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Q9UBG0

- MRC2_HUMAN

UniProt

Q9UBG0 - MRC2_HUMAN

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Protein

C-type mannose receptor 2

Gene

MRC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. collagen binding Source: UniProt

GO - Biological processi

  1. collagen catabolic process Source: UniProt
  2. endocytosis Source: UniProtKB-KW
  3. osteoblast differentiation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type mannose receptor 2
Alternative name(s):
C-type lectin domain family 13 member E
Endocytic receptor 180
Macrophage mannose receptor 2
Urokinase-type plasminogen activator receptor-associated protein
Short name:
UPAR-associated protein
Short name:
Urokinase receptor-associated protein
CD_antigen: CD280
Gene namesi
Name:MRC2
Synonyms:CLEC13E, ENDO180, KIAA0709, UPARAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16875. MRC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 14141384ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1415 – 143521HelicalSequence AnalysisAdd
BLAST
Topological domaini1436 – 147944CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. focal adhesion Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi472 – 4721N → D: Reduced sugar-binding activity. 1 Publication
Mutagenesisi1452 – 14521Y → A: No alteration of distribution and trafficking. 1 Publication
Mutagenesisi1464 – 14641E → A: Increased cell surface distribution. 1 Publication
Mutagenesisi1468 – 14692LV → AA: Reduction of endocytotic activity; distribution almost restricted to the cell surface. 1 Publication

Organism-specific databases

PharmGKBiPA134988161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 14791449C-type mannose receptor 2PRO_0000046078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 68By similarity
Glycosylationi69 – 691N-linked (GlcNAc...) (complex)2 Publications
Disulfide bondi93 ↔ 112By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi187 ↔ 213By similarity
Disulfide bondi201 ↔ 228By similarity
Disulfide bondi266 ↔ 359By similarity
Disulfide bondi335 ↔ 351By similarity
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi410 ↔ 504By similarity
Disulfide bondi481 ↔ 496By similarity
Glycosylationi588 – 5881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi618 ↔ 635By similarity
Disulfide bondi704 ↔ 808By similarity
Disulfide bondi785 ↔ 800By similarity
Disulfide bondi853 ↔ 950By similarity
Disulfide bondi927 ↔ 942By similarity
Glycosylationi954 – 9541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1029 – 10291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1078 ↔ 1098By similarity
Cross-linki1142 – 1142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO-1)
Disulfide bondi1220 ↔ 1234By similarity
Glycosylationi1350 – 13501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1369 ↔ 1384By similarity

Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9UBG0.
PaxDbiQ9UBG0.
PRIDEiQ9UBG0.

PTM databases

PhosphoSiteiQ9UBG0.

Expressioni

Tissue specificityi

Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.2 Publications

Gene expression databases

BgeeiQ9UBG0.
CleanExiHS_MRC2.
ExpressionAtlasiQ9UBG0. baseline and differential.
GenevestigatoriQ9UBG0.

Organism-specific databases

HPAiHPA041991.

Interactioni

Subunit structurei

Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.By similarity1 Publication

Protein-protein interaction databases

BioGridi115231. 6 interactions.
IntActiQ9UBG0. 1 interaction.
STRINGi9606.ENSP00000307513.

Structurei

3D structure databases

ProteinModelPortaliQ9UBG0.
SMRiQ9UBG0. Positions 161-645, 681-811, 828-952, 972-1109, 1145-1243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 167127Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini182 – 23049Fibronectin type-IIPROSITE-ProRule annotationAdd
BLAST
Domaini244 – 360117C-type lectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 505117C-type lectin 2PROSITE-ProRule annotationAdd
BLAST
Domaini528 – 644117C-type lectin 3PROSITE-ProRule annotationAdd
BLAST
Domaini678 – 809132C-type lectin 4PROSITE-ProRule annotationAdd
BLAST
Domaini832 – 951120C-type lectin 5PROSITE-ProRule annotationAdd
BLAST
Domaini979 – 1107129C-type lectin 6PROSITE-ProRule annotationAdd
BLAST
Domaini1132 – 1243112C-type lectin 7PROSITE-ProRule annotationAdd
BLAST
Domaini1273 – 1393121C-type lectin 8PROSITE-ProRule annotationAdd
BLAST

Domaini

C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
Fibronectin type-II domain mediates collagen-binding.
Ricin B-type lectin domain contacts with the second C-type lectin domain.By similarity

Sequence similaritiesi

Contains 8 C-type lectin domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-II domain.PROSITE-ProRule annotation
Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288621.
GeneTreeiENSGT00720000108514.
HOGENOMiHOG000231191.
HOVERGENiHBG053606.
InParanoidiQ9UBG0.
KOiK06560.
OMAiMEMNEQQ.
OrthoDBiEOG7FFMQR.
PhylomeDBiQ9UBG0.
TreeFamiTF316663.

Family and domain databases

Gene3Di2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
[Graphical view]
SMARTiSM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 3 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UBG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPGRPAPAP WPRHLLRCVL LLGCLHLGRP GAPGDAALPE PNVFLIFSHG
60 70 80 90 100
LQGCLEAQGG QVRVTPACNT SLPAQRWKWV SRNRLFNLGT MQCLGTGWPG
110 120 130 140 150
TNTTASLGMY ECDREALNLR WHCRTLGDQL SLLLGARTSN ISKPGTLERG
160 170 180 190 200
DQTRSGQWRI YGSEEDLCAL PYHEVYTIQG NSHGKPCTIP FKYDNQWFHG
210 220 230 240 250
CTSTGREDGH LWCATTQDYG KDERWGFCPI KSNDCETFWD KDQLTDSCYQ
260 270 280 290 300
FNFQSTLSWR EAWASCEQQG ADLLSITEIH EQTYINGLLT GYSSTLWIGL
310 320 330 340 350
NDLDTSGGWQ WSDNSPLKYL NWESDQPDNP SEENCGVIRT ESSGGWQNRD
360 370 380 390 400
CSIALPYVCK KKPNATAEPT PPDRWANVKV ECEPSWQPFQ GHCYRLQAEK
410 420 430 440 450
RSWQESKKAC LRGGGDLVSI HSMAELEFIT KQIKQEVEEL WIGLNDLKLQ
460 470 480 490 500
MNFEWSDGSL VSFTHWHPFE PNNFRDSLED CVTIWGPEGR WNDSPCNQSL
510 520 530 540 550
PSICKKAGQL SQGAAEEDHG CRKGWTWHSP SCYWLGEDQV TYSEARRLCT
560 570 580 590 600
DHGSQLVTIT NRFEQAFVSS LIYNWEGEYF WTALQDLNST GSFFWLSGDE
610 620 630 640 650
VMYTHWNRDQ PGYSRGGCVA LATGSAMGLW EVKNCTSFRA RYICRQSLGT
660 670 680 690 700
PVTPELPGPD PTPSLTGSCP QGWASDTKLR YCYKVFSSER LQDKKSWVQA
710 720 730 740 750
QGACQELGAQ LLSLASYEEE HFVANMLNKI FGESEPEIHE QHWFWIGLNR
760 770 780 790 800
RDPRGGQSWR WSDGVGFSYH NFDRSRHDDD DIRGCAVLDL ASLQWVAMQC
810 820 830 840 850
DTQLDWICKI PRGTDVREPD DSPQGRREWL RFQEAEYKFF EHHSTWAQAQ
860 870 880 890 900
RICTWFQAEL TSVHSQAELD FLSHNLQKFS RAQEQHWWIG LHTSESDGRF
910 920 930 940 950
RWTDGSIINF ISWAPGKPRP VGKDKKCVYM TASREDWGDQ RCLTALPYIC
960 970 980 990 1000
KRSNVTKETQ PPDLPTTALG GCPSDWIQFL NKCFQVQGQE PQSRVKWSEA
1010 1020 1030 1040 1050
QFSCEQQEAQ LVTITNPLEQ AFITASLPNV TFDLWIGLHA SQRDFQWVEQ
1060 1070 1080 1090 1100
EPLMYANWAP GEPSGPSPAP SGNKPTSCAV VLHSPSAHFT GRWDDRSCTE
1110 1120 1130 1140 1150
ETHGFICQKG TDPSLSPSPA ALPPAPGTEL SYLNGTFRLL QKPLRWHDAL
1160 1170 1180 1190 1200
LLCESRNASL AYVPDPYTQA FLTQAARGLR TPLWIGLAGE EGSRRYSWVS
1210 1220 1230 1240 1250
EEPLNYVGWQ DGEPQQPGGC TYVDVDGAWR TTSCDTKLQG AVCGVSSGPP
1260 1270 1280 1290 1300
PPRRISYHGS CPQGLADSAW IPFREHCYSF HMELLLGHKE ARQRCQRAGG
1310 1320 1330 1340 1350
AVLSILDEME NVFVWEHLQS YEGQSRGAWL GMNFNPKGGT LVWQDNTAVN
1360 1370 1380 1390 1400
YSNWGPPGLG PSMLSHNSCY WIQSNSGLWR PGACTNITMG VVCKLPRAEQ
1410 1420 1430 1440 1450
SSFSPSALPE NPAALVVVLM AVLLLLALLT AALILYRRRQ SIERGAFEGA
1460 1470
RYSRSSSSPT EATEKNILVS DMEMNEQQE
Length:1,479
Mass (Da):166,674
Last modified:January 11, 2011 - v2
Checksum:iAAAA5286F91DF7E7
GO

Sequence cautioni

The sequence BAA31684.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431V → I.1 Publication
Corresponds to variant rs2014055 [ dbSNP | Ensembl ].
VAR_025304
Natural varianti1156 – 11561R → H.5 Publications
Corresponds to variant rs2429387 [ dbSNP | Ensembl ].
VAR_025305

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107292 mRNA. Translation: AAF14192.1.
AF134838 mRNA. Translation: AAD30280.1.
AB014609 mRNA. Translation: BAA31684.2. Different initiation.
AC080038 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94341.1.
CH471109 Genomic DNA. Translation: EAW94342.1.
BC146647 mRNA. Translation: AAI46648.1.
BC150212 mRNA. Translation: AAI50213.1.
BC153884 mRNA. Translation: AAI53885.1.
CCDSiCCDS11634.1.
RefSeqiNP_006030.2. NM_006039.4.
UniGeneiHs.7835.

Genome annotation databases

EnsembliENST00000303375; ENSP00000307513; ENSG00000011028.
GeneIDi9902.
KEGGihsa:9902.
UCSCiuc002jad.4. human.

Polymorphism databases

DMDMi317373394.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Endo180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107292 mRNA. Translation: AAF14192.1 .
AF134838 mRNA. Translation: AAD30280.1 .
AB014609 mRNA. Translation: BAA31684.2 . Different initiation.
AC080038 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94341.1 .
CH471109 Genomic DNA. Translation: EAW94342.1 .
BC146647 mRNA. Translation: AAI46648.1 .
BC150212 mRNA. Translation: AAI50213.1 .
BC153884 mRNA. Translation: AAI53885.1 .
CCDSi CCDS11634.1.
RefSeqi NP_006030.2. NM_006039.4.
UniGenei Hs.7835.

3D structure databases

ProteinModelPortali Q9UBG0.
SMRi Q9UBG0. Positions 161-645, 681-811, 828-952, 972-1109, 1145-1243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115231. 6 interactions.
IntActi Q9UBG0. 1 interaction.
STRINGi 9606.ENSP00000307513.

Protein family/group databases

MEROPSi I63.001.

PTM databases

PhosphoSitei Q9UBG0.

Polymorphism databases

DMDMi 317373394.

Proteomic databases

MaxQBi Q9UBG0.
PaxDbi Q9UBG0.
PRIDEi Q9UBG0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303375 ; ENSP00000307513 ; ENSG00000011028 .
GeneIDi 9902.
KEGGi hsa:9902.
UCSCi uc002jad.4. human.

Organism-specific databases

CTDi 9902.
GeneCardsi GC17P060704.
H-InvDB HIX0018596.
HIX0027238.
HGNCi HGNC:16875. MRC2.
HPAi HPA041991.
MIMi 612264. gene.
neXtProti NX_Q9UBG0.
PharmGKBi PA134988161.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288621.
GeneTreei ENSGT00720000108514.
HOGENOMi HOG000231191.
HOVERGENi HBG053606.
InParanoidi Q9UBG0.
KOi K06560.
OMAi MEMNEQQ.
OrthoDBi EOG7FFMQR.
PhylomeDBi Q9UBG0.
TreeFami TF316663.

Enzyme and pathway databases

Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).

Miscellaneous databases

ChiTaRSi MRC2. human.
GenomeRNAii 9902.
NextBioi 37337.
PROi Q9UBG0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UBG0.
CleanExi HS_MRC2.
ExpressionAtlasi Q9UBG0. baseline and differential.
Genevestigatori Q9UBG0.

Family and domain databases

Gene3Di 2.10.10.10. 1 hit.
3.10.100.10. 8 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000562. FN_type2_col-bd.
IPR013806. Kringle-like.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF00040. fn2. 1 hit.
PF00059. Lectin_C. 8 hits.
[Graphical view ]
SMARTi SM00034. CLECT. 8 hits.
SM00059. FN2. 1 hit.
SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF56436. SSF56436. 8 hits.
SSF57440. SSF57440. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 3 hits.
PS50041. C_TYPE_LECTIN_2. 8 hits.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A urokinase receptor-associated protein with specific collagen binding properties."
    Behrendt N., Jensen O.N., Engelholm L.H., Moertz E., Mann M., Danoe K.
    J. Biol. Chem. 275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 350-360, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, VARIANT HIS-1156.
  2. "Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor."
    Sheikh H., Yarwood H., Ashworth A., Isacke C.M.
    J. Cell Sci. 113:1021-1032(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, GLYCOSYLATION, TISSUE SPECIFICITY, VARIANTS ILE-43 AND HIS-1156.
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-1156.
    Tissue: Brain.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-1156.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-1156.
  7. "Characterization of a novel member of the macrophage mannose receptor type C lectin family."
    Wu K., Yuan J., Lasky L.A.
    J. Biol. Chem. 271:21323-21330(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family."
    Howard M.J., Isacke C.M.
    J. Biol. Chem. 277:32320-32331(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF TYR-1452; GLU-1464 AND 1468-LEU-VAL-1469.
  9. "Characterization of sugar binding by the mannose receptor family member, Endo180."
    East L., Rushton S., Taylor M.E., Isacke C.M.
    J. Biol. Chem. 277:50469-50475(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, MUTAGENESIS OF ASN-472.
  10. "Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor."
    Wienke D., MacFadyen J.R., Isacke C.M.
    Mol. Biol. Cell 14:3592-3604(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-69.
    Tissue: Liver.
  12. Cited for: GLYCOSYLATION AT ASN-69.
  13. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
    Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice N.A., Eriksson J.E., Sistonen L.
    J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-1142.
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMRC2_HUMAN
AccessioniPrimary (citable) accession number: Q9UBG0
Secondary accession number(s): A6H8K4
, D3DU08, Q7LGE7, Q9Y5P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3