Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UBH6 (XPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xenotropic and polytropic retrovirus receptor 1
Alternative name(s):
Protein SYG1 homolog
Xenotropic and polytropic murine leukemia virus receptor X3
Short name=X-receptor
Gene names
Name:XPR1
Synonyms:SYG1, XR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function in G-protein coupled signal transduction By similarity. Potential receptor for xenotropic and polytropic murine leukemia retroviruses. Ref.1 Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Tissue specificity

Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. Ref.2 Ref.3

Developmental stage

Expressed in fetal liver. Ref.2 Ref.3

Sequence similarities

Belongs to the SYG1 (TC 2.A.94) family. [View classification]

Contains 1 EXS domain.

Contains 1 SPX domain.

Caution

It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UBH6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UBH6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     437-501: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696696Xenotropic and polytropic retrovirus receptor 1
PRO_0000315853

Regions

Topological domain1 – 236236Cytoplasmic Potential
Transmembrane237 – 25721Helical; Potential
Topological domain258 – 2647Extracellular Potential
Transmembrane265 – 28521Helical; Potential
Topological domain286 – 31833Cytoplasmic Potential
Transmembrane319 – 33921Helical; Potential
Topological domain340 – 3456Extracellular Potential
Transmembrane346 – 36823Helical; Potential
Topological domain369 – 3768Cytoplasmic Potential
Transmembrane377 – 39721Helical; Potential
Topological domain398 – 4025Extracellular Potential
Transmembrane403 – 42321Helical; Potential
Topological domain424 – 47350Cytoplasmic Potential
Transmembrane474 – 49623Helical; Potential
Topological domain497 – 50711Extracellular Potential
Transmembrane508 – 52821Helical; Potential
Topological domain529 – 696168Cytoplasmic Potential
Domain1 – 177177SPX
Domain439 – 643205EXS

Amino acid modifications

Modified residue6681Phosphoserine Ref.9
Modified residue6901Phosphothreonine Ref.8 Ref.9 Ref.11

Natural variations

Alternative sequence437 – 50165Missing in isoform 2.
VSP_030748
Natural variant4911T → A. Ref.3
Corresponds to variant rs1061012 [ dbSNP | Ensembl ].
VAR_038350

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B5B4BABF5CA2503A

FASTA69681,535
        10         20         30         40         50         60 
MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY FAKFEEKFFQ 

        70         80         90        100        110        120 
TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE STGVTTLRQR RKPVFHLSHE 

       130        140        150        160        170        180 
ERVQHRNIKD LKLAFSEFYL SLILLQNYQN LNFTGFRKIL KKHDKILETS RGADWRVAHV 

       190        200        210        220        230        240 
EVAPFYTCKK INQLISETEA VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF 

       250        260        270        280        290        300 
CGIFIVLNIT LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV 

       310        320        330        340        350        360 
LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA LYGFMVFFLI 

       370        380        390        400        410        420 
NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL NSLSVILMDL EYMICFYSLE 

       430        440        450        460        470        480 
LKWDESKGLL PNNSEESGIC HKYTYGVRAI VQCIPAWLRF IQCLRRYRDT KRAFPHLVNA 

       490        500        510        520        530        540 
GKYSTTFFMV TFAALYSTHK ERGHSDTMVF FYLWIVFYII SSCYTLIWDL KMDWGLFDKN 

       550        560        570        580        590        600 
AGENTFLREE IVYPQKAYYY CAIIEDVILR FAWTIQISIT STTLLPHSGD IIATVFAPLE 

       610        620        630        640        650        660 
VFRRFVWNFF RLENEHLNNC GEFRAVRDIS VAPLNADDQT LLEQMMDQDD GVRNRQKNRS 

       670        680        690 
WKYNQSISLR RPRLASQSKA RDTKVLIEDT DDEANT 

« Hide

Isoform 2 [UniParc].

Checksum: EAFF4C1162AC29AB
Show »

FASTA63173,919

References

« Hide 'large scale' references
[1]"Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1."
Yang Y.-L., Guo L., Xu S., Holland C.A., Kitamura T., Hunter K., Cunningham J.M.
Nat. Genet. 21:216-219(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES.
[2]"Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses."
Tailor C.S., Nouri A., Lee C.G., Kozak C., Kabat D.
Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Lymphocyte.
[3]"A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction."
Battini J.-L., Rasko J.E.J., Miller A.D.
Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-491.
Tissue: Cervix carcinoma.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[7]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-696 (ISOFORM 1).
Tissue: Testis.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF115389 mRNA. Translation: AAD17211.1.
AF089744 mRNA. Translation: AAD10196.1.
AF099082 mRNA. Translation: AAD08928.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1.
AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1.
AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1.
AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1.
CH471067 Genomic DNA. Translation: EAW91086.1.
BC041142 mRNA. Translation: AAH41142.1.
AL133058 mRNA. Translation: CAB61383.1.
AL137583 mRNA. Translation: CAB70825.1.
CCDSCCDS1340.1. [Q9UBH6-1]
CCDS44284.1. [Q9UBH6-2]
PIRT42660.
RefSeqNP_001129141.1. NM_001135669.1. [Q9UBH6-2]
NP_004727.2. NM_004736.3. [Q9UBH6-1]
UniGeneHs.227656.

3D structure databases

ProteinModelPortalQ9UBH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114647. 3 interactions.
IntActQ9UBH6. 1 interaction.
STRING9606.ENSP00000356562.

PTM databases

PhosphoSiteQ9UBH6.

Polymorphism databases

DMDM74753221.

Proteomic databases

MaxQBQ9UBH6.
PaxDbQ9UBH6.
PRIDEQ9UBH6.

Protocols and materials databases

DNASU9213.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367589; ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
ENST00000367590; ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
GeneID9213.
KEGGhsa:9213.
UCSCuc001goi.3. human. [Q9UBH6-1]
uc009wxn.3. human. [Q9UBH6-2]

Organism-specific databases

CTD9213.
GeneCardsGC01P180601.
H-InvDBHIX0001390.
HGNCHGNC:12827. XPR1.
HPAHPA016563.
MIM605237. gene.
neXtProtNX_Q9UBH6.
PharmGKBPA37420.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5409.
HOGENOMHOG000046196.
HOVERGENHBG108684.
InParanoidQ9UBH6.
OMAICNSYSY.
OrthoDBEOG7VQJCG.
PhylomeDBQ9UBH6.
TreeFamTF314643.

Gene expression databases

BgeeQ9UBH6.
CleanExHS_XPR1.
GenevestigatorQ9UBH6.

Family and domain databases

InterProIPR004342. EXS_C.
IPR004331. SPX_N.
[Graphical view]
PfamPF03124. EXS. 1 hit.
PF03105. SPX. 1 hit.
[Graphical view]
PROSITEPS51380. EXS. 1 hit.
PS51382. SPX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9213.
NextBio34539.
PROQ9UBH6.
SOURCESearch...

Entry information

Entry nameXPR1_HUMAN
AccessionPrimary (citable) accession number: Q9UBH6
Secondary accession number(s): O95719 expand/collapse secondary AC list , Q7L8K9, Q8IW20, Q9NT19, Q9UFB9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM