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Protein

Recombining binding protein suppressor of hairless-like protein

Gene

RBPJL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative transcription factor, which cooperates with EBNA2 to activate transcription.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi80 – 878By similarity
DNA bindingi221 – 23010By similarity
DNA bindingi293 – 32937By similarityAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: Ensembl
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless-like protein
Alternative name(s):
Transcription factor RBP-L
Gene namesi
Name:RBPJL
Synonyms:RBPL, RBPSUHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13761. RBPJL.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400876.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Recombining binding protein suppressor of hairless-like proteinPRO_0000208570Add
BLAST

Proteomic databases

MaxQBiQ9UBG7.
PaxDbiQ9UBG7.
PRIDEiQ9UBG7.

PTM databases

PhosphoSiteiQ9UBG7.

Expressioni

Gene expression databases

BgeeiQ9UBG7.
CleanExiHS_RBPJL.
ExpressionAtlasiQ9UBG7. baseline and differential.
GenevestigatoriQ9UBG7.

Organism-specific databases

HPAiCAB006846.

Interactioni

Subunit structurei

Interacts weakly with EBNA2. Does not interact with any Notch proteins (By similarity).By similarity

Protein-protein interaction databases

BioGridi116448. 1 interaction.
DIPiDIP-60277N.
STRINGi9606.ENSP00000341243.

Structurei

3D structure databases

ProteinModelPortaliQ9UBG7.
SMRiQ9UBG7. Positions 52-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini387 – 512126IPT/TIGAdd
BLAST

Sequence similaritiesi

Belongs to the Su(H) family.Curated
Contains 1 IPT/TIG domain.Curated

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiQ9UBG7.
KOiK06053.
OMAiDADKRKH.
OrthoDBiEOG7BP826.
PhylomeDBiQ9UBG7.
TreeFamiTF314117.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBG7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT
60 70 80 90 100
TILRGGVRRC LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG
110 120 130 140 150
WRVKPGQDQA HQAGETGPTV CGYMGLDSAS GSATETQKLN FEQQPDSREF
160 170 180 190 200
GCAKTLYISD ADKRKHFRLV LRLVLRGGRE LGTFHSRLIK VISKPSQKKQ
210 220 230 240 250
SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA SARQWAAFTL
260 270 280 290 300
HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL
310 320 330 340 350
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR
360 370 380 390 400
ALLNDSSCWT IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA
410 420 430 440 450
TLELHGENFH AGLKVWFGDV EAETMYRSPR SLVCVVPDVA AFCSDWRWLR
460 470 480 490 500
APITIPMSLV RADGLFYPSA FSFTYTPEYS VRPGHPGVPE PATDADALLE
510
SIHQEFTRTN FHLFIQT
Length:517
Mass (Da):56,751
Last modified:May 18, 2010 - v3
Checksum:i1DB1505A800F7788
GO
Isoform 2 (identifier: Q9UBG7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: Missing.

Show »
Length:516
Mass (Da):56,594
Checksum:i272055B8A51C1A00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4314SPRS → YGVEPAV in BAA86121. 1 PublicationCurated
Sequence conflicti428 – 4314SPRS → YGVEPAV in BAA88232. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei427 – 4271Missing in isoform 2. 2 PublicationsVSP_039150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027710 mRNA. Translation: BAA87051.1.
AB024964 mRNA. Translation: BAA88232.1.
AB026048 mRNA. Translation: BAA86121.1.
AL021578 Genomic DNA. Translation: CAI21079.1.
AL021578 Genomic DNA. Translation: CAI21080.1.
CH471077 Genomic DNA. Translation: EAW75864.1.
CCDSiCCDS13349.1. [Q9UBG7-1]
CCDS63283.1. [Q9UBG7-2]
RefSeqiNP_001268377.1. NM_001281448.1.
NP_001268378.1. NM_001281449.1. [Q9UBG7-2]
NP_055091.2. NM_014276.3. [Q9UBG7-1]
UniGeneiHs.248217.
Hs.278489.

Genome annotation databases

EnsembliENST00000343694; ENSP00000341243; ENSG00000124232. [Q9UBG7-1]
ENST00000372743; ENSP00000361828; ENSG00000124232. [Q9UBG7-2]
GeneIDi11317.
KEGGihsa:11317.
UCSCiuc002xns.3. human. [Q9UBG7-1]

Polymorphism databases

DMDMi296452986.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027710 mRNA. Translation: BAA87051.1.
AB024964 mRNA. Translation: BAA88232.1.
AB026048 mRNA. Translation: BAA86121.1.
AL021578 Genomic DNA. Translation: CAI21079.1.
AL021578 Genomic DNA. Translation: CAI21080.1.
CH471077 Genomic DNA. Translation: EAW75864.1.
CCDSiCCDS13349.1. [Q9UBG7-1]
CCDS63283.1. [Q9UBG7-2]
RefSeqiNP_001268377.1. NM_001281448.1.
NP_001268378.1. NM_001281449.1. [Q9UBG7-2]
NP_055091.2. NM_014276.3. [Q9UBG7-1]
UniGeneiHs.248217.
Hs.278489.

3D structure databases

ProteinModelPortaliQ9UBG7.
SMRiQ9UBG7. Positions 52-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116448. 1 interaction.
DIPiDIP-60277N.
STRINGi9606.ENSP00000341243.

PTM databases

PhosphoSiteiQ9UBG7.

Polymorphism databases

DMDMi296452986.

Proteomic databases

MaxQBiQ9UBG7.
PaxDbiQ9UBG7.
PRIDEiQ9UBG7.

Protocols and materials databases

DNASUi11317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343694; ENSP00000341243; ENSG00000124232. [Q9UBG7-1]
ENST00000372743; ENSP00000361828; ENSG00000124232. [Q9UBG7-2]
GeneIDi11317.
KEGGihsa:11317.
UCSCiuc002xns.3. human. [Q9UBG7-1]

Organism-specific databases

CTDi11317.
GeneCardsiGC20P043935.
HGNCiHGNC:13761. RBPJL.
HPAiCAB006846.
neXtProtiNX_Q9UBG7.
PharmGKBiPA162400876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295376.
GeneTreeiENSGT00390000005197.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
InParanoidiQ9UBG7.
KOiK06053.
OMAiDADKRKH.
OrthoDBiEOG7BP826.
PhylomeDBiQ9UBG7.
TreeFamiTF314117.

Miscellaneous databases

GenomeRNAii11317.
NextBioi42995.
PROiQ9UBG7.

Gene expression databases

BgeeiQ9UBG7.
CleanExiHS_RBPJL.
ExpressionAtlasiQ9UBG7. baseline and differential.
GenevestigatoriQ9UBG7.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human mRNA for transcription factor RBP-L."
    Saito T., Miyajima N.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Isaka S., Koyama K., Nakamura Y., Okamura S., Azuma C., Kimura T.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRBPJL_HUMAN
AccessioniPrimary (citable) accession number: Q9UBG7
Secondary accession number(s): O95723
, Q5QPU9, Q5QPV0, Q9ULV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.