Reviewed, UniProtKB/Swiss-Prot Q9UBH0 (IL1F5_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-1 family member 5
      Short name=IL-1F5
Alternative name(s):
    Interleukin-1 delta
      Short name=IL-1 delta
    FIL1 delta
    Interleukin-1-like protein 1
      Short name=IL-1L1
    Interleukin-1 HY1
      Short name=IL-1HY1
    Interleukin-1 receptor antagonist homolog 1
      Short name=IL-1ra homolog 1
    IL-1-related protein 3
      Short name=IL-1RP3

Gene names

Name:	IL1F5
Synonyms:	FIL1D, IL1HY1, IL1L1, IL1RP3
ORF Names:	UNQ1896/PRO4342

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Subcellular location	Secreted.
Tissue specificity	Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Induction	By phorbol ester (PMA) and lipopolysaccharide (LPS) treatment in macrophage cell line.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-1 receptor antagonist activity Ref.2 Traceable author statement. Source: ProtInc interleukin-1 receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 155	155	Interleukin-1 family member 5		PRO_0000153642
Amino acid modifications
	Disulfide bond	8 ↔ 154		By similarity
Natural variations
	Natural variant	47	1	N → S		VAR_023239

Sequences

	Sequence		Length	Mass (Da)
	Q9UBH0-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B96DB5EFA2612E25	FASTA	155	16,962
	10 20 30 40 50 60 MVLSGALCFR MKDSALKVLY LHNNQLLAGG LHAGKVIKGE EISVVPNRWL DASLSPVILG 70 80 90 100 110 120 VQGGSQCLSC GVGQEPTLTL EPVNIMELYL GAKESKSFTF YRRDMGLTSS FESAAYPGWF 130 140 150 LCTVPEADQP VRLTQLPENG GWNAPITDFY FQQCD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Four new members expand the IL-1 superfamily." Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E. J. Biol. Chem. 275:1169-1175(2000) [PubMed: 10625660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"IL1HY1: a novel interleukin-1 receptor antagonist gene." Mulero J.J., Pace A.M., Nelken S.T., Loeb D.B., Correa T.R., Drmanac R., Ford J.E. Biochem. Biophys. Res. Commun. 263:702-706(1999) [PubMed: 10512743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal skin.
[3]	"A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities." Barton J.L., Herbst R., Bosisio D., Higgins L., Nicklin M.J.H. Eur. J. Immunol. 30:3299-3308(2000) [PubMed: 11093146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[4]	"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A. J. Immunol. 167:1440-1446(2001) [PubMed: 11466363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Identification and gene organization of three novel members of the IL-1 family on human chromosome 2." Busfield S.J., Comrack C.A., Yu G., Chickering T.W., Smutko J.S., Zhou H., Leiby K.R., Holmgren L.M., Gearing D.P., Pan Y. Genomics 66:213-216(2000) [PubMed: 10860666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.
[9]	SeattleSNPs variation discovery resource Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-47.
[10]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-1 entry

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF201830 mRNA. Translation: AAF25210.1. AF186094 mRNA. Translation: AAF02757.1. AJ242737 mRNA. Translation: CAB59822.1. AJ242738 mRNA. Translation: CAB59823.1. AJ271338 Genomic DNA. Translation: CAB67704.1. AF216693 Genomic DNA. Translation: AAF76981.1. AF230377 mRNA. Translation: AAF91274.1. BN000002 Genomic DNA. Translation: CAD29877.1. AY359117 mRNA. Translation: AAQ89475.1. AK290249 mRNA. Translation: BAF82938.1. AY972853 Genomic DNA. Translation: AAX59031.1. AC016724 Genomic DNA. Translation: AAY14990.1. CH471217 Genomic DNA. Translation: EAW73617.1. BC024747 mRNA. Translation: AAH24747.1.
IPI	IPI00017500.
PIR	JC7104.
RefSeq	NP_036407.1. NP_775262.1.
UniGene	Hs.516301
3D structure databases
HSSP	HSSP built from PDB template 1ILR based on UniProtKB P18510.
SMR	Q9UBH0. Positions 2-155.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UBH0. 4 interactions.
STRING	Q9UBH0.
Proteomic databases
PRIDE	Q9UBH0.
Genome annotation databases
Ensembl	ENST00000346807; ENSP00000259212; ENSG00000136695; Homo sapiens. [Genome view] ENST00000393200; ENSP00000376896; ENSG00000136695; Homo sapiens. [Genome view] ENST00000437409; ENSP00000409262; ENSG00000136695; Homo sapiens. [Genome view]
GeneID	26525.
KEGG	hsa:26525.
UCSC	uc002tis.1. human.
Organism-specific databases
CTD	26525.
GeneCards	GC02P113532.
H-InvDB	HIX0002388.
HGNC	HGNC:15561. IL1F5.
MIM	605507. gene.
PharmGKB	PA38388.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UBH0.
HOVERGEN	Q9UBH0.
OMA	RMKDSAL.
Gene expression databases
ArrayExpress	Q9UBH0.
Bgee	Q9UBH0.
CleanEx	HS_IL1F5.
Genevestigator	Q9UBH0.
GermOnline	ENSG00000136695. Homo sapiens.
Family and domain databases
InterPro	IPR003297. IL_rcpt_IL1RA. IPR000975. Interleukin_1. [Graphical view]
Pfam	PF00340. IL1. 1 hit. [Graphical view]
PRINTS	PR00264. INTERLEUKIN1. PR01360. INTRLEUKIN1X.
ProDom	PD002536. Interleukin_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00125. IL1. 1 hit. [Graphical view]
PROSITE	PS00253. INTERLEUKIN_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48854.
SOURCE	Search...

Entry information

Entry name

IL1F5_HUMAN

Accession

Primary (citable) accession number: Q9UBH0
Secondary accession number(s): A8K2I4, Q56AT9, Q7RTZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.