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Q9UBH6

- XPR1_HUMAN

UniProt

Q9UBH6 - XPR1_HUMAN

Protein

Xenotropic and polytropic retrovirus receptor 1

Gene

XPR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May function in G-protein coupled signal transduction By similarity. Potential receptor for xenotropic and polytropic murine leukemia retroviruses.By similarity2 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. receptor activity Source: ProtInc
    3. transmembrane signaling receptor activity Source: ProtInc
    4. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xenotropic and polytropic retrovirus receptor 1
    Alternative name(s):
    Protein SYG1 homolog
    Xenotropic and polytropic murine leukemia virus receptor X3
    Short name:
    X-receptor
    Gene namesi
    Name:XPR1
    Synonyms:SYG1, XR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:12827. XPR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37420.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696696Xenotropic and polytropic retrovirus receptor 1PRO_0000315853Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei668 – 6681Phosphoserine1 Publication
    Modified residuei690 – 6901Phosphothreonine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UBH6.
    PaxDbiQ9UBH6.
    PRIDEiQ9UBH6.

    PTM databases

    PhosphoSiteiQ9UBH6.

    Expressioni

    Tissue specificityi

    Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle.2 Publications

    Developmental stagei

    Expressed in fetal liver.2 Publications

    Gene expression databases

    BgeeiQ9UBH6.
    CleanExiHS_XPR1.
    GenevestigatoriQ9UBH6.

    Organism-specific databases

    HPAiHPA016563.

    Interactioni

    Protein-protein interaction databases

    BioGridi114647. 3 interactions.
    IntActiQ9UBH6. 1 interaction.
    STRINGi9606.ENSP00000356562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 236236CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2647ExtracellularSequence Analysis
    Topological domaini286 – 31833CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini340 – 3456ExtracellularSequence Analysis
    Topological domaini369 – 3768CytoplasmicSequence Analysis
    Topological domaini398 – 4025ExtracellularSequence Analysis
    Topological domaini424 – 47350CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini497 – 50711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini529 – 696168CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei474 – 49623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 177177SPXPROSITE-ProRule annotationAdd
    BLAST
    Domaini439 – 643205EXSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EXS domain.PROSITE-ProRule annotation
    Contains 1 SPX domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5409.
    HOGENOMiHOG000046196.
    HOVERGENiHBG108684.
    InParanoidiQ9UBH6.
    OMAiICNSYSY.
    OrthoDBiEOG7VQJCG.
    PhylomeDBiQ9UBH6.
    TreeFamiTF314643.

    Family and domain databases

    InterProiIPR004342. EXS_C.
    IPR004331. SPX_N.
    [Graphical view]
    PfamiPF03124. EXS. 1 hit.
    PF03105. SPX. 1 hit.
    [Graphical view]
    PROSITEiPS51380. EXS. 1 hit.
    PS51382. SPX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBH6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKFAEHLSAH ITPEWRKQYI QYEAFKDMLY SAQDQAPSVE VTDEDTVKRY    50
    FAKFEEKFFQ TCEKELAKIN TFYSEKLAEA QRRFATLQNE LQSSLDAQKE 100
    STGVTTLRQR RKPVFHLSHE ERVQHRNIKD LKLAFSEFYL SLILLQNYQN 150
    LNFTGFRKIL KKHDKILETS RGADWRVAHV EVAPFYTCKK INQLISETEA 200
    VVTNELEDGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLF CGIFIVLNIT 250
    LVLAAVFKLE TDRSIWPLIR IYRGGFLLIE FLFLLGINTY GWRQAGVNHV 300
    LIFELNPRSN LSHQHLFEIA GFLGILWCLS LLACFFAPIS VIPTYVYPLA 350
    LYGFMVFFLI NPTKTFYYKS RFWLLKLLFR VFTAPFHKVG FADFWLADQL 400
    NSLSVILMDL EYMICFYSLE LKWDESKGLL PNNSEESGIC HKYTYGVRAI 450
    VQCIPAWLRF IQCLRRYRDT KRAFPHLVNA GKYSTTFFMV TFAALYSTHK 500
    ERGHSDTMVF FYLWIVFYII SSCYTLIWDL KMDWGLFDKN AGENTFLREE 550
    IVYPQKAYYY CAIIEDVILR FAWTIQISIT STTLLPHSGD IIATVFAPLE 600
    VFRRFVWNFF RLENEHLNNC GEFRAVRDIS VAPLNADDQT LLEQMMDQDD 650
    GVRNRQKNRS WKYNQSISLR RPRLASQSKA RDTKVLIEDT DDEANT 696
    Length:696
    Mass (Da):81,535
    Last modified:May 1, 2000 - v1
    Checksum:iB5B4BABF5CA2503A
    GO
    Isoform 2 (identifier: Q9UBH6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         437-501: Missing.

    Show »
    Length:631
    Mass (Da):73,919
    Checksum:iEAFF4C1162AC29AB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti491 – 4911T → A.1 Publication
    Corresponds to variant rs1061012 [ dbSNP | Ensembl ].
    VAR_038350

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei437 – 50165Missing in isoform 2. 1 PublicationVSP_030748Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115389 mRNA. Translation: AAD17211.1.
    AF089744 mRNA. Translation: AAD10196.1.
    AF099082 mRNA. Translation: AAD08928.1.
    AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1.
    AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1.
    AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1.
    AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1.
    AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1.
    AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1.
    CH471067 Genomic DNA. Translation: EAW91086.1.
    BC041142 mRNA. Translation: AAH41142.1.
    AL133058 mRNA. Translation: CAB61383.1.
    AL137583 mRNA. Translation: CAB70825.1.
    CCDSiCCDS1340.1. [Q9UBH6-1]
    CCDS44284.1. [Q9UBH6-2]
    PIRiT42660.
    RefSeqiNP_001129141.1. NM_001135669.1. [Q9UBH6-2]
    NP_004727.2. NM_004736.3. [Q9UBH6-1]
    UniGeneiHs.227656.

    Genome annotation databases

    EnsembliENST00000367589; ENSP00000356561; ENSG00000143324. [Q9UBH6-2]
    ENST00000367590; ENSP00000356562; ENSG00000143324. [Q9UBH6-1]
    GeneIDi9213.
    KEGGihsa:9213.
    UCSCiuc001goi.3. human. [Q9UBH6-1]
    uc009wxn.3. human. [Q9UBH6-2]

    Polymorphism databases

    DMDMi74753221.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115389 mRNA. Translation: AAD17211.1 .
    AF089744 mRNA. Translation: AAD10196.1 .
    AF099082 mRNA. Translation: AAD08928.1 .
    AL590085 , AL162431 , AL358434 Genomic DNA. Translation: CAH70457.1 .
    AL590085 , AL162431 , AL358434 Genomic DNA. Translation: CAH70458.1 .
    AL162431 , AL358434 , AL590085 Genomic DNA. Translation: CAH74089.1 .
    AL162431 , AL358434 , AL590085 Genomic DNA. Translation: CAH74090.1 .
    AL358434 , AL162431 , AL590085 Genomic DNA. Translation: CAH74113.1 .
    AL358434 , AL162431 , AL590085 Genomic DNA. Translation: CAH74114.1 .
    CH471067 Genomic DNA. Translation: EAW91086.1 .
    BC041142 mRNA. Translation: AAH41142.1 .
    AL133058 mRNA. Translation: CAB61383.1 .
    AL137583 mRNA. Translation: CAB70825.1 .
    CCDSi CCDS1340.1. [Q9UBH6-1 ]
    CCDS44284.1. [Q9UBH6-2 ]
    PIRi T42660.
    RefSeqi NP_001129141.1. NM_001135669.1. [Q9UBH6-2 ]
    NP_004727.2. NM_004736.3. [Q9UBH6-1 ]
    UniGenei Hs.227656.

    3D structure databases

    ProteinModelPortali Q9UBH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114647. 3 interactions.
    IntActi Q9UBH6. 1 interaction.
    STRINGi 9606.ENSP00000356562.

    PTM databases

    PhosphoSitei Q9UBH6.

    Polymorphism databases

    DMDMi 74753221.

    Proteomic databases

    MaxQBi Q9UBH6.
    PaxDbi Q9UBH6.
    PRIDEi Q9UBH6.

    Protocols and materials databases

    DNASUi 9213.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367589 ; ENSP00000356561 ; ENSG00000143324 . [Q9UBH6-2 ]
    ENST00000367590 ; ENSP00000356562 ; ENSG00000143324 . [Q9UBH6-1 ]
    GeneIDi 9213.
    KEGGi hsa:9213.
    UCSCi uc001goi.3. human. [Q9UBH6-1 ]
    uc009wxn.3. human. [Q9UBH6-2 ]

    Organism-specific databases

    CTDi 9213.
    GeneCardsi GC01P180601.
    H-InvDB HIX0001390.
    HGNCi HGNC:12827. XPR1.
    HPAi HPA016563.
    MIMi 605237. gene.
    neXtProti NX_Q9UBH6.
    PharmGKBi PA37420.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5409.
    HOGENOMi HOG000046196.
    HOVERGENi HBG108684.
    InParanoidi Q9UBH6.
    OMAi ICNSYSY.
    OrthoDBi EOG7VQJCG.
    PhylomeDBi Q9UBH6.
    TreeFami TF314643.

    Miscellaneous databases

    GenomeRNAii 9213.
    NextBioi 34539.
    PROi Q9UBH6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UBH6.
    CleanExi HS_XPR1.
    Genevestigatori Q9UBH6.

    Family and domain databases

    InterProi IPR004342. EXS_C.
    IPR004331. SPX_N.
    [Graphical view ]
    Pfami PF03124. EXS. 1 hit.
    PF03105. SPX. 1 hit.
    [Graphical view ]
    PROSITEi PS51380. EXS. 1 hit.
    PS51382. SPX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1."
      Yang Y.-L., Guo L., Xu S., Holland C.A., Kitamura T., Hunter K., Cunningham J.M.
      Nat. Genet. 21:216-219(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES.
    2. "Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses."
      Tailor C.S., Nouri A., Lee C.G., Kozak C., Kabat D.
      Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Lymphocyte.
    3. "A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction."
      Battini J.-L., Rasko J.E.J., Miller A.D.
      Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-491.
      Tissue: Cervix carcinoma.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-696 (ISOFORM 1).
      Tissue: Testis.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiXPR1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBH6
    Secondary accession number(s): O95719
    , Q7L8K9, Q8IW20, Q9NT19, Q9UFB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3