeiENSGT00500000044895.
HOGENOMiHOG000046196.
HOVERGENiHBG108684.
InParanoidiQ9UBH6.
OMAiVLYGFMV.
OrthoDBiEOG7VQJCG.
PhylomeDBiQ9UBH6.
TreeFamiTF314643.

Miscellaneous databases

GenomeRNAii9213.
PROiQ9UBH6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBH6.
CleanExiHS_XPR1.
ExpressionAtlasiQ9UBH6. baseline and differential.
GenevisibleiQ9UBH6. HS.

Family and domain databases

InterProiIPR004342. EXS_C.
IPR004331. SPX_dom.
[Graphical view]
PfamiPF03124. EXS. 1 hit.
PF03105. SPX. 3 hits.
[Graphical view]
PROSITEiPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1."
    Yang Y.-L., Guo L., Xu S., Holland C.A., Kitamura T., Hunter K., Cunningham J.M.
    Nat. Genet. 21:216-219(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses."
    Tailor C.S., Nouri A., Lee C.G., Kozak C., Kabat D.
    Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Lymphocyte.
  3. "A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction."
    Battini J.-L., Rasko J.E.J., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-491.
    Tissue: Cervix carcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-696 (ISOFORM 1).
    Tissue: Testis.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans."
    Giovannini D., Touhami J., Charnet P., Sitbon M., Battini J.L.
    Cell Rep. 3:1866-1873(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  13. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  14. Cited for: FUNCTION, INVOLVEMENT IN IBGC6, VARIANTS IBGC6 ASN-136; PRO-140; PRO-145 AND SER-218, CHARACTERIZATION OF VARIANTS IBGC6 ASN-136; PRO-140; PRO-145 AND SER-218.
  15. "Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains."
    Wild R., Gerasimaite R., Jung J.Y., Truffault V., Pavlovic I., Schmidt A., Saiardi A., Jessen H.J., Poirier Y., Hothorn M., Mayer A.
    Science 0:0-0(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.43 ANGSTROMS) OF 1-207, DOMAIN, FUNCTION.

Entry informationi

Entry nameiXPR1_HUMAN
AccessioniPrimary (citable) accession number: Q9UBH6
Secondary accession number(s): O95719
, Q7L8K9, Q8IW20, Q9NT19, Q9UFB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.