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Q9UBG7

- RBPJL_HUMAN

UniProt

Q9UBG7 - RBPJL_HUMAN

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Protein

Recombining binding protein suppressor of hairless-like protein

Gene
RBPJL, RBPL, RBPSUHL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Putative transcription factor, which cooperates with EBNA2 to activate transcription By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi80 – 878 By similarity
DNA bindingi221 – 23010 By similarity
DNA bindingi293 – 32937 By similarityAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: Ensembl
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless-like protein
Alternative name(s):
Transcription factor RBP-L
Gene namesi
Name:RBPJL
Synonyms:RBPL, RBPSUHL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:13761. RBPJL.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400876.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Recombining binding protein suppressor of hairless-like proteinPRO_0000208570Add
BLAST

Proteomic databases

MaxQBiQ9UBG7.
PaxDbiQ9UBG7.
PRIDEiQ9UBG7.

PTM databases

PhosphoSiteiQ9UBG7.

Expressioni

Gene expression databases

ArrayExpressiQ9UBG7.
BgeeiQ9UBG7.
CleanExiHS_RBPJL.
GenevestigatoriQ9UBG7.

Organism-specific databases

HPAiCAB006846.

Interactioni

Subunit structurei

Interacts weakly with EBNA2. Does not interact with any Notch proteins By similarity.

Protein-protein interaction databases

BioGridi116448. 1 interaction.
DIPiDIP-60277N.
STRINGi9606.ENSP00000341243.

Structurei

3D structure databases

ProteinModelPortaliQ9UBG7.
SMRiQ9UBG7. Positions 52-478.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini387 – 512126IPT/TIGAdd
BLAST

Sequence similaritiesi

Belongs to the Su(H) family.
Contains 1 IPT/TIG domain.

Phylogenomic databases

eggNOGiNOG295376.
HOGENOMiHOG000253907.
HOVERGENiHBG006618.
KOiK06053.
OMAiDADKRKH.
OrthoDBiEOG7BP826.
PhylomeDBiQ9UBG7.
TreeFamiTF314117.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamiPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMiSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UBG7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT    50
TILRGGVRRC LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG 100
WRVKPGQDQA HQAGETGPTV CGYMGLDSAS GSATETQKLN FEQQPDSREF 150
GCAKTLYISD ADKRKHFRLV LRLVLRGGRE LGTFHSRLIK VISKPSQKKQ 200
SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA SARQWAAFTL 250
HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL 300
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR 350
ALLNDSSCWT IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA 400
TLELHGENFH AGLKVWFGDV EAETMYRSPR SLVCVVPDVA AFCSDWRWLR 450
APITIPMSLV RADGLFYPSA FSFTYTPEYS VRPGHPGVPE PATDADALLE 500
SIHQEFTRTN FHLFIQT 517
Length:517
Mass (Da):56,751
Last modified:May 18, 2010 - v3
Checksum:i1DB1505A800F7788
GO
Isoform 2 (identifier: Q9UBG7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: Missing.

Show »
Length:516
Mass (Da):56,594
Checksum:i272055B8A51C1A00
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei427 – 4271Missing in isoform 2. VSP_039150

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti428 – 4314SPRS → YGVEPAV in BAA86121. 1 Publication
Sequence conflicti428 – 4314SPRS → YGVEPAV in BAA88232. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027710 mRNA. Translation: BAA87051.1.
AB024964 mRNA. Translation: BAA88232.1.
AB026048 mRNA. Translation: BAA86121.1.
AL021578 Genomic DNA. Translation: CAI21079.1.
AL021578 Genomic DNA. Translation: CAI21080.1.
CH471077 Genomic DNA. Translation: EAW75864.1.
CCDSiCCDS13349.1. [Q9UBG7-1]
CCDS63283.1. [Q9UBG7-2]
RefSeqiNP_001268377.1. NM_001281448.1.
NP_001268378.1. NM_001281449.1. [Q9UBG7-2]
NP_055091.2. NM_014276.3. [Q9UBG7-1]
UniGeneiHs.248217.
Hs.278489.

Genome annotation databases

EnsembliENST00000343694; ENSP00000341243; ENSG00000124232. [Q9UBG7-1]
ENST00000372743; ENSP00000361828; ENSG00000124232. [Q9UBG7-2]
GeneIDi11317.
KEGGihsa:11317.
UCSCiuc002xns.3. human. [Q9UBG7-1]

Polymorphism databases

DMDMi296452986.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027710 mRNA. Translation: BAA87051.1 .
AB024964 mRNA. Translation: BAA88232.1 .
AB026048 mRNA. Translation: BAA86121.1 .
AL021578 Genomic DNA. Translation: CAI21079.1 .
AL021578 Genomic DNA. Translation: CAI21080.1 .
CH471077 Genomic DNA. Translation: EAW75864.1 .
CCDSi CCDS13349.1. [Q9UBG7-1 ]
CCDS63283.1. [Q9UBG7-2 ]
RefSeqi NP_001268377.1. NM_001281448.1.
NP_001268378.1. NM_001281449.1. [Q9UBG7-2 ]
NP_055091.2. NM_014276.3. [Q9UBG7-1 ]
UniGenei Hs.248217.
Hs.278489.

3D structure databases

ProteinModelPortali Q9UBG7.
SMRi Q9UBG7. Positions 52-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116448. 1 interaction.
DIPi DIP-60277N.
STRINGi 9606.ENSP00000341243.

PTM databases

PhosphoSitei Q9UBG7.

Polymorphism databases

DMDMi 296452986.

Proteomic databases

MaxQBi Q9UBG7.
PaxDbi Q9UBG7.
PRIDEi Q9UBG7.

Protocols and materials databases

DNASUi 11317.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343694 ; ENSP00000341243 ; ENSG00000124232 . [Q9UBG7-1 ]
ENST00000372743 ; ENSP00000361828 ; ENSG00000124232 . [Q9UBG7-2 ]
GeneIDi 11317.
KEGGi hsa:11317.
UCSCi uc002xns.3. human. [Q9UBG7-1 ]

Organism-specific databases

CTDi 11317.
GeneCardsi GC20P043935.
HGNCi HGNC:13761. RBPJL.
HPAi CAB006846.
neXtProti NX_Q9UBG7.
PharmGKBi PA162400876.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295376.
HOGENOMi HOG000253907.
HOVERGENi HBG006618.
KOi K06053.
OMAi DADKRKH.
OrthoDBi EOG7BP826.
PhylomeDBi Q9UBG7.
TreeFami TF314117.

Miscellaneous databases

GenomeRNAii 11317.
NextBioi 42995.
PROi Q9UBG7.

Gene expression databases

ArrayExpressi Q9UBG7.
Bgeei Q9UBG7.
CleanExi HS_RBPJL.
Genevestigatori Q9UBG7.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view ]
Pfami PF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view ]
SUPFAMi SSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human mRNA for transcription factor RBP-L."
    Saito T., Miyajima N.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Isaka S., Koyama K., Nakamura Y., Okamura S., Azuma C., Kimura T.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRBPJL_HUMAN
AccessioniPrimary (citable) accession number: Q9UBG7
Secondary accession number(s): O95723
, Q5QPU9, Q5QPV0, Q9ULV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi