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Q9UBG7

- RBPJL_HUMAN

UniProt

Q9UBG7 - RBPJL_HUMAN

Protein

Recombining binding protein suppressor of hairless-like protein

Gene

RBPJL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Putative transcription factor, which cooperates with EBNA2 to activate transcription.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi80 – 878By similarity
    DNA bindingi221 – 23010By similarity
    DNA bindingi293 – 32937By similarityAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: InterPro
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: Ensembl
    2. signal transduction Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Recombining binding protein suppressor of hairless-like protein
    Alternative name(s):
    Transcription factor RBP-L
    Gene namesi
    Name:RBPJL
    Synonyms:RBPL, RBPSUHL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:13761. RBPJL.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400876.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Recombining binding protein suppressor of hairless-like proteinPRO_0000208570Add
    BLAST

    Proteomic databases

    MaxQBiQ9UBG7.
    PaxDbiQ9UBG7.
    PRIDEiQ9UBG7.

    PTM databases

    PhosphoSiteiQ9UBG7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UBG7.
    BgeeiQ9UBG7.
    CleanExiHS_RBPJL.
    GenevestigatoriQ9UBG7.

    Organism-specific databases

    HPAiCAB006846.

    Interactioni

    Subunit structurei

    Interacts weakly with EBNA2. Does not interact with any Notch proteins By similarity.By similarity

    Protein-protein interaction databases

    BioGridi116448. 1 interaction.
    DIPiDIP-60277N.
    STRINGi9606.ENSP00000341243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UBG7.
    SMRiQ9UBG7. Positions 52-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini387 – 512126IPT/TIGAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Su(H) family.Curated
    Contains 1 IPT/TIG domain.Curated

    Phylogenomic databases

    eggNOGiNOG295376.
    HOGENOMiHOG000253907.
    HOVERGENiHBG006618.
    KOiK06053.
    OMAiDADKRKH.
    OrthoDBiEOG7BP826.
    PhylomeDBiQ9UBG7.
    TreeFamiTF314117.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.1450. 1 hit.
    InterProiIPR015350. Beta-trefoil_DNA-bd_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR015351. LAG1_DNA-bd.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view]
    PfamiPF09270. BTD. 1 hit.
    PF09271. LAG1-DNAbind. 1 hit.
    [Graphical view]
    SUPFAMiSSF110217. SSF110217. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UBG7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT    50
    TILRGGVRRC LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG 100
    WRVKPGQDQA HQAGETGPTV CGYMGLDSAS GSATETQKLN FEQQPDSREF 150
    GCAKTLYISD ADKRKHFRLV LRLVLRGGRE LGTFHSRLIK VISKPSQKKQ 200
    SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA SARQWAAFTL 250
    HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL 300
    LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR 350
    ALLNDSSCWT IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA 400
    TLELHGENFH AGLKVWFGDV EAETMYRSPR SLVCVVPDVA AFCSDWRWLR 450
    APITIPMSLV RADGLFYPSA FSFTYTPEYS VRPGHPGVPE PATDADALLE 500
    SIHQEFTRTN FHLFIQT 517
    Length:517
    Mass (Da):56,751
    Last modified:May 18, 2010 - v3
    Checksum:i1DB1505A800F7788
    GO
    Isoform 2 (identifier: Q9UBG7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         427-427: Missing.

    Show »
    Length:516
    Mass (Da):56,594
    Checksum:i272055B8A51C1A00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti428 – 4314SPRS → YGVEPAV in BAA86121. 1 PublicationCurated
    Sequence conflicti428 – 4314SPRS → YGVEPAV in BAA88232. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei427 – 4271Missing in isoform 2. 2 PublicationsVSP_039150

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027710 mRNA. Translation: BAA87051.1.
    AB024964 mRNA. Translation: BAA88232.1.
    AB026048 mRNA. Translation: BAA86121.1.
    AL021578 Genomic DNA. Translation: CAI21079.1.
    AL021578 Genomic DNA. Translation: CAI21080.1.
    CH471077 Genomic DNA. Translation: EAW75864.1.
    CCDSiCCDS13349.1. [Q9UBG7-1]
    CCDS63283.1. [Q9UBG7-2]
    RefSeqiNP_001268377.1. NM_001281448.1.
    NP_001268378.1. NM_001281449.1. [Q9UBG7-2]
    NP_055091.2. NM_014276.3. [Q9UBG7-1]
    UniGeneiHs.248217.
    Hs.278489.

    Genome annotation databases

    EnsembliENST00000343694; ENSP00000341243; ENSG00000124232. [Q9UBG7-1]
    ENST00000372743; ENSP00000361828; ENSG00000124232. [Q9UBG7-2]
    GeneIDi11317.
    KEGGihsa:11317.
    UCSCiuc002xns.3. human. [Q9UBG7-1]

    Polymorphism databases

    DMDMi296452986.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB027710 mRNA. Translation: BAA87051.1 .
    AB024964 mRNA. Translation: BAA88232.1 .
    AB026048 mRNA. Translation: BAA86121.1 .
    AL021578 Genomic DNA. Translation: CAI21079.1 .
    AL021578 Genomic DNA. Translation: CAI21080.1 .
    CH471077 Genomic DNA. Translation: EAW75864.1 .
    CCDSi CCDS13349.1. [Q9UBG7-1 ]
    CCDS63283.1. [Q9UBG7-2 ]
    RefSeqi NP_001268377.1. NM_001281448.1.
    NP_001268378.1. NM_001281449.1. [Q9UBG7-2 ]
    NP_055091.2. NM_014276.3. [Q9UBG7-1 ]
    UniGenei Hs.248217.
    Hs.278489.

    3D structure databases

    ProteinModelPortali Q9UBG7.
    SMRi Q9UBG7. Positions 52-478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116448. 1 interaction.
    DIPi DIP-60277N.
    STRINGi 9606.ENSP00000341243.

    PTM databases

    PhosphoSitei Q9UBG7.

    Polymorphism databases

    DMDMi 296452986.

    Proteomic databases

    MaxQBi Q9UBG7.
    PaxDbi Q9UBG7.
    PRIDEi Q9UBG7.

    Protocols and materials databases

    DNASUi 11317.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343694 ; ENSP00000341243 ; ENSG00000124232 . [Q9UBG7-1 ]
    ENST00000372743 ; ENSP00000361828 ; ENSG00000124232 . [Q9UBG7-2 ]
    GeneIDi 11317.
    KEGGi hsa:11317.
    UCSCi uc002xns.3. human. [Q9UBG7-1 ]

    Organism-specific databases

    CTDi 11317.
    GeneCardsi GC20P043935.
    HGNCi HGNC:13761. RBPJL.
    HPAi CAB006846.
    neXtProti NX_Q9UBG7.
    PharmGKBi PA162400876.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295376.
    HOGENOMi HOG000253907.
    HOVERGENi HBG006618.
    KOi K06053.
    OMAi DADKRKH.
    OrthoDBi EOG7BP826.
    PhylomeDBi Q9UBG7.
    TreeFami TF314117.

    Miscellaneous databases

    GenomeRNAii 11317.
    NextBioi 42995.
    PROi Q9UBG7.

    Gene expression databases

    ArrayExpressi Q9UBG7.
    Bgeei Q9UBG7.
    CleanExi HS_RBPJL.
    Genevestigatori Q9UBG7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.1450. 1 hit.
    InterProi IPR015350. Beta-trefoil_DNA-bd_dom.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR015351. LAG1_DNA-bd.
    IPR008967. p53-like_TF_DNA-bd.
    [Graphical view ]
    Pfami PF09270. BTD. 1 hit.
    PF09271. LAG1-DNAbind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110217. SSF110217. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human mRNA for transcription factor RBP-L."
      Saito T., Miyajima N.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Isaka S., Koyama K., Nakamura Y., Okamura S., Azuma C., Kimura T.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRBPJL_HUMAN
    AccessioniPrimary (citable) accession number: Q9UBG7
    Secondary accession number(s): O95723
    , Q5QPU9, Q5QPV0, Q9ULV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3