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Protein

Recombining binding protein suppressor of hairless-like protein

Gene

RBPJL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transcription factor, which cooperates with EBNA2 to activate transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi80 – 87By similarity8
DNA bindingi221 – 230By similarity10
DNA bindingi293 – 329By similarityAdd BLAST37

GO - Molecular functioni

GO - Biological processi

  • signal transduction Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless-like protein
Alternative name(s):
Transcription factor RBP-L
Gene namesi
Name:RBPJL
Synonyms:RBPL, RBPSUHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124232.10
HGNCiHGNC:13761 RBPJL
MIMi616104 gene
neXtProtiNX_Q9UBG7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124232
PharmGKBiPA162400876

Polymorphism and mutation databases

DMDMi296452986

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085701 – 517Recombining binding protein suppressor of hairless-like proteinAdd BLAST517

Proteomic databases

MaxQBiQ9UBG7
PaxDbiQ9UBG7
PeptideAtlasiQ9UBG7
PRIDEiQ9UBG7

PTM databases

iPTMnetiQ9UBG7
PhosphoSitePlusiQ9UBG7

Expressioni

Gene expression databases

BgeeiENSG00000124232
CleanExiHS_RBPJL
ExpressionAtlasiQ9UBG7 baseline and differential
GenevisibleiQ9UBG7 HS

Organism-specific databases

HPAiCAB006846

Interactioni

Subunit structurei

Interacts weakly with EBNA2. Does not interact with any Notch proteins (By similarity).By similarity

Protein-protein interaction databases

BioGridi116448, 2 interactors
DIPiDIP-60277N
IntActiQ9UBG7, 2 interactors
STRINGi9606.ENSP00000341243

Structurei

3D structure databases

ProteinModelPortaliQ9UBG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini387 – 512IPT/TIGAdd BLAST126

Sequence similaritiesi

Belongs to the Su(H) family.Curated

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
HOGENOMiHOG000253907
HOVERGENiHBG006618
InParanoidiQ9UBG7
KOiK06053
OMAiDADKRKH
OrthoDBiEOG091G057S
PhylomeDBiQ9UBG7
TreeFamiTF314117

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 2 hits
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UBG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT
60 70 80 90 100
TILRGGVRRC LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG
110 120 130 140 150
WRVKPGQDQA HQAGETGPTV CGYMGLDSAS GSATETQKLN FEQQPDSREF
160 170 180 190 200
GCAKTLYISD ADKRKHFRLV LRLVLRGGRE LGTFHSRLIK VISKPSQKKQ
210 220 230 240 250
SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA SARQWAAFTL
260 270 280 290 300
HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL
310 320 330 340 350
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR
360 370 380 390 400
ALLNDSSCWT IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA
410 420 430 440 450
TLELHGENFH AGLKVWFGDV EAETMYRSPR SLVCVVPDVA AFCSDWRWLR
460 470 480 490 500
APITIPMSLV RADGLFYPSA FSFTYTPEYS VRPGHPGVPE PATDADALLE
510
SIHQEFTRTN FHLFIQT
Length:517
Mass (Da):56,751
Last modified:May 18, 2010 - v3
Checksum:i1DB1505A800F7788
GO
Isoform 2 (identifier: Q9UBG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: Missing.

Show »
Length:516
Mass (Da):56,594
Checksum:i272055B8A51C1A00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428 – 431SPRS → YGVEPAV in BAA86121 (Ref. 2) Curated4
Sequence conflicti428 – 431SPRS → YGVEPAV in BAA88232 (Ref. 2) Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039150427Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027710 mRNA Translation: BAA87051.1
AB024964 mRNA Translation: BAA88232.1
AB026048 mRNA Translation: BAA86121.1
AL021578 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75864.1
CCDSiCCDS13349.1 [Q9UBG7-1]
CCDS63283.1 [Q9UBG7-2]
RefSeqiNP_001268377.1, NM_001281448.1
NP_001268378.1, NM_001281449.1 [Q9UBG7-2]
NP_055091.2, NM_014276.3 [Q9UBG7-1]
UniGeneiHs.248217
Hs.278489

Genome annotation databases

EnsembliENST00000343694; ENSP00000341243; ENSG00000124232 [Q9UBG7-1]
ENST00000372743; ENSP00000361828; ENSG00000124232 [Q9UBG7-2]
GeneIDi11317
KEGGihsa:11317
UCSCiuc002xns.5 human [Q9UBG7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBPJL_HUMAN
AccessioniPrimary (citable) accession number: Q9UBG7
Secondary accession number(s): O95723
, Q5QPU9, Q5QPV0, Q9ULV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health