Q9UBH6 (XPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xenotropic and polytropic retrovirus receptor 1

Alternative name(s):
Protein SYG1 homolog
Xenotropic and polytropic murine leukemia virus receptor X3
Short name=X-receptor

Gene names

Name:	XPR1
Synonyms:	SYG1, XR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function in G-protein coupled signal transduction By similarity. Potential receptor for xenotropic and polytropic murine leukemia retroviruses. Ref.1 Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Tissue specificity	Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. Ref.2 Ref.3
Developmental stage	Expressed in fetal liver. Ref.2 Ref.3
Sequence similarities	Belongs to the SYG1 (TC 2.A.94) family. [View classification] Contains 1 EXS domain. Contains 1 SPX domain.
Caution	It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Host cell receptor for virus entry Receptor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	G-protein coupled receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UBH6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UBH6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     437-501: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 696	696	Xenotropic and polytropic retrovirus receptor 1		PRO_0000315853
Regions
	Topological domain	1 – 236	236	Cytoplasmic Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Topological domain	258 – 264	7	Extracellular Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Topological domain	286 – 318	33	Cytoplasmic Potential
	Transmembrane	319 – 339	21	Helical; Potential
	Topological domain	340 – 345	6	Extracellular Potential
	Transmembrane	346 – 368	23	Helical; Potential
	Topological domain	369 – 376	8	Cytoplasmic Potential
	Transmembrane	377 – 397	21	Helical; Potential
	Topological domain	398 – 402	5	Extracellular Potential
	Transmembrane	403 – 423	21	Helical; Potential
	Topological domain	424 – 473	50	Cytoplasmic Potential
	Transmembrane	474 – 496	23	Helical; Potential
	Topological domain	497 – 507	11	Extracellular Potential
	Transmembrane	508 – 528	21	Helical; Potential
	Topological domain	529 – 696	168	Cytoplasmic Potential
	Domain	1 – 177	177	SPX
	Domain	439 – 643	205	EXS
Amino acid modifications
	Modified residue	666	1	Phosphoserine Ref.8
	Modified residue	668	1	Phosphoserine Ref.8 Ref.9
	Modified residue	690	1	Phosphothreonine Ref.8 Ref.9 Ref.10
Natural variations
	Alternative sequence	437 – 501	65	Missing in isoform 2.		VSP_030748
	Natural variant	491	1	T → A. Ref.3 Corresponds to variant rs1061012 [ dbSNP | Ensembl ].		VAR_038350

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B5B4BABF5CA2503A	FASTA	696	81,535
	10 20 30 40 50 60 MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY FAKFEEKFFQ 70 80 90 100 110 120 TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE STGVTTLRQR RKPVFHLSHE 130 140 150 160 170 180 ERVQHRNIKD LKLAFSEFYL SLILLQNYQN LNFTGFRKIL KKHDKILETS RGADWRVAHV 190 200 210 220 230 240 EVAPFYTCKK INQLISETEA VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF 250 260 270 280 290 300 CGIFIVLNIT LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV 310 320 330 340 350 360 LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA LYGFMVFFLI 370 380 390 400 410 420 NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL NSLSVILMDL EYMICFYSLE 430 440 450 460 470 480 LKWDESKGLL PNNSEESGIC HKYTYGVRAI VQCIPAWLRF IQCLRRYRDT KRAFPHLVNA 490 500 510 520 530 540 GKYSTTFFMV TFAALYSTHK ERGHSDTMVF FYLWIVFYII SSCYTLIWDL KMDWGLFDKN 550 560 570 580 590 600 AGENTFLREE IVYPQKAYYY CAIIEDVILR FAWTIQISIT STTLLPHSGD IIATVFAPLE 610 620 630 640 650 660 VFRRFVWNFF RLENEHLNNC GEFRAVRDIS VAPLNADDQT LLEQMMDQDD GVRNRQKNRS 670 680 690 WKYNQSISLR RPRLASQSKA RDTKVLIEDT DDEANT
	Isoform 2 [UniParc]. Checksum: EAFF4C1162AC29AB	FASTA	631	73,919
	10 20 30 40 50 60 MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY FAKFEEKFFQ 70 80 90 100 110 120 TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE STGVTTLRQR RKPVFHLSHE 130 140 150 160 170 180 ERVQHRNIKD LKLAFSEFYL SLILLQNYQN LNFTGFRKIL KKHDKILETS RGADWRVAHV 190 200 210 220 230 240 EVAPFYTCKK INQLISETEA VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF 250 260 270 280 290 300 CGIFIVLNIT LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV 310 320 330 340 350 360 LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA LYGFMVFFLI 370 380 390 400 410 420 NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL NSLSVILMDL EYMICFYSLE 430 440 450 460 470 480 LKWDESKGLL PNNSEERGHS DTMVFFYLWI VFYIISSCYT LIWDLKMDWG LFDKNAGENT 490 500 510 520 530 540 FLREEIVYPQ KAYYYCAIIE DVILRFAWTI QISITSTTLL PHSGDIIATV FAPLEVFRRF 550 560 570 580 590 600 VWNFFRLENE HLNNCGEFRA VRDISVAPLN ADDQTLLEQM MDQDDGVRNR QKNRSWKYNQ 610 620 630 SISLRRPRLA SQSKARDTKV LIEDTDDEAN T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1." Yang Y.-L., Guo L., Xu S., Holland C.A., Kitamura T., Hunter K., Cunningham J.M. Nat. Genet. 21:216-219(1999) [PubMed: 9988277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES.
[2]	"Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses." Tailor C.S., Nouri A., Lee C.G., Kozak C., Kabat D. Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999) [PubMed: 9927670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Lymphocyte.
[3]	"A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction." Battini J.-L., Rasko J.E.J., Miller A.D. Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999) [PubMed: 9990033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-491. Tissue: Cervix carcinoma.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-696 (ISOFORM 1). Tissue: Testis.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666; SER-668 AND THR-690, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF115389 mRNA. Translation: AAD17211.1. AF089744 mRNA. Translation: AAD10196.1. AF099082 mRNA. Translation: AAD08928.1. AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1. AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1. AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1. AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1. AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1. AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1. CH471067 Genomic DNA. Translation: EAW91086.1. BC041142 mRNA. Translation: AAH41142.1. AL133058 mRNA. Translation: CAB61383.1. AL137583 mRNA. Translation: CAB70825.1.
IPI	IPI00217110. IPI00295447.
PIR	T42660.
RefSeq	NP_001129141.1. NM_001135669.1. NP_004727.2. NM_004736.3.
UniGene	Hs.227656.
3D structure databases
ProteinModelPortal	Q9UBH6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UBH6.
PTM databases
PhosphoSite	Q9UBH6.
Polymorphism databases
DMDM	74753221.
Proteomic databases
PRIDE	Q9UBH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367590; ENSP00000356562; ENSG00000143324.
GeneID	9213.
KEGG	hsa:9213.
UCSC	uc001goi.1. human. uc009wxn.1. human.
Organism-specific databases
CTD	9213.
GeneCards	GC01P180601.
H-InvDB	HIX0001390.
HGNC	HGNC:12827. XPR1.
HPA	HPA016563.
MIM	605237. gene.
neXtProt	NX_Q9UBH6.
PharmGKB	PA37420.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04888.
GeneTree	ENSGT00500000044895.
HOGENOM	HBG446089.
HOVERGEN	HBG108684.
InParanoid	Q9UBH6.
OMA	WTVQISI.
OrthoDB	EOG45MN4R.
PhylomeDB	Q9UBH6.
Gene expression databases
ArrayExpress	Q9UBH6.
Bgee	Q9UBH6.
CleanEx	HS_XPR1.
Genevestigator	Q9UBH6.
Family and domain databases
InterPro	IPR004342. EXS_C. IPR004331. SPX_N. [Graphical view]
Pfam	PF03124. EXS. 1 hit. PF03105. SPX. 1 hit. [Graphical view]
PROSITE	PS51380. EXS. 1 hit. PS51382. SPX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	34539.
SOURCE	Search...

Entry information

Entry name

XPR1_HUMAN

Accession

Primary (citable) accession number: Q9UBH6
Secondary accession number(s): O95719 , Q7L8K9, Q8IW20, Q9NT19, Q9UFB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.