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Protein

Interleukin-36 receptor antagonist protein

Gene

IL36RN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.3 Publications

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. interleukin-1 receptor antagonist activity Source: ProtInc
  3. interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

  1. antifungal humoral response Source: UniProtKB
  2. cytokine-mediated signaling pathway Source: GO_Central
  3. innate immune response Source: UniProtKB-KW
  4. negative regulation of cytokine-mediated signaling pathway Source: UniProtKB
  5. negative regulation of interferon-gamma secretion Source: UniProtKB
  6. negative regulation of interleukin-17 production Source: UniProtKB
  7. negative regulation of interleukin-6 production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-36 receptor antagonist protein
Short name:
IL-36Ra1 Publication
Alternative name(s):
FIL1 delta
IL-1-related protein 3
Short name:
IL-1RP3
Interleukin-1 HY1
Short name:
IL-1HY1
Interleukin-1 delta
Short name:
IL-1 delta
Interleukin-1 family member 5
Short name:
IL-1F5
Interleukin-1 receptor antagonist homolog 1
Short name:
IL-1ra homolog 1
Interleukin-1-like protein 1
Short name:
IL-1L1
Gene namesi
Name:IL36RN
Synonyms:FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3
ORF Names:UNQ1896/PRO4342
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:15561. IL36RN.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Psoriasis 14, pustular3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.

See also OMIM:614204
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271L → P in PSORS14; expression of the protein is severely impaired compared to wild-type; the mutant protein is substantially less able to inhibit IL1RL2 signaling than wild-type. 1 Publication
VAR_066646
Natural varianti48 – 481R → W in PSORS14. 1 Publication
VAR_066647
Natural varianti113 – 1131S → L in PSORS14. 1 Publication
Corresponds to variant rs144478519 [ dbSNP | Ensembl ].
VAR_066648
Natural varianti123 – 1231T → R in PSORS14; shows impaired expression of the mutant protein which fails to antagonize the IL-36 signaling pathway. 1 Publication
VAR_068972

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614204. phenotype.
Orphaneti163931. Acrodermatitis continua suppurativa of Hallopeau.
247353. Generalized pustular psoriasis.
163927. Pustulosis palmaris et plantaris.
PharmGKBiPA38388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 155154Interleukin-36 receptor antagonist proteinPRO_0000153642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi8 ↔ 154By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UBH0.
PRIDEiQ9UBH0.

Expressioni

Tissue specificityi

Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.1 Publication

Inductioni

By phorbol ester (PMA) and bacterial lipopolysaccharides (LPS) treatment in macrophage cell line. By Aspergillus fumigatus conidia in peripheral blood mnonocytes.1 Publication

Gene expression databases

BgeeiQ9UBH0.
CleanExiHS_IL1F5.
ExpressionAtlasiQ9UBH0. baseline and differential.
GenevestigatoriQ9UBH0.

Organism-specific databases

HPAiHPA034542.

Interactioni

Protein-protein interaction databases

BioGridi117728. 7 interactions.
IntActiQ9UBH0. 5 interactions.
MINTiMINT-1194342.
STRINGi9606.ENSP00000259212.

Structurei

Secondary structure

1
155
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 135Combined sources
Beta strandi18 – 225Combined sources
Beta strandi25 – 295Combined sources
Beta strandi42 – 465Combined sources
Helixi52 – 543Combined sources
Beta strandi55 – 617Combined sources
Turni62 – 654Combined sources
Beta strandi66 – 694Combined sources
Beta strandi72 – 754Combined sources
Beta strandi79 – 824Combined sources
Helixi85 – 895Combined sources
Helixi96 – 983Combined sources
Beta strandi99 – 1046Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi120 – 1234Combined sources
Beta strandi132 – 1354Combined sources
Beta strandi149 – 1535Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4P0JX-ray2.30A/B2-135[»]
A/B147-155[»]
4P0KX-ray1.70A2-49[»]
A55-135[»]
A147-155[»]
4P0LX-ray1.55A2-49[»]
A55-135[»]
A147-155[»]
ProteinModelPortaliQ9UBH0.
SMRiQ9UBH0. Positions 4-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiNOG46537.
GeneTreeiENSGT00530000062899.
HOVERGENiHBG052099.
InParanoidiQ9UBH0.
KOiK05483.
OMAiMKDSALK.
OrthoDBiEOG7QG45K.
PhylomeDBiQ9UBH0.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003297. IL-1RA/IL-36.
IPR027171. IL-36RA.
[Graphical view]
PANTHERiPTHR10078:SF7. PTHR10078:SF7. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL
60 70 80 90 100
DASLSPVILG VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF
110 120 130 140 150
YRRDMGLTSS FESAAYPGWF LCTVPEADQP VRLTQLPENG GWNAPITDFY

FQQCD
Length:155
Mass (Da):16,962
Last modified:May 1, 2000 - v1
Checksum:iB96DB5EFA2612E25
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271L → P in PSORS14; expression of the protein is severely impaired compared to wild-type; the mutant protein is substantially less able to inhibit IL1RL2 signaling than wild-type. 1 Publication
VAR_066646
Natural varianti47 – 471N → S.1 Publication
Corresponds to variant rs28938777 [ dbSNP | Ensembl ].
VAR_023239
Natural varianti48 – 481R → W in PSORS14. 1 Publication
VAR_066647
Natural varianti113 – 1131S → L in PSORS14. 1 Publication
Corresponds to variant rs144478519 [ dbSNP | Ensembl ].
VAR_066648
Natural varianti123 – 1231T → R in PSORS14; shows impaired expression of the mutant protein which fails to antagonize the IL-36 signaling pathway. 1 Publication
VAR_068972

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201830 mRNA. Translation: AAF25210.1.
AF186094 mRNA. Translation: AAF02757.1.
AJ242737 mRNA. Translation: CAB59822.1.
AJ242738 mRNA. Translation: CAB59823.1.
AJ271338 Genomic DNA. Translation: CAB67704.1.
AF216693 Genomic DNA. Translation: AAF76981.1.
AF230377 mRNA. Translation: AAF91274.1.
BN000002 Genomic DNA. Translation: CAD29877.1.
AY359117 mRNA. Translation: AAQ89475.1.
AK290249 mRNA. Translation: BAF82938.1.
AY972853 Genomic DNA. Translation: AAX59031.1.
AC016724 Genomic DNA. Translation: AAY14990.1.
CH471217 Genomic DNA. Translation: EAW73617.1.
BC024747 mRNA. Translation: AAH24747.1.
CCDSiCCDS2111.1.
PIRiJC7104.
RefSeqiNP_036407.1. NM_012275.2.
NP_775262.1. NM_173170.1.
XP_005263695.1. XM_005263638.1.
UniGeneiHs.516301.

Genome annotation databases

EnsembliENST00000346807; ENSP00000259212; ENSG00000136695.
ENST00000393200; ENSP00000376896; ENSG00000136695.
GeneIDi26525.
KEGGihsa:26525.
UCSCiuc002tis.3. human.

Polymorphism databases

DMDMi25008600.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201830 mRNA. Translation: AAF25210.1.
AF186094 mRNA. Translation: AAF02757.1.
AJ242737 mRNA. Translation: CAB59822.1.
AJ242738 mRNA. Translation: CAB59823.1.
AJ271338 Genomic DNA. Translation: CAB67704.1.
AF216693 Genomic DNA. Translation: AAF76981.1.
AF230377 mRNA. Translation: AAF91274.1.
BN000002 Genomic DNA. Translation: CAD29877.1.
AY359117 mRNA. Translation: AAQ89475.1.
AK290249 mRNA. Translation: BAF82938.1.
AY972853 Genomic DNA. Translation: AAX59031.1.
AC016724 Genomic DNA. Translation: AAY14990.1.
CH471217 Genomic DNA. Translation: EAW73617.1.
BC024747 mRNA. Translation: AAH24747.1.
CCDSiCCDS2111.1.
PIRiJC7104.
RefSeqiNP_036407.1. NM_012275.2.
NP_775262.1. NM_173170.1.
XP_005263695.1. XM_005263638.1.
UniGeneiHs.516301.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4P0JX-ray2.30A/B2-135[»]
A/B147-155[»]
4P0KX-ray1.70A2-49[»]
A55-135[»]
A147-155[»]
4P0LX-ray1.55A2-49[»]
A55-135[»]
A147-155[»]
ProteinModelPortaliQ9UBH0.
SMRiQ9UBH0. Positions 4-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117728. 7 interactions.
IntActiQ9UBH0. 5 interactions.
MINTiMINT-1194342.
STRINGi9606.ENSP00000259212.

Polymorphism databases

DMDMi25008600.

Proteomic databases

PaxDbiQ9UBH0.
PRIDEiQ9UBH0.

Protocols and materials databases

DNASUi26525.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346807; ENSP00000259212; ENSG00000136695.
ENST00000393200; ENSP00000376896; ENSG00000136695.
GeneIDi26525.
KEGGihsa:26525.
UCSCiuc002tis.3. human.

Organism-specific databases

CTDi26525.
GeneCardsiGC02P113817.
HGNCiHGNC:15561. IL36RN.
HPAiHPA034542.
MIMi605507. gene.
614204. phenotype.
neXtProtiNX_Q9UBH0.
Orphaneti163931. Acrodermatitis continua suppurativa of Hallopeau.
247353. Generalized pustular psoriasis.
163927. Pustulosis palmaris et plantaris.
PharmGKBiPA38388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46537.
GeneTreeiENSGT00530000062899.
HOVERGENiHBG052099.
InParanoidiQ9UBH0.
KOiK05483.
OMAiMKDSALK.
OrthoDBiEOG7QG45K.
PhylomeDBiQ9UBH0.
TreeFamiTF300203.

Miscellaneous databases

GeneWikiiIL1F5.
GenomeRNAii26525.
NextBioi48854.
PROiQ9UBH0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBH0.
CleanExiHS_IL1F5.
ExpressionAtlasiQ9UBH0. baseline and differential.
GenevestigatoriQ9UBH0.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003297. IL-1RA/IL-36.
IPR027171. IL-36RA.
[Graphical view]
PANTHERiPTHR10078:SF7. PTHR10078:SF7. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01360. INTRLEUKIN1X.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal skin.
  3. "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities."
    Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H.
    Eur. J. Immunol. 30:3299-3308(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2."
    Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A.
    J. Immunol. 167:1440-1446(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  5. "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2."
    Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S., Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y.
    Genomics 66:213-216(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "A sequence-based map of the nine genes of the human interleukin-1 cluster."
    Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K.
    Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  9. SeattleSNPs variation discovery resource
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-47.
  10. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  13. "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
    Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A., Sims J.E.
    J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CLEAVAGE OF INITIATOR METHIONINE.
  14. "The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses."
    Gresnigt M.S., Roesler B., Jacobs C.W., Becker K.L., Joosten L.A., van der Meer J.W., Netea M.G., Dinarello C.A., van de Veerdonk F.L.
    Eur. J. Immunol. 43:416-426(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  15. "Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis."
    Onoufriadis A., Simpson M.A., Pink A.E., Di Meglio P., Smith C.H., Pullabhatla V., Knight J., Spain S.L., Nestle F.O., Burden A.D., Capon F., Trembath R.C., Barker J.N.
    Am. J. Hum. Genet. 89:432-437(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PSORS14 TRP-48 AND LEU-113.
  16. Cited for: VARIANT PSORS14 PRO-27, CHARACTERIZATION OF VARIANT PSORS14 PRO-27.
  17. "Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis."
    Farooq M., Nakai H., Fujimoto A., Fujikawa H., Matsuyama A., Kariya N., Aizawa A., Fujiwara H., Ito M., Shimomura Y.
    Hum. Mutat. 34:176-183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PSORS14 ARG-123, CHARACTERIZATION OF VARIANT PSORS14 ARG-123.

Entry informationi

Entry nameiI36RA_HUMAN
AccessioniPrimary (citable) accession number: Q9UBH0
Secondary accession number(s): A8K2I4, Q56AT9, Q7RTZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.