Reviewed,
UniProtKB/Swiss-Prot Q9UBH6 (XPR1_HUMAN)
Last modified
June 16, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Xenotropic and polytropic retrovirus receptor 1 Alternative name(s): Protein SYG1 homolog Xenotropic and polytropic murine leukemia virus receptor X3 Short name=X-receptor | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 696 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May function in G-protein coupled signal transduction By similarity. Potential receptor for xenotropic and polytropic murine leukemia retroviruses. |
| Subcellular location | Cell membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. Ref.2 Ref.3 |
| Developmental stage | |
| Sequence similarities | Belongs to the SYG1 family. Contains 1 EXS domain. Contains 1 SPX domain. |
| Caution | It is unclear whether its ability to act as a receptor for xenotropic and polytropic murine leukemia retroviruses is relevant in vivo and whether such viruses can infect human. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Transmembrane |
| Molecular function | Receptor |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Ref.3 Traceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | G-protein coupled receptor activity Ref.3 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9UBH6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9UBH6-2) The sequence of this isoform differs from the canonical sequence as follows: 437-501: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 696 | 696 | Xenotropic and polytropic retrovirus receptor 1 | PRO_0000315853 | |||||
Regions | |||||||||
| Topological domain | 1 – 236 | 236 | Cytoplasmic Potential | ||||||
| Transmembrane | 237 – 257 | 21 | Potential | ||||||
| Topological domain | 258 – 264 | 7 | Extracellular Potential | ||||||
| Transmembrane | 265 – 285 | 21 | Potential | ||||||
| Topological domain | 286 – 318 | 33 | Cytoplasmic Potential | ||||||
| Transmembrane | 319 – 339 | 21 | Potential | ||||||
| Topological domain | 340 – 345 | 6 | Extracellular Potential | ||||||
| Transmembrane | 346 – 368 | 23 | Potential | ||||||
| Topological domain | 369 – 376 | 8 | Cytoplasmic Potential | ||||||
| Transmembrane | 377 – 397 | 21 | Potential | ||||||
| Topological domain | 398 – 402 | 5 | Extracellular Potential | ||||||
| Transmembrane | 403 – 423 | 21 | Potential | ||||||
| Topological domain | 424 – 473 | 50 | Cytoplasmic Potential | ||||||
| Transmembrane | 474 – 496 | 23 | Potential | ||||||
| Topological domain | 497 – 507 | 11 | Extracellular Potential | ||||||
| Transmembrane | 508 – 528 | 21 | Potential | ||||||
| Topological domain | 529 – 696 | 168 | Cytoplasmic Potential | ||||||
| Domain | 1 – 177 | 177 | SPX | ||||||
| Domain | 439 – 643 | 205 | EXS | ||||||
Amino acid modifications | |||||||||
| Modified residue | 666 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 668 | 1 | Phosphoserine Ref.8 Ref.9 | ||||||
| Modified residue | 690 | 1 | Phosphothreonine Ref.8 Ref.9 | ||||||
Natural variations | |||||||||
| Alternative sequence | 437 – 501 | 65 | Missing in isoform 2. | VSP_030748 | |||||
| Natural variant | 491 | 1 | T → A: dbSNP rs1061012. Ref.3 | VAR_038350 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1." Yang Y.-L., Guo L., Xu S., Holland C.A., Kitamura T., Hunter K., Cunningham J.M. Nat. Genet. 21:216-219(1999) [PubMed: 9988277] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RECEPTOR FOR MURINE RETROVIRUSES. |
| [2] | "Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses." Tailor C.S., Nouri A., Lee C.G., Kozak C., Kabat D. Proc. Natl. Acad. Sci. U.S.A. 96:927-932(1999) [PubMed: 9927670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Lymphocyte. |
| [3] | "A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: possible role in G protein-coupled signal transduction." Battini J.-L., Rasko J.E.J., Miller A.D. Proc. Natl. Acad. Sci. U.S.A. 96:1385-1390(1999) [PubMed: 9990033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS RECEPTOR FOR MURINE RETROVIRUSES, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT ALA-491. Tissue: Cervix carcinoma. |
| [4] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis. |
| [7] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-696 (ISOFORM 1). Tissue: Testis. |
| [8] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666; SER-668 AND THR-690, MASS SPECTROMETRY. |
| [9] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF115389 mRNA. Translation: AAD17211.1. AF089744 mRNA. Translation: AAD10196.1. AF099082 mRNA. Translation: AAD08928.1. AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70457.1. AL590085, AL162431, AL358434 Genomic DNA. Translation: CAH70458.1. AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74089.1. AL162431, AL358434, AL590085 Genomic DNA. Translation: CAH74090.1. AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74113.1. AL358434, AL162431, AL590085 Genomic DNA. Translation: CAH74114.1. CH471067 Genomic DNA. Translation: EAW91086.1. BC041142 mRNA. Translation: AAH41142.1. AL133058 mRNA. Translation: CAB61383.1. AL137583 mRNA. Translation: CAB70825.1. | |
| IPI | IPI00217110. IPI00295447. |
| PIR | T42660. |
| RefSeq | NP_001129141.1. NP_004727.2. |
| UniGene | Hs.227656 Hs.648372 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9UBH6. |
Genome annotation databases | |
| Ensembl | ENSG00000143324. Homo sapiens. [Contig view] |
| GeneID | 9213. |
Organism-specific databases | |
| GeneCards | GC01P178867. |
| HGNC | HGNC:12827. XPR1. |
| HPA | HPA016563. |
| MIM | 605237. gene. |
| PharmGKB | PA37420. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9UBH6. |
| OMA | Q9UBH6. VYPLVLY. |
Gene expression databases | |
| ArrayExpress | Q9UBH6. |
| Bgee | Q9UBH6. |
| CleanEx | HS_XPR1. |
Family and domain databases | |
| InterPro | IPR004342. EXS_C. IPR004331. SPX_N. [Graphical view] |
| Pfam | PF03124. EXS. 1 hit. PF03105. SPX. 1 hit. [Graphical view] |
| PROSITE | PS51380. EXS. 1 hit. PS51382. SPX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 34539. |
| SOURCE | Search... |
Entry information
| Entry name | XPR1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UBH6 Secondary accession number(s): O95719 Q9UFB9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


