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Q9UBG7 (RBPJL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Recombining binding protein suppressor of hairless-like protein
Alternative name(s):
Transcription factor RBP-L
Gene names
Name:RBPJL
Synonyms:RBPL, RBPSUHL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative transcription factor, which cooperates with EBNA2 to activate transcription By similarity.

Subunit structure

Interacts weakly with EBNA2. Does not interact with any Notch proteins By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the Su(H) family.

Contains 1 IPT/TIG domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UBG7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UBG7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Recombining binding protein suppressor of hairless-like protein
PRO_0000208570

Regions

Domain387 – 512126IPT/TIG
DNA binding80 – 878 By similarity
DNA binding221 – 23010 By similarity
DNA binding293 – 32937 By similarity

Natural variations

Alternative sequence4271Missing in isoform 2.
VSP_039150

Experimental info

Sequence conflict428 – 4314SPRS → YGVEPAV in BAA86121. Ref.2
Sequence conflict428 – 4314SPRS → YGVEPAV in BAA88232. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 1DB1505A800F7788

FASTA51756,751
        10         20         30         40         50         60 
MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT TILRGGVRRC 

        70         80         90        100        110        120 
LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG WRVKPGQDQA HQAGETGPTV 

       130        140        150        160        170        180 
CGYMGLDSAS GSATETQKLN FEQQPDSREF GCAKTLYISD ADKRKHFRLV LRLVLRGGRE 

       190        200        210        220        230        240 
LGTFHSRLIK VISKPSQKKQ SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA 

       250        260        270        280        290        300 
SARQWAAFTL HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL 

       310        320        330        340        350        360 
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR ALLNDSSCWT 

       370        380        390        400        410        420 
IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA TLELHGENFH AGLKVWFGDV 

       430        440        450        460        470        480 
EAETMYRSPR SLVCVVPDVA AFCSDWRWLR APITIPMSLV RADGLFYPSA FSFTYTPEYS 

       490        500        510 
VRPGHPGVPE PATDADALLE SIHQEFTRTN FHLFIQT 

« Hide

Isoform 2 [UniParc].

Checksum: 272055B8A51C1A00
Show »

FASTA51656,594

References

« Hide 'large scale' references
[1]"Human mRNA for transcription factor RBP-L."
Saito T., Miyajima N.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]Isaka S., Koyama K., Nakamura Y., Okamura S., Azuma C., Kimura T.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB027710 mRNA. Translation: BAA87051.1.
AB024964 mRNA. Translation: BAA88232.1.
AB026048 mRNA. Translation: BAA86121.1.
AL021578 Genomic DNA. Translation: CAI21079.1.
AL021578 Genomic DNA. Translation: CAI21080.1.
CH471077 Genomic DNA. Translation: EAW75864.1.
CCDSCCDS13349.1. [Q9UBG7-1]
CCDS63283.1. [Q9UBG7-2]
RefSeqNP_001268377.1. NM_001281448.1.
NP_001268378.1. NM_001281449.1. [Q9UBG7-2]
NP_055091.2. NM_014276.3. [Q9UBG7-1]
UniGeneHs.248217.
Hs.278489.

3D structure databases

ProteinModelPortalQ9UBG7.
SMRQ9UBG7. Positions 52-478.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116448. 1 interaction.
DIPDIP-60277N.
STRING9606.ENSP00000341243.

PTM databases

PhosphoSiteQ9UBG7.

Polymorphism databases

DMDM296452986.

Proteomic databases

MaxQBQ9UBG7.
PaxDbQ9UBG7.
PRIDEQ9UBG7.

Protocols and materials databases

DNASU11317.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343694; ENSP00000341243; ENSG00000124232. [Q9UBG7-1]
ENST00000372743; ENSP00000361828; ENSG00000124232. [Q9UBG7-2]
GeneID11317.
KEGGhsa:11317.
UCSCuc002xns.3. human. [Q9UBG7-1]

Organism-specific databases

CTD11317.
GeneCardsGC20P043935.
HGNCHGNC:13761. RBPJL.
HPACAB006846.
neXtProtNX_Q9UBG7.
PharmGKBPA162400876.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295376.
HOGENOMHOG000253907.
HOVERGENHBG006618.
KOK06053.
OMADADKRKH.
OrthoDBEOG7BP826.
PhylomeDBQ9UBG7.
TreeFamTF314117.

Gene expression databases

ArrayExpressQ9UBG7.
BgeeQ9UBG7.
CleanExHS_RBPJL.
GenevestigatorQ9UBG7.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.1450. 1 hit.
InterProIPR015350. Beta-trefoil_DNA-bd_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR015351. LAG1_DNA-bd.
IPR008967. p53-like_TF_DNA-bd.
[Graphical view]
PfamPF09270. BTD. 1 hit.
PF09271. LAG1-DNAbind. 1 hit.
[Graphical view]
SUPFAMSSF110217. SSF110217. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi11317.
NextBio42995.
PROQ9UBG7.

Entry information

Entry nameRBPJL_HUMAN
AccessionPrimary (citable) accession number: Q9UBG7
Secondary accession number(s): O95723 expand/collapse secondary AC list , Q5QPU9, Q5QPV0, Q9ULV9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM