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Protein

Cornulin

Gene

CRNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.2 Publications

Cofactori

Ca2+1 PublicationNote: Binds Ca2+.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi62 – 7312high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

GO - Biological processi

  • response to heat Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cornulin
Alternative name(s):
53 kDa putative calcium-binding protein
53 kDa squamous epithelial-induced stress protein
58 kDa heat shock protein
Squamous epithelial heat shock protein 53
Tumor-related protein
Gene namesi
Name:CRNN
Synonyms:C1orf10, DRC1, PDRC1, SEP53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1230. CRNN.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25601.

Polymorphism and mutation databases

BioMutaiCRNN.
DMDMi74761891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495CornulinPRO_0000305586Add
BLAST

Proteomic databases

EPDiQ9UBG3.
PaxDbiQ9UBG3.
PeptideAtlasiQ9UBG3.
PRIDEiQ9UBG3.

PTM databases

iPTMnetiQ9UBG3.
PhosphoSiteiQ9UBG3.

Expressioni

Tissue specificityi

Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).7 Publications

Inductioni

Up-regulated after heat shock, ponasterone A and deoxycholic acid.3 Publications

Gene expression databases

BgeeiQ9UBG3.
CleanExiHS_CRNN.
GenevisibleiQ9UBG3. HS.

Organism-specific databases

HPAiCAB026182.
HPA024343.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi119069. 23 interactions.
IntActiQ9UBG3. 1 interaction.
STRINGi9606.ENSP00000271835.

Structurei

3D structure databases

ProteinModelPortaliQ9UBG3.
SMRiQ9UBG3. Positions 4-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 8436EF-handPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi139 – 389251Gln-richAdd
BLAST

Domaini

The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.

Sequence similaritiesi

Belongs to the S100-fused protein family.Curated
Contains 1 EF-hand domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IH2F. Eukaryota.
ENOG4111DAC. LUCA.
GeneTreeiENSGT00530000063634.
HOGENOMiHOG000111974.
HOVERGENiHBG072082.
InParanoidiQ9UBG3.
OMAiGQTRGTE.
OrthoDBiEOG7QC7VH.
PhylomeDBiQ9UBG3.
TreeFamiTF338665.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR026792. Cornulin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF26. PTHR11639:SF26. 2 hits.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UBG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD
60 70 80 90 100
PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ
110 120 130 140 150
ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP
160 170 180 190 200
GVQTQGQATG SAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR
210 220 230 240 250
NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT
260 270 280 290 300
GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ
310 320 330 340 350
TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ
360 370 380 390 400
AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP
410 420 430 440 450
GGQAQTGAST ESGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET
460 470 480 490
VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP
Length:495
Mass (Da):53,533
Last modified:May 1, 2000 - v1
Checksum:iC4882A11B4E64DC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271A → V.
Corresponds to variant rs35639220 [ dbSNP | Ensembl ].
VAR_048469
Natural varianti374 – 3741Q → H.
Corresponds to variant rs6695830 [ dbSNP | Ensembl ].
VAR_048470
Natural varianti480 – 4801G → S.
Corresponds to variant rs3829868 [ dbSNP | Ensembl ].
VAR_048471

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077831 mRNA. Translation: AAD55747.1.
AF185276 Genomic DNA. Translation: AAF00514.1.
AK316568 mRNA. Translation: BAG38157.1.
AL135842 Genomic DNA. Translation: CAI23349.1.
CH471121 Genomic DNA. Translation: EAW53381.1.
BC030807 mRNA. Translation: AAH30807.1.
CCDSiCCDS1010.1.
RefSeqiNP_057274.1. NM_016190.2.
UniGeneiHs.242057.

Genome annotation databases

EnsembliENST00000271835; ENSP00000271835; ENSG00000143536.
GeneIDi49860.
KEGGihsa:49860.
UCSCiuc001ezx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077831 mRNA. Translation: AAD55747.1.
AF185276 Genomic DNA. Translation: AAF00514.1.
AK316568 mRNA. Translation: BAG38157.1.
AL135842 Genomic DNA. Translation: CAI23349.1.
CH471121 Genomic DNA. Translation: EAW53381.1.
BC030807 mRNA. Translation: AAH30807.1.
CCDSiCCDS1010.1.
RefSeqiNP_057274.1. NM_016190.2.
UniGeneiHs.242057.

3D structure databases

ProteinModelPortaliQ9UBG3.
SMRiQ9UBG3. Positions 4-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119069. 23 interactions.
IntActiQ9UBG3. 1 interaction.
STRINGi9606.ENSP00000271835.

PTM databases

iPTMnetiQ9UBG3.
PhosphoSiteiQ9UBG3.

Polymorphism and mutation databases

BioMutaiCRNN.
DMDMi74761891.

Proteomic databases

EPDiQ9UBG3.
PaxDbiQ9UBG3.
PeptideAtlasiQ9UBG3.
PRIDEiQ9UBG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271835; ENSP00000271835; ENSG00000143536.
GeneIDi49860.
KEGGihsa:49860.
UCSCiuc001ezx.3. human.

Organism-specific databases

CTDi49860.
GeneCardsiCRNN.
HGNCiHGNC:1230. CRNN.
HPAiCAB026182.
HPA024343.
MIMi611312. gene.
neXtProtiNX_Q9UBG3.
PharmGKBiPA25601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH2F. Eukaryota.
ENOG4111DAC. LUCA.
GeneTreeiENSGT00530000063634.
HOGENOMiHOG000111974.
HOVERGENiHBG072082.
InParanoidiQ9UBG3.
OMAiGQTRGTE.
OrthoDBiEOG7QC7VH.
PhylomeDBiQ9UBG3.
TreeFamiTF338665.

Miscellaneous databases

GenomeRNAii49860.
NextBioi53028.
PROiQ9UBG3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UBG3.
CleanExiHS_CRNN.
GenevisibleiQ9UBG3. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR026792. Cornulin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF26. PTHR11639:SF26. 2 hits.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer."
    Xu Z., Wang M.-R., Xu X., Cai Y., Han Y.-L., Wu K.-M., Wang J., Chen B.-S., Wang X.-Q., Wu M.
    Genomics 69:322-330(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal esophagus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Esophagus.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  6. "The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response."
    Yagui-Beltran A., Craig A.L., Lawrie L., Thompson D., Pospisilova S., Johnston D., Kernohan N., Hopwood D., Dillon J.F., Hupp T.R.
    Eur. J. Biochem. 268:5343-5355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Chromosome 1 open reading frame 10 (C1orf10) gene is frequently down-regulated and inhibits cell proliferation in oral squamous cell carcinoma."
    Imai F.L., Uzawa K., Nimura Y., Moriya T., Imai M.A., Shiiba M., Bukawa H., Yokoe H., Tanzawa H.
    Int. J. Biochem. Cell Biol. 37:1641-1655(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION, TISSUE SPECIFICITY.
  8. "Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation."
    Contzler R., Favre B., Huber M., Hohl D.
    J. Invest. Dermatol. 124:990-997(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease."
    Johnston N., Dettmar P.W., Lively M.O., Postma G.N., Belafsky P.C., Birchall M., Koufman J.A.
    Ann. Otol. Rhinol. Laryngol. 115:47-58(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury."
    Darragh J., Hunter M., Pohler E., Nelson L., Dillon J.F., Nenutil R., Vojtesek B., Ross P.E., Kernohan N., Hupp T.R.
    FEBS J. 273:1930-1947(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  11. "Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers."
    Luthra M.G., Ajani J.A., Izzo J., Ensor J., Wu T.T., Rashid A., Zhang L., Phan A., Fukami N., Luthra R.
    Clin. Cancer Res. 13:912-919(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCRNN_HUMAN
AccessioniPrimary (citable) accession number: Q9UBG3
Secondary accession number(s): B2RE60, Q8N613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds calcium with an affinity similar to that of the S100 proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.